SI1095064T1 - Amidi hialuronske kisline in njihovi derivati ter postopek njihove priprave - Google Patents

Amidi hialuronske kisline in njihovi derivati ter postopek njihove priprave

Info

Publication number
SI1095064T1
SI1095064T1 SI9930816T SI9930816T SI1095064T1 SI 1095064 T1 SI1095064 T1 SI 1095064T1 SI 9930816 T SI9930816 T SI 9930816T SI 9930816 T SI9930816 T SI 9930816T SI 1095064 T1 SI1095064 T1 SI 1095064T1
Authority
SI
Slovenia
Prior art keywords
group
hyaluronic acid
arylaliphatic
cycloaliphatic
aliphatic
Prior art date
Application number
SI9930816T
Other languages
English (en)
Inventor
Davide Bellini
Alessandra Topai
Original Assignee
Fidia Farmaceutici
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Farmaceutici filed Critical Fidia Farmaceutici
Publication of SI1095064T1 publication Critical patent/SI1095064T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • External Artificial Organs (AREA)
SI9930816T 1998-07-06 1999-07-06 Amidi hialuronske kisline in njihovi derivati ter postopek njihove priprave SI1095064T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT98PD000169A ITPD980169A1 (it) 1998-07-06 1998-07-06 Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
PCT/IB1999/001254 WO2000001733A1 (en) 1998-07-06 1999-07-06 Amides of hyaluronic acid and the derivatives thereof and a process for their preparation
EP99929619A EP1095064B1 (en) 1998-07-06 1999-07-06 Amides of hyaluronic acid and the derivatives thereof and a process for their preparation

Publications (1)

Publication Number Publication Date
SI1095064T1 true SI1095064T1 (sl) 2005-12-31

Family

ID=11392271

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9930816T SI1095064T1 (sl) 1998-07-06 1999-07-06 Amidi hialuronske kisline in njihovi derivati ter postopek njihove priprave

Country Status (14)

