SG11201503821YA - Oligonucleotide conjugates - Google Patents

Oligonucleotide conjugates

Info

Publication number
SG11201503821YA
SG11201503821YA SG11201503821YA SG11201503821YA SG11201503821YA SG 11201503821Y A SG11201503821Y A SG 11201503821YA SG 11201503821Y A SG11201503821Y A SG 11201503821YA SG 11201503821Y A SG11201503821Y A SG 11201503821YA SG 11201503821Y A SG11201503821Y A SG 11201503821YA
Authority
SG
Singapore
Prior art keywords
oligonucleotide conjugates
conjugates
oligonucleotide
Prior art date
Application number
SG11201503821YA
Other languages
English (en)
Inventor
Nanna Albæk
Henrik Frydenlund Hansen
Susanne Kammler
Jacob Ravn
HENRIK øRUM
Original Assignee
Roche Innovation Ct Copenhagen As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Innovation Ct Copenhagen As filed Critical Roche Innovation Ct Copenhagen As
Publication of SG11201503821YA publication Critical patent/SG11201503821YA/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3517—Marker; Tag
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    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised

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SG11201503821YA 2012-11-15 2013-11-14 Oligonucleotide conjugates SG11201503821YA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12192773 2012-11-15
EP13153296 2013-01-30
EP13157237 2013-02-28
EP13174092 2013-06-27
PCT/EP2013/073858 WO2014076195A1 (en) 2012-11-15 2013-11-14 Oligonucleotide conjugates

Publications (1)

Publication Number Publication Date
SG11201503821YA true SG11201503821YA (en) 2015-06-29

Family

ID=49584733

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201503821YA SG11201503821YA (en) 2012-11-15 2013-11-14 Oligonucleotide conjugates
SG10201804331TA SG10201804331TA (en) 2012-11-15 2013-11-14 Oligonucleotide conjugates

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201804331TA SG10201804331TA (en) 2012-11-15 2013-11-14 Oligonucleotide conjugates

Country Status (22)

Country Link
US (4) US20150291958A1 (bg)
EP (3) EP3406718A1 (bg)
JP (3) JP2016503300A (bg)
KR (2) KR20150083920A (bg)
CN (3) CN117126846A (bg)
AU (2) AU2013346767B2 (bg)
BR (2) BR112015010116A2 (bg)
CA (2) CA2889596C (bg)
DK (2) DK2920304T3 (bg)
ES (1) ES2724853T3 (bg)
HK (2) HK1210213A1 (bg)
HR (1) HRP20190826T1 (bg)
IL (2) IL238448B (bg)
MX (2) MX363068B (bg)
MY (1) MY173826A (bg)
NZ (1) NZ708171A (bg)
PL (1) PL2920304T3 (bg)
RU (3) RU2653438C2 (bg)
SG (2) SG11201503821YA (bg)
SI (1) SI2920304T1 (bg)
WO (2) WO2014076196A1 (bg)
ZA (1) ZA201503375B (bg)

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