CR20200179A - Sales de inhibidores de tam - Google Patents

Sales de inhibidores de tam

Info

Publication number
CR20200179A
CR20200179A CR20200179A CR20200179A CR20200179A CR 20200179 A CR20200179 A CR 20200179A CR 20200179 A CR20200179 A CR 20200179A CR 20200179 A CR20200179 A CR 20200179A CR 20200179 A CR20200179 A CR 20200179A
Authority
CR
Costa Rica
Prior art keywords
salts
derivatives useful
pyrrolotriazine derivatives
phenyl
inhibitors
Prior art date
Application number
CR20200179A
Other languages
English (en)
Inventor
Yongzhong Wu
Yongchun Pan
Qun Li
Jiacheng Zhou
Zhongjiang Jia
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of CR20200179A publication Critical patent/CR20200179A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente solicitud proporciona formas de sal de N-(4-(4-Amino-7-(1-isobutirilpiperidin-4-il)pirrolo[1,2-f][1,2,4]triazin-5-il)fenil)-1-isopropil-2,4-dioxo-3-(piridin-2-il)-1,2,3,4-tetrahidropirimidina-5-carboxamida y N-(4-(4-Amino-7-(1-isobutirilpiperidin-4-il)pirrolo[1,2-f][1,2,4]triazin-5-il)fenil)-1-isopropil-2,4-dioxo-3-fenil-1,2,3,4-tetrahidropirimidina-5-carboxamida, que son útiles como inhibidores de cinasas TAM, así como procesos e intermedios relacionados con estas.
CR20200179A 2017-09-27 2018-09-26 Sales de inhibidores de tam CR20200179A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762564070P 2017-09-27 2017-09-27
US201862714196P 2018-08-03 2018-08-03
PCT/US2018/052925 WO2019067594A1 (en) 2017-09-27 2018-09-26 SALTS OF PYRROLOTRIAZINE DERIVATIVES USEFUL AS TAM INHIBITORS

Publications (1)

Publication Number Publication Date
CR20200179A true CR20200179A (es) 2020-11-02

Family

ID=63794769

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20200179A CR20200179A (es) 2017-09-27 2018-09-26 Sales de inhibidores de tam

Country Status (32)

Country Link
US (3) US10633387B2 (es)
EP (2) EP3988552A1 (es)
JP (1) JP2024059647A (es)
KR (1) KR20200088308A (es)
CN (1) CN111386273B (es)
AU (2) AU2018342471B2 (es)
BR (1) BR112020006145A2 (es)
CA (1) CA3077308A1 (es)
CL (2) CL2020000791A1 (es)
CO (1) CO2020005009A2 (es)
CR (1) CR20200179A (es)
CY (1) CY1124952T1 (es)
DK (1) DK3687996T3 (es)
EC (1) ECSP20021655A (es)
ES (1) ES2904458T3 (es)
GE (1) GEP20227429B (es)
HU (1) HUE057190T2 (es)
IL (1) IL273579A (es)
JO (1) JOP20200081A1 (es)
LT (1) LT3687996T (es)
MA (1) MA50655B1 (es)
MD (1) MD3687996T2 (es)
MX (1) MX2020003375A (es)
PE (1) PE20210002A1 (es)
PH (1) PH12020550143A1 (es)
PL (1) PL3687996T3 (es)
PT (1) PT3687996T (es)
RS (1) RS62872B1 (es)
SG (1) SG11202002821UA (es)
SI (1) SI3687996T1 (es)
TW (1) TWI821200B (es)
WO (1) WO2019067594A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10053465B2 (en) 2015-08-26 2018-08-21 Incyte Corporation Pyrrolopyrimidine derivatives as TAM inhibitors
CA3019145A1 (en) 2016-03-28 2017-10-05 Incyte Corporation Pyrrolotriazine compounds as tam inhibitors
WO2018119374A1 (en) 2016-12-22 2018-06-28 Cadent Therapeutics Nmda receptor modulators and uses thereof
LT3687996T (lt) 2017-09-27 2022-01-10 Incyte Corporation Pirolotriazino darinių druskos, naudingos kaip tam inhibitoriai
PE20211805A1 (es) 2018-06-29 2021-09-14 Incyte Corp Formulaciones de un inhibidor de axl/mer
CR20210125A (es) 2018-08-03 2021-06-30 Cadent Therapeutics Inc Moduladores del receptor nmda heteroaromático y usos de los mismos
AU2021230385A1 (en) 2020-03-06 2022-09-22 Incyte Corporation Combination therapy comprising AXL/MER and PD-1/PD-L1 inhibitors
EP4180433A1 (en) * 2020-07-10 2023-05-17 Beijing Findcure Biosciences, Ltd. Triazine compound and composition and use thereof
CN115028648A (zh) * 2021-03-03 2022-09-09 武汉誉祥医药科技有限公司 三并环化合物及其药物组合物和应用

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200201506T2 (tr) 1999-09-17 2002-10-21 Abbott Gmbh & Co. Kg Terapötik maddeler olarak kinaz inhibitörleri
CA2413330A1 (en) 2000-06-28 2002-01-03 Smithkline Beecham P.L.C. Wet milling process
AU2003272175A1 (en) 2002-10-21 2004-05-04 Aprea Ab Reactivation of wild type p53 in human tumour cells by a low molecular weight compound
US20050203063A1 (en) 2003-09-12 2005-09-15 Raymond Deshaies Proteasome pathway inhibitors and related methods
UY28931A1 (es) 2004-06-03 2005-12-30 Bayer Pharmaceuticals Corp Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis
AR053090A1 (es) 2004-07-20 2007-04-25 Osi Pharm Inc Imidazotriazinas como inhibidores de proteina quinasas y su uso para la preparacion de medicamentos
UY29177A1 (es) 2004-10-25 2006-05-31 Astex Therapeutics Ltd Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos
SI1951724T1 (sl) 2005-11-17 2011-09-30 Osi Pharmaceuticals Llc Kondenzirani biciklični mTOR inhibitorji
KR20130141706A (ko) 2005-12-02 2013-12-26 바이엘 헬스케어 엘엘씨 과다-증식성 장애 및 맥관형성과 관련된 질환의 치료에 유용한 치환된 4-아미노-피롤로트리아진 유도체
PE20070855A1 (es) 2005-12-02 2007-10-14 Bayer Pharmaceuticals Corp Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas
ES2611588T3 (es) 2005-12-13 2017-05-09 Incyte Holdings Corporation Pirrolo[2,3-b]piridinas y pirrolo[2,3-b]pirimidinas sustituidas con heteroarilo como inhibidores de quinasas Janus
CA2633035C (en) 2005-12-15 2016-05-10 Rigel Pharmaceuticals, Inc. Kinase inhibitors and their uses
KR101432316B1 (ko) 2006-04-12 2014-08-29 버텍스 파마슈티칼스 인코포레이티드 증식성 장애의 치료를 위한 단백질 키나제 ｐｌｋ1 억제제로서의 4,5-디히드로-［1,2,4］트리아졸로［4,3-ｆ］프테리딘
JP2009536161A (ja) 2006-04-25 2009-10-08 アステックス、セラピューティックス、リミテッド 医薬化合物
WO2008045978A1 (en) 2006-10-10 2008-04-17 Rigel Pharmaceuticals, Inc. Pinane-substituted pyrimidinediamine derivatives useful as axl inhibitors
DE602007012473D1 (de) 2006-12-14 2011-03-24 Vertex Pharma Als proteinkinaseinhibitoren geeignete verbindungen
ES2406930T3 (es) 2006-12-29 2013-06-10 Rigel Pharmaceuticals, Inc. Triazoles sustituidos con arilo bicíclico y heteroarilo bicíclico útiles como inhibidores de AXL
PT2078010E (pt) 2006-12-29 2014-05-07 Rigel Pharmaceuticals Inc Triazoles substituídos com heteroarilos policíclicos úteis como inibidores de axl
JP5567837B2 (ja) 2006-12-29 2014-08-06 ライジェル ファーマシューティカルズ， インコーポレイテッド Ａｘｌインヒビターとして有用なＮ３−ヘテロアリール置換トリアゾールおよびＮ５−ヘテロアリール置換トリアゾール
US8168415B2 (en) 2007-02-07 2012-05-01 The Regents Of The University Of Colorado Axl fusion proteins as Axl tyrosine kinase inhibitors
NZ583061A (en) 2007-08-15 2012-06-29 Vertex Pharma 4-(9-(3,3-difluorocyclopentyl)-5,7,7-trimethyl-6-oxo-6,7,8,9-tetrahydro-5h-pyrimido[4,5-b[1,4]diazepin-2-ylamino)-3-methoxybenzamide derivatives as inhibitors of the human protein kinases plk1 to plk4 for the treatment of proliferative diseases
GB0719803D0 (en) 2007-10-10 2007-11-21 Cancer Rec Tech Ltd Therapeutic compounds and their use
AU2008315746A1 (en) 2007-10-25 2009-04-30 Astrazeneca Ab Pyridine and pyrazine derivatives useful in the treatment of cell proliferative disorders
ES2424259T3 (es) 2007-10-26 2013-09-30 Rigel Pharmaceuticals, Inc. Triazoles sustituidos con arilo policíclico y heteroarilo policíclico, útiles como agentes inhibidores del Axl
BRPI0821209A2 (pt) 2007-12-19 2019-09-24 Amgen Inc composto, composição farmacêutica, métodos de tratar câncer, para reduzir o tamanho de tumor, para tratar distúrbios, e para reduzir metástase em um tumor.
AR070127A1 (es) 2008-01-11 2010-03-17 Novartis Ag Pirrolo - pirimidinas y pirrolo -piridinas
