RU2017108862A - Лечение патологических состояний суставов - Google Patents
Лечение патологических состояний суставов Download PDFInfo
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- RU2017108862A RU2017108862A RU2017108862A RU2017108862A RU2017108862A RU 2017108862 A RU2017108862 A RU 2017108862A RU 2017108862 A RU2017108862 A RU 2017108862A RU 2017108862 A RU2017108862 A RU 2017108862A RU 2017108862 A RU2017108862 A RU 2017108862A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Claims (33)
1. Способ лечения патологического состояния сустава, включающий введение нуждающемуся в этом животному эффективного количества фармацевтической композиции, содержащей DA-DKP, в многодозовом режиме.
2. Способ по п. 1, в котором патологическим состоянием сустава является заболевание сустава.
3. Способ по п. 2, в котором заболеванием сустава является дегенеративное заболевание сустава.
4. Способ по п. 3, в котором дегенеративным заболеванием сустава является остеоартрит.
5. Способ по п. 1, в котором патологическим состоянием сустава является поражение сустава.
6. Способ по п. 5, в котором поражением сустава является по меньшей мере одно из следующих: травматическое поражение и послеоперационное поражение.
7. Способ по п. 5, в котором поражением сустава является хроническое повреждение травматического характера.
8. Способ по п. 1, в котором патологическим состоянием сустава является воспаление.
9. Способ по п. 1, в котором композицию вводят с помощью пути введения, выбранного из группы, включающей локальное введение, местное введение и инъекцию.
10. Способ по п. 9, в котором введение с помощью инъекции проводят с помощью внутрисуставной инъекции.
11. Способ по п. 10, в котором композиция, вводимая с помощью внутрисуставной инъекции, представляет собой композицию, имеющая концентрацию DA-DKP, равную от примерно 50 мкМ до примерно 350 мкМ.
12. Способ по п. 1, в котором композиция дополнительно содержит N-ацетилтриптофан (NAT), каприловую кислоту, каприлат или их комбинации.
13. Способ по п. 10, в котором композиция, представляет собой композицию, имеющая концентрацию NAT, каприловой кислоты, каприлата или их комбинации, равную от примерно 4 мМ до примерно 20 мМ.
14. Способ по п. 1, в котором DA-DKP содержится в композиции, полученной путем удаления альбумина из раствора композиции сывороточного альбумина человека.
15. Способ по п. 14, в котором стадия удаления альбумина включает обработку композиции сывороточного альбумина человека по методике разделения, выбранной из группы, включающей ультрафильтрование, центрифугирование в градиенте плотности сахарозы, хроматографию, осаждение соли и обработку ультразвуком.
16. Способ по п. 15, в котором стадия удаления включает пропускание композиции сывороточного альбумина человека через ультрафильтрующую мембрану, обладающую номинальной задерживаемой молекулярной массой, которая обеспечивает удерживание альбумина и при использовании которой полученный фильтрат содержит DA-DKP.
17. Способ по п. 16, в котором ультрафильтрующая мембрана обладает номинальной задерживаемой молекулярной массой, равной менее 50 кДа, менее 40 кДа, менее 30 кДа, менее 20 кДа, менее 10 кДа, менее 5 кДа или менее 3 кДа.
18. Способ по п. 14, в котором композиция дополнительно содержит NAT, каприловую кислоту, каприлат или их комбинации.
19. Способ по п. 18, в котором композиция, представляет собой композицию, имеющую концентрацию NAT, каприловой кислоты, каприлата или их комбинации, равной от примерно 4 мМ до примерно 20 мМ.
20. Способ по п. 1, в котором фармацевтическая композиция дополнительно содержит второе лекарственное средство, выбранное из группы, включающей анальгетическое, противовоспалительное лекарственное средство и их комбинации.
21. Способ по п. 1, в котором количество доз в многодозовом режиме равно от 2 до 10.
22. Способ по п. 1, в котором количество доз в многодозовом режиме равно от 2 до 8.
23. Способ по п. 1, в котором количество доз в многодозовом режиме равно от 2 до 6.
24. Способ по п. 1, в котором количество доз в многодозовом режиме равно от 2 до 4.
25. Способ по п. 1, в котором количество доз в многодозовом режиме равно 3.
26. Способ по п. 1, в котором промежуток времени между дозами в многодозовом режиме составляет от 2 дней до 6 недель.
27. Способ по п. 1, в котором промежуток времени между дозами в многодозовом режиме составляет от 2 дней до 6 недель.
28. Способ по п. 1, в котором промежуток времени между дозами в многодозовом режиме составляет от 2 дней до 5 недель.
29. Способ по п. 1, в котором промежуток времени между дозами в многодозовом режиме составляет от 2 дней до 4 недель.
30. Способ по п. 1, в котором промежуток времени между дозами в многодозовом режиме составляет от 2 дней до 3 недель.
31. Способ по п. 1, в котором промежуток времени между дозами в многодозовом режиме составляет от 1 недели до 3 недель.
32. Способ по п. 1, в котором промежуток времени между дозами в многодозовом режиме составляет примерно 2 недели.