Country Link
US (2) US7884087B1 (sl)
EP (2) EP1589036A1 (sl)
JP (3) JP2002519481A (sl)
AT (1) ATE297413T1 (sl)
AU (1) AU761986B2 (sl)
CA (1) CA2339066C (sl)
DE (1) DE69925733T2 (sl)
DK (1) DK1095064T3 (sl)
ES (1) ES2244198T3 (sl)
IL (2) IL140604A0 (sl)
IT (1) ITPD980169A1 (sl)
PT (1) PT1095064E (sl)
SI (1) SI1095064T1 (sl)
WO (1) WO2000001733A1 (sl)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITPD980169A1 (it) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
DE60107560T2 (de) * 2000-05-03 2006-01-05 FIDIA ADVANCED BIOPOLYMERS, S.R.L., Abano Terme Preadipozyten enthaltende biomaterialien zur regeneration von weichgewebe
IT1317359B1 (it) * 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Polisaccaridi percarbossilati, quali l'acido ialuronico, processo perla loro preparazione e loro impiego in campo farmaceutico e
KR100375299B1 (ko) * 2000-10-10 2003-03-10 주식회사 엘지생명과학 히알루론산의 가교결합형 아마이드 유도체와 이의 제조방법
US7060297B2 (en) 2000-11-06 2006-06-13 Alcon, Inc. Carrageenan viscoelastics for ocular surgery
SV2003000753A (es) 2000-12-05 2003-06-16 Brigham & Womens Hospital Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico
ITPD20010032A1 (it) 2001-02-09 2002-08-09 Fidia Advanced Biopolymers Srl Innesti ingegnerizzati per la riparazione di difetti osteocondrali
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
JP2003190259A (ja) * 2001-12-28 2003-07-08 Hisako Ogawara 人工臓器用チャンバー
ITPD20020003A1 (it) * 2002-01-11 2003-07-11 Fidia Advanced Biopolymers Srl Biomateriali a base di acido ialuronico come terapia anti-angiogenicanella cura dei tumori.
ITPD20020064A1 (it) 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
DE10393060D2 (de) * 2002-05-09 2005-05-04 Hemoteq Gmbh Reduktion der Schallemission von dünnwadigen Bauteilen in Magnetresonazgeräten
ITMI20021666A1 (it) * 2002-07-26 2004-01-26 Jasper Ltd Liability Co Derivati dell'acido ialuronico
ITPD20020271A1 (it) * 2002-10-18 2004-04-19 Fidia Farmaceutici Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati.
CA2503489C (en) * 2002-10-25 2013-09-10 Essentia Biosystems, Inc. Modulation of zinc levels to improve tissue properties
CN1739017B (zh) 2002-12-11 2011-04-06 弗罗桑医疗设备公司 用作拭子的基于明胶的材料
WO2004060404A1 (ja) * 2002-12-27 2004-07-22 Chugai Seiyaku Kabushiki Kaisha 薬物担体
US6982298B2 (en) 2003-01-10 2006-01-03 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8137688B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US7465766B2 (en) 2004-01-08 2008-12-16 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8138265B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
CA2520865A1 (en) 2003-03-31 2004-10-21 The Brigham And Women's Hospital, Inc. Zwitterionic immunomodulators for the treatment of asthma and allergy
EP1666518B1 (en) 2003-09-08 2018-03-28 Chugai Seiyaku Kabushiki Kaisha Hyaluronic acid modification products and drug carriers using them
WO2005054302A1 (ja) * 2003-12-05 2005-06-16 Chugai Seiyaku Kabushiki Kaisha 薬物担体及びその製造方法
NZ549010A (en) * 2004-01-07 2010-07-30 Seikagaku Kogyo Co Ltd Hyaluronic acid derivative and drug containing the same
CN1921896B (zh) 2004-01-30 2010-11-24 弗罗桑公司 止血喷雾剂和组合物
ITPD20040053A1 (it) * 2004-02-27 2004-05-27 Fidia Advanced Biopolymers Srl Biomateriali costituiti da derivati dell'acido ialuronico come nuova terapia di cura per la protezione e la la riparazione della cartilagine articolare danneggiata per osteoartrosi
ITMI20041373A1 (it) 2004-07-09 2004-10-09 Lima Lto S P A N-metil-ammidi di carbossimetilcellulosa acido alginico o carbossimetalamido
CN102382308B (zh) * 2004-07-09 2014-04-16 克利夫兰临床基金会 羟基苯交联大分子网络及其应用
JP4959557B2 (ja) 2004-07-09 2012-06-27 フェロサン メディカル デバイシーズ エイ／エス ヒアルロン酸含有止血合成剤
EP1790665B1 (en) * 2004-09-07 2014-11-05 Chugai Seiyaku Kabushiki Kaisha Process for producing water-soluble modified hyaluronic acid
ITPD20050056A1 (it) * 2005-03-02 2006-09-03 Fidia Farmaceutici Derivati ammidici del'acido ialuronico in osteoartrosi
JP4902134B2 (ja) * 2005-04-25 2012-03-21 帝人株式会社 癒着防止材
ITPD20050206A1 (it) 2005-07-07 2007-01-08 Fidia Advanced Biopolymers Srl Biomateriali in forma di fibra da impiegarsi come dispositivi medici nel trattamento delle ferite e loro processi di produzione
US20080221063A1 (en) * 2005-07-08 2008-09-11 Astrazeneca Ab Heterocyclic Sulfonamide Derivatives As Inhibitors Of Factor Xa
ITPD20050242A1 (it) 2005-08-03 2007-02-04 Fidia Farmaceutici Bioconiugati antitumorali dell'acido ialuronico o dei suoi derivati, ottenibili per coniugazione chimica diretta o indiretta, e loro impiego in campo farmaceutico
CA2625532C (en) * 2005-10-12 2013-10-01 Seikagaku Corporation Agent for applying to mucosa containing a hydrophobic group binding type glycosaminoglycan
AU2012201314B2 (en) * 2005-10-12 2014-04-10 Seikagaku Corporation Agent for applying to mucosa and method for production thereof
US8206726B2 (en) 2006-02-06 2012-06-26 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
AU2014200868B2 (en) * 2006-12-06 2016-01-07 Seikagaku Corporation Pharmaceutical agent having long-lasting effect of treating arthritic disorders
TWI528964B (zh) 2006-12-06 2016-04-11 生化學工業股份有限公司 治療關節失調之長效藥劑
US8329870B2 (en) 2007-01-04 2012-12-11 Hepacore Ltd. Water soluble reactive derivatives of carboxy polysaccharides and fibrinogen conjugates thereof
CN101020725B (zh) * 2007-03-23 2010-09-15 天津大学 一类双亲性壳聚糖长链烷基季铵盐及其制备方法
ITMI20071267A1 (it) 2007-06-22 2008-12-23 Fidia Farmaceutici Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative
ITMI20071724A1 (it) 2007-09-05 2009-03-06 Fidia Farmaceutici Formulazioni topiche antivirali in forma di gel bioadesivo
JP2011503104A (ja) 2007-11-09 2011-01-27 カリフォルニア インスティテュート オブ テクノロジー 免疫調節化合物ならびに関連組成物および方法
KR101577471B1 (ko) 2007-11-16 2015-12-14 알러간, 인코포레이티드 자색반병의 치료를 위한 조성물 및 방법
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
ITMI20072416A1 (it) 2007-12-21 2009-06-22 Sigea Srl Derivati polisaccaridici dell'acido lipoico, loro preparazione ed uso come dermocosmetici e presidi medicali
WO2009102967A2 (en) 2008-02-13 2009-08-20 The Cleveland Clinic Foundation Molecular enhancement of extracellular matrix and methods of use
EP2259803B2 (en) 2008-02-29 2019-03-13 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US8410180B2 (en) 2008-04-30 2013-04-02 The Cleveland Clinic Foundation Methods to treat urinary incontinence
US8450475B2 (en) 2008-08-04 2013-05-28 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
WO2010028025A1 (en) 2008-09-02 2010-03-11 Gurtner Geoffrey C Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
US8624077B2 (en) 2008-10-02 2014-01-07 L.R.R.&D. Ltd. Interface layer wound dressing
JP2010163485A (ja) * 2009-01-13 2010-07-29 Teijin Ltd カルボキシ多糖類の溶液
EP2420517A4 (en) 2009-04-17 2013-04-03 Teijin Ltd POLYSAC CHARID DERIVATIVE AND HYDROGEL THEREOF
IT1399351B1 (it) 2009-06-16 2013-04-16 Fidia Farmaceutici Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi
IT1394570B1 (it) 2009-07-02 2012-07-05 Fidia Farmaceutici Materiale biologico adatto per la terapia dell osteoartrosi del danno dei legamenti e per il trattamento delle patologie delle articolazioni.
IT1395392B1 (it) * 2009-08-27 2012-09-14 Fidia Farmaceutici Geli viscoelastici come nuovi filler
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
CA2792729C (en) 2010-03-12 2016-06-28 Allergan Industrie, Sas Fluid compositions for improving skin conditions
DK2550027T4 (da) 2010-03-22 2019-05-13 Allergan Inc Tværbundne polysaccharid- og protein-polysaccharid-hydrogeler til blødvævsforøgelse
DK2555753T3 (en) 2010-04-07 2018-11-26 California Inst Of Techn Vesicle for delivering a compound to a mucosal membrane as well as corresponding compositions, methods and systems
CA2800174A1 (en) 2010-05-20 2011-11-24 June L. Round Antigen specific tregs and related compositions, methods and systems