RU2010146474A (ru) 2008-04-16 2012-05-27 Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. (De) Производные хинолина в качестве ингибиторов axl киназ
KR20110039278A (ko) 2008-06-23 2011-04-15 버텍스 파마슈티칼스 인코포레이티드 단백질 키나제 억제제
ES2399319T3 (es) 2008-07-09 2013-03-27 Rigel Pharmaceuticals, Inc. Triazoles sustituidos con heteroarilos bicíclicos que contienen puentes útiles como inhibidores de AXL
CA2730231C (en) 2008-07-09 2016-10-18 Rigel Pharmaceuticals, Inc. Polycyclic heteroaryl substituted triazoles useful as axl inhibitors
US20120230991A1 (en) 2008-07-29 2012-09-13 Douglas Kim Graham Methods and compounds for enhancing anti-cancer therapy
US20100075973A1 (en) 2008-08-28 2010-03-25 Takeda Pharmaceutical Company Limited Polo-like kinase inhibitors
TW201035100A (en) 2008-12-19 2010-10-01 Cephalon Inc Pyrrolotriazines as ALK and JAK2 inhibitors
JP2012517426A (ja) 2009-02-09 2012-08-02 アステックス ファーマシューティカルズ インコーポレイテッド ピロロピリミジニルａｘｌキナーゼ阻害剤
US8765754B2 (en) 2009-04-29 2014-07-01 Locus Pharmaceuticals, Inc. Pyrrolotriazine compounds
EA025520B1 (ru) 2009-05-22 2017-01-30 Инсайт Холдингс Корпорейшн N-(ГЕТЕРО)АРИЛПИРРОЛИДИНОВЫЕ ПРОИЗВОДНЫЕ ПИРАЗОЛ-4-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ И ПИРРОЛ-3-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ
CN104945420A (zh) 2009-06-29 2015-09-30 因塞特公司 作为pi3k抑制剂的嘧啶酮类
TW201113285A (en) 2009-09-01 2011-04-16 Incyte Corp Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
WO2011038185A2 (en) 2009-09-25 2011-03-31 Vertex Pharmaceuticals Incorporated Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
EP2311809A1 (en) 2009-10-16 2011-04-20 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Quinolinyloxyphenylsulfonamides
US8604217B2 (en) 2009-11-12 2013-12-10 Selvita S.A. Compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent
TW201130842A (en) 2009-12-18 2011-09-16 Incyte Corp Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors
NZ602313A (en) 2010-03-10 2014-08-29 Incyte Corp Piperidin-4-yl azetidine derivatives as jak1 inhibitors
US8791257B2 (en) 2010-03-31 2014-07-29 Bristol-Myers Squibb Company Substituted pyrrolotriazines as protein kinase inhibitors
CN102471342A (zh) 2010-05-05 2012-05-23 沃泰克斯药物股份有限公司 用作PKC-θ抑制剂的4取代的吡唑并吡啶类
EP2423208A1 (en) 2010-08-28 2012-02-29 Lead Discovery Center GmbH Pharmaceutically active compounds as Axl inhibitors
RU2014118677A (ru) 2010-10-08 2015-11-20 Элан Фармасьютикалз, Инк. Ингибиторы киназ типа polo
ITRM20100537A1 (it) 2010-10-12 2012-04-12 Consiglio Nazionale Ricerche Aptamero inibitore del recettore tirosina chinasi axl per uso in terapia
WO2012068440A1 (en) 2010-11-19 2012-05-24 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
CA2818542A1 (en) 2010-11-19 2012-05-24 Incyte Corporation Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
AR084366A1 (es) 2010-12-20 2013-05-08 Incyte Corp N-(1-(fenil sustituido)etil)-9h-purin-6-aminas como inhibidores de pi3k
ES2590778T3 (es) 2011-02-28 2016-11-23 Calitor Sciences, Llc Compuestos de quinolina sustituida
CA2830516C (en) 2011-03-23 2017-01-24 Amgen Inc. Fused tricyclic dual inhibitors of cdk 4/6 and flt3
HUE046988T2 (hu) 2011-04-01 2020-04-28 Univ Utah Res Found Szubsztituált N-fenilpirimidin-2-amin analógok mint AXL kináz inhibitorok
WO2012177606A1 (en) 2011-06-20 2012-12-27 Incyte Corporation Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
CA2840518A1 (en) 2011-07-01 2013-01-10 Bayer Intellectual Property Gmbh Hydroxymethylaryl-substituted pyrrolotriazines as alk1 inhibitors
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
