ATE295541T1 - Verfahren und vorrichtung zur untersuchung von wirksstoffskandidaten und zur bestimmung ihrer pharmakokinetischen parametern - Google Patents
Verfahren und vorrichtung zur untersuchung von wirksstoffskandidaten und zur bestimmung ihrer pharmakokinetischen parameternInfo
- Publication number
- ATE295541T1 ATE295541T1 AT00946608T AT00946608T ATE295541T1 AT E295541 T1 ATE295541 T1 AT E295541T1 AT 00946608 T AT00946608 T AT 00946608T AT 00946608 T AT00946608 T AT 00946608T AT E295541 T1 ATE295541 T1 AT E295541T1
- Authority
- AT
- Austria
- Prior art keywords
- drug candidate
- binding interaction
- drug
- adme
- pharmacokinetic parameters
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Optical Measuring Cells (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33686599A | 1999-06-18 | 1999-06-18 | |
PCT/SE2000/001297 WO2000079268A2 (en) | 1999-06-18 | 2000-06-19 | Method and apparatus for assaying a drug candidate to estimate a pharmacokinetic parameter associated therewith |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE295541T1 true ATE295541T1 (de) | 2005-05-15 |
Family
ID=23318018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00946608T ATE295541T1 (de) | 1999-06-18 | 2000-06-19 | Verfahren und vorrichtung zur untersuchung von wirksstoffskandidaten und zur bestimmung ihrer pharmakokinetischen parametern |
Country Status (7)
Country | Link |
---|---|
US (2) | US6808938B2 (de) |
EP (1) | EP1188058B1 (de) |
JP (1) | JP4543187B2 (de) |
AT (1) | ATE295541T1 (de) |
AU (1) | AU775060B2 (de) |
DE (1) | DE60020119T2 (de) |
WO (1) | WO2000079268A2 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020093654A1 (en) * | 2000-07-11 | 2002-07-18 | Lieberman Robert A. | Apparatus and method for imaging |
US7193711B2 (en) * | 2000-07-11 | 2007-03-20 | Maven Technologies, Llc | Imaging method and apparatus |
US6594011B1 (en) | 2000-07-11 | 2003-07-15 | Maven Technologies, Llc | Imaging apparatus and method |
US7023547B2 (en) * | 2000-07-11 | 2006-04-04 | Maven Technologies, Llc | Apparatus including a biochip for imaging of biological samples and method |
US7126688B2 (en) * | 2000-07-11 | 2006-10-24 | Maven Technologies, Llc | Microarray scanning |
US7518724B2 (en) * | 2000-07-11 | 2009-04-14 | Maven Technologies | Image acquisition, processing, and display |
US6833920B2 (en) | 2000-07-11 | 2004-12-21 | Maven Technologies Llc | Apparatus and method for imaging |
JP2004507718A (ja) * | 2000-07-28 | 2004-03-11 | ライオン バイオサイエンス アクチェンゲゼルシャフト | 化合物のadme/tox特性を予測するためのシステム及び方法 |
AU2001279068A1 (en) * | 2000-07-28 | 2002-02-13 | Lion Bioscience Ag | Regional intestinal permeability model |
JP4027048B2 (ja) * | 2001-02-23 | 2007-12-26 | 富士フイルム株式会社 | 全反射減衰を利用した測定方法および測定装置 |
US20050032243A1 (en) * | 2001-07-25 | 2005-02-10 | Pollack Gary M. | Method and apparatus for rapid determination of ligand-protein binding using charcoal adsorption |
US20030044992A1 (en) * | 2001-08-31 | 2003-03-06 | Chao Anthony C. | Cell-based multiplexing ADME analysis using focused fluid flow |
DE60219952T2 (de) | 2001-12-05 | 2008-01-17 | Sense Proteomic Ltd., Maidenhead | Proteinarrays für allelische Varianten und deren Verwendungen |
DE10160270A1 (de) | 2001-12-07 | 2003-06-26 | Bayer Ag | Computersystem und Verfahren zur Berechnung von ADME-Eigenschaften |
EP1469309A4 (de) * | 2001-12-27 | 2007-11-21 | Japan Science & Tech Agency | Verfahren zur beurteilung der zellaktivität |
KR100555793B1 (ko) * | 2002-06-25 | 2006-03-03 | 주식회사 마크로젠 | 고분자 그래프팅에 의해 표면이 개질된 바이오 지지체 및 그 제조방법 |
US20060199220A1 (en) * | 2002-09-16 | 2006-09-07 | Blackburn Jonathan M | Protein arrays and uses thereof |
EP1439394A1 (de) * | 2002-12-20 | 2004-07-21 | Graffinity Pharmaceuticals Aktiengesellschaft | Verfahren und Vorrichtung zum Erstellen von ADME Profilen in der frühen Wirkstoffentwicklung |
