MD3687996T2 - Săruri de derivați de pirolotriazină utile ca inhibitori TAM - Google Patents

Săruri de derivați de pirolotriazină utile ca inhibitori TAM

Info

Publication number
MD3687996T2
MD3687996T2 MDE20200803T MDE20200803T MD3687996T2 MD 3687996 T2 MD3687996 T2 MD 3687996T2 MD E20200803 T MDE20200803 T MD E20200803T MD E20200803 T MDE20200803 T MD E20200803T MD 3687996 T2 MD3687996 T2 MD 3687996T2
Authority
MD
Moldova
Prior art keywords
salts
derivatives useful
pyrrolotriazine derivatives
phenyl
tam inhibitors
Prior art date
Application number
MDE20200803T
Other languages
English (en)
Inventor
Zhongjiang Jia
Yongzhong Wu
Yongchun Pan
Jiacheng Zhou
Qun Li
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of MD3687996T2 publication Critical patent/MD3687996T2/ro

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Prezenta cerere de brevet furnizează forme de sare de N-(4-(4-amino-7-(1-izobutirilpiperidin-4-il)pirolo[1,2-f][1,2,4]triazin-5-il)fenil)-1-izopropil-2,4-dioxo-3-(piridin-2-il)-1,2,3,4-tetrahidropirimidin-5-carboxamidă şi N-(4-(amino-7-(1-izobutirilpiperidin-4-il)pirolo[1,2-f][1,2,4]triazin-5-il)fenil)-1-izopropil-2,4-dioxo-3-fenil-1,2,3,4-tetrahidropirimidin-5-carboxamidă, care sunt utile ca inhibitori de kinaze TAM, precum şi procesele şi intermediarii înrudiţi cu acestea.
MDE20200803T 2017-09-27 2018-09-26 Săruri de derivați de pirolotriazină utile ca inhibitori TAM MD3687996T2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762564070P 2017-09-27 2017-09-27
US201862714196P 2018-08-03 2018-08-03
PCT/US2018/052925 WO2019067594A1 (en) 2017-09-27 2018-09-26 SALTS OF PYRROLOTRIAZINE DERIVATIVES USEFUL AS TAM INHIBITORS

Publications (1)

Publication Number Publication Date
MD3687996T2 true MD3687996T2 (ro) 2022-04-30

Family

ID=63794769

Family Applications (1)

Application Number Title Priority Date Filing Date
MDE20200803T MD3687996T2 (ro) 2017-09-27 2018-09-26 Săruri de derivați de pirolotriazină utile ca inhibitori TAM

Country Status (33)

Country Link
US (3) US10633387B2 (ro)
EP (2) EP3988552A1 (ro)
JP (2) JP7504791B2 (ro)
KR (1) KR20200088308A (ro)
CN (1) CN111386273B (ro)
AU (2) AU2018342471B2 (ro)
BR (1) BR112020006145A2 (ro)
CA (1) CA3077308A1 (ro)
CL (2) CL2020000791A1 (ro)
CO (1) CO2020005009A2 (ro)
CR (1) CR20200179A (ro)
CY (1) CY1124952T1 (ro)
DK (1) DK3687996T3 (ro)
EC (1) ECSP20021655A (ro)
ES (1) ES2904458T3 (ro)
GE (1) GEP20227429B (ro)
HU (1) HUE057190T2 (ro)
IL (1) IL273579A (ro)
JO (1) JOP20200081A1 (ro)
LT (1) LT3687996T (ro)
MA (1) MA50655B1 (ro)
MD (1) MD3687996T2 (ro)
MX (1) MX2020003375A (ro)
PE (1) PE20210002A1 (ro)
PH (1) PH12020550143A1 (ro)
PL (1) PL3687996T3 (ro)
PT (1) PT3687996T (ro)
RS (1) RS62872B1 (ro)
SA (1) SA520411638B1 (ro)
SG (1) SG11202002821UA (ro)
SI (1) SI3687996T1 (ro)
TW (1) TWI821200B (ro)
WO (1) WO2019067594A1 (ro)

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MX2020003375A (es) 2020-08-03
EP3687996B1 (en) 2021-11-03
EP3988552A1 (en) 2022-04-27
JP2020535168A (ja) 2020-12-03
WO2019067594A1 (en) 2019-04-04
JOP20200081A1 (ar) 2020-04-30
ECSP20021655A (es) 2020-07-31
AU2018342471B2 (en) 2023-08-24
PT3687996T (pt) 2022-01-21
CN111386273B (zh) 2024-06-14
US10633387B2 (en) 2020-04-28
MA50655A (fr) 2021-06-02
IL273579A (en) 2020-05-31
PL3687996T3 (pl) 2022-02-21
US20200347065A1 (en) 2020-11-05
RS62872B1 (sr) 2022-02-28
CA3077308A1 (en) 2019-04-04
US20190112313A1 (en) 2019-04-18
BR112020006145A2 (pt) 2020-10-20
AU2018342471A1 (en) 2020-04-23
JP7504791B2 (ja) 2024-06-24
US20220227770A1 (en) 2022-07-21
GEP20227429B (en) 2022-10-25
ES2904458T3 (es) 2022-04-05
TWI821200B (zh) 2023-11-11
CN111386273A (zh) 2020-07-07
CR20200179A (es) 2020-11-02
SG11202002821UA (en) 2020-04-29
PE20210002A1 (es) 2021-01-05
SA520411638B1 (ar) 2024-03-28
KR20200088308A (ko) 2020-07-22
HUE057190T2 (hu) 2022-04-28
TW201920186A (zh) 2019-06-01
CL2022001014A1 (es) 2022-11-18
EP3687996A1 (en) 2020-08-05
LT3687996T (lt) 2022-01-10
PH12020550143A1 (en) 2020-12-07
JP2024059647A (ja) 2024-05-01
CO2020005009A2 (es) 2020-05-29
SI3687996T1 (sl) 2022-04-29
CY1124952T1 (el) 2023-01-05
AU2023270198A1 (en) 2023-12-14
DK3687996T3 (da) 2022-01-10
CL2020000791A1 (es) 2020-09-25
MA50655B1 (fr) 2021-11-30
US11104682B2 (en) 2021-08-31

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