PE20210002A1 - Sales de derivados de pirrolotriazina utiles como inhibidores tam - Google Patents
Sales de derivados de pirrolotriazina utiles como inhibidores tamInfo
- Publication number
- PE20210002A1 PE20210002A1 PE2020000404A PE2020000404A PE20210002A1 PE 20210002 A1 PE20210002 A1 PE 20210002A1 PE 2020000404 A PE2020000404 A PE 2020000404A PE 2020000404 A PE2020000404 A PE 2020000404A PE 20210002 A1 PE20210002 A1 PE 20210002A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- acid
- isobutyrylpiperidin
- tetrahydropyrimidine
- triazin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
La presente invencion se refiere a: una sal de acido maleico de N-(4-(4-Amino-7-(1-isobutirilpiperidin-4-il)pirrolo[1,2-f][1,2,4]triazin-5-il)fenil)-1-isopropil-2,4-dioxo-3-(piridin-2-il)-1,2,3,4-tetrahidropirimidina-5-carboxamida de formula I, que tiene una relacion estequiometrica de 1:1 de N-(4-(4-Amino-7-(1-isobutirilpiperidin-4-il)pirrolo[1,2-f][1,2,4]triazin-5-il)fenil)-1-isopropil-2,4-dioxo-3-(piridin-2-il)-1,2,3,4-tetrahidropirimidina-5-carboxamida con respecto a acido maleico, que comprende los siguientes picos de difraccion de rayos X en polvo (XRPD) en terminos de 2-theta: 4,3°, 8,4°, 12,6°, 13,2° y 18,5°, asi como a sus sales de acido fosforico, acido maleico, acido clorhidrico, acido salicilico, acido metanosulfonico y acido etanosulfonico ; y a una sal de acido hemi-sulfurico de N-(4-(4-Amino-7-(1-isobutirilpiperidin-4-il)pirrolo[1,2-f][1,2,4]triazin-5-il)fenil)-1-isopropil-2,4-dioxo-3-fenil-1,2,3,4-tetrahidropirimidina-5-carboxamida de formula II, que tiene una relacion estequiometrica de 1:0,5 de N-(4-(4-Amino-7-(1-isobutirilpiperidin-4-il)pirrolo[1,2-f][1,2,4]triazin-5-il)fenil)-1-isopropil-2,4-dioxo-3-fenil-1,2,3,4-tetrahidropirimidina-5-carboxamida con respecto a acido sulfurico, que comprende los siguientes picos XRPD en terminos de 2-theta: 5,3°, 8,5°, 15,3°, 20,1° y 24,9°. Tambien se refiere a una composicion que los contiene y a sus procesos de preparacion. Dichos compuestos son inhibidores de TAM utiles en el tratamiento del cancer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762564070P | 2017-09-27 | 2017-09-27 | |
US201862714196P | 2018-08-03 | 2018-08-03 | |
PCT/US2018/052925 WO2019067594A1 (en) | 2017-09-27 | 2018-09-26 | SALTS OF PYRROLOTRIAZINE DERIVATIVES USEFUL AS TAM INHIBITORS |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20210002A1 true PE20210002A1 (es) | 2021-01-05 |
Family
ID=63794769
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2020000404A PE20210002A1 (es) | 2017-09-27 | 2018-09-26 | Sales de derivados de pirrolotriazina utiles como inhibidores tam |
Country Status (32)
Country | Link |
---|---|
US (3) | US10633387B2 (es) |
EP (2) | EP3988552A1 (es) |
JP (1) | JP2020535168A (es) |
KR (1) | KR20200088308A (es) |
CN (1) | CN111386273A (es) |
AU (2) | AU2018342471B2 (es) |
BR (1) | BR112020006145A2 (es) |
CA (1) | CA3077308A1 (es) |
CL (2) | CL2020000791A1 (es) |
CO (1) | CO2020005009A2 (es) |
CR (1) | CR20200179A (es) |
CY (1) | CY1124952T1 (es) |
DK (1) | DK3687996T3 (es) |
EC (1) | ECSP20021655A (es) |
ES (1) | ES2904458T3 (es) |
GE (1) | GEP20227429B (es) |
HU (1) | HUE057190T2 (es) |
IL (1) | IL273579A (es) |
JO (1) | JOP20200081A1 (es) |
LT (1) | LT3687996T (es) |
MA (1) | MA50655B1 (es) |
MD (1) | MD3687996T2 (es) |
MX (1) | MX2020003375A (es) |
PE (1) | PE20210002A1 (es) |
PH (1) | PH12020550143A1 (es) |
PL (1) | PL3687996T3 (es) |
PT (1) | PT3687996T (es) |
RS (1) | RS62872B1 (es) |
SG (1) | SG11202002821UA (es) |
SI (1) | SI3687996T1 (es) |
TW (1) | TWI821200B (es) |
WO (1) | WO2019067594A1 (es) |
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US10053465B2 (en) | 2015-08-26 | 2018-08-21 | Incyte Corporation | Pyrrolopyrimidine derivatives as TAM inhibitors |
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CA3047403A1 (en) | 2016-12-22 | 2018-06-28 | Cadent Therapeutics, Inc. | Nmda receptor modulators and uses thereof |
EP3988552A1 (en) * | 2017-09-27 | 2022-04-27 | Incyte Corporation | Salts of pyrrolotriazine derivatives useful as tam inhibitors |
AR117600A1 (es) * | 2018-06-29 | 2021-08-18 | Incyte Corp | Formulaciones de un inhibidor de axl / mer |
CA3108519A1 (en) | 2018-08-03 | 2020-04-30 | Cadent Therapeutics, Inc. | Heteroaromatic nmda receptor modulators and uses thereof |
IL296065A (en) | 2020-03-06 | 2022-10-01 | Incyte Corp | Combined treatment including axl/mer and pd-1/pd-l1 inhibitors |
CN113912628B (zh) * | 2020-07-10 | 2023-05-02 | 北京范恩柯尔生物科技有限公司 | 三嗪类化合物及其组合物和用途 |
CN115028648A (zh) * | 2021-03-03 | 2022-09-09 | 武汉誉祥医药科技有限公司 | 三并环化合物及其药物组合物和应用 |
JPWO2023286719A1 (es) * | 2021-07-13 | 2023-01-19 |
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2018
- 2018-09-26 EP EP21196789.8A patent/EP3988552A1/en active Pending
- 2018-09-26 ES ES18783341T patent/ES2904458T3/es active Active
- 2018-09-26 SI SI201830551T patent/SI3687996T1/sl unknown
- 2018-09-26 PT PT187833413T patent/PT3687996T/pt unknown
- 2018-09-26 HU HUE18783341A patent/HUE057190T2/hu unknown
- 2018-09-26 TW TW107133765A patent/TWI821200B/zh active
- 2018-09-26 CN CN201880073539.6A patent/CN111386273A/zh active Pending
- 2018-09-26 CR CR20200179A patent/CR20200179A/es unknown
- 2018-09-26 US US16/142,514 patent/US10633387B2/en active Active
- 2018-09-26 JP JP2020517516A patent/JP2020535168A/ja active Pending
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2021
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2022
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