SE462454B - Maetyta foer anvaendning i biosensorer - Google Patents

Maetyta foer anvaendning i biosensorer

Info

Publication number
SE462454B
SE462454B SE8804073A SE8804073A SE462454B SE 462454 B SE462454 B SE 462454B SE 8804073 A SE8804073 A SE 8804073A SE 8804073 A SE8804073 A SE 8804073A SE 462454 B SE462454 B SE 462454B
Authority
SE
Sweden
Prior art keywords
measuring surface
groups
surface according
dextran
hydrogel
Prior art date
Application number
SE8804073A
Other languages
English (en)
Swedish (sv)
Other versions
SE8804073L (sv
SE8804073D0 (sv
Inventor
J Bergstroem
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20373907&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE462454(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of SE8804073D0 publication Critical patent/SE8804073D0/xx
Priority to SE8804073A priority Critical patent/SE462454B/sv
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Priority to JP1511405A priority patent/JP2815120B2/ja
Priority to PCT/SE1989/000642 priority patent/WO1990005303A1/en
Priority to DE68926255T priority patent/DE68926255T2/de
Priority to US07/681,531 priority patent/US5242828A/en
Priority to AT89912283T priority patent/ATE136651T1/de
Priority to EP89912283A priority patent/EP0589867B1/en
Publication of SE8804073L publication Critical patent/SE8804073L/xx
Publication of SE462454B publication Critical patent/SE462454B/sv
Priority to US08/279,089 priority patent/US5436161A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SE8804073A 1988-11-10 1988-11-10 Maetyta foer anvaendning i biosensorer SE462454B (sv)

Priority Applications (8)

Application Number Priority Date Filing Date Title
SE8804073A SE462454B (sv) 1988-11-10 1988-11-10 Maetyta foer anvaendning i biosensorer
EP89912283A EP0589867B1 (en) 1988-11-10 1989-11-09 Sensing surfaces capable of selective biomolecular interactions, to be used in biosensor systems
JP1511405A JP2815120B2 (ja) 1988-11-10 1989-11-09 バイオセンサーシステムに使用する選択的生体分子相互作用の可能な検出表面
AT89912283T ATE136651T1 (de) 1988-11-10 1989-11-09 Fühleroberflächen, fähig zur selektiven biomolekularen interaktionen zur verwendung in biosensorsystemen
PCT/SE1989/000642 WO1990005303A1 (en) 1988-11-10 1989-11-09 Sensing surfaces capable of selective biomolecular interactions, to be used in biosensor systems
DE68926255T DE68926255T2 (de) 1988-11-10 1989-11-09 Fühleroberflächen, fähig zur selektiven biomolekularen interaktionen zur verwendung in biosensorsystemen
US07/681,531 US5242828A (en) 1988-11-10 1989-11-09 Sensing surfaces capable of selective biomolecular interactions, to be used in biosensor systems
US08/279,089 US5436161A (en) 1988-11-10 1994-07-22 Matrix coating for sensing surfaces capable of selective biomolecular interactions, to be used in biosensor systems

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8804073A SE462454B (sv) 1988-11-10 1988-11-10 Maetyta foer anvaendning i biosensorer

Publications (3)

Publication Number Publication Date
SE8804073D0 SE8804073D0 (sv) 1988-11-10
SE8804073L SE8804073L (sv) 1990-05-11
SE462454B true SE462454B (sv) 1990-06-25

Family

ID=20373907

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8804073A SE462454B (sv) 1988-11-10 1988-11-10 Maetyta foer anvaendning i biosensorer

Country Status (7)

Country Link
US (2) US5242828A (ja)
EP (1) EP0589867B1 (ja)
JP (1) JP2815120B2 (ja)
AT (1) ATE136651T1 (ja)
DE (1) DE68926255T2 (ja)
SE (1) SE462454B (ja)
WO (1) WO1990005303A1 (ja)

