UY37703A - Compuestos heteroarílicos bicíclicos 6-6 fusionados y su uso como inhibidores de lats - Google Patents

Compuestos heteroarílicos bicíclicos 6-6 fusionados y su uso como inhibidores de lats

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Publication number
UY37703A
UY37703A UY0001037703A UY37703A UY37703A UY 37703 A UY37703 A UY 37703A UY 0001037703 A UY0001037703 A UY 0001037703A UY 37703 A UY37703 A UY 37703A UY 37703 A UY37703 A UY 37703A
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UY
Uruguay
Prior art keywords
compounds
fused
hyderoaritical
bicyclic
lats
Prior art date
Application number
UY0001037703A
Other languages
English (en)
Inventor
Tingting Mo
Frada Berenshteyn
Xueshi Hao
Z Hoffman Timothy
Qihui Jin
Arnaud Lacoste
Jun Liu
A Liu Yahu
Xin Qu
Jianfeng Pan
Feng Xie Yun
Shanshan Yan
Yefen Zou
Cameron Lee
Jan Tchorz
Klaus Maibaum Juergen
Original Assignee
Novartis Ag
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Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of UY37703A publication Critical patent/UY37703A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

La presente invención se refiere a Compuestos Heteroarílicos Bicíclicos 6-6 Fusionados de la Fórmula A2 o A1 y su uso como Inhibidores de LATS, o una sal, estereoisómero o una composición farmacéutica del mismo; en donde las variables son como se definen en la presente. La presente invención se refiere además a un método de inhibición de LATS en una población celular que usa un compuesto de la Fórmula A1, o una sal, estereoisómero o composición farmacéutica de los mismos. La invención proporciona además un método de preparación de compuestos de la invención, y sus usos terapéuticos.
UY0001037703A 2017-04-28 2018-04-26 Compuestos heteroarílicos bicíclicos 6-6 fusionados y su uso como inhibidores de lats UY37703A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762491526P 2017-04-28 2017-04-28
US201762491484P 2017-04-28 2017-04-28
US201762491573P 2017-04-28 2017-04-28
US201762491475P 2017-04-28 2017-04-28
US201862650232P 2018-03-29 2018-03-29

Publications (1)

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UY37703A true UY37703A (es) 2018-11-30

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UY0001037703A UY37703A (es) 2017-04-28 2018-04-26 Compuestos heteroarílicos bicíclicos 6-6 fusionados y su uso como inhibidores de lats

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US (2) US11458138B2 (es)
EP (1) EP3615537B1 (es)
JP (2) JP7247102B2 (es)
KR (1) KR20190142776A (es)
CN (3) CN114703144A (es)
AU (2) AU2018260495B2 (es)
BR (1) BR112019022512A2 (es)
CA (1) CA3056906A1 (es)
CL (1) CL2019003049A1 (es)
CO (1) CO2019011873A2 (es)
CR (1) CR20190483A (es)
CU (2) CU20190086A7 (es)
DO (1) DOP2019000273A (es)
EC (1) ECSP19076732A (es)
IL (2) IL269293B (es)
JO (1) JOP20190257A1 (es)
MA (1) MA49285A (es)
MX (1) MX2019012756A (es)
PE (1) PE20200292A1 (es)
PH (1) PH12019502436A1 (es)
SG (1) SG11201908615RA (es)
TW (1) TW201843140A (es)
UY (1) UY37703A (es)
WO (1) WO2018198077A2 (es)

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RU2019138304A3 (es) 2021-07-13
TW201843140A (zh) 2018-12-16
MA49285A (fr) 2020-03-04
CO2019011873A2 (es) 2020-01-17
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IL269293B (en) 2022-06-01
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CA3056906A1 (en) 2018-11-01
CU20200080A7 (es) 2021-05-12
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