MX9705559A - Derivados de acido neuraminico, su preparacion y su uso en medicina. - Google Patents

Derivados de acido neuraminico, su preparacion y su uso en medicina.

Info

Publication number
MX9705559A
MX9705559A MX9705559A MX9705559A MX9705559A MX 9705559 A MX9705559 A MX 9705559A MX 9705559 A MX9705559 A MX 9705559A MX 9705559 A MX9705559 A MX 9705559A MX 9705559 A MX9705559 A MX 9705559A
Authority
MX
Mexico
Prior art keywords
group
acid derivatives
neuraminic acid
alkyl group
rao
Prior art date
Application number
MX9705559A
Other languages
English (en)
Inventor
Takeshi Honda
Yoshiyuki Kobayashi
Takeshi Masuda
Makoto Yamashita
Masami Arai
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of MX9705559A publication Critical patent/MX9705559A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Abstract

Los compuestos de la formula (I): [en donde R1 es alquilo o halogenoalquilo; R2 y R3 representan cada una hidrogeno o acilo alifático; X es hidroxi, halogeno, alcoxi o un grupo de la formula RaO-; en donde Ra es acilo alifático; Y es un grupo de la formula RbRcN- o RbRcNO- en donde Rb y Rc son cada una hidrogeno o alquilo; y Z es oxígeno o azufre] tienen excelente actividad inhibidora de sialidasa y, por lo tanto, son utiles para el tratamiento o la prevencion de la influenza y otras enfermedades virales, en donde la reproduccion del virus es susceptible a los inhibidores de sialidasa.
MX9705559A 1996-07-22 1997-07-22 Derivados de acido neuraminico, su preparacion y su uso en medicina. MX9705559A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19186296 1996-07-22
JP8688897 1997-04-04

Publications (1)

Publication Number Publication Date
MX9705559A true MX9705559A (es) 1998-05-31

Family

ID=26427962

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9705559A MX9705559A (es) 1996-07-22 1997-07-22 Derivados de acido neuraminico, su preparacion y su uso en medicina.

Country Status (20)