WO2012008722A2 (ko) * 2010-07-12 2012-01-19 신풍제약 주식회사 조직 증강용 충전 조성물
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
CZ305040B6 (cs) 2010-09-14 2015-04-08 Contipro Biotech S.R.O. Způsob přípravy vysoce substituovaných amidů kyseliny hyaluronové
CN101972489A (zh) * 2010-09-30 2011-02-16 吴奕光 一种新型创面自修复生物材料及其制备方法和用途
ES2385239B1 (es) 2010-09-30 2013-06-19 Proteos Biotech S.L.U. Uso de colagenasa g recombinante, colagenasa h recombinante y pz-peptidasa recombinante para el tratamiento de enfermedades que cursan con alteraciones del colágeno.
JP6141180B2 (ja) 2011-03-03 2017-06-07 中外製薬株式会社 アミノ−カルボン酸により修飾されたヒアルロン酸誘導体
WO2012140650A2 (en) 2011-04-12 2012-10-18 Hepacore Ltd. Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
WO2012167079A2 (en) 2011-06-03 2012-12-06 Allergan, Inc. Dermal filler compositions including antioxidants
US8658593B2 (en) 2011-06-06 2014-02-25 The Cleveland Clinic Foundation Treatment of extracellular matrix to reduce inflammation
US9539281B2 (en) 2011-07-12 2017-01-10 The Brigham And Women's Hospital, Inc. Lipid-containing PSA compositions, methods of isolation and methods of use thereof
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
CA2865349C (en) 2012-03-06 2021-07-06 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
JP6104232B2 (ja) 2012-03-27 2017-03-29 テルモ株式会社 コーティング組成物および医療機器
WO2013146380A1 (ja) * 2012-03-27 2013-10-03 テルモ株式会社 コーティング組成物および医療機器
WO2013146381A1 (ja) * 2012-03-27 2013-10-03 テルモ株式会社 薬剤コート層およびこれを有する医療機器
ITPD20120098A1 (it) 2012-03-30 2013-10-01 Fidia Farmaceutici "nuove formulazioni faramaceutiche contenenti condroitin solfato e derivati dell'acido ialuronico"
ITPD20120173A1 (it) * 2012-05-31 2013-12-01 Fidia Farmaceutici "nuovo sistema di rilascio di proteine idrofobiche"
RU2636240C2 (ru) 2012-06-12 2017-11-21 Ферросан Медикал Дивайсиз А/С Сухая гемостатическая композиция
US11564971B2 (en) 2012-09-05 2023-01-31 Chugai Seiyaku Kabushiki Kaisha Hyaluronic acid derivative having amino acid and steryl group introduced thereinto
CN103720712A (zh) * 2012-10-10 2014-04-16 上海工程技术大学 一种制备季铵化壳聚糖纳米碘消毒剂的方法
CZ2012841A3 (cs) * 2012-11-27 2014-02-19 Contipro Biotech S.R.O. Vlákna založená na hydrofobizovaném hyaluronanu, způsob jejich přípravy a použití, textilie na jejich bázi a použití
JP6363119B2 (ja) * 2013-03-14 2018-07-25 アナコティ リミテッド ヒアルロン酸誘導体
ITPD20130110A1 (it) 2013-04-24 2014-10-25 Fidia Farmaceutici Composizioni farmaceutiche comprendenti acido ialuronico per il trattamento del black disc
JP2016521284A (ja) 2013-05-10 2016-07-21 カリフォルニア インスティチュート オブ テクノロジー 大腸ガンのプロバイオティクスによる防止および処置
RU2700162C2 (ru) 2013-06-21 2019-09-13 Ферросан Медикал Дивайсиз А/С Расширенная под вакуумом сухая композиция и шприц для ее сохранения
JP6357228B2 (ja) 2013-07-10 2018-07-11 マトリックス バイオロジー インスティテュート 高い弾性を有するヒアルロナンの組成物およびその使用
US9572832B2 (en) * 2013-08-29 2017-02-21 Holy Stone Healthcare Co., Ltd. Compound of glycosaminoglycan and its fabrication method as well as application
US10047172B2 (en) 2013-09-30 2018-08-14 Galderma S.A. Single step functionalization and cross-linking of hyaluronic acid
WO2015048988A1 (en) 2013-10-02 2015-04-09 Ao Technology Ag Thermosensitive hyaluronic acid conjugates and methods for the preparation thereof
EP3079731B1 (en) 2013-12-11 2018-08-08 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
CA3187647A1 (en) 2014-06-15 2015-12-23 Yeda Research And Development Co. Ltd. Surface treatment by water-soluble polymers and lipids/liposomes
CZ2014451A3 (cs) * 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
ES2761558T3 (es) 2014-09-30 2020-05-20 Allergan Ind Sas Composiciones de hidrogel estables que incluyen aditivos
BR112017007466B1 (pt) 2014-10-13 2021-03-02 Ferrosan Medical Devices A/S método para preparar uma composição seca, método para reconstituir a composição seca, pasta, composição seca, recipiente, kit homeostático, e, uso de uma composição seca