HUE043703T2 (hu) 2011-09-02 2019-09-30 Incyte Holdings Corp Heterociklusos aminok PI3K inhibitorokként
CN102408411B (zh) 2011-09-19 2014-10-22 北京康辰药业股份有限公司 一种含喹啉基的羟肟酸类化合物及其制备方法、以及含有该化合物的药物组合物及其应用
CA2850617A1 (en) 2011-10-03 2013-04-11 The University Of North Carolina At Chapel Hill Pyrrolopyrimidine compounds for the treatment of cancer
EP3045453A1 (en) 2011-11-14 2016-07-20 Cephalon, Inc. Uracil derivatives as axl and c-met kinase inhibitors
EP2788000B1 (en) 2011-12-06 2018-05-30 Merck Sharp & Dohme Corp. Pyrrolopyrimidines as janus kinase inhibitors
KR102078530B1 (ko) 2012-01-31 2020-02-18 다이이찌 산쿄 가부시키가이샤 피리돈 유도체들
WO2013162061A1 (ja) 2012-04-26 2013-10-31 第一三共株式会社 二環性ピリミジン化合物
US9193733B2 (en) 2012-05-18 2015-11-24 Incyte Holdings Corporation Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
CN104981247A (zh) 2012-09-06 2015-10-14 普莱希科公司 用于激酶调节的化合物和方法及其适应症
EP2900673A4 (en) 2012-09-26 2016-10-19 Univ California MODULATION OF IRE1
EP2909211A4 (en) 2012-10-17 2016-06-22 Univ North Carolina PYRAZOLOPYRIMIDINE COMPOUNDS FOR CANCER TREATMENT
CN104918945B (zh) 2012-11-01 2018-01-05 因赛特公司 作为jak抑制剂的三环稠合噻吩衍生物
CN104936963B (zh) 2012-11-20 2017-11-28 普罗齐纳斯有限公司 作为蛋白激酶抑制剂的硫醚衍生物
US20140199728A1 (en) 2013-01-14 2014-07-17 Amgen Inc. Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
WO2014164729A1 (en) 2013-03-12 2014-10-09 Arqule, Inc. Substituted tricyclic pyrazolo-pyrimidine compounds
TWI649308B (zh) 2013-07-24 2019-02-01 小野藥品工業股份有限公司 喹啉衍生物
WO2015068767A1 (ja) 2013-11-08 2015-05-14 小野薬品工業株式会社 ピロロピリミジン誘導体
WO2015132799A2 (en) 2014-02-03 2015-09-11 Cadila Healthcare Limited Novel heterocyclic compounds
JP6621477B2 (ja) 2014-12-18 2019-12-18 ファイザー・インク ピリミジンおよびトリアジン誘導体ならびにａｘｌ阻害薬としてのそれらの使用
US9840503B2 (en) 2015-05-11 2017-12-12 Incyte Corporation Heterocyclic compounds and uses thereof
WO2017027717A1 (en) 2015-08-12 2017-02-16 Incyte Corporation Bicyclic fused pyrimidine compounds as tam inhibitors
US10053465B2 (en) 2015-08-26 2018-08-21 Incyte Corporation Pyrrolopyrimidine derivatives as TAM inhibitors
WO2017062797A1 (en) 2015-10-07 2017-04-13 The University Of North Carolina At Chapel Hill The methods for treatment of tumors
CA3000803C (en) 2015-10-13 2020-03-24 Nihon Nohyaku Co., Ltd. Oxime group-containing condensed heterocyclic compound or salt thereof, agricultural and horticultural insecticide comprising the compound, and method for using the insecticide
ES2911678T3 (es) 2015-11-14 2022-05-20 Sunshine Lake Pharma Co Ltd Forma cristalina de un compuesto de quinolina sustituida y composiciones farmacéuticas de la misma
EP3373934B1 (en) 2015-11-14 2020-05-20 Sunshine Lake Pharma Co., Ltd. Crystalline form of a substituted quinoline compound and pharmaceutical compositions thereof
CA3019145A1 (en) * 2016-03-28 2017-10-05 Incyte Corporation Pyrrolotriazine compounds as tam inhibitors
JP6999574B2 (ja) 2016-04-22 2022-01-18 インサイト・コーポレイション Ｌｓｄ１阻害剤の製剤
US10138248B2 (en) * 2016-06-24 2018-11-27 Incyte Corporation Substituted imidazo[2,1-f][1,2,4]triazines, substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-b]pyridazines and substituted imidazo[1,2-a]pyrazines as PI3K-γ inhibitors
JOP20170153A1 (ar) 2016-07-15 2019-01-30 Lilly Co Eli نظائر urocortin-2 جديدة معدلة بحمض دهني لعلاج داء السكري وأمراض الكلى المزمنة
EP3484524B1 (en) 2016-07-15 2022-11-09 Ionis Pharmaceuticals, Inc. Compounds and methods for modulation of smn2
LT3687996T (lt) 2017-09-27 2022-01-10 Incyte Corporation Pirolotriazino darinių druskos, naudingos kaip tam inhibitoriai
PE20211805A1 (es) 2018-06-29 2021-09-14 Incyte Corp Formulaciones de un inhibidor de axl/mer