Families Citing this family (499)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE462454B (sv) * 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
WO1992003732A2 (en) * 1990-08-28 1992-03-05 Bioprobe International, Inc. Compositions and methods for enhanced binding in biological assays
SE501013C2 (sv) * 1990-10-01 1994-10-17 Pharmacia Biosensor Ab Förfarande för förbättring av analys med bindning till fast fas
DE59106527D1 (de) * 1990-11-14 1995-10-26 Hoffmann La Roche Immunsensorischer Wandler und Verfahren zu seiner Herstellung.
US5763191A (en) * 1990-12-12 1998-06-09 Boehringer Mannheim Gmbh Universal binding film
JPH06507709A (ja) * 1991-06-04 1994-09-01 ファイスンズ　ピーエルシー 分析装置
USRE40835E1 (en) * 1992-01-16 2009-07-07 BioGenx Laboratories, Inc. Enhancement of immunochemical staining in aldehyde-fixed tissue
DE4216980C2 (de) * 1992-05-19 1994-04-21 Eppendorf Geraetebau Netheler Immunosensorisches Nachweisverfahren
WO1993025910A1 (en) * 1992-06-05 1993-12-23 Pharmacia Biosensor Ab Assay for multiple analytes with co-immobilized ligands
DK100592D0 (da) * 1992-08-10 1992-08-10 Mouritsen & Elsner Aps Metode til kemisk kobling paa faste faser
US5656504A (en) * 1992-10-26 1997-08-12 Pharmacia Biosensor Ab Method of preventing undesired binding in solid phase assays
WO1994019694A1 (en) * 1993-02-19 1994-09-01 Arris Pharmaceutical Corporation Thin film hpmp matrix systems and methods for constructing and displaying ligands
US5919712A (en) 1993-05-18 1999-07-06 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5395587A (en) * 1993-07-06 1995-03-07 Smithkline Beecham Corporation Surface plasmon resonance detector having collector for eluted ligate
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US20010055581A1 (en) 1994-03-18 2001-12-27 Lawrence Tamarkin Composition and method for delivery of biologically-active factors
BE1008221A3 (fr) * 1994-03-28 1996-02-20 Anda Biolog Sa Support solide fixant au moins un composant a activite biologique comprenant un site reactionnel, stabilise et procede pour son obtention.
GB9419001D0 (en) 1994-09-21 1994-11-09 Applied Research Systems Assay method
DE4433980C2 (de) * 1994-09-23 1996-08-22 Boehringer Ingelheim Int Verfahren und Biosensorhit zur Untersuchung der Wechselwirkung von Biomolekülen mittels Oberflächen-Plasma-Resonanz
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US6472148B1 (en) 1994-09-26 2002-10-29 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
SE9403245D0 (sv) * 1994-09-26 1994-09-26 Pharmacia Biosensor Ab Improvements relating to bilayer lipid membranes
JP3362192B2 (ja) * 1994-12-06 2003-01-07 味の素株式会社 検査方法及び検査薬
US5567301A (en) * 1995-03-01 1996-10-22 Illinois Institute Of Technology Antibody covalently bound film immunobiosensor
US5629213A (en) * 1995-03-03 1997-05-13 Kornguth; Steven E. Analytical biosensor
IL114692A (en) * 1995-07-21 1999-10-28 Yissum Res Dev Co Determination of an analyte in a liquid medium
GB9518429D0 (en) * 1995-09-08 1995-11-08 Pharmacia Biosensor A rapid method for providing kinetic and structural data in molecular interaction analysis
US6107080A (en) * 1996-04-25 2000-08-22 Mcgill University Biosensor device and method
WO1997041425A1 (en) * 1996-04-25 1997-11-06 Pence, Inc. Biosensor device and method
US5955379A (en) * 1996-04-25 1999-09-21 Mcgill University Biosensor device and method
US6165335A (en) * 1996-04-25 2000-12-26 Pence And Mcgill University Biosensor device and method
US6130037A (en) * 1996-04-25 2000-10-10 Pence And Mcgill University Biosensor device and method
US5852229A (en) * 1996-05-29 1998-12-22 Kimberly-Clark Worldwide, Inc. Piezoelectric resonator chemical sensing device
DE19622628A1 (de) * 1996-06-05 1997-12-11 Boehringer Mannheim Gmbh Stabilisierung von Metallkonjugaten
SE9602545L (sv) 1996-06-25 1997-12-26 Michael Mecklenburg Metod för att diskriminera komplexa biologiska prover
US5780251A (en) * 1996-06-27 1998-07-14 Fci Fiberchem, Inc. Ultrasensitive single-step, solid-state competitive immunoassay sensor with interference modifier and/or gel layer
US6020047A (en) * 1996-09-04 2000-02-01 Kimberly-Clark Worldwide, Inc. Polymer films having a printed self-assembling monolayer
US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US7393645B2 (en) 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
GB9623820D0 (en) * 1996-11-16 1997-01-08 Secr Defence Surface plasma resonance sensor
US5846843A (en) * 1996-11-18 1998-12-08 The University Of Toledo Sensor using long range surface plasmon resonance with diffraction double-grating
SE9604575D0 (sv) * 1996-12-12 1996-12-12 Biacore Ab Method and system for analyte determination
US5922550A (en) * 1996-12-18 1999-07-13 Kimberly-Clark Worldwide, Inc. Biosensing devices which produce diffraction images
US6048623A (en) * 1996-12-18 2000-04-11 Kimberly-Clark Worldwide, Inc. Method of contact printing on gold coated films
US6306584B1 (en) 1997-01-21 2001-10-23 President And Fellows Of Harvard College Electronic-property probing of biological molecules at surfaces
US5958704A (en) * 1997-03-12 1999-09-28 Ddx, Inc. Sensing system for specific substance and molecule detection
US6180288B1 (en) 1997-03-21 2001-01-30 Kimberly-Clark Worldwide, Inc. Gel sensors and method of use thereof
EP0977994A1 (en) * 1997-04-24 2000-02-09 American Home Products Corporation Method for the identification and characterization of nuclear receptor ligands
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US7560237B2 (en) 1997-06-12 2009-07-14 Osmetech Technology Inc. Electronics method for the detection of analytes
ES2183394T5 (es) * 1997-07-28 2012-05-03 Gen-Probe Incorporated Análisis de la secuencia de ácidos nucleicos
US7229841B2 (en) * 2001-04-30 2007-06-12 Cytimmune Sciences, Inc. Colloidal metal compositions and methods
US6407218B1 (en) * 1997-11-10 2002-06-18 Cytimmune Sciences, Inc. Method and compositions for enhancing immune response and for the production of in vitro mabs
DE19751658A1 (de) * 1997-11-21 1999-07-29 Wolfbeis Otto S Prof Dr Verfahren zur Bildung lateral organisierter Strukturen auf Trägeroberflächen
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6060256A (en) * 1997-12-16 2000-05-09 Kimberly-Clark Worldwide, Inc. Optical diffraction biosensor
DE19757302A1 (de) 1997-12-22 1999-07-01 Siemens Ag Beschichtung von Metalloberflächen insbesondere für die Mikroelektronik
US6087102A (en) 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
JP2002501001A (ja) 1998-01-22 2002-01-15 パーデュー・リサーチ・ファウンデーション 官能性多孔性珪素表面
US7090804B2 (en) 1998-01-27 2006-08-15 Clinical Mirco Sensors, Inc. Amplification of nucleic acids with electronic detection
ATE393912T1 (de) 1998-02-04 2008-05-15 Invitrogen Corp Microarrays und ihre verwendungen
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6472224B1 (en) 1998-04-17 2002-10-29 Franz Schleicher Biosensor with modified precious metal surface and process for the preparation thereof
DE19817180C2 (de) * 1998-04-17 2000-04-27 Biotul Bio Instr Gmbh Biosensor mit modifizierter Edelmetalloberfläche und Verfahren zu seiner Herstellung
DE19818360C2 (de) * 1998-04-24 2000-05-31 Suisse Electronique Microtech Dextranbeschichtete Oberfläche
CA2331189A1 (en) 1998-05-06 1999-11-11 Clinical Micro Sensors, Inc. Electronic methods for the detection of analytes utilizing monolayers
US6692696B1 (en) * 1998-06-18 2004-02-17 ARETé ASSOCIATES Biosensor
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US20050244954A1 (en) * 1998-06-23 2005-11-03 Blackburn Gary F Binding acceleration techniques for the detection of analytes
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US20020119579A1 (en) * 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
US6897073B2 (en) 1998-07-14 2005-05-24 Zyomyx, Inc. Non-specific binding resistant protein arrays and methods for making the same
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6576478B1 (en) 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6682942B1 (en) 1998-07-14 2004-01-27 Zyomyx, Inc. Microdevices for screening biomolecules
US6573107B1 (en) * 1998-08-05 2003-06-03 The University Of Wyoming Immunochemical detection of an explosive substance in the gas phase through surface plasmon resonance spectroscopy
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
AU1241000A (en) * 1998-10-27 2000-05-15 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
JP3657790B2 (ja) * 1998-11-09 2005-06-08 独立行政法人科学技術振興機構 Ｓｐｒセンサー用金属薄膜、その製法およびそれを用いた測定方法
US6221579B1 (en) 1998-12-11 2001-04-24 Kimberly-Clark Worldwide, Inc. Patterned binding of functionalized microspheres for optical diffraction-based biosensors
US6579673B2 (en) 1998-12-17 2003-06-17 Kimberly-Clark Worldwide, Inc. Patterned deposition of antibody binding protein for optical diffraction-based biosensors
US6833267B1 (en) * 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
ATE275728T1 (de) * 1999-01-12 2004-09-15 Ebara Corp Verfahren und biosensor zum nachweis von antigenen
EP1144677B1 (en) * 1999-01-25 2006-07-26 Micronas Holding GmbH Immobilization of molecules on surfaces via polymer brushes
EP1035218A1 (en) * 1999-03-03 2000-09-13 BioChip Technologies GmbH Immobilization of molecules on surfaces via polymer brushes
AUPP856399A0 (en) * 1999-02-08 1999-03-04 Australian Membrane And Biotechnology Research Institute Improved compounds for protein binding
DE19908525C2 (de) * 1999-02-26 2001-05-31 Inst Chemo Biosensorik Wasserlösliches Copolymer und Verwendung hiervon
US6787368B1 (en) 1999-03-02 2004-09-07 Helix Biopharma Corporation Biosensor method for detecting analytes in a liquid
JP2002537858A (ja) 1999-03-10 2002-11-12 エーエスエム サイエンティフィック， インコーポレイテッド 核酸の配列を直接決定するための方法
GB9907813D0 (en) 1999-04-06 1999-06-02 Medical Biosystems Ltd Synthesis
DE19916638C2 (de) * 1999-04-13 2002-11-07 Jandratek Gmbh Oberflächen zur Verbesserung des Bindungsverhaltens von Analytmolekülen auf der Basis kovalent gebundener hydrophiler Spacer an Hydrogelen
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6942771B1 (en) * 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US20040053290A1 (en) * 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
GB9909245D0 (en) 1999-04-22 1999-06-16 Univ Cranfield Reactive polymers and their application in reactions and assays
ATE504937T1 (de) * 1999-04-27 2011-04-15 Bio Rad Laboratories Probenhalter für ein gasphaseionenspektrometer
