MX352928B - Compuestos de piridazina-amida. - Google Patents
Compuestos de piridazina-amida.Info
- Publication number
- MX352928B MX352928B MX2014008158A MX2014008158A MX352928B MX 352928 B MX352928 B MX 352928B MX 2014008158 A MX2014008158 A MX 2014008158A MX 2014008158 A MX2014008158 A MX 2014008158A MX 352928 B MX352928 B MX 352928B
- Authority
- MX
- Mexico
- Prior art keywords
- syk inhibitors
- amide compounds
- pyridazine
- pyridazine amide
- syk
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
La presente invención se refiere al uso de nuevos derivados de triazolopiridina de la fórmula I: (ver Fórmula) en la que todos los sustituyentes variables tienen los significados aquí definidos, dichos compuestos son inhibidores de la SYK y son útiles para el tratamiento de enfermedades autoinmunes e inflamatorias.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261584859P | 2012-01-10 | 2012-01-10 | |
US201261696855P | 2012-09-05 | 2012-09-05 | |
PCT/EP2013/050136 WO2013104573A1 (en) | 2012-01-10 | 2013-01-07 | Pyridazine amide compounds and their use as syk inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014008158A MX2014008158A (es) | 2014-10-14 |
MX352928B true MX352928B (es) | 2017-12-13 |
Family
ID=47553049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014008158A MX352928B (es) | 2012-01-10 | 2013-01-07 | Compuestos de piridazina-amida. |
Country Status (12)
Country | Link |
---|---|
US (1) | US8901124B2 (es) |
EP (1) | EP2802567B1 (es) |
JP (1) | JP6109192B2 (es) |
KR (1) | KR20140108594A (es) |
CN (1) | CN104159891B (es) |
AR (1) | AR089682A1 (es) |
CA (1) | CA2860547A1 (es) |
HK (1) | HK1203934A1 (es) |
MX (1) | MX352928B (es) |
RU (1) | RU2627661C2 (es) |
TW (1) | TWI557115B (es) |
WO (1) | WO2013104573A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2883534A1 (en) * | 2012-10-19 | 2014-04-24 | F. Hoffmann-La Roche Ag | Inhibitors of syk |
CN104884454B (zh) * | 2012-11-08 | 2017-11-28 | 百时美施贵宝公司 | 用作IL‑12、IL‑23和/或IFNα应答调节剂的酰胺取代的杂环化合物 |
WO2015123453A1 (en) * | 2014-02-14 | 2015-08-20 | Portola Pharmaceuticals, Inc. | Pyridazine compounds as jak inhibitors |
MX2017015574A (es) * | 2015-06-02 | 2018-08-09 | Pharmacyclics Llc | Inhibidores de tirosina quinasa de bruton. |
CN105777748A (zh) * | 2016-04-05 | 2016-07-20 | 叶芳 | 一种7-氮杂吲哚及其制备方法 |
CN110475774B (zh) * | 2017-03-30 | 2023-06-02 | 百时美施贵宝公司 | 用于制备Tyk2抑制剂的方法 |
BR112020009606A2 (pt) * | 2017-11-21 | 2020-11-03 | Bristol-Myers Squibb Company | compostos heteroaril sulfona piridina alquil de amidasubstituídos |
EP3731840A4 (en) * | 2017-12-29 | 2021-09-15 | Orfan Biotech Inc. | NADPH OXIDASE INHIBITORS AND THEIR USE |
US11597721B2 (en) | 2018-03-22 | 2023-03-07 | Bristol-Myers Squibb Company | Heterocyclic compounds comprising pyridine useful as modulators of IL-12, IL-23 and/or IFNα responses |
SG11202012930RA (en) | 2018-07-06 | 2021-01-28 | Orfan Biotech Inc | Triazole glycolate oxidase inhibitors |
CN110818641B (zh) * | 2018-08-07 | 2022-10-14 | 北京诺诚健华医药科技有限公司 | 哒嗪-3-甲酰胺类化合物、其制备方法及其在医药学上的应用 |
SG11202104017VA (en) | 2018-10-22 | 2021-05-28 | Esker Therapeutics Inc | Tyk2 inhibitors and uses thereof |
CN110128422B (zh) * | 2019-01-04 | 2022-03-18 | 金凯(辽宁)生命科技股份有限公司 | 5-甲氧基-7-氮杂吲哚的合成方法 |
CA3129665A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
CA3138473A1 (en) | 2019-04-30 | 2020-11-05 | Celgene Corporation | Combination therapies comprising apremilast and tyk2 inhibitors |
WO2021089791A1 (en) | 2019-11-08 | 2021-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
AU2021289665A1 (en) | 2020-06-10 | 2022-12-15 | Aligos Therapeutics, Inc. | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
CN112107580A (zh) * | 2020-09-29 | 2020-12-22 | 北京鑫开元医药科技有限公司 | 一种脾酪氨酸激酶抑制剂的制剂组合物及其制备方法 |
CN115160297B (zh) * | 2020-12-22 | 2023-03-31 | 益方生物科技(上海)股份有限公司 | 杂芳基化合物及其制备方法和用途 |
AU2022306289A1 (en) | 2021-07-09 | 2024-01-18 | Aligos Therapeutics, Inc. | Anti-viral compounds |
WO2023108536A1 (en) * | 2021-12-16 | 2023-06-22 | Lynk Pharmaceuticals Co. Ltd. | Tyk2 inhibitors and compositions and methods thereof |
CN116693449A (zh) * | 2022-03-04 | 2023-09-05 | 上海致根医药科技有限公司 | 用作tyk2抑制剂的化合物、其制备方法及其在医药上的应用 |
WO2023231997A1 (zh) * | 2022-05-31 | 2023-12-07 | 上海华汇拓医药科技有限公司 | 一种哒嗪类化合物、其制备方法和用途 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4622047B2 (ja) * | 1999-06-09 | 2011-02-02 | アステラス製薬株式会社 | 新規なヘテロ環カルボキサミド誘導体 |
DE60017898T2 (de) * | 1999-06-09 | 2006-01-12 | Yamanouchi Pharmaceutical Co., Ltd. | Neuartige heterocyclische carboxamidderivate |
US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
JP2008013499A (ja) * | 2006-07-06 | 2008-01-24 | Sankyo Co Ltd | 5−シアノニコチンアミド誘導体 |
ES2462642T3 (es) | 2007-12-14 | 2014-05-26 | F. Hoffmann-La Roche Ag | Nuevos derivados de imidazo[1,2-a]piridina e imidazo[1,2-b]piridazina |
PL2250172T3 (pl) | 2008-02-25 | 2012-01-31 | Hoffmann La Roche | Pirolopirazynowe inhibitory kinazy |
PT2247592E (pt) | 2008-02-25 | 2011-11-03 | Hoffmann La Roche | Inibidores de pirrolpirazina-cinase |
CA2713718A1 (en) | 2008-02-25 | 2009-09-03 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine kinase inhibitors |
WO2009106441A1 (en) | 2008-02-25 | 2009-09-03 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine kinase inhibitors |
CN101945877B (zh) | 2008-02-25 | 2013-07-03 | 霍夫曼-拉罗奇有限公司 | 吡咯并吡嗪激酶抑制剂 |
KR101773313B1 (ko) * | 2008-04-16 | 2017-08-31 | 포톨라 파마슈티컬스, 인코포레이티드 | syk 또는 JAK 키나제 억제제로서의 2,6-디아미노-피리미딘-5-일-카르복스아미드 |
EA024109B1 (ru) * | 2008-04-16 | 2016-08-31 | Портола Фармасьютиклз, Инк. | Ингибиторы протеинкиназ |
ES2546502T3 (es) * | 2008-04-16 | 2015-09-24 | Portola Pharmaceuticals, Inc. | 2,6-Diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o JAK quinasas |
NZ593460A (en) | 2008-12-08 | 2013-11-29 | Gilead Connecticut Inc | Imidazopyrazine syk inhibitors |
PA8854101A1 (es) | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
US8518945B2 (en) | 2010-03-22 | 2013-08-27 | Hoffmann-La Roche Inc. | Pyrrolopyrazine kinase inhibitors |
US8481541B2 (en) | 2010-03-22 | 2013-07-09 | Hoffmann-La Roche Inc. | Pyrrolopyrazine kinase inhibitors |
RU2012152354A (ru) | 2010-05-20 | 2014-06-27 | Ф. Хоффманн-Ля Рош Аг | Производные пирролопиразина в качестве ингибиторов syk и jak |
BR112012029437A2 (pt) | 2010-05-20 | 2017-03-07 | F Hoffmann - La Roche Ag | derivados de pirrolo[2,3-b]pirazina-7-carboxamida e seu uso como inibidores de jak e syk |
-
2013
- 2013-01-07 JP JP2014550711A patent/JP6109192B2/ja not_active Expired - Fee Related
- 2013-01-07 CA CA2860547A patent/CA2860547A1/en not_active Abandoned
- 2013-01-07 MX MX2014008158A patent/MX352928B/es active IP Right Grant
- 2013-01-07 KR KR1020147021869A patent/KR20140108594A/ko not_active Application Discontinuation
- 2013-01-07 AR ARP130100059A patent/AR089682A1/es unknown
- 2013-01-07 CN CN201380013410.3A patent/CN104159891B/zh not_active Expired - Fee Related
- 2013-01-07 EP EP13700132.7A patent/EP2802567B1/en not_active Not-in-force
- 2013-01-07 RU RU2014131707A patent/RU2627661C2/ru not_active IP Right Cessation
- 2013-01-07 WO PCT/EP2013/050136 patent/WO2013104573A1/en active Application Filing
- 2013-01-09 TW TW102100756A patent/TWI557115B/zh not_active IP Right Cessation
- 2013-01-10 US US13/738,098 patent/US8901124B2/en not_active Expired - Fee Related
-
2015
- 2015-05-07 HK HK15104335.9A patent/HK1203934A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
TWI557115B (zh) | 2016-11-11 |
EP2802567A1 (en) | 2014-11-19 |
RU2627661C2 (ru) | 2017-08-09 |
TW201332978A (zh) | 2013-08-16 |
CN104159891A (zh) | 2014-11-19 |
HK1203934A1 (en) | 2015-11-06 |
CA2860547A1 (en) | 2013-07-18 |
AR089682A1 (es) | 2014-09-10 |
CN104159891B (zh) | 2016-09-07 |
US20130178478A1 (en) | 2013-07-11 |
MX2014008158A (es) | 2014-10-14 |
EP2802567B1 (en) | 2017-03-01 |
US8901124B2 (en) | 2014-12-02 |
JP6109192B2 (ja) | 2017-04-05 |
JP2015503575A (ja) | 2015-02-02 |
KR20140108594A (ko) | 2014-09-11 |
WO2013104573A1 (en) | 2013-07-18 |
RU2014131707A (ru) | 2016-03-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX352928B (es) | Compuestos de piridazina-amida. | |
MX343561B (es) | Compuestos de imidazolpiridazina. | |
MX2014002442A (es) | Inhibidores de pirrolopirazina cinasa. | |
MX342310B (es) | Compuestos de tiazolopirimidina. | |
PH12017502141A1 (en) | Compounds and their methods of use | |
PH12018502125A1 (en) | Bipyrazole derivatives as jak inhibitors | |
PH12015502248B1 (en) | 6-(5-hydroxy-1h-pyrazol-1-yl)nicotinamide derivatives and their use as phd inhibitors | |
MX2015001207A (es) | Compuestos de heteroarilo y heterociclo novedosos, composición y métodos de los mismos. | |
EA201400735A1 (ru) | Производные альфа-амино бороновой кислоты, селективные ингибиторы иммунопротеасомы | |
MX349548B (es) | Compuestos de tienopirimidina. | |
AU2012213775A8 (en) | 7-azaindole derivatives | |
PL2250172T3 (pl) | Pirolopirazynowe inhibitory kinazy | |
TW200942543A (en) | Pyrrolopyrazine kinase inhibitors | |
MA33939B1 (fr) | 5-alcynyl-pyrimidines | |
UY33888A (es) | Derivados de (1,2,4) triazolo [4,3-a) quinoxalina como inhibidores de fosfodiesterasas | |
EA201491149A1 (ru) | Пиразолопиридиновые производные, способы их получения и их терапевтическое применение | |
MX348451B (es) | Derivados de n-[(1h-pirazol-1-il)aril]-1h-indol o 1h-indazol-3-carboxamida, su preparación y su uso como antagonistas p2y12. | |
CA2878796C (en) | Derivatives of pyridinone as inhibitors for tissue transglutaminase | |
EA201491376A1 (ru) | Производные 1h-пирроло[2,3-b]пиридина и их применение в качестве ингибиторов киназы | |
PH12015501175A1 (en) | Substituted pyridopyrazines as syk inhibitors | |
NZ711192A (en) | Process for making benzoxazepin compounds | |
MX2016006975A (es) | Compuestos, composicion farmaceutica y metodos para su uso en el tratamiento de enfermedades inflamatorias. | |
MY160902A (en) | Process for the preparation of the L-arginine salt of perindopril | |
IN2015DN00950A (es) | ||
MX359399B (es) | Inhibidores de 17alfa-hidroxilasa/c17-20-liasa. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |