ES2189323T3 - Procedimiento para la preparacion de 3-amino-2-oxo-pirrolidinas, productos intermedios y su utilizacion. - Google Patents

Procedimiento para la preparacion de 3-amino-2-oxo-pirrolidinas, productos intermedios y su utilizacion.

Info

Publication number
ES2189323T3
ES2189323T3 ES99116580T ES99116580T ES2189323T3 ES 2189323 T3 ES2189323 T3 ES 2189323T3 ES 99116580 T ES99116580 T ES 99116580T ES 99116580 T ES99116580 T ES 99116580T ES 2189323 T3 ES2189323 T3 ES 2189323T3
Authority
ES
Spain
Prior art keywords
halo
alkyl
substituted
optionally
alkoxyalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99116580T
Other languages
English (en)
Inventor
Karlheinz Drauz
Ingo Klement
Gunter Knaup
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH filed Critical Degussa GmbH
Application granted granted Critical
Publication of ES2189323T3 publication Critical patent/ES2189323T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • C07C381/12—Sulfonium compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

La producción de derivados de la 3-amino-2-pirrolidinona, útiles como productos intermedios para la obtención de compuestos biológicamente activos, comprende la ciclación de un nuevo derivado de la metionina S-sustituida. Los derivados de la 3-amino-2-pirrolidinona (I) y sus sales se producen mediante la ciclación de un derivado de la metionina S-sustituido (II). Los derivados de la metionina S-sustituida (II) son nuevos. La producción de los derivados de la 3-amino-2-pirrolidinona (I) y de sus sales comprende la ciclación de un derivado de la metionina S-sustituida (II): R1 = H, alquilo, alquenilo, alcoxialquilo o acilo opcionalmente sustituidos con halo o grupos que contengan N, O, P o S; cicloalquilo opcionalmente insaturado, opcionalmente sustituido con alquilo, alquenilo, acilo, alcóxido, alcoxialquilo, halo o grupos que contengan N, O, P o S y que contengan opcionalmente heteroátomos en el anillo; arilo, aralquilo, heteroarilo o heteroaralquilo opcionalmente sustituido en el anillo con alquilo, alquenilo, alquinilo, acilo, alcóxido, alcoxialquilo, halo, CN, CONH2 o grupos que contengan N, O, P o S; o un aminoácido N- enlazado o un grupo peptídico; R2 = H, alquilo, alquenilo, alquinilo o alcoxialquilo opcionalmente sustituido con halo o grupos que contengan N, O, P o S; cicloalquilo opcionalmente insaturado, opcionalmente sustituido con alquilo, alquenilo, acilo, alcóxido, alcoxialquilo, halo o grupos que contengan N, O, P o S y/o que opcionalmente contengan heteroátomos en el anillo; arilo, aralquilo, heteroarilo o heteroaralquilo opcionalmente sustituido en el anillo con alquilo, alquenilo, alquinilo, acilo, alcóxido, alcoxialquilo, halo o grupos que contengan N, O, P o S; R3 = H; acilo, un aminoácido C- enlazado o un grupo peptídico; o un grupo de protección peptídico; e Y = alquileno opcionalmente sustituido con alquilo, halo, OH o fenilo; o aralquilo opcionalmente sustituido con alquilo, halo u OH. Las definiciones completas se dan en el campo DEFINICIONES (Definiciones Completas). También se incluyen reivindicaciones independientes para lo siguiente: 1) derivados de la metionina S-sustituidos de la fórmula (II) y sus sales de adición y 2) la preparación de compuestos de la fórmula (II).
ES99116580T 1998-09-11 1999-08-25 Procedimiento para la preparacion de 3-amino-2-oxo-pirrolidinas, productos intermedios y su utilizacion. Expired - Lifetime ES2189323T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19841895A DE19841895A1 (de) 1998-09-11 1998-09-11 Neues Verfahren zur Herstellung von 3-Amino-2-oxo-pyrrolidinen, neue Zwischenprodukte und deren Verwendung

Publications (1)

Publication Number Publication Date
ES2189323T3 true ES2189323T3 (es) 2003-07-01

Family

ID=7880819

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99116580T Expired - Lifetime ES2189323T3 (es) 1998-09-11 1999-08-25 Procedimiento para la preparacion de 3-amino-2-oxo-pirrolidinas, productos intermedios y su utilizacion.

Country Status (7)

Country Link
US (1) US6156908A (es)
EP (1) EP0985665B1 (es)
JP (1) JP2000086626A (es)
AT (1) ATE229504T1 (es)
DE (2) DE19841895A1 (es)
DK (1) DK0985665T3 (es)
ES (1) ES2189323T3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8583001A1 (es) 2002-09-20 2004-04-23 Hoffmann La Roche Derivados de 4-pirrolidino-fenil-bencil eter como inhibidores de mao-b
WO2005007641A1 (en) * 2003-07-03 2005-01-27 Euro-Celtique S.A. 2-pyridine alkyne derivatives useful for treating pain
CA2543287A1 (en) 2003-10-23 2005-05-06 F.Hoffmann-La Roche Ag Benzazepine derivatives as mao-b inhibitors
CA2555961A1 (en) * 2004-02-23 2005-09-09 Trustees Of Tufts College Lactams as conformationally constrained peptidomimetic inhibitors
GB0518235D0 (en) * 2005-09-07 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4377515A (en) * 1979-10-01 1983-03-22 Merck & Co., Inc. Long lasting agonists and antagonists of LH-RH
US5721366A (en) * 1993-03-31 1998-02-24 G. D. Searle & Co Platelet aggregation inhibitors
US5610296A (en) * 1994-12-05 1997-03-11 G. D. Searle & Co. Process for the preparation of amidino phenyl pyrrolidine beta-alanine urea analogs

Also Published As

Publication number Publication date
DE19841895A1 (de) 2000-03-23
JP2000086626A (ja) 2000-03-28
EP0985665A1 (de) 2000-03-15
ATE229504T1 (de) 2002-12-15
US6156908A (en) 2000-12-05
DK0985665T3 (da) 2003-03-17
EP0985665B1 (de) 2002-12-11
DE59903722D1 (de) 2003-01-23

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