US6127129A (en) * 1999-05-04 2000-10-03 Wisconsin Alumni Research Foundation Process to create biomolecule and/or cellular arrays on metal surfaces and product produced thereby
US6489102B2 (en) 1999-08-05 2002-12-03 Wisconsin Alumni Research Foundation Biomolecule and/or cellular arrays on metal surfaces and product produced thereby
ATE295541T1 (de) * 1999-06-18 2005-05-15 Biacore Ab Verfahren und vorrichtung zur untersuchung von wirksstoffskandidaten und zur bestimmung ihrer pharmakokinetischen parametern
EP1208126B1 (en) 1999-07-02 2006-04-12 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto
ATE340996T1 (de) 1999-07-05 2006-10-15 Novartis Pharma Gmbh Verfahren zur anwendung einer sensoreinheit
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
AU6075900A (en) * 1999-07-07 2001-01-22 Mirus Corporation Substrates for nucleic acid immobilization onto solid supports
CA2380258C (en) 1999-07-26 2008-07-15 Clinical Micro Sensors, Inc. Sequence determination of nucleic acids using electronic detection
EP1212458A4 (en) 1999-07-30 2005-01-05 Surromed Inc INSTRUMENTS, METHODS AND REAGENTS FOR PLASMON SURFACE RESONANCE
US6908736B1 (en) 1999-10-06 2005-06-21 Medical Biosystems, Ltd. DNA sequencing method
GB9923644D0 (en) 1999-10-06 1999-12-08 Medical Biosystems Ltd DNA sequencing
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US8111401B2 (en) 1999-11-05 2012-02-07 Robert Magnusson Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats
US6399295B1 (en) 1999-12-17 2002-06-04 Kimberly-Clark Worldwide, Inc. Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors
WO2001050131A1 (en) * 2000-01-06 2001-07-12 Motorola, Inc. Three-dimensional network for biomolecule detection
US7998412B2 (en) 2000-01-07 2011-08-16 Smart Holograms Limited Ophthalmic device comprising a holographic sensor
GB0000209D0 (en) 2000-01-07 2000-03-01 Holmetrica Limited Holographic multiplexed image sensor
US6728429B1 (en) 2000-02-16 2004-04-27 Biotell, Inc. Optical detection
US6824669B1 (en) * 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
US6541071B1 (en) * 2000-03-23 2003-04-01 Corning Incorporated Method for fabricating supported bilayer-lipid membranes
CA2408291C (en) 2000-05-04 2014-07-15 Yale University High density protein arrays for screening of protein activity
DE10027776A1 (de) * 2000-06-07 2002-02-14 Roche Diagnostics Gmbh Neuartige core-shell Partikel
JP4382265B2 (ja) * 2000-07-12 2009-12-09 日本電気株式会社 酸化シリコン膜の形成方法及びその形成装置
WO2002006373A1 (en) * 2000-07-17 2002-01-24 University Of Utah Research Foundation Hydrogel films and methods of making and using therefor
EP1348125A1 (en) * 2000-10-26 2003-10-01 Glaucus Proteomics B.V. Products with biofunctional coating
US20030092075A1 (en) * 2000-10-30 2003-05-15 Sru Biosystems, Llc Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors
US7175980B2 (en) * 2000-10-30 2007-02-13 Sru Biosystems, Inc. Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities
US20030113766A1 (en) * 2000-10-30 2003-06-19 Sru Biosystems, Llc Amine activated colorimetric resonant biosensor
US7217574B2 (en) 2000-10-30 2007-05-15 Sru Biosystems, Inc. Method and apparatus for biosensor spectral shift detection
US7202076B2 (en) 2000-10-30 2007-04-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7875434B2 (en) 2000-10-30 2011-01-25 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7153702B2 (en) 2000-10-30 2006-12-26 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7575939B2 (en) * 2000-10-30 2009-08-18 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7306827B2 (en) 2000-10-30 2007-12-11 Sru Biosystems, Inc. Method and machine for replicating holographic gratings on a substrate
US7101660B2 (en) 2000-10-30 2006-09-05 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7300803B2 (en) * 2000-10-30 2007-11-27 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7264973B2 (en) * 2000-10-30 2007-09-04 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant optical biosensor
US7142296B2 (en) * 2000-10-30 2006-11-28 Sru Biosystems, Inc. Method and apparatus for detecting biomolecular interactions
US7118710B2 (en) * 2000-10-30 2006-10-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7615339B2 (en) 2000-10-30 2009-11-10 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US6951715B2 (en) * 2000-10-30 2005-10-04 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7023544B2 (en) 2000-10-30 2006-04-04 Sru Biosystems, Inc. Method and instrument for detecting biomolecular interactions
US7371562B2 (en) * 2000-10-30 2008-05-13 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7070987B2 (en) * 2000-10-30 2006-07-04 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US6686431B2 (en) * 2000-11-01 2004-02-03 Avery Dennison Corporation Optical coating having low refractive index
AU2001213911A1 (en) * 2000-11-02 2002-05-15 Jandratek Gmbh Surfaces comprising a hydrophilic spacer, covalently bonded to hydrogels
US20050084908A1 (en) * 2000-11-06 2005-04-21 Chugai Seiyaku Kabushiki Kaisha Methods for detecting binding of low-molecular-weight compound and its binding partner molecule
US6967074B2 (en) * 2000-11-08 2005-11-22 Surface Logix, Inc. Methods of detecting immobilized biomolecules
US7351575B2 (en) * 2000-11-08 2008-04-01 Surface Logix, Inc. Methods for processing biological materials using peelable and resealable devices
US7371563B2 (en) 2000-11-08 2008-05-13 Surface Logix, Inc. Peelable and resealable devices for biochemical assays
US7001740B2 (en) * 2000-11-08 2006-02-21 Surface Logix, Inc. Methods of arraying biological materials using peelable and resealable devices
US7439056B2 (en) 2000-11-08 2008-10-21 Surface Logix Inc. Peelable and resealable devices for arraying materials
US6803205B2 (en) * 2000-11-08 2004-10-12 Surface Logix, Inc. Methods of measuring enzyme activity using peelable and resealable devices
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
DE10062173C1 (de) * 2000-12-14 2002-08-08 Inst Chemo Biosensorik Verfahren zur Bestimmung von Analytkonzentrationen
FR2818378B1 (fr) * 2000-12-14 2003-06-13 Commissariat Energie Atomique Dispositif de renforcement de fluorescence large bande a faibles pertes et capteur optique biologique ou chimique l'utilisant
AU2002246978A1 (en) 2001-01-10 2002-07-24 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface
US20030003018A1 (en) * 2001-04-02 2003-01-02 Prolinx Incorporated Systems and apparatus for the analysis of molecular interactions
EP1392504A4 (en) * 2001-04-02 2008-03-05 Agilent Technologies Inc SENSOR SURFACES FOR DETECTING ANALYTES
US6730487B2 (en) * 2001-04-03 2004-05-04 Trustees Of Columbia University In The City Of New York Surface plasmon resonance biosensor for measurement of anti-glycolipid antibody levels in neuropathy
US20020192841A1 (en) * 2001-04-27 2002-12-19 Masayoshi Kojima Measurement chip for biosensor
EP1386158B1 (de) * 2001-05-09 2008-05-14 Andreas Hofmann Gegenstand mit einer ungeladenen, funktionalisierten hydrogeloberfläche
US6825032B2 (en) * 2001-05-14 2004-11-30 Sigma-Aldrich Co. High capacity assay platforms
DE10126341A1 (de) * 2001-05-30 2002-12-12 Siemens Ag Elektrochemischer DNA-Sensor, Verfahren zur Herstellung und Betrieb eines solchen DNA-Sensors
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
AU2002348683A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
DE60239132D1 (de) 2001-06-12 2011-03-24 Pelikan Technologies Inc Gerät zur erhöhung der erfolgsrate im hinblick auf die durch einen fingerstich erhaltene blutausbeute
EP1404232B1 (en) 2001-06-12 2009-12-02 Pelikan Technologies Inc. Blood sampling apparatus and method
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
EP1395185B1 (en) 2001-06-12 2010-10-27 Pelikan Technologies Inc. Electric lancet actuator
ES2336081T3 (es) 2001-06-12 2010-04-08 Pelikan Technologies Inc. Dispositivo de puncion de auto-optimizacion con medios de adaptacion a variaciones temporales en las propiedades cutaneas.
SE0102331D0 (sv) * 2001-06-29 2001-06-29 Biacore Ab Flow cell method
FR2828491B1 (fr) * 2001-08-07 2003-10-10 Warner Lambert Co Nouvelle membrane supportee, preparation et utilisations
US20030040027A1 (en) * 2001-08-16 2003-02-27 Gerd Ritter Method for determining protein component in a biological sample
JP2003075447A (ja) 2001-09-03 2003-03-12 Fuji Photo Film Co Ltd 表面プラズモン共鳴バイオセンサー用測定チップ
JP4435454B2 (ja) * 2001-09-03 2010-03-17 富士フイルム株式会社 バイオセンサー用表面
FI118061B (fi) * 2001-09-24 2007-06-15 Beanor Oy Menetelmä ja bioanturi analyysiä varten
NL1019317C2 (nl) * 2001-11-06 2003-05-07 Tno Detectie van een geladen deeltje.
DE10153954A1 (de) * 2001-11-06 2003-05-22 Preventor U Tbc Gmbh Schicht mit selektiv perfluorierter Oberfläche
WO2003046198A2 (de) * 2001-11-28 2003-06-05 Graffinity Pharmaceuticals Ag Verfahren zur selektion und identifikation von peptid- oder proteinmolekülen mittels phage display
AU2002352069A1 (en) * 2001-11-28 2003-06-10 Graffinity Pharmaceuticals Ag Surface plasmon resonance (spr) sensor surface support
DE10220602A1 (de) * 2001-11-28 2003-06-26 Graffinity Pharmaceuticals Ag Verfahren zur Selektion und Identifikation von Peptid- oder Proteinmolekülen mittels Phage Display
US7102752B2 (en) 2001-12-11 2006-09-05 Kimberly-Clark Worldwide, Inc. Systems to view and analyze the results from diffraction-based diagnostics
US7098041B2 (en) 2001-12-11 2006-08-29 Kimberly-Clark Worldwide, Inc. Methods to view and analyze the results from diffraction-based diagnostics
US7129096B2 (en) * 2001-12-11 2006-10-31 Duke University Sensor for use in testing biological, biochemical, chemical or environmental samples
WO2003056337A1 (en) * 2001-12-21 2003-07-10 Biacore Ab Immobilization of binding agents
US8367013B2 (en) 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US6837171B1 (en) 2002-04-29 2005-01-04 Palmer/Snyder Furniture Company Lightweight table with unitized table top
FI115166B (fi) 2001-12-31 2005-03-15 Biofons Oy Diagnostisia menetelmiä
US20030153026A1 (en) * 2002-01-04 2003-08-14 Javier Alarcon Entrapped binding protein as biosensors
US20050239155A1 (en) * 2002-01-04 2005-10-27 Javier Alarcon Entrapped binding protein as biosensors
MXPA04006875A (es) * 2002-01-18 2004-12-06 Control Delivery Sys Inc Sistema de gel polimerico para suministro controlado de cofarmacos.
CN100516879C (zh) * 2002-01-29 2009-07-22 旭化成株式会社 生物传感器、用于磁性分子以及待测量目标的测量方法
NL1020090C2 (nl) * 2002-02-28 2003-08-29 Tno Nieuwe coating voor biosensoren.
EP1343010A1 (en) * 2002-03-04 2003-09-10 Glaucus Proteomics B.V. Matrix for coupling of a biological molecule, method for producing and use of said matrix
