CU20190086A7 - Compuestos de heteroarilo bicíclicos 6-6 fusionados útiles como inhibidores de lats - Google Patents

Compuestos de heteroarilo bicíclicos 6-6 fusionados útiles como inhibidores de lats

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Publication number
CU20190086A7
CU20190086A7 CU2019000086A CU20190086A CU20190086A7 CU 20190086 A7 CU20190086 A7 CU 20190086A7 CU 2019000086 A CU2019000086 A CU 2019000086A CU 20190086 A CU20190086 A CU 20190086A CU 20190086 A7 CU20190086 A7 CU 20190086A7
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CU
Cuba
Prior art keywords
bicyclic heteroaryl
compounds useful
heteroaryl compounds
fused bicyclic
lats
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CU2019000086A
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English (en)
Inventor
Dirk Behnke
Frada Berenshteyn
Xueshi Hao
Timothy Hoffman
Qihui Jin
Arnaud Lacoste
Cameron Lee
Yahu Liu
Jun Liu
Juergen Klaus Maibaum
Tingting Mo
Jiangfeng Pan
Xin Qu
Jan Tchorz
Yun Feng Xie
Shanshan Yan
Yefen Zou
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Novartis Ag
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Publication date
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Publication of CU20190086A7 publication Critical patent/CU20190086A7/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Abstract

<p>La presente invención se refiere a compuestos de heteroarilo bicíclicos 6-6 fusionados de la Fórmula A2 o A1 para utilizar como inhibidores de LATS, o una sal, un estereoisómero a o una composición farmacéutica de dichos compuestos; donde las variables son como se definen en el presente documento (A1 & A2).</p> <p>ESPACIO PARA LAS FÓRMULAS</p> <p>La presente invención se refiere además a un método de inhibición de LATS en una población de células, usando un compuesto de Formula A1, o una sal, un estereoisómero o una composición farmacéutica de dicho compuesto. La presente invención proporciona además un método para preparar y fabricar compuestos de la invención.</p>
CU2019000086A 2017-04-28 2018-04-26 Compuestos de heteroarilo bicíclicos 6-6 fusionados útiles como inhibidores de lats CU20190086A7 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762491526P 2017-04-28 2017-04-28
US201762491573P 2017-04-28 2017-04-28
US201762491475P 2017-04-28 2017-04-28
US201762491484P 2017-04-28 2017-04-28
US201862650232P 2018-03-29 2018-03-29
PCT/IB2018/052919 WO2018198077A2 (en) 2017-04-28 2018-04-26 6-6 fused bicyclic heteroaryl compounds and their use as lats inhibitors

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CU2019000086A CU20190086A7 (es) 2017-04-28 2018-04-26 Compuestos de heteroarilo bicíclicos 6-6 fusionados útiles como inhibidores de lats
CU2020000080A CU20200080A7 (es) 2017-04-28 2018-04-26 Kit que comprende un inhibidor de lats para el suministro ocular

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CU2020000080A CU20200080A7 (es) 2017-04-28 2018-04-26 Kit que comprende un inhibidor de lats para el suministro ocular

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US (2) US11458138B2 (es)
EP (1) EP3615537B1 (es)
JP (2) JP7247102B2 (es)
KR (1) KR20190142776A (es)
CN (3) CN110573511B (es)
AU (2) AU2018260495B2 (es)
BR (1) BR112019022512A2 (es)
CA (1) CA3056906A1 (es)
CL (1) CL2019003049A1 (es)
CO (1) CO2019011873A2 (es)
CR (1) CR20190483A (es)
CU (2) CU20190086A7 (es)
DO (1) DOP2019000273A (es)
EC (1) ECSP19076732A (es)
IL (2) IL269293B (es)
JO (1) JOP20190257A1 (es)
MA (1) MA49285A (es)
MX (1) MX2019012756A (es)
PE (1) PE20200292A1 (es)
PH (1) PH12019502436A1 (es)
SG (1) SG11201908615RA (es)
TW (1) TW201843140A (es)
UY (1) UY37703A (es)
WO (1) WO2018198077A2 (es)

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