Country Link
EP (1) EP0823428B1 (es)
KR (1) KR100506578B1 (es)
CN (1) CN1127494C (es)
AT (1) ATE211468T1 (es)
AU (1) AU700926B2 (es)
CA (1) CA2210492C (es)
CZ (1) CZ291960B6 (es)
DE (1) DE69709795T2 (es)
DK (1) DK0823428T3 (es)
ES (1) ES2167682T3 (es)
HK (1) HK1007879A1 (es)
HU (1) HU223494B1 (es)
ID (1) ID17474A (es)
IL (1) IL121305A (es)
MX (1) MX9705559A (es)
NO (1) NO317704B1 (es)
NZ (1) NZ328353A (es)
PT (1) PT823428E (es)
RU (1) RU2124509C1 (es)
TW (1) TW418200B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451766B1 (en) 1996-07-22 2002-09-17 Sankyo Company, Limited Neuraminic acid derivatives, their preparation and their medical use
US6340702B1 (en) 1996-07-22 2002-01-22 Sankyo Company, Limited Neuraminic acid derivatives, their preparation and their medical use
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
TWI291462B (en) 2000-04-25 2007-12-21 Daiichi Sankyo Co Ltd Hydrate crystal of neuraminic acid compound
FR2809104B1 (fr) * 2000-05-19 2002-08-02 Univ Paris Curie Procede de traitement de matiere vegetale, compositions comportant des derives du type n-acylglucosamine, utilisation de ces composes en tant qu'agents bio- protecteurs, et matiere vegetale traitee.
AU2001256759A1 (en) * 2000-05-19 2001-11-26 Sankyo Company Limited Sialic acid derivatives
AUPR001000A0 (en) 2000-09-08 2000-10-05 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
WO2002076980A1 (fr) * 2001-03-27 2002-10-03 Sankyo Company, Limited Derives d'acide sialique
WO2002092555A1 (fr) * 2001-05-11 2002-11-21 Sankyo Company, Limited Derives d'acides sialiques
ES2372996T3 (es) * 2007-03-07 2012-01-30 Daiichi Sankyo Company, Limited Fármaco para el tratamiento de gripe.
TWI460182B (zh) * 2007-04-11 2014-11-11 Daiichi Sankyo Co Ltd 原酸酯之製造方法
KR100930963B1 (ko) * 2008-02-26 2009-12-11 한국기계연구원 적층형 압전파이로트 밸브를 이용한 공조기용 팽창밸브
KR20110098760A (ko) * 2008-11-28 2011-09-01 시플라 리미티드 자나미비르의 제조방법 및 상기 제조방법에 사용되는 중간체
TWI491416B (zh) 2008-12-24 2015-07-11 Daiichi Sankyo Co Ltd 吸入用乾燥粉末醫藥組成物
EP2429991B1 (en) 2009-05-15 2014-09-10 Redx Pharma Limited Redox drug derivatives
CN102532080A (zh) * 2010-12-29 2012-07-04 中国科学院上海药物研究所 新型唾液酸衍生物及其制备方法,包含该衍生物的药物组合物,以及其用途
EP2792676A4 (en) * 2011-12-16 2015-10-07 Daiichi Sankyo Co Ltd PROCESS FOR PREPARING NEURAMINE ACID DERIVATIVES
CN111018901B (zh) * 2013-09-09 2021-09-03 中国科学院上海有机化学研究所 扎那米韦和拉那米韦的中间体及其合成方法
CN114843564B (zh) * 2022-03-28 2023-08-25 电子科技大学 一种阴阳离子共掺杂的固体氧化物电池氧电极材料及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP249A (en) * 1990-04-24 1993-03-17 Biota Scient Management Pty Ltd Anti-viral compounds.
AU659501B2 (en) * 1991-10-23 1995-05-18 Biota Scientific Management Pty Ltd Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of alpha-D-neuraminic acid
GB9325841D0 (en) * 1993-12-17 1994-02-23 Glaxo Group Ltd Chemical compounds
GB9400206D0 (en) * 1994-01-07 1994-03-02 Glaxo Group Ltd Chemical compound
AUPM354694A0 (en) * 1994-01-27 1994-02-17 Biota Scientific Management Pty Ltd Chemical compounds
GB9516276D0 (en) * 1995-08-08 1995-10-11 Biota Scient Management Chemical compounds

Also Published As

Publication number Publication date
EP0823428A2 (en) 1998-02-11
IL121305A (en) 2003-01-12
AU700926B2 (en) 1999-01-14
CZ231697A3 (cs) 1998-02-18
CN1172807A (zh) 1998-02-11
NO973363D0 (no) 1997-07-21
NZ328353A (en) 1998-03-25
HU223494B1 (hu) 2004-08-30
ATE211468T1 (de) 2002-01-15
NO973363L (no) 1998-01-23
HU9701270D0 (en) 1997-09-29
EP0823428A3 (en) 1998-02-25
IL121305A0 (en) 1998-01-04
CN1127494C (zh) 2003-11-12
CZ291960B6 (cs) 2003-06-18
HUP9701270A3 (en) 2002-08-28
CA2210492C (en) 2002-10-29
CA2210492A1 (en) 1998-01-22
TW418200B (en) 2001-01-11
PT823428E (pt) 2002-04-29
DE69709795T2 (de) 2002-09-26
DE69709795D1 (de) 2002-02-28
HK1007879A1 (en) 1999-04-30
KR980009253A (ko) 1998-04-30
EP0823428B1 (en) 2002-01-02
ES2167682T3 (es) 2002-05-16
HUP9701270A2 (hu) 1999-09-28
NO317704B1 (no) 2004-12-06
KR100506578B1 (ko) 2005-12-26
DK0823428T3 (da) 2002-02-18
ID17474A (id) 1998-01-08
RU2124509C1 (ru) 1999-01-10
AU2866297A (en) 1998-07-02

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