WO2003075012A1 (en) * 2002-03-04 2003-09-12 Steinberg Holding B.V. Matrix for coupling of a biological molecule, method for producing and use of said matrix
US7419821B2 (en) 2002-03-05 2008-09-02 I-Stat Corporation Apparatus and methods for analyte measurement and immunoassay
EP1489415A4 (en) * 2002-03-11 2006-02-22 Toudai Tlo Ltd POLY (ETHYLENE OXIDE) SURFACE WITH BRUSH TYPE STRUCTURE HAVING HIGH DENSITY
SE0200949D0 (sv) * 2002-03-27 2002-03-27 Biacore Ab Method and system for curve quality control
JP4406287B2 (ja) * 2002-03-27 2010-01-27 ジーイー・ヘルスケア・バイオ−サイエンシーズ・アーベー 応答曲線の質の制御を包含する、分子結合相互作用の検出のための方法、システムおよびコンピュータプログラム
CN1646912A (zh) * 2002-04-03 2005-07-27 独立行政法人科学技术振兴机构 担载了聚乙二醇化纳米粒子的生物传感器芯片表面
US7892185B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) * 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7491178B2 (en) * 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US20030218130A1 (en) * 2002-05-02 2003-11-27 Ciphergen Biosystems, Inc. Biochips with surfaces coated with polysaccharide-based hydrogels
US7223368B2 (en) 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7223534B2 (en) 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7485453B2 (en) * 2002-05-03 2009-02-03 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7214530B2 (en) 2002-05-03 2007-05-08 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
US7771922B2 (en) 2002-05-03 2010-08-10 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic device
US7118855B2 (en) * 2002-05-03 2006-10-10 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US20050169883A1 (en) * 2002-05-06 2005-08-04 Prestwich Glenn D. Preblocking with non-ha gags increases effectiveness of ha conjugated anticancer agents
US8785179B2 (en) * 2002-05-22 2014-07-22 Texas Instruments Incorporated Biosensor and method
JP4468803B2 (ja) * 2002-05-31 2010-05-26 ジーイー・ヘルスケア・バイオ−サイエンシーズ・アーベー 結合剤を基板表面にカップリングさせる方法
US7122640B2 (en) * 2002-06-10 2006-10-17 Phynexus, Inc. Open channel solid phase extraction systems and methods
US7151167B2 (en) * 2002-06-10 2006-12-19 Phynexus, Inc. Open channel solid phase extraction systems and methods
US7879621B2 (en) 2003-05-08 2011-02-01 Phynexus, Inc. Open channel solid phase extraction systems and methods
US20040224329A1 (en) * 2003-05-08 2004-11-11 Gjerde Douglas T. Three-dimensional solid phase extraction surfaces
US7091049B2 (en) 2002-06-26 2006-08-15 Kimberly-Clark Worldwide, Inc. Enhanced diffraction-based biosensor devices
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7314763B2 (en) 2002-08-27 2008-01-01 Kimberly-Clark Worldwide, Inc. Fluidics-based assay devices
US20040043508A1 (en) * 2002-09-03 2004-03-04 Frutos Anthony G. Polymer-coated substrates for binding biological molecules
US7927822B2 (en) * 2002-09-09 2011-04-19 Sru Biosystems, Inc. Methods for screening cells and antibodies
US7429492B2 (en) * 2002-09-09 2008-09-30 Sru Biosystems, Inc. Multiwell plates with integrated biosensors and membranes
US7169550B2 (en) * 2002-09-26 2007-01-30 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
GB2393704B (en) * 2002-10-02 2006-03-15 Aircraft Materials Ltd Improvements to an aerial delivery system and restraint assembly therefor
US7781172B2 (en) 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US7309614B1 (en) 2002-12-04 2007-12-18 Sru Biosystems, Inc. Self-referencing biodetection method and patterned bioassays
US7247500B2 (en) 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US20040191815A1 (en) * 2003-01-15 2004-09-30 Motoki Kyo Array having oligonucleotides on a metal substrate
AU2003217249A1 (en) * 2003-01-22 2004-08-23 The Arizona Board Of Regents On Behalf Of The University Of Arizona Coupled plasmon-waveguide resonance spectroscopic sensors for pharmaceutical and chemical testing
WO2005016115A2 (en) * 2003-01-23 2005-02-24 Montana State University Biosensors utilizing dendrimer-immobilized ligands and their use thereof
JP2004251807A (ja) * 2003-02-21 2004-09-09 Nipro Corp エンドトキシン測定用センサ、測定方法、診断方法、製造方法およびセンサ再生方法
US20070082019A1 (en) * 2003-02-21 2007-04-12 Ciphergen Biosystems Inc. Photocrosslinked hydrogel surface coatings
US7851209B2 (en) 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US20040197819A1 (en) 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
WO2004097368A2 (en) * 2003-04-28 2004-11-11 Ciphergen Biosystems, Inc. Improved immunoassays
DE10319572A1 (de) * 2003-04-30 2004-11-25 Kist-Europe Forschungsgesellschaft Mbh Verfahren zur Bestimmung der Konzentration eines Analyten
US20040241721A1 (en) * 2003-05-08 2004-12-02 Gjerde Douglas T. Open channel solid phase extraction systems and methods
EP1628567B1 (en) 2003-05-30 2010-08-04 Pelikan Technologies Inc. Method and apparatus for fluid injection
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US20040248323A1 (en) 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US20050048493A1 (en) * 2003-08-27 2005-03-03 Zyomyx, Inc. Film layer for detection of immobilized analytes
US20050053949A1 (en) * 2003-09-08 2005-03-10 Silin Vitalii Ivanovich Biochip for proteomics applications
JP4363935B2 (ja) * 2003-09-17 2009-11-11 株式会社豊田中央研究所 生体物質の光固定化・回収方法及び表面プラズモン共鳴センサー
US8298780B2 (en) * 2003-09-22 2012-10-30 X-Body, Inc. Methods of detection of changes in cells
WO2005029077A1 (en) * 2003-09-24 2005-03-31 Biacore Ab Method and system for molecular interaction analysis
SE0302525D0 (sv) * 2003-09-24 2003-09-24 Biacore Ab Method and system for interaction analysis
US20050130226A1 (en) * 2003-09-26 2005-06-16 The University Of Cincinnati Fully integrated protein lab-on-a-chip with smart microfluidics for spot array generation
WO2005033659A2 (en) 2003-09-29 2005-04-14 Pelikan Technologies, Inc. Method and apparatus for an improved sample capture device
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
JP2007510928A (ja) * 2003-11-06 2007-04-26 エス アール ユー バイオシステムズ，インコーポレイテッド 高密度アミン機能化表面
EP2369348A1 (en) 2003-11-07 2011-09-28 Ciphergen Biosystems, Inc. Biomarkers for Alzheimer's disease
US7943395B2 (en) 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US20050112703A1 (en) * 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
DE602004004753T2 (de) * 2003-11-28 2008-01-31 C.S.E.M. Centre Suisse D'electronique Et De Microtechnique S.A. Photolinker-makromoleküle, mit den linkern modifizierte metallische substrate und liganden sowie verfahren zur herstellung davon
EP1694301A4 (en) 2003-12-02 2009-11-18 Cytimmune Sciences Inc METHOD AND COMPOSITIONS FOR THE PRODUCTION OF MONOCLONAL ANTIBODIES
US20050181497A1 (en) * 2003-12-04 2005-08-18 Fuji Photo Film Co., Ltd. Solid substrate used for sensors
ATE525478T1 (de) 2003-12-05 2011-10-15 Univ Mcgill Serumbiomarker für morbus chagas
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
US7501289B2 (en) * 2003-12-25 2009-03-10 Fujifilm Corporation Biosensor
JP2005189198A (ja) * 2003-12-26 2005-07-14 Fuji Photo Film Co Ltd 光学デバイス
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
EP1706026B1 (en) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
CA2554755A1 (en) * 2004-01-28 2005-08-11 Cytimmune Sciences, Inc. Functionalized colloidal metal compositions and methods
US20050233378A1 (en) * 2004-03-26 2005-10-20 Fuji Photo Film Co., Ltd. Biosensor
US20070184222A1 (en) * 2004-04-20 2007-08-09 University Of Rochester Hydrogel-supported porous semiconductor devices
AU2005236075A1 (en) 2004-04-26 2005-11-03 Children's Medical Center Corporation Platelet biomarkers for the detection of disease
EP1751546A2 (en) 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Printable hydrogel for biosensors
US7473551B2 (en) 2004-05-21 2009-01-06 Atonomics A/S Nano-mechanic microsensors and methods for detecting target analytes
US7470549B2 (en) * 2004-05-26 2008-12-30 Fujifilm Corporation Measurement method using biosensor
US7323347B2 (en) * 2004-05-27 2008-01-29 Sensata Technologies, Inc. Biosensor surface structures and methods
US20050265648A1 (en) * 2004-06-01 2005-12-01 Daniel Roitman Evanescent wave sensor containing nanostructures and methods of using the same
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
JP4799557B2 (ja) * 2004-06-09 2011-10-26 ベクトン・ディキンソン・アンド・カンパニー 多検体センサー
GB0413082D0 (en) 2004-06-11 2004-07-14 Medical Biosystems Ltd Method
US7521226B2 (en) 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
US20070009198A1 (en) * 2004-07-02 2007-01-11 Robert Petcavich Fiber optic bio-sensor
JP2006046984A (ja) * 2004-08-02 2006-02-16 Fuji Photo Film Co Ltd バイオセンサー
US20060068424A1 (en) * 2004-08-13 2006-03-30 Fuji Photo Film Co., Ltd. Biosensor
GB0420062D0 (en) * 2004-09-09 2004-10-13 Akubio Ltd Assay methods,materials and preparations
US8183057B2 (en) * 2004-09-14 2012-05-22 Mitsubishi Chemical Corporation Biomaterial construct, its producing method, biomaterial support, target material purifying method, affinity chromatography container, separation chip, analyzing method and analyzing separator for target material, biomaterial complex, and its support, sensor chip, solid support with biomaterial fixed thereon
US20060073534A1 (en) * 2004-10-05 2006-04-06 The University Of Georgia Research Foundation, Inc Method for cleaving and deglycosylating antibodies to promote ligand binding
SE0402476D0 (sv) * 2004-10-13 2004-10-13 Biacore Ab Preparation and use of a reactive solid support surface
JP2006153831A (ja) * 2004-10-27 2006-06-15 Mitsubishi Chemicals Corp カンチレバーセンサ、センサシステム及び検体液中の検出対象物質の検出方法
US20070149775A1 (en) * 2004-11-23 2007-06-28 Hans Sigrist Photolinker Macromolecules, Metallic Substrates and Ligands Modified with Said Linkers, and Process of Preparation thereof
US20060110594A1 (en) * 2004-11-24 2006-05-25 Frutos Anthony G Polymer-coated substrates for binding biomolecules and methods of making and using thereof
US20060128031A1 (en) * 2004-12-15 2006-06-15 Robotti Karla M Addressable recovery of bound analytes from an evanescent wave sensor
KR100597788B1 (ko) * 2004-12-17 2006-07-06 삼성전자주식회사 프로그램 동작 속도를 개선하는 불휘발성 반도체 메모리장치의 페이지 버퍼와 이에 대한 구동방법
US7349080B2 (en) * 2004-12-30 2008-03-25 Corning Incorporated Label-independent detection of unpurified analytes
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
ATE501267T1 (de) * 2005-01-06 2011-03-15 Eastern Virginia Med School Apolipoprotein-a-ii-isoform als biomarker für prostatakrebs
US7245370B2 (en) * 2005-01-06 2007-07-17 Hewlett-Packard Development Company, L.P. Nanowires for surface-enhanced Raman scattering molecular sensors