US8741577B2 (en) * | 2003-04-07 | 2014-06-03 | Bio-Rad Laboratories Inc. | Surface immobilised multilayer structure of vesicles |
EP1668363A1 (de) * | 2003-09-24 | 2006-06-14 | Biacore AB | Verfahren und system zur analyse molekularer wechselwirkungen |
US7470549B2 (en) * | 2004-05-26 | 2008-12-30 | Fujifilm Corporation | Measurement method using biosensor |
SE0401633D0 (sv) * | 2004-06-24 | 2004-06-24 | Biacore Ab | Method for detecting molecular surface interactions |
AU2005257705A1 (en) * | 2004-06-24 | 2006-01-05 | Ge Healthcare Bio-Sciences Ab | Method for detecting molecular surface interactions |
JP4371954B2 (ja) | 2004-08-31 | 2009-11-25 | 富士フイルム株式会社 | 表面プラズモン共鳴分析による被験物質の解析方法 |
JP4580291B2 (ja) * | 2005-06-30 | 2010-11-10 | 富士フイルム株式会社 | バイオセンサーを用いた測定方法 |
US20070003559A1 (en) * | 2005-07-01 | 2007-01-04 | Wyeth | Methods of determining pharmacokinetics of targeted therapies |
CA2614039C (en) | 2005-07-22 | 2015-10-13 | Five Prime Therapeutics, Inc. | Compositions and methods of treating disease with fgfr fusion proteins |
US7704695B2 (en) * | 2005-07-29 | 2010-04-27 | Xenoport, Inc. | Screening of compounds for BGT1 transporter activity |
WO2007016164A2 (en) * | 2005-07-29 | 2007-02-08 | Xenoport, Inc. | Cat1 transporters expressed in blood brain barrier cells |
WO2007016159A2 (en) * | 2005-07-29 | 2007-02-08 | Xenoport, Inc. | Gat2 transporters expressed in blood brain barrier cells |
ATE445843T1 (de) * | 2005-08-30 | 2009-10-15 | Perkinelmer Cellular Technolog | Verfahren zum nachweis einer biochemischen interaktion |
WO2008031209A1 (en) * | 2006-09-16 | 2008-03-20 | Terence Gilhuly | Improved sensors and sensing for monitoring neuromuscular blockade |
US7931791B2 (en) * | 2006-10-25 | 2011-04-26 | Southern Illinois University Carbondale | Method of detecting analyte-biomolecule interactions |
US7867783B2 (en) | 2007-02-22 | 2011-01-11 | Maven Technologies, Llc | Apparatus and method for performing ligand binding assays on microarrays in multiwell plates |
US7863037B1 (en) | 2007-04-04 | 2011-01-04 | Maven Technologies, Llc | Ligand binding assays on microarrays in closed multiwell plates |
US20090041633A1 (en) * | 2007-05-14 | 2009-02-12 | Dultz Shane C | Apparatus and method for performing ligand binding assays on microarrays in multiwell plates |
US7799558B1 (en) | 2007-05-22 | 2010-09-21 | Dultz Shane C | Ligand binding assays on microarrays in closed multiwell plates |
US8039270B2 (en) * | 2008-05-22 | 2011-10-18 | Maven Technologies, Llc | Apparatus and method for performing ligand binding assays on microarrays in multiwell plates |
US7981664B1 (en) | 2008-05-22 | 2011-07-19 | Maven Technologies, Llc | Apparatus and method for performing ligand binding assays on microarrays in multiwell plates |
WO2010147625A2 (en) * | 2009-06-15 | 2010-12-23 | Brandeis University | Systems and methods for determining process conditions in confined volumes |
CN106913902A (zh) | 2009-11-09 | 2017-07-04 | 聚光灯技术合伙有限责任公司 | 多糖基水凝胶 |
AU2010314994B2 (en) | 2009-11-09 | 2016-10-06 | Spotlight Technology Partners Llc | Fragmented hydrogels |
EP2507619B1 (de) * | 2009-11-30 | 2018-04-04 | GE Healthcare Bio-Sciences AB | Verfahren und system zur bindungsverhaltensanalyse |
CN102667448B (zh) * | 2009-11-30 | 2015-02-04 | 通用电气健康护理生物科学股份公司 | 用于相互作用分析的方法和系统 |
US8355133B2 (en) * | 2009-12-30 | 2013-01-15 | Maven Technologies, Llc | Biological testing with sawtooth-shaped prisms |
TWI382087B (zh) * | 2010-05-24 | 2013-01-11 | Univ Taipei Medical | 一種篩檢拓樸異構酶抑制劑之裝置及其方法 |
GB2490652A (en) * | 2011-04-18 | 2012-11-14 | Microtest Matrices Ltd | Methods of quantifying antibodies, especially IgE antibodies in a sample |
JP5828507B2 (ja) * | 2011-09-07 | 2015-12-09 | 国立大学法人金沢大学 | 尿検査方法及び尿検査用キット |
EP2791667B1 (de) | 2011-12-13 | 2018-03-28 | 3M Innovative Properties Company | Verfahren zur identifizierung und quantitativen bestimmung einer unbekannten organischen verbindung in einem gasförmigen medium |