WO2016102446A1 (en) 2014-12-24 2016-06-30 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
JP6613300B2 (ja) * 2015-03-31 2019-11-27 キユーピー株式会社 ヒアルロン酸誘導体およびその製造方法、ならびにヒアルロン酸誘導体を含む化粧料、食品組成物および医薬組成物
US11331335B2 (en) 2015-06-10 2022-05-17 California Institute Of Technology Sepsis treatment and related compositions methods and systems
CA2986981A1 (en) 2015-07-03 2017-01-12 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
CN108135167B (zh) 2015-08-19 2021-07-09 哈佛学院院长及董事 脂化psa组合物和方法
EP3842047A1 (en) 2015-09-24 2021-06-30 Matrix Biology Institute High elasticity hyaluronan compositions and methods of use thereof
EP3252082A1 (en) * 2016-05-31 2017-12-06 Galderma S.A. Method for deacetylation of biopolymers
BR112018013523B1 (pt) 2015-12-29 2022-06-14 Galderma S.A. Produto de hidrogel compreendendo moléculas de glicosaminoglicano reticuladas e processo para preparação de um produto de hidrogel
EP3448394B1 (en) 2016-04-27 2023-09-13 Anika Therapeutics, Inc. Compositions for use in treating tendon degeneration
PT3623390T (pt) 2016-05-31 2023-10-27 Galderma Sa Reticulador de hidrato de carbono
EP3484441A4 (en) 2016-07-15 2020-03-18 President and Fellows of Harvard College GLYCOLIPID COMPOSITIONS AND METHODS OF USE
WO2018024902A1 (en) * 2016-08-04 2018-02-08 Biokawthar Technologies Uses of hydrophobically-modified hyaluronic acid through amide and/or hydrazide linkages in cosmetics and/or dermatology
CZ2016826A3 (cs) 2016-12-22 2018-07-04 Contipro A.S. Léčivý prostředek s nosičem na bázi hyaluronanu a/nebo jeho derivátů, způsob výroby a použití
CN110891611B (zh) 2017-03-22 2024-03-29 阿森迪斯制药公司 水凝胶交联透明质酸前药组合物和方法
IT201700122135A1 (it) * 2017-10-26 2019-04-26 Jointherapeutics S R L Acido ialuronico funzionalizzato o suo derivato nel trattamento di stati infiammatori
WO2020144372A1 (en) 2019-01-10 2020-07-16 The Provost, Fellows, Scholars And Other Members Of Board Of Trinity College Dublin Composite viscoelastic hydrogel, and uses thereof for sealing a channel in tissue
CA3087820A1 (en) 2018-01-10 2019-07-18 The Provost, Fellows, Scholars And Other Members Of Board Of Trinity College Dublin System and methods for sealing a channel in tissue
IT201800001890A1 (it) * 2018-01-25 2019-07-25 Fidia Farm Spa Composizioni farmaceutiche per il trattamento del dolore postoperatorio
IT201900006250A1 (it) 2019-04-23 2020-10-23 Fidia Farm Spa Medicazione per il trattamento della cute lesa
KR20210008479A (ko) 2018-05-09 2021-01-22 훼로산 메디칼 디바이스 에이/에스 지혈 조성물을 제조하는 방법
KR102240726B1 (ko) * 2019-01-31 2021-04-16 주식회사 에스엔비아 방사성 동위원소가 표지된 광가교성 하이드로젤 및 그 제조 방법
WO2020181356A1 (en) * 2019-03-08 2020-09-17 Queen's University At Kingston Hyaluronic acid derivatives for wound healing
CN109762078B (zh) * 2019-04-09 2019-07-23 中国科学院烟台海岸带研究所 一种羟丙基三甲基氯化铵壳聚糖-羧基多糖复合盐及制备方法和应用
IT201900006038A1 (it) 2019-04-18 2020-10-18 Fidia Farm Spa Composizioni farmaceutiche comprendenti statine e derivati dell’acido ialuronico
JP2022529953A (ja) * 2019-04-19 2022-06-27 ジョインセラピュイティクス エッセ．エッレ．エッレ． 官能化ヒアルロン酸の架橋ポリマーと、炎症状態の治療におけるその使用
WO2020240034A1 (en) 2019-05-31 2020-12-03 University College Dublin Hyaluronic acid-based hybrid hydrogel
IT201900009933A1 (it) 2019-06-24 2020-12-24 Fidia Farm Spa Composizioni farmaceutiche comprendenti derivati ammidici dell'acido ialuronico per uso nel trattamento di traumi ossei, in particolare in pazienti con problemi di osteopenia o osteoporosi
CN110760014A (zh) * 2019-11-19 2020-02-07 恩施徕福硒业有限公司 一种从茯苓中提取硒多糖的提取装置及工艺
US11730691B2 (en) 2019-12-02 2023-08-22 Galderma Holding SA High molecular weight esthetic compositions
IT202000005692A1 (it) 2020-03-17 2021-09-17 Fidia Farm Spa Bio-inchiostro per stampa 3D, relativo coniugato e processo di preparazione di un intermedio costituito da un linker fotoreattivo
IT202100032111A1 (it) 2021-12-22 2023-06-22 Fidia Farm Spa Nuovi sostituti biocompatibili dell’umor vitreo

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55161801A (en) * 1979-06-06 1980-12-16 Seikagaku Kogyo Co Ltd Fluorescence-labeled acid mucopolysaccharide and preparation thereof
US4851521A (en) 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US4937270A (en) 1987-09-18 1990-06-26 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
IT1217458B (it) 1988-05-02 1990-03-22 Crinos Ind Farmacoriologica S Sulfoamino derivati di condroitin solfati,del dermatan solfato e dell' acido ialuronico e loro proprieta' farmacologiche
US5510418A (en) 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
JPH0755961B2 (ja) 1989-04-18 1995-06-14 工業技術院長 新規なヒアルロン酸誘導体及びその製造方法
EP0416250A3 (en) 1989-08-01 1991-08-28 The Research Foundation Of State University Of New York N-acylurea and o-acylisourea derivatives of hyaluronic acid
US5733891A (en) * 1990-10-18 1998-03-31 Shiseido Co., Ltd. Compound for medicinal ingredient and hyaluronic acid and process for producing the same
CA2070672C (en) 1990-10-18 2002-10-08 Kazuo Akima Compound of medicinal ingredient and hyaluronic acid and process for producing the same
JP2855307B2 (ja) * 1992-02-05 1999-02-10 生化学工業株式会社 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法
US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
IT1260154B (it) * 1992-07-03 1996-03-28 Lanfranco Callegaro Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
IT1263316B (it) * 1993-02-12 1996-08-05 Fidia Advanced Biopolymers Srl Tessuto non tessuto multistrato in cui uno degli strati e' costituito essenzialmente da esteri dell'acido ialuronico
IT1268955B1 (it) * 1994-03-11 1997-03-18 Fidia Advanced Biopolymers Srl Esteri attivi di polisaccaridi carbossilici
CA2162957C (en) 1994-11-17 2011-08-02 Michinori Waki Cinnamic acid derivative
IT1281876B1 (it) * 1995-05-10 1998-03-03 Fidia Advanced Biopolymers Srl Acido ialuronico e suoi derivati esterei per la preparazione di matrici per il rilascio controllato di farmaci.
JP4018181B2 (ja) 1995-11-07 2007-12-05 生化学工業株式会社 グリコサミノグリカン誘導体およびその製造法
JP3047801B2 (ja) 1995-12-20 2000-06-05 株式会社日立製作所 プラズマ処理方法及び装置
JP3925955B2 (ja) 1996-04-26 2007-06-06 株式会社クラレ 癒着防止材
JP3955652B2 (ja) 1996-10-15 2007-08-08 株式会社ネーテック 合成アミノ糖類誘導体及びその製造方法
JPH10298164A (ja) * 1997-02-27 1998-11-10 Tanabe Seiyaku Co Ltd イソキノリノン誘導体、その製法及びその合成中間体
CA2285542C (en) * 1997-04-04 2007-07-17 Fidia Advanced Biopolymers Srl N-sulphated hyaluronic acid compounds, derivatives thereof and a process for their preparation
JP3410476B2 (ja) * 1997-04-18 2003-05-26 大鵬薬品工業株式会社 新規なエポキシコハク酸アミド誘導体又はその塩
GB9710990D0 (en) * 1997-05-28 1997-07-23 Danisco Modification process
ITPD980169A1 (it) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
IT1303735B1 (it) 1998-11-11 2001-02-23 Falorni Italia Farmaceutici S Acidi ialuronici reticolati e loro usi medici.
KR100375299B1 (ko) 2000-10-10 2003-03-10 주식회사 엘지생명과학 히알루론산의 가교결합형 아마이드 유도체와 이의 제조방법
KR20040009891A (ko) 2002-07-26 2004-01-31 주식회사 엘지생명과학 히알루론산의 유도체 겔 및 그 제조방법

Also Published As

Publication number Publication date
ATE297413T1 (de) 2005-06-15
WO2000001733A1 (en) 2000-01-13
CA2339066C (en) 2012-04-03
JP2011174079A (ja) 2011-09-08
AU761986B2 (en) 2003-06-12
US8575129B2 (en) 2013-11-05
EP1589036A1 (en) 2005-10-26
ES2244198T3 (es) 2005-12-01
ITPD980169A1 (it) 2000-01-06
JP2007031721A (ja) 2007-02-08
PT1095064E (pt) 2005-10-31
DK1095064T3 (da) 2005-10-03
CA2339066A1 (en) 2000-01-13
JP2002519481A (ja) 2002-07-02
DE69925733D1 (de) 2005-07-14
IL140604A0 (en) 2002-02-10
JP4791921B2 (ja) 2011-10-12
US7884087B1 (en) 2011-02-08
EP1095064A1 (en) 2001-05-02
AU4639799A (en) 2000-01-24
DE69925733T2 (de) 2006-03-16
EP1095064B1 (en) 2005-06-08
US20100158796A1 (en) 2010-06-24
IL140604A (en) 2010-06-16

Similar Documents

Publication Publication Date Title
IL140604A0 (en) Amides of hyaluronic acid and the derivatives thereof and a process for their preparation
DK0731085T3 (da) Stilbenderivater og farmaceutiske sammensætinger indeholdende disse
ES8802494A1 (es) Procedimiento para la obtencion de derivados de acidos benzoheterociclilalcanoicos
ZA918893B (en) Mono-n-substituted 1,4,7,10-tetraazacyclododecane derivatives,process for their production and pharmaceutical agents containing these derivatives
CA2086654A1 (en) Novel pharmaceutically active 1,2,4-triaminobenzene derivatives, processes for their preparation and pharmaceutical compositions containing them
FI950309A0 (fi) Proliiniamidijohdannaisia
HUP0004853A2 (hu) Hepatitis C inhibitor peptidek, eljárás ezek előállítására, azokat tartalmazó gyógyszerkészítmények, alkalmazásuk és intermediereik
HUT64842A (en) Method for producing pharmaceutical preparatives containing 2-[n-(2-amino-ethyl)-amino]-acetic acid derivatives
AU2505297A (en) Acylated N-hydroxymethyl thalidomide prodrugs having an immunomodulatory effect
MX9705559A (es) Derivados de acido neuraminico, su preparacion y su uso en medicina.
DE69624582D1 (de) Ester und amide als pla2-inhibitoren
HK1040237A1 (en) Fused polycyclic amino acids as pharmaceutical agents.
MX9605737A (es) Transfeccion de celulas.
PH24709A (en) Allylmercaptoacetylsydnonimines and pharmaceutical compositions thereof
DE69429753T2 (de) Anitbiotisch wirksame Cephalosporine und Verfahren zu ihrer Herstellung
ES2189323T3 (es) Procedimiento para la preparacion de 3-amino-2-oxo-pirrolidinas, productos intermedios y su utilizacion.
AU2630095A (en) Novel amine derivative, process for producing the same, and use thereof as antiarrhythmic
IL95619A0 (en) N-azabicyclo(3.3.0)octane amides of aromatic acids and pharmaceutical compositions containing them
CA2277151A1 (en) Synthesis of acyclic nucleoside derivatives
CA2251060A1 (en) Acylated n-hydroxy methyl thalidomide prodrugs with immunomodulator action
IT1276710B1 (it) Derivati dell'acido fosfinico ad attivita' inibitrice delle metallopeptidasi
HUP9903414A2 (en) 3-alkoxypyridine-2-carboxylic acid amide esters,their preparation and their use as drugs
EP0826663A3 (en) Alkynylamino acid derivatives and their use as pharmaceutical compounds