BR112014004971A2 - heterociclilaminas como inibidores de pi3k - Google Patents

heterociclilaminas como inibidores de pi3k

Info

Publication number
BR112014004971A2
BR112014004971A2 BR112014004971A BR112014004971A BR112014004971A2 BR 112014004971 A2 BR112014004971 A2 BR 112014004971A2 BR 112014004971 A BR112014004971 A BR 112014004971A BR 112014004971 A BR112014004971 A BR 112014004971A BR 112014004971 A2 BR112014004971 A2 BR 112014004971A2
Authority
BR
Brazil
Prior art keywords
pi3ks
activity
heterocyclylamines
diseases
pi3k inhibitors
Prior art date
Application number
BR112014004971A
Other languages
English (en)
Other versions
BR112014004971B1 (pt
BR112014004971A8 (pt
Inventor
P Combs Andrew
Douty Brent
He Chunhong
W Yue Eddy
Glenn Joseph
B Sparks Richard
Mei Song
P Maduskuie Thomas
Yao Wenqing
Zhu Wenyu
Li Yun-Long
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Priority to BR122019020716-0A priority Critical patent/BR122019020716B1/pt
Publication of BR112014004971A2 publication Critical patent/BR112014004971A2/pt
Publication of BR112014004971A8 publication Critical patent/BR112014004971A8/pt
Publication of BR112014004971B1 publication Critical patent/BR112014004971B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

abstract the present invention provides heterocyclylamine derivatives of formula i: i wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (pi3ks) and are useful in the treatment of diseases related to the activity of pi3ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases. tradução do resumo resumo patente de invenção: "heterociclilaminas como inibidores de pi3k". a presente invenção fornece derivados de heterociclilamina de fórmula i: em que as variáveis são definidas aqui, que modulam a atividade de fosfoinositida 3-quinases (pi3ks) e são úteis no tratamento de doenças relacionadas à atividade de pi3ks incluindo, por exemplo, distúrbios inflamatórios, distúrbios de base imunológica, câncer, e outras doenças.
BR112014004971-8A 2011-09-02 2012-08-31 compostos heterociclilaminas, sua composição farmacêutica e seus usos BR112014004971B1 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122019020716-0A BR122019020716B1 (pt) 2011-09-02 2012-08-31 heterociclilaminas como inibidores de pi3k e composição farmacêutica que as compreende

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161530866P 2011-09-02 2011-09-02
US61/530,866 2011-09-02
US201261594882P 2012-02-03 2012-02-03
US61/594,882 2012-02-03
US201261677445P 2012-07-30 2012-07-30
US61/677,445 2012-07-30
PCT/US2012/053398 WO2013033569A1 (en) 2011-09-02 2012-08-31 Heterocyclylamines as pi3k inhibitors

Publications (3)

Publication Number Publication Date
BR112014004971A2 true BR112014004971A2 (pt) 2017-03-21
BR112014004971A8 BR112014004971A8 (pt) 2019-11-05
BR112014004971B1 BR112014004971B1 (pt) 2021-02-09

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
BR112014004971-8A BR112014004971B1 (pt) 2011-09-02 2012-08-31 compostos heterociclilaminas, sua composição farmacêutica e seus usos
BR122019020716-0A BR122019020716B1 (pt) 2011-09-02 2012-08-31 heterociclilaminas como inibidores de pi3k e composição farmacêutica que as compreende

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR122019020716-0A BR122019020716B1 (pt) 2011-09-02 2012-08-31 heterociclilaminas como inibidores de pi3k e composição farmacêutica que as compreende

Country Status (37)

Country Link
US (8) US9199982B2 (pt)
EP (4) EP3513793B1 (pt)
JP (8) JP6067709B2 (pt)
KR (7) KR101982475B1 (pt)
CN (1) CN106986867B (pt)
AR (1) AR087760A1 (pt)
AU (5) AU2012301721B2 (pt)
BR (2) BR112014004971B1 (pt)
CA (1) CA2846652C (pt)
CL (1) CL2014000517A1 (pt)
CO (1) CO6910199A2 (pt)
CR (2) CR20180293A (pt)
CY (3) CY1118679T1 (pt)
DK (3) DK3513793T3 (pt)
EA (2) EA033646B1 (pt)
EC (1) ECSP14013274A (pt)
ES (3) ES2722524T3 (pt)
HK (1) HK1199644A1 (pt)
HR (3) HRP20170285T1 (pt)
HU (3) HUE030869T2 (pt)
IL (6) IL299533A (pt)
LT (3) LT3513793T (pt)
ME (2) ME02595B (pt)
MX (2) MX2020004502A (pt)
MY (1) MY179332A (pt)
NZ (1) NZ769326A (pt)
PE (2) PE20141726A1 (pt)
PH (2) PH12017501766A1 (pt)
PL (3) PL2751109T3 (pt)
PT (3) PT3513793T (pt)
RS (3) RS55737B1 (pt)
SG (3) SG10201912484RA (pt)
SI (3) SI3196202T1 (pt)
SM (1) SMT201700111B (pt)
TW (6) TWI717002B (pt)
WO (1) WO2013033569A1 (pt)
ZA (1) ZA201904877B (pt)

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