PT3330255T - Processo para a fabricação de modeladores do regulador da condutância transmembranar da fibrose quística - Google Patents

Processo para a fabricação de modeladores do regulador da condutância transmembranar da fibrose quística

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Publication number
PT3330255T
PT3330255T PT171932676T PT17193267T PT3330255T PT 3330255 T PT3330255 T PT 3330255T PT 171932676 T PT171932676 T PT 171932676T PT 17193267 T PT17193267 T PT 17193267T PT 3330255 T PT3330255 T PT 3330255T
Authority
PT
Portugal
Prior art keywords
cystic fibrosis
fibrosis transmembrane
conductance regulator
transmembrane conductance
modulators
Prior art date
Application number
PT171932676T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of PT3330255T publication Critical patent/PT3330255T/pt

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    • C07C205/39Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/42Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/43Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/233Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • C07C229/66Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring the carbon skeleton being further substituted by doubly-bound oxygen atoms
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PT171932676T 2009-03-20 2010-03-19 Processo para a fabricação de modeladores do regulador da condutância transmembranar da fibrose quística PT3330255T (pt)

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KR20110130492A (ko) 2011-12-05
US20140012003A1 (en) 2014-01-09
KR101727762B1 (ko) 2017-04-17

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