33. Способ лечения остеоартрита, включающий введение с помощью внутрисуставной инъекции в пораженный сустав первой дозы, второй дозы и третьей дозы, в котором каждая первая доза, вторая доза и третья доза содержит 4 мл фракции сывороточного альбумина человека, имеющей ММ, равную <5000, , и в котором вторую дозу вводят через две недели после первой дозы и третью дозу вводят через две недели после второй дозы.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462038682P | 2014-08-18 | 2014-08-18 | |
US62/038,682 | 2014-08-18 | ||
PCT/US2015/045706 WO2016028790A1 (en) | 2014-08-18 | 2015-08-18 | Treatment of joint conditions |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2020136589A Division RU2020136589A (ru) | 2014-08-18 | 2015-08-18 | Лечение дегенеративных заболеваний суставов |
Publications (3)
Publication Number | Publication Date |
---|---|
RU2017108862A true RU2017108862A (ru) | 2018-09-20 |
RU2017108862A3 RU2017108862A3 (ru) | 2019-01-23 |
RU2736513C2 RU2736513C2 (ru) | 2020-11-17 |
Family
ID=55301320
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2017108862A RU2736513C2 (ru) | 2014-08-18 | 2015-08-18 | Лечение патологических состояний суставов |
RU2020136589A RU2020136589A (ru) | 2014-08-18 | 2015-08-18 | Лечение дегенеративных заболеваний суставов |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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RU2020136589A RU2020136589A (ru) | 2014-08-18 | 2015-08-18 | Лечение дегенеративных заболеваний суставов |
Country Status (10)
Country | Link |
---|---|
US (4) | US9956217B2 (ru) |
EP (2) | EP4066836A1 (ru) |
JP (3) | JP6723222B2 (ru) |
KR (1) | KR20170045274A (ru) |
CN (1) | CN106604915A (ru) |
AU (1) | AU2015305611B2 (ru) |
CA (1) | CA2958080A1 (ru) |
IL (2) | IL250513B (ru) |
RU (2) | RU2736513C2 (ru) |
WO (1) | WO2016028790A1 (ru) |
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CN110551175B (zh) * | 2018-06-04 | 2021-07-02 | 首都医科大学 | 氨基酸和氨甲环酸修饰的二酮哌嗪,其制备,活性及应用 |
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- 2015-08-18 RU RU2017108862A patent/RU2736513C2/ru active
- 2015-08-18 US US14/829,289 patent/US9956217B2/en active Active
- 2015-08-18 WO PCT/US2015/045706 patent/WO2016028790A1/en active Application Filing
- 2015-08-18 EP EP15833436.7A patent/EP3183240A4/en not_active Withdrawn
- 2015-08-18 RU RU2020136589A patent/RU2020136589A/ru unknown
- 2015-08-18 JP JP2017509768A patent/JP6723222B2/ja not_active Expired - Fee Related
- 2015-08-18 CA CA2958080A patent/CA2958080A1/en not_active Abandoned
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2017
- 2017-02-08 IL IL250513A patent/IL250513B/en unknown
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2018
- 2018-03-22 US US15/933,016 patent/US10342793B2/en not_active Expired - Fee Related
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2019
- 2019-05-20 US US16/416,710 patent/US11090301B2/en active Active
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2020
- 2020-06-23 JP JP2020107654A patent/JP2020164538A/ja not_active Withdrawn
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2021
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- 2021-07-20 IL IL285003A patent/IL285003A/en unknown
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2022
- 2022-04-13 JP JP2022066206A patent/JP2022095876A/ja active Pending
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Publication number | Publication date |
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EP4066836A1 (en) | 2022-10-05 |
US11090301B2 (en) | 2021-08-17 |
JP2020164538A (ja) | 2020-10-08 |
US9956217B2 (en) | 2018-05-01 |
AU2015305611A1 (en) | 2017-04-06 |
WO2016028790A1 (en) | 2016-02-25 |
JP2017524024A (ja) | 2017-08-24 |
US20200000800A1 (en) | 2020-01-02 |
EP3183240A4 (en) | 2018-06-27 |
US20160045493A1 (en) | 2016-02-18 |
US20190022087A1 (en) | 2019-01-24 |
CA2958080A1 (en) | 2016-02-25 |
KR20170045274A (ko) | 2017-04-26 |
EP3183240A1 (en) | 2017-06-28 |
RU2020136589A (ru) | 2020-12-24 |
US10342793B2 (en) | 2019-07-09 |
US20210330668A1 (en) | 2021-10-28 |
JP2022095876A (ja) | 2022-06-28 |
JP6723222B2 (ja) | 2020-07-15 |
RU2017108862A3 (ru) | 2019-01-23 |
CN106604915A (zh) | 2017-04-26 |
IL250513A0 (en) | 2017-03-30 |
AU2015305611B2 (en) | 2020-04-23 |
IL250513B (en) | 2021-08-31 |
RU2736513C2 (ru) | 2020-11-17 |
IL285003A (en) | 2021-08-31 |
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