MX2022009572A - Composiciones de pirrolo[2,3-b]piridina-3-carboxamida y métodos para mejorar la pérdida de audición. - Google Patents

Composiciones de pirrolo[2,3-b]piridina-3-carboxamida y métodos para mejorar la pérdida de audición.

Info

Publication number
MX2022009572A
MX2022009572A MX2022009572A MX2022009572A MX2022009572A MX 2022009572 A MX2022009572 A MX 2022009572A MX 2022009572 A MX2022009572 A MX 2022009572A MX 2022009572 A MX2022009572 A MX 2022009572A MX 2022009572 A MX2022009572 A MX 2022009572A
Authority
MX
Mexico
Prior art keywords
pyrrolo
pyridine
hearing loss
methods
ameliorating hearing
Prior art date
Application number
MX2022009572A
Other languages
English (en)
Inventor
John David Ginn
Rui Liang
Ksenia Gnedeva
A James Hudspeth
Nathaniel Kastan
Peter T Meinke
David John Huggins
Nigel John Liverton
Leigh Ashley Baxt
Robert Walter Myers
Original Assignee
Univ Rockefeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rockefeller filed Critical Univ Rockefeller
Publication of MX2022009572A publication Critical patent/MX2022009572A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describe N-(tiazol-2(3H)-iliden 3-sustituido)-1H-pirrolo[2,3-b] piridin-3-carboxamidas y N-(oxazol-2(3H)- iliden 3-sustituido)-1H- pirrolo[2,3-b]piridin-3-carboxamidas (ver Fórmulas) Los compuestos activan Yap e inhiben las cinasas Lats. Por lo tanto, son útiles para tratar la pérdida de audición.
MX2022009572A 2020-02-05 2021-02-05 Composiciones de pirrolo[2,3-b]piridina-3-carboxamida y métodos para mejorar la pérdida de audición. MX2022009572A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062970425P 2020-02-05 2020-02-05
PCT/US2021/016848 WO2021158936A1 (en) 2020-02-05 2021-02-05 Pyrrolo [2,3-b]pyridine-3-carboxamide compositions and methods for ameliorating hearing loss

Publications (1)

Publication Number Publication Date
MX2022009572A true MX2022009572A (es) 2022-12-13

Family

ID=77199407

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022009572A MX2022009572A (es) 2020-02-05 2021-02-05 Composiciones de pirrolo[2,3-b]piridina-3-carboxamida y métodos para mejorar la pérdida de audición.

Country Status (8)

Country Link
US (1) US20230137893A1 (es)
EP (1) EP4100008A4 (es)
JP (1) JP2023512823A (es)
CN (1) CN115515579A (es)
AU (1) AU2021215925A1