Also Published As

Publication number Publication date
CL2022001014A1 (es) 2022-11-18
GEP20227429B (en) 2022-10-25
MX2020003375A (es) 2020-08-03
JP2020535168A (ja) 2020-12-03
US11104682B2 (en) 2021-08-31
US10633387B2 (en) 2020-04-28
ES2904458T3 (es) 2022-04-05
PL3687996T3 (pl) 2022-02-21
US20190112313A1 (en) 2019-04-18
HUE057190T2 (hu) 2022-04-28
SI3687996T1 (sl) 2022-04-29
EP3687996B1 (en) 2021-11-03
CO2020005009A2 (es) 2020-05-29
CL2020000791A1 (es) 2020-09-25
BR112020006145A2 (pt) 2020-10-20
ECSP20021655A (es) 2020-07-31
CA3077308A1 (en) 2019-04-04
PT3687996T (pt) 2022-01-21
MA50655A (fr) 2021-06-02
US20220227770A1 (en) 2022-07-21
SG11202002821UA (en) 2020-04-29
KR20200088308A (ko) 2020-07-22
CY1124952T1 (el) 2023-01-05
CN111386273B (zh) 2024-06-14
DK3687996T3 (da) 2022-01-10
RS62872B1 (sr) 2022-02-28
LT3687996T (lt) 2022-01-10
MD3687996T2 (ro) 2022-04-30
JP2024059647A (ja) 2024-05-01
TW201920186A (zh) 2019-06-01
EP3988552A1 (en) 2022-04-27
EP3687996A1 (en) 2020-08-05
AU2023270198A1 (en) 2023-12-14
TWI821200B (zh) 2023-11-11
PH12020550143A1 (en) 2020-12-07
IL273579A (en) 2020-05-31
WO2019067594A1 (en) 2019-04-04
AU2018342471B2 (en) 2023-08-24
AU2018342471A1 (en) 2020-04-23
PE20210002A1 (es) 2021-01-05
US20200347065A1 (en) 2020-11-05
CN111386273A (zh) 2020-07-07
MA50655B1 (fr) 2021-11-30
JOP20200081A1 (ar) 2020-04-30

