MX360262B - Heterociclilaminas como inhibidores de fosfoinositida 3-cinasas (pi3k). - Google Patents

Heterociclilaminas como inhibidores de fosfoinositida 3-cinasas (pi3k).

Info

Publication number
MX360262B
MX360262B MX2014002360A MX2014002360A MX360262B MX 360262 B MX360262 B MX 360262B MX 2014002360 A MX2014002360 A MX 2014002360A MX 2014002360 A MX2014002360 A MX 2014002360A MX 360262 B MX360262 B MX 360262B
Authority
MX
Mexico
Prior art keywords
heterocyclylamines
pi3k inhibitors
activity
pi3ks
diseases
Prior art date
Application number
MX2014002360A
Other languages
English (en)
Other versions
MX2014002360A (es
Inventor
Yao Wenqing
Li Yun-Long
P Combs Andrew
W Yue Eddy
Mei Song
Zhu Wenyu
Glenn Joseph
P Maduskuie Thomas Jr
B Sparks Richard
Douty Brent
He Chunhong
Original Assignee
Incyte Holdings Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Holdings Corp filed Critical Incyte Holdings Corp
Publication of MX2014002360A publication Critical patent/MX2014002360A/es
Publication of MX360262B publication Critical patent/MX360262B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona derivados de heterociclilamina de la fórmula I: (ver Fórmula) en donde las variables se definen en la presente, que modulan la actividad de las fosfoinositida 3-cinasas (PI3Ks) y son de utilidad en el tratamiento de enfermedades relacionadas con la actividad de PI3Ks que incluyen, por ejemplo, trastornos inflamatorios, trastornos con base inmune, cáncer y otras enfermedades.
MX2014002360A 2011-09-02 2012-08-31 Heterociclilaminas como inhibidores de fosfoinositida 3-cinasas (pi3k). MX360262B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161530866P 2011-09-02 2011-09-02
US201261594882P 2012-02-03 2012-02-03
US201261677445P 2012-07-30 2012-07-30
PCT/US2012/053398 WO2013033569A1 (en) 2011-09-02 2012-08-31 Heterocyclylamines as pi3k inhibitors

Publications (2)

Publication Number Publication Date
MX2014002360A MX2014002360A (es) 2014-04-25
MX360262B true MX360262B (es) 2018-10-26

Family

ID=47071429

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2014002360A MX360262B (es) 2011-09-02 2012-08-31 Heterociclilaminas como inhibidores de fosfoinositida 3-cinasas (pi3k).
MX2020004502A MX389479B (es) 2011-09-02 2012-08-31 Heterociclilaminas como inhibidores de fosfoinositida 3-cinasas (pi3k)
MX2018009889A MX373199B (es) 2011-09-02 2012-08-31 Heterociclilaminas como inhibidores de fosfoinositida 3-cinasas (pi3k).

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2020004502A MX389479B (es) 2011-09-02 2012-08-31 Heterociclilaminas como inhibidores de fosfoinositida 3-cinasas (pi3k)
MX2018009889A MX373199B (es) 2011-09-02 2012-08-31 Heterociclilaminas como inhibidores de fosfoinositida 3-cinasas (pi3k).

Country Status (37)

Country Link
US (10) US9199982B2 (es)
EP (4) EP3888657B1 (es)
JP (9) JP6067709B2 (es)
KR (7) KR102030609B1 (es)
CN (1) CN106986867B (es)
AR (1) AR087760A1 (es)
AU (6) AU2012301721B2 (es)
BR (2) BR112014004971B1 (es)
CA (1) CA2846652C (es)
CL (1) CL2014000517A1 (es)
CO (1) CO6910199A2 (es)
CR (2) CR20180293A (es)
CY (3) CY1118679T1 (es)
DK (3) DK3196202T3 (es)
EA (2) EA033646B1 (es)
EC (1) ECSP14013274A (es)
ES (4) ES3036260T3 (es)
HR (3) HRP20170285T1 (es)
HU (3) HUE043703T2 (es)
IL (7) IL299533B2 (es)
LT (3) LT3196202T (es)
ME (2) ME03397B (es)
MX (3) MX360262B (es)
MY (1) MY179332A (es)
NZ (1) NZ769326A (es)
PE (2) PE20141726A1 (es)
PH (4) PH12014500470B1 (es)
PL (3) PL3513793T3 (es)
PT (3) PT2751109T (es)
RS (3) RS55737B1 (es)
SG (3) SG11201400232WA (es)
SI (3) SI2751109T1 (es)
SM (4) SMT201900243T1 (es)
TW (6) TWI619714B (es)
UA (1) UA121539C2 (es)
WO (1) WO2013033569A1 (es)
ZA (1) ZA201904877B (es)

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