AU2006200582B2 (en) * 2005-02-23 2008-09-25 Aisin Seiki Kabushiki Kaisha Door lock apparatus for a vehicle
DE602006009980D1 (de) * 2005-02-23 2009-12-10 Fujifilm Corp Biosensor
JP4270511B2 (ja) * 2005-02-28 2009-06-03 富士フイルム株式会社 バイオセンサー
US7397558B2 (en) * 2005-03-17 2008-07-08 Hewlett-Packard Development Company, L.P. Ordered array of nanoparticles for efficient nanoenhanced Raman scattering detection and methods of forming the same
JP4435708B2 (ja) * 2005-03-22 2010-03-24 富士フイルム株式会社 バイオセンサー
JP4435709B2 (ja) * 2005-03-22 2010-03-24 富士フイルム株式会社 バイオセンサー
US7292334B1 (en) * 2005-03-25 2007-11-06 Hewlett-Packard Development Company, L.P. Binary arrays of nanoparticles for nano-enhanced Raman scattering molecular sensors
US20060223184A1 (en) * 2005-04-05 2006-10-05 Frutos Anthony G Supports useful in incorporating biomolecules into cells and methods of using thereof
US20070196833A1 (en) * 2005-04-21 2007-08-23 Gjerde Douglas T Open channel solid phase extraction systems and methods
US7648844B2 (en) 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
US7611908B2 (en) 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US7749445B2 (en) 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
EP1724584A1 (en) * 2005-05-19 2006-11-22 Agilent Technologies, Inc. Evanescent wave sensor with attached ligand
EP1883815A4 (en) * 2005-05-20 2008-10-22 Univ Rmit TEST DEVICE
JP2006329631A (ja) * 2005-05-23 2006-12-07 Hitachi Ltd 分子間相互作用検出装置およびそれを用いた分子回収装置
US7396676B2 (en) 2005-05-31 2008-07-08 Agilent Technologies, Inc. Evanescent wave sensor with attached ligand
JP5167486B2 (ja) * 2005-06-09 2013-03-21 国立大学法人東京農工大学 反射率変化型センサ、光学式測定装置、反射率変化型センサの製造方法、並びに反射率変化型センサ用自己組織化微粒子単層膜、自己組織化微粒子単層膜及びこれら単層膜の製造方法
US20070016378A1 (en) * 2005-06-13 2007-01-18 Biacore Ab Method and system for affinity analysis
WO2007002527A2 (en) 2005-06-24 2007-01-04 Ciphergen Biosystems, Inc. BIOMARKERS FOR OVARIAN CANCER: β-2 MICROGLOBULIN
JP2007057458A (ja) * 2005-08-26 2007-03-08 Fujifilm Corp バイオセンサー
US20070048747A1 (en) * 2005-09-01 2007-03-01 Leslie Thomas M Methods for assaying analytes
US7342656B2 (en) * 2005-10-17 2008-03-11 Hewlett-Packard Development Company, L.P. Dynamically variable separation among nanoparticles for nano-enhanced Raman spectroscopy (NERS) molecular sensing
US7372562B2 (en) * 2005-10-17 2008-05-13 Hewlett-Packard Development Company, L.P. Dynamic random separation among nanoparticles for nano enhanced Raman spectroscopy (NERS) molecular sensing
CN101341409B (zh) * 2005-10-27 2012-11-28 生物辐射海法有限公司 结合层及其制备方法和用途
US20070117152A1 (en) * 2005-11-08 2007-05-24 Fujifilm Corporation Biosensor
ATE492651T1 (de) * 2005-11-10 2011-01-15 Bristol Myers Squibb Pharma Co Moesin, caveolin 1 und yes-assoziiertes protein 1 als prädiktive marker der reaktion auf dasatinib bei brustkrebs
WO2007061981A2 (en) 2005-11-21 2007-05-31 Lumera Corporation Surface plasmon resonance spectrometer with an actuator-driven angle scanning mechanism
US8227261B2 (en) * 2005-11-23 2012-07-24 Bioscale, Inc. Methods and apparatus for assay measurements
EP1923703B1 (en) 2005-11-25 2015-05-06 FUJIFILM Corporation A method for producing a biosensor having a covalently bound thin polymeric coat
US7463358B2 (en) 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
US20090215086A1 (en) * 2005-12-12 2009-08-27 Momar Ndao Biomarkers for Babesia
US7781203B2 (en) 2005-12-29 2010-08-24 Corning Incorporated Supports for assaying analytes and methods of making and using thereof
CA2640614A1 (en) * 2006-01-27 2007-08-09 Eastern Virginia Medical School Proteomic fingerprinting of human ivf-derived embryos: identification of biomarkers of developmental potential
US20070176728A1 (en) * 2006-01-31 2007-08-02 Ranganath Tirumala R Tiled periodic metal film sensors
EP1826563A1 (en) * 2006-02-22 2007-08-29 Fujifilm Corporation Biosensor
US20070196233A1 (en) * 2006-02-23 2007-08-23 Fujifilm Corporation Biosensor and method for immobilizing a physiologically active substance
WO2007106466A2 (en) 2006-03-11 2007-09-20 The Board Of Trustees Of The Leland Stanford Junior University Beta-2 microglobulin as a biomarker for peripheral artery disease
GB0605302D0 (en) * 2006-03-16 2006-04-26 Akubio Ltd Improvements in or relating to coating surfaces
US8080430B2 (en) * 2006-04-25 2011-12-20 Canon Kabushiki Kaisha Target substance detection material and method and kit for detecting target substance
US7511808B2 (en) * 2006-04-27 2009-03-31 Hewlett-Packard Development Company, L.P. Analyte stages including tunable resonant cavities and Raman signal-enhancing structures
CA2675596A1 (en) * 2006-06-06 2007-12-13 Societe De Commercialisation Des Produits De La Recherche Appliquee - So Cpra-Sciences Et Genie S.E.C. Assay supports comprising a peg support, said support attached from a peg solution in cloud point (theta solvent) conditions
WO2008008284A2 (en) 2006-07-14 2008-01-17 The Regents Of The University Of California Cancer biomarkers and methods of use threof
US20100279422A1 (en) * 2006-08-21 2010-11-04 Cmed Technologies Ltd. Method of surface plasmon resonance (spr) technology to detect genomic disorders for prenatal diagnosis
WO2008033073A1 (en) * 2006-09-14 2008-03-20 Ge Healthcare Bio-Sciences Ab A method of determining analyte concentration
WO2008036465A2 (en) * 2006-09-18 2008-03-27 CMED Technologies Ltd. Office of Walkers Limited A method to assess cancer susceptibility and differential diagnosis of metastases of unknown primary tumors
WO2008036470A2 (en) * 2006-09-19 2008-03-27 Cmed Technologies Ltd. A method for screening of infectious agents in blood
US20100021971A1 (en) * 2006-09-21 2010-01-28 Cmed Technologies Ltd. Method to remove repetitive sequences from human dna
WO2008036474A2 (en) * 2006-09-21 2008-03-27 Cmed Technologies Ltd. A method to detect tumor markers and diagnosis of undifferenciated tumors
WO2008094312A2 (en) * 2006-09-25 2008-08-07 Cmed Technologies Ltd. A method of surface plasmon resonance (spr) technology to detect genomic disorders for postnatal diagnosis
WO2008070227A2 (en) * 2006-09-25 2008-06-12 Cmed Technologies Ltd. A method for the identification of human immunodeficiency virus related antibodies in blood
US20090311699A1 (en) * 2006-09-25 2009-12-17 Cmed Technologies Ltd. Method of surface plasmon resonance (spr) to detect genomic aberrations in patients with chronic lymphocytic leukemia
US20100041018A1 (en) * 2006-09-25 2010-02-18 Cmed Technologies Ltd. Method to detect virus related immunological markers for the diagnosis of hepatitis c virus infection
WO2008082710A2 (en) * 2006-09-25 2008-07-10 Cmed Technologies Ltd. A method of surface plasmon resonance (spr) technology to detect genomic aberrations in patients with multiple myeloma
US20100028856A1 (en) * 2006-09-25 2010-02-04 Cmed Technologies Ltd. Method to detect virus related immunological markers for the diagnosis of hepatitis b virus infection
WO2008066996A2 (en) * 2006-09-27 2008-06-05 Cmed Technologies Ltd. A method to detect treponema pallidum immunological markers for the diagnosis of syphilis
US8158343B2 (en) * 2006-09-27 2012-04-17 Cmed Technologies Ltd. Method to detect virus related immunological markers for the diagnosis of respiratory tract infections
US8114682B2 (en) * 2006-09-27 2012-02-14 Cmed Technologies Ltd. Method for the quantitative evaluation of sex hormones in a serum sample
US8110409B2 (en) * 2006-09-27 2012-02-07 Cmed Technologies Ltd. Method to measure serum biomarkers for the diagnosis of liver fibrosis
US20100021930A1 (en) * 2006-09-27 2010-01-28 Cmed Technologies Ltd. Application of surface plasmon resonance technology to maternal serum screening for congenital birth defects
US20100004872A1 (en) * 2006-09-27 2010-01-07 Cmed Technologies Ltd. Method for quantitative measurement of cardiac biochemical markers
WO2008067007A2 (en) * 2006-09-28 2008-06-05 Cmed Technologies Ltd. A method for quantitative measurement of thyroid homrones and related antibodies in a serum sample
WO2008067006A2 (en) * 2006-09-28 2008-06-05 Cmed Technologies Ltd. A method for quantitative detection of diabetes related immunological markers
JP2008107315A (ja) * 2006-09-29 2008-05-08 Fujifilm Corp 生体分子の固定化方法
US20080187977A1 (en) 2007-01-31 2008-08-07 Fujifilm Corporation Method for production of physiologically active substance-immobilized substrate
JP2008286775A (ja) * 2007-01-31 2008-11-27 Fujifilm Corp 生理活性物質固定基板の製造方法及び基板
US20080188010A1 (en) 2007-02-01 2008-08-07 Fujifilm Corporation Biosensor substrate
CN101261226B (zh) * 2007-03-08 2010-12-08 北京宏荣博曼生物科技有限责任公司 一种基于聚乙二醇的表面等离子共振仪芯片
WO2008123948A1 (en) 2007-03-27 2008-10-16 Vermillion, Inc. Biomarkers for ovarian cancer
JP2008249502A (ja) 2007-03-30 2008-10-16 Fujifilm Corp 生理活性物質を固定化した固体基板
CA2683082A1 (en) * 2007-04-19 2008-10-30 Sru Biosystems, Inc. Method for employing a biosensor to detect small molecules that bind directly to immobilized targets
WO2008154238A1 (en) * 2007-06-06 2008-12-18 Siemens Healthcare Diagnostics Inc. Predictive diagnostics for kidney disease
CN101802611A (zh) 2007-07-11 2010-08-11 Sru生物系统公司 鉴别离子通道调节剂的方法
US9134307B2 (en) 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
EP2015071A1 (en) * 2007-07-13 2009-01-14 FUJIFILM Corporation Carrier, process for producing same, bioreactor, and chip for surface plasmon resonance analysis
JP2009063335A (ja) 2007-09-05 2009-03-26 Fujifilm Corp 生理活性物質と被験物質との相互作用の測定方法
US8354280B2 (en) * 2007-09-06 2013-01-15 Bioscale, Inc. Reusable detection surfaces and methods of using same
US20110014118A1 (en) * 2007-09-21 2011-01-20 Lawrence Tamarkin Nanotherapeutic colloidal metal compositions and methods
CA2700378A1 (en) * 2007-09-21 2009-03-29 Cytimmune Sciences, Inc. Nanotherapeutic colloidal metal compositions and methods
JP2009075016A (ja) 2007-09-21 2009-04-09 Fujifilm Corp バイオセンサーの製造方法及びバイオセンサー
JP5021408B2 (ja) 2007-09-26 2012-09-05 富士フイルム株式会社 バイオセンサー
WO2009045216A1 (en) 2007-10-04 2009-04-09 Cmed Technologies Ltd. Application of surface plasmon resonance technology for detecting and genotyping hpv
WO2009062151A1 (en) 2007-11-08 2009-05-14 Cytimmune Sciences, Inc. Compositions and methods for generating antibodies
FR2924225B1 (fr) * 2007-11-27 2016-12-09 Genoptics Biopuces fonctionnalisees pour le couplage spr-ms
CN101932728B (zh) 2007-11-30 2013-06-19 西门子医疗保健诊断公司 脂连蛋白受体片段和使用方法
JP2009145189A (ja) 2007-12-13 2009-07-02 Fujifilm Corp バイオセンサー
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
WO2009105583A1 (en) * 2008-02-19 2009-08-27 Anstron Technologies Company Fluorescence resonance energy transfer (fret) binding assays that are surface-based
WO2009114292A1 (en) 2008-03-10 2009-09-17 Lineagen, Inc. Copd biomarker signatures
WO2009118343A1 (en) * 2008-03-27 2009-10-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for determining the occurrence of a liver disease in a subject
US8257936B2 (en) 2008-04-09 2012-09-04 X-Body Inc. High resolution label free analysis of cellular properties
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
CA2722466A1 (en) 2008-04-29 2009-11-05 Tariq Ghayur Dual variable domain immunoglobulins and uses thereof
JP2009286968A (ja) * 2008-05-30 2009-12-10 Canon Inc グラフトポリマー含有基体、その製造方法および磁気バイオセンサ
CN102046815A (zh) * 2008-06-02 2011-05-04 通用电气健康护理生物科学股份公司 用于病毒检测的方法
EP2297209A4 (en) 2008-06-03 2012-08-01 Abbott Lab IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND USES THEREOF
US20100015721A1 (en) * 2008-06-04 2010-01-21 Sru Biosystems, Inc. Detection of Promiscuous Small Submicrometer Aggregates
BRPI0913397B8 (pt) * 2008-06-04 2021-05-25 Grifols Therapeutics Inc método para preparar plasmina
WO2010005364A1 (en) * 2008-07-08 2010-01-14 Ge Healthcare Bio-Sciences Ab Separation medium for chromatography of various biomolecules
WO2010123720A1 (en) 2009-04-23 2010-10-28 Siemens Healthcare Diagnostics Inc. Monomeric and dimeric forms of adiponectin receptor fragments and methods of use
US20110152120A1 (en) * 2008-08-22 2011-06-23 Ge Healthcare Bio-Sciences Ab method of characterizing antibodies
EP2192410B1 (en) * 2008-11-26 2012-07-11 Corning Incorporated Nanoparticulate affininty capture for label independent detections system
EP2192409B1 (en) 2008-11-26 2014-04-23 Corning Incorporated Label independent detection biosensor composition and methods thereof
US8349325B2 (en) 2008-12-23 2013-01-08 Abbott Laboratories Soluble FMS-like tyrosine kinase-1 (sFLT-1) antibody and related composition, kit, methods of using, and materials and method for making
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
JP5789521B2 (ja) 2009-03-03 2015-10-07 グリフオルス・セラピユーテイクス・インコーポレーテツドＧｒｉｆｏｌｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． プラスミノーゲンを製造するための組成物、方法およびキット；ならびにそれから製造されるプラスミン
BRPI1013688A8 (pt) 2009-03-05 2017-02-14 Abbott Lab Proteínas de ligação de il-17.
EP2233925A1 (en) 2009-03-26 2010-09-29 Corning Inc. Immobilization method for protein having low isoelectric point
JP4922341B2 (ja) * 2009-05-14 2012-04-25 シャープ株式会社 標的認識分子および標的認識分子を固定化する方法
EP2281632B1 (en) * 2009-07-02 2013-11-13 Amic AB Capillary driven assay device and its manufacture
CA2780294C (en) 2009-11-09 2018-01-16 Spotlight Technology Partners Llc Polysaccharide based hydrogels
CA2780274C (en) 2009-11-09 2018-06-26 Spotlight Technology Partners Llc Fragmented hydrogels
EP2507619B1 (en) 2009-11-30 2018-04-04 GE Healthcare Bio-Sciences AB Method and system for binding behavior analysis
JP5683606B2 (ja) 2009-11-30 2015-03-11 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 相互作用の分析のための方法及びシステム
US8841137B2 (en) * 2010-02-25 2014-09-23 University Of Rochester Hybrid target analyte responsive polymer sensor with optical amplification
EP2362220A1 (en) 2010-02-25 2011-08-31 Corning Incorporated Affinity hydrogel and label independent detection methods thereof
US20110229921A1 (en) 2010-03-18 2011-09-22 Abbott Laboratories METHODS OF ASSAYING URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (uNGAL) IN THE PROGNOSIS OF CADAVERIC KIDNEY TRANSPLANT FUNCTION IN A PATIENT, INCLUDING A PATIENT DIAGNOSED WITH DELAYED GRAFT FUNCTION (DGF), A METHOD OF ASSAYING uNGAL IN THE ASSESSMENT OF RISK OF DGF IN A PATIENT DIAGNOSED WITH EARLY GRAFT FUNCTION (EGF), AND RELATED KITS
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US20120003639A1 (en) 2010-04-27 2012-01-05 Prelude, Inc. Cancer biomarkers and methods of use thereof
MY161302A (en) 2010-05-14 2017-04-14 Abbvie Inc IL-1 binding proteins
WO2011155435A1 (ja) * 2010-06-07 2011-12-15 コニカミノルタホールディングス株式会社 近接場増強蛍光センサチップ
WO2011163558A1 (en) 2010-06-25 2011-12-29 Abbott Laboratories Materials and methods for assay of anti-hepatitis c virus (hcv) antibodies
WO2012006500A2 (en) 2010-07-08 2012-01-12 Abbott Laboratories Monoclonal antibodies against hepatitis c virus core protein
UY33492A (es) 2010-07-09 2012-01-31 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
JP2013537415A (ja) 2010-08-03 2013-10-03 アッヴィ・インコーポレイテッド 二重可変ドメイン免疫グロブリンおよびその使用
US9746481B2 (en) 2010-10-14 2017-08-29 The Johns Hopkins University Biomarkers of brain injury
US20120115244A1 (en) 2010-11-09 2012-05-10 Abbott Laboratories Materials and methods for immunoassay of pterins
PE20141060A1 (es) 2010-12-21 2014-09-26 Abbvie Inc Inmunoglobulinas de dominio variable dual biespecificas de il-1 alfa y beta y su uso
JP5772612B2 (ja) * 2011-01-27 2015-09-02 コニカミノルタ株式会社 表面プラズモン励起増強蛍光分光法を利用する蛍光測定装置用センサチップを用いたアッセイ方法、およびアッセイ用キット
CA2830403A1 (en) 2011-03-15 2012-09-20 University Of Utah Research Foundation Methods of diagnosing and treating vascular associated maculopathy and symptoms thereof
WO2012155134A2 (en) 2011-05-12 2012-11-15 The Johns Hopkins University Assay reagents for a neurogranin diagnostic kit
WO2013063095A1 (en) 2011-10-24 2013-05-02 Abbvie Inc. Immunobinders directed against sclerostin
CA2853114A1 (en) 2011-10-24 2013-05-02 Abbvie Inc. Bispecific immunobinders directed against tnf and il-17
DE102011057021A1 (de) * 2011-12-23 2013-06-27 Forschungszentrum Jülich GmbH Verfahren zur selektiven Quantifizierung von A-Beta-Aggregaten
US8993248B2 (en) 2011-12-31 2015-03-31 Abbott Laboratories Truncated human vitamin D binding protein and mutation and fusion thereof and related materials and methods of use
WO2013106886A1 (en) 2012-01-20 2013-07-25 Adelaide Research & Innovation Pty Ltd Biomarkers for gastric cancer and uses thereof
WO2013186672A2 (en) 2012-06-10 2013-12-19 Bio-Rad Laboratories Inc. Optical detection system for liquid samples
UY34905A (es) 2012-07-12 2014-01-31 Abbvie Inc Proteínas de unión a il-1
EP2885429B1 (en) 2012-08-16 2019-03-13 The Trustees of Columbia University in the City of New York Diagnostic markers of indolent prostate cancer
AU2013202668B2 (en) 2012-12-24 2014-12-18 Adelaide Research & Innovation Pty Ltd Inhibition of cancer growth and metastasis
RU2527699C1 (ru) 2013-02-20 2014-09-10 федеральное государственное автономное образовательное учреждение высшего профессионального образования "Московский физико-технический институт (государственный университет) Биологический сенсор и способ создания биологического сенсора
CA2906417C (en) 2013-03-14 2022-06-21 Robert Ziemann Hcv core lipid binding domain monoclonal antibodies
WO2014143342A1 (en) 2013-03-14 2014-09-18 Abbott Laboratories Hcv ns3 recombinant antigens and mutants thereof for improved antibody detection
EP2968526A4 (en) 2013-03-14 2016-11-09 Abbott Lab ANTIGEN-ANTIBODY COMBINATION ASSAY OF HEPATITIS C VIRUS AND METHODS AND COMPOSITIONS FOR USE THEREWITH
US9005901B2 (en) 2013-03-15 2015-04-14 Abbott Laboratories Assay with internal calibration
US9157910B2 (en) 2013-03-15 2015-10-13 Abbott Laboratories Assay with increased dynamic range
CA3210220A1 (en) 2013-05-10 2014-11-13 Johns Hopkins University Compositions for ovarian cancer assessment having improved specificity
EP3757226A3 (en) 2013-07-17 2021-05-05 The Johns Hopkins University A multi-protein biomarker assay for brain injury detection and outcome
CN115586329A (zh) 2013-11-19 2023-01-10 思拓凡瑞典有限公司 用快速分离测定相互作用动力学的方法
EP3100048B1 (en) 2014-01-29 2021-05-05 Cytiva Sweden AB Method and system for interaction analysis
EP3161454B1 (en) 2014-06-24 2019-02-06 GE Healthcare Bio-Sciences AB Normalization of mass transport properties on optical sensor surfaces
WO2015200833A2 (en) 2014-06-27 2015-12-30 Abbott Laboratories COMPOSITIONS AND METHODS FOR DETECTING HUMAN PEGIVIRUS 2 (HPgV-2)
WO2016044697A1 (en) 2014-09-19 2016-03-24 The Johns Hopkins University Biomarkers of cognitive dysfunction
US10088483B2 (en) 2014-10-29 2018-10-02 Abbott Laboratories Subject anti-HCV antibody detection assays employing NS3 capture peptides
EP3213071B1 (en) 2014-10-30 2019-07-10 GE Healthcare Bio-Sciences AB Method to determine solvent correction curves
WO2016090323A1 (en) 2014-12-05 2016-06-09 Prelude, Inc. Dcis recurrence and invasive breast cancer
SG11201705023SA (en) 2015-01-20 2017-07-28 Basf Coatings Gmbh Process for producing flexible organic-inorganic laminates
EP3259594A4 (en) 2015-02-20 2018-12-26 The Johns Hopkins University Biomarkers of myocardial injury
WO2017011329A1 (en) 2015-07-10 2017-01-19 West Virginia University Markers of stroke and stroke severity
DE102015115359B4 (de) 2015-09-11 2023-07-27 Bpc Arnold Gmbh Biopharma Consulting Biosensorchip
EP3386594B1 (en) 2015-12-11 2023-05-03 The General Hospital Corporation Combination of a platelet-derived growth factor receptor alpha inhibitor and a histone lysine demethylase inhibitor for treating drug-tolerant glioblastoma
GB201709503D0 (en) * 2017-06-15 2017-08-02 Method and device for assay improvement
SG11202001068YA (en) 2017-08-16 2020-03-30 Medimmune Llc Compositions and methods for treatment of atopic dermatitis and treatment selection
BR112020024715A2 (pt) 2018-06-04 2021-03-23 Avon Products. Inc. biomarcadores proteicos para identificar e tratar o envelhecimento da pele e afecções cutâneas
JP2022500504A (ja) 2018-09-14 2022-01-04 プレリュード コーポレーションPrelude Corporation 浸潤性乳癌のリスクを有する対象の治療の選択方法
WO2020214795A1 (en) * 2019-04-16 2020-10-22 Laboratory Corporation Of America Holdings Methods and systems for detecting antibodies by surface plasmon resonance
GB201917630D0 (en) * 2019-12-03 2020-01-15 Ge Healthcare Bio Sciences Ab Method for determination of aggregates
US12116637B2 (en) 2020-07-24 2024-10-15 The Regents Of The University Of Michigan Compositions and methods for detecting and treating high grade subtypes of uterine cancer
WO2023122723A1 (en) 2021-12-23 2023-06-29 The Broad Institute, Inc. Panels and methods for diagnosing and treating lung cancer
WO2024041955A2 (en) 2022-08-25 2024-02-29 Cytiva Sweden Ab Sensor surface-based sample analysis
WO2024133882A1 (en) * 2022-12-23 2024-06-27 Cytacoat Ab A medical device comprising a coating for mitigation of formation and/or growth of biofilm
WO2024165605A1 (en) 2023-02-07 2024-08-15 Cytiva Sweden Ab Method and system for analyte-ligand interaction analysis

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3912614A (en) * 1972-01-10 1975-10-14 Int Biophysics Corp Sensor
US4330440A (en) * 1977-02-08 1982-05-18 Development Finance Corporation Of New Zealand Activated matrix and method of activation
US4287300A (en) * 1979-07-26 1981-09-01 Syva Company Charge effects in enzyme immunoassays
WO1983002954A1 (en) * 1982-02-23 1983-09-01 Ventrex Lab Inc Multipurpose supports for immunological and biological use
JPH0627742B2 (ja) * 1982-12-21 1994-04-13 コムテツク リサ−チ ユニツト リミテツド 検定方法及びそのための装置
GB8509491D0 (en) * 1985-04-12 1985-05-15 Plessey Co Plc Optic waveguide biosensors
GB8509492D0 (en) * 1985-04-12 1985-05-15 Plessey Co Plc Optical assay
GB8530715D0 (en) * 1985-12-13 1986-01-22 Unilever Plc Microchemical testing
AU601386B2 (en) * 1985-12-20 1990-09-13 Syntex (U.S.A.) Inc. Particle separation method
US4829009A (en) * 1986-02-21 1989-05-09 The Regents Of The University Of California Noise controlled immunoassays
JP2591750B2 (ja) * 1986-06-26 1997-03-19 オ−ソ・ダイアグノステイツク・システムズ・インコ−ポレ−テツド 免疫分析システム
GB8618133D0 (en) * 1986-07-24 1986-09-03 Pa Consulting Services Biosensors
IL85137A (en) * 1987-01-21 1992-02-16 Ares Serono Res & Dev Ltd Method of assaying for a ligand using surface plasmon resonance effect
CA1321488C (en) * 1987-08-22 1993-08-24 Martin Francis Finlan Biological sensors
US4842783A (en) * 1987-09-03 1989-06-27 Cordis Corporation Method of producing fiber optic chemical sensors incorporating photocrosslinked polymer gels
GB2217447A (en) * 1988-04-21 1989-10-25 Atomic Energy Authority Uk Bonding to metal surfaces
SE462454B (sv) * 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
CA1341592C (en) * 1989-07-07 2009-04-14 Abbott Laboratories Ion capture reagents and methods for performing binding assays

Also Published As

Publication number Publication date
EP0589867A1 (en) 1994-04-06
ATE136651T1 (de) 1996-04-15
US5242828A (en) 1993-09-07
SE8804073L (sv) 1990-05-11
DE68926255D1 (de) 1996-05-15
US5436161A (en) 1995-07-25
EP0589867B1 (en) 1996-04-10
WO1990005303A1 (en) 1990-05-17
SE8804073D0 (sv) 1988-11-10
DE68926255T2 (de) 1996-10-31
JP2815120B2 (ja) 1998-10-27
JPH04501605A (ja) 1992-03-19

Similar Documents

Publication Publication Date Title
SE462454B (sv) Maetyta foer anvaendning i biosensorer
Shen et al. Site-selective orientated immobilization of antibodies and conjugates for immunodiagnostics development
Gao et al. Oriented immobilization of antibodies onto sensing platforms-A critical review
Duschl et al. Surface engineering: optimization of antigen presentation in self-assembled monolayers
JP4234596B2 (ja) 分析のための方法及びバイオセンサー
JP2814639B2 (ja) センサーユニット及びバイオセンサーシステムにおけるその使用
EP0553229B1 (en) Improvement in solid phase binding assay
Dutta et al. Engineering bioactive surfaces with Fischer carbene complex: protein A on self-assembled monolayer for antibody sensing
Li et al. N-heterocyclic carbene self-assembled monolayers on gold as surface plasmon resonance biosensors
Dietl et al. Epitope-imprinted polymers for biomacromolecules: Recent strategies, future challenges and selected applications
Deng et al. A highly sensitive immunosorbent assay based on biotinylated graphene oxide and the quartz crystal microbalance
Vashist et al. Antibody immobilization and surface functionalization chemistries for immunodiagnostics
JPH0731205B2 (ja) 担持材料及びその製法
Chung et al. Immunosensor with a controlled orientation of antibodies by using NeutrAvidin–protein A complex at immunoaffinity layer
Schramm et al. Strategies for the immobilization of antibodies
Tamarit-Lopez et al. Development of hapten-linked microimmunoassays on polycarbonate discs
Oh et al. Nano-scale probe fabrication using self-assembly technique and application to detection of Escherichia coli O 157∶ H7
Vikholm Self-assembly of antibody fragments and polymers onto gold for immunosensing
Liu et al. Rapid and regenerable surface plasmon resonance determinations of biomarker concentration and biomolecular interaction based on tris-nitrilotriacetic acid chips
Batalla et al. Covalent immobilization of antibodies on finally inert support surfaces through their surface regions having the highest densities in carboxyl groups
Di Nardo et al. MIP-based immunoassays: A critical review
US20080206893A1 (en) Biosensor and Method
Brightbill et al. Preblocking procedure to mitigate nonselective protein adsorption for Carboxyl-SAMs used in biosensing
JPH04268455A (ja) イムノセンソリートランスデューサー
Liu et al. Quantitative FT-IRRAS spectroscopic studies of the interaction of avidin with biotin on functionalized quartz surfaces

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 8804073-8

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 8804073-8

Format of ref document f/p: F