Similar Documents

Publication Publication Date Title
PH12020550143A1 (en) Salts of pyrrolotriazine derivatives useful as tam inhibitors
PH12017502090A1 (en) Heterocyclic amides as kinase inhibitors
WO2017108723A3 (en) PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS
PE20191613A1 (es) Compuestos de pirazolo[1,5-a]piridina sustituidos como inhibidores de la quinasa ret
EP3797109A4 (en) HETEROCYCLIC COMPOUNDS USED AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF
EP3672973A4 (en) HETEROCYCLIC COMPOUNDS USED AS KINASE INHIBITORS, COMPOSITIONS INCLUDING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF
NZ627454A (en) 2-amino, 6-phenyl substituted pyrido [2,3-d] pyrimidine derivatives useful as raf kinase inhibitors
EA201591255A1 (ru) ПРОИЗВОДНЫЕ ПИРРОЛО[2,3-d]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-РОДСТВЕННЫХ КИНАЗ (JAK)
MX2021004659A (es) Derivados de aminopirimidina/pirazina como inhibidores de ctps1.
EA202091475A1 (ru) ПРОИЗВОДНЫЕ 5-(2-(2,5-ДИФТОРФЕНИЛ)ПИРРОЛИДИН-1-ИЛ)-3-(1H-ПИРАЗОЛ-1-ИЛ)ПИРАЗОЛО[1,5-а]ПИРИМИДИНА И РОДСТВЕННЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ Trk КИНАЗЫ ДЛЯ ЛЕЧЕНИЯ РАКА
CL2019001694A1 (es) Compuestos de pirazolopirimidina y métodos de uso de los mismos.
CL2021002656A1 (es) Compuestos de pirrolotriazina, inhibidores selectivos de proteínas quinasas kit y pdgfralfa; composición y uso.
CY1122423T1 (el) Παραγωγα πυριμιδινης χρησιμα ως εκλεκτικοι αναστολεις jak3 kai/ή jak1
MX2015013365A (es) Derivados de urea y su uso como inhibidores de proteina de union de acidos grasos (puag).
EP3697762A4 (en) AMINE SUBSTITUTED HETEROCYCLIC COMPOUNDS, USED AS EHMT2 INHIBITORS, SALTS THEREOF, AND THEIR METHODS OF SYNTHESIS
PH12020551465A1 (en) Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds
EA202090384A1 (ru) Промежуточные соединения, используемые для синтеза селективного ингибитора протеинкиназы, и способы их получения
IL276160A (en) A salt of the compound pyrazolo[5,1-]pyrimidine and its crystals
MX2021004918A (es) Derivados de benzodiazepina heterociclica fusionada y usos de estos.
MX2020012718A (es) Derivados de benzodiazepinas novedosos y usos de los mismos.
WO2018166993A3 (en) PYRAZOLOCHLOROPHENYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
PH12020550485A1 (en) Crystalline salts of a b-raf kinase inhibitor
EA202090836A1 (ru) Соли производных пирролотриазинов, пригодных для использования в качестве ингибиторов tam
MX2015013374A (es) Derivados de urea y su uso como inhibidores de proteina de uniuon a acidos grasos (puag).
AR112838A1 (es) Sales de inhibidores de tam