EP3254108A1 (de) | 2015-02-06 | 2017-12-13 | University of Rochester | Auf polymermikropartikel basierendes verfahren zur sondenablagerung in markierungsfreien biosensoren |
CN114791477B (zh) * | 2021-01-25 | 2023-12-05 | 北京中医药大学 | 一种大蜜丸质构感官属性检测方法在质量控制中的应用 |
WO2022123332A1 (en) * | 2021-08-09 | 2022-06-16 | Debasish Banerjee | Bioavailability and bioequivalence through intrinsic activity and kd measurements in vivo in humans |
CN114112980B (zh) * | 2022-01-24 | 2022-05-10 | 武汉宏韧生物医药股份有限公司 | 一种基于数据分析的药物组分检测方法与系统 |
Family Cites Families (16)
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US4548066A (en) * | 1984-08-07 | 1985-10-22 | Rca Corporation | Press workpiece thickness measuring system and method |
US5338659A (en) | 1991-04-02 | 1994-08-16 | Terrapin Technologies, Inc. | Method for determining analyte concentration by cross-reactivity profiling |
SE8804074D0 (sv) * | 1988-11-10 | 1988-11-10 | Pharmacia Ab | Sensorenhet och dess anvaendning i biosensorsystem |
SE8902043L (sv) | 1988-11-10 | 1990-05-11 | Pharmacia Ab | Foerfarande foer karakterisering av makromolekyler |
SE462454B (sv) | 1988-11-10 | 1990-06-25 | Pharmacia Ab | Maetyta foer anvaendning i biosensorer |
SE462408B (sv) * | 1988-11-10 | 1990-06-18 | Pharmacia Ab | Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet |
SE501013C2 (sv) | 1990-10-01 | 1994-10-17 | Pharmacia Biosensor Ab | Förfarande för förbättring av analys med bindning till fast fas |
US5395587A (en) * | 1993-07-06 | 1995-03-07 | Smithkline Beecham Corporation | Surface plasmon resonance detector having collector for eluted ligate |
US5485277A (en) | 1994-07-26 | 1996-01-16 | Physical Optics Corporation | Surface plasmon resonance sensor and methods for the utilization thereof |
US5620850A (en) | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
SE9503028D0 (sv) | 1995-09-01 | 1995-09-01 | Pharmacia Biosensor Ab | Method of analysing chemical and physical interactions at a sensor surface |
GB9518429D0 (en) | 1995-09-08 | 1995-11-08 | Pharmacia Biosensor | A rapid method for providing kinetic and structural data in molecular interaction analysis |
NZ516848A (en) * | 1997-06-20 | 2004-03-26 | Ciphergen Biosystems Inc | Retentate chromatography apparatus with applications in biology and medicine |
CA2299283A1 (en) * | 1997-08-08 | 1999-02-18 | Supratek Pharma, Inc. | Methods of identifying biological agent compositions |
US6289286B1 (en) * | 1998-05-29 | 2001-09-11 | Biacore Ab | Surface regeneration of biosensors and characterization of biomolecules associated therewith |
US6651008B1 (en) * | 1999-05-14 | 2003-11-18 | Cytokinetics, Inc. | Database system including computer code for predictive cellular bioinformatics |
-
2000
- 2000-06-19 WO PCT/SE2000/001297 patent/WO2000079268A2/en active IP Right Grant
- 2000-06-19 JP JP2001505186A patent/JP4543187B2/ja not_active Expired - Fee Related
- 2000-06-19 EP EP00946608A patent/EP1188058B1/de not_active Expired - Lifetime
- 2000-06-19 AU AU60340/00A patent/AU775060B2/en not_active Ceased
- 2000-06-19 DE DE60020119T patent/DE60020119T2/de not_active Expired - Lifetime
- 2000-06-19 AT AT00946608T patent/ATE295541T1/de not_active IP Right Cessation
-
2001
- 2001-08-03 US US09/921,496 patent/US6808938B2/en not_active Expired - Lifetime
-
2004
- 2004-09-22 US US10/946,732 patent/US20050037418A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP4543187B2 (ja) | 2010-09-15 |
US20050037418A1 (en) | 2005-02-17 |
US6808938B2 (en) | 2004-10-26 |
AU775060B2 (en) | 2004-07-15 |
EP1188058A2 (de) | 2002-03-20 |
AU6034000A (en) | 2001-01-09 |
DE60020119D1 (de) | 2005-06-16 |
US20020019019A1 (en) | 2002-02-14 |
JP2003502668A (ja) | 2003-01-21 |
WO2000079268A2 (en) | 2000-12-28 |
WO2000079268A3 (en) | 2001-07-19 |
DE60020119T2 (de) | 2005-10-06 |
EP1188058B1 (de) | 2005-05-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |