DK3687996T3 - Salte af pyrrolotriazinderivater anvendelige som tam-inhibitorer - Google Patents

Salte af pyrrolotriazinderivater anvendelige som tam-inhibitorer Download PDF

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Publication number
DK3687996T3
DK3687996T3 DK18783341.3T DK18783341T DK3687996T3 DK 3687996 T3 DK3687996 T3 DK 3687996T3 DK 18783341 T DK18783341 T DK 18783341T DK 3687996 T3 DK3687996 T3 DK 3687996T3
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Prior art keywords
salts
pyrrolotriazine derivatives
derivatives use
tam inhibitors
tam
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DK18783341.3T
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English (en)
Inventor
Jiacheng Zhou
Qun Li
Zhongjiang Jia
Yongzhong Wu
Yongchun Pan
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Incyte Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK18783341.3T 2017-09-27 2018-09-26 Salte af pyrrolotriazinderivater anvendelige som tam-inhibitorer DK3687996T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762564070P 2017-09-27 2017-09-27
US201862714196P 2018-08-03 2018-08-03
PCT/US2018/052925 WO2019067594A1 (en) 2017-09-27 2018-09-26 SALTS OF PYRROLOTRIAZINE DERIVATIVES USEFUL AS TAM INHIBITORS

Publications (1)

Publication Number Publication Date
DK3687996T3 true DK3687996T3 (da) 2022-01-10

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DK18783341.3T DK3687996T3 (da) 2017-09-27 2018-09-26 Salte af pyrrolotriazinderivater anvendelige som tam-inhibitorer

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US (3) US10633387B2 (da)
EP (2) EP3988552A1 (da)
JP (2) JP7504791B2 (da)
KR (1) KR20200088308A (da)
CN (1) CN111386273B (da)
AU (2) AU2018342471B2 (da)
BR (1) BR112020006145A2 (da)
CA (1) CA3077308A1 (da)
CL (2) CL2020000791A1 (da)
CO (1) CO2020005009A2 (da)
CR (1) CR20200179A (da)
CY (1) CY1124952T1 (da)
DK (1) DK3687996T3 (da)
EC (1) ECSP20021655A (da)
ES (1) ES2904458T3 (da)
GE (1) GEP20227429B (da)
HU (1) HUE057190T2 (da)
IL (1) IL273579A (da)
JO (1) JOP20200081A1 (da)
LT (1) LT3687996T (da)
MA (1) MA50655B1 (da)
MD (1) MD3687996T2 (da)
MX (1) MX2020003375A (da)
PE (1) PE20210002A1 (da)
PH (1) PH12020550143A1 (da)
PL (1) PL3687996T3 (da)
PT (1) PT3687996T (da)
RS (1) RS62872B1 (da)
SA (1) SA520411638B1 (da)
SG (1) SG11202002821UA (da)
SI (1) SI3687996T1 (da)
TW (1) TWI821200B (da)
WO (1) WO2019067594A1 (da)

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CN115028648B (zh) * 2021-03-03 2024-08-30 武汉誉祥医药科技有限公司 三并环化合物及其药物组合物和应用
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Publication number Publication date
AU2018342471A1 (en) 2020-04-23
PT3687996T (pt) 2022-01-21
SI3687996T1 (sl) 2022-04-29
US20220227770A1 (en) 2022-07-21
ES2904458T3 (es) 2022-04-05
AU2018342471B2 (en) 2023-08-24
TWI821200B (zh) 2023-11-11
PE20210002A1 (es) 2021-01-05
PL3687996T3 (pl) 2022-02-21
JOP20200081A1 (ar) 2020-04-30
JP2024059647A (ja) 2024-05-01
IL273579A (en) 2020-05-31
ECSP20021655A (es) 2020-07-31
MX2020003375A (es) 2020-08-03
MD3687996T2 (ro) 2022-04-30
BR112020006145A2 (pt) 2020-10-20
MA50655B1 (fr) 2021-11-30
JP2020535168A (ja) 2020-12-03
US10633387B2 (en) 2020-04-28
CR20200179A (es) 2020-11-02
LT3687996T (lt) 2022-01-10
TW201920186A (zh) 2019-06-01
HUE057190T2 (hu) 2022-04-28
CO2020005009A2 (es) 2020-05-29
US20190112313A1 (en) 2019-04-18
SA520411638B1 (ar) 2024-03-28
EP3988552A1 (en) 2022-04-27
WO2019067594A1 (en) 2019-04-04
JP7504791B2 (ja) 2024-06-24
US20200347065A1 (en) 2020-11-05
CN111386273B (zh) 2024-06-14
PH12020550143A1 (en) 2020-12-07
CL2022001014A1 (es) 2022-11-18
CA3077308A1 (en) 2019-04-04
SG11202002821UA (en) 2020-04-29
KR20200088308A (ko) 2020-07-22
RS62872B1 (sr) 2022-02-28
US11104682B2 (en) 2021-08-31
EP3687996B1 (en) 2021-11-03
MA50655A (fr) 2021-06-02
CL2020000791A1 (es) 2020-09-25
CY1124952T1 (el) 2023-01-05
CN111386273A (zh) 2020-07-07
AU2023270198A1 (en) 2023-12-14
EP3687996A1 (en) 2020-08-05
GEP20227429B (en) 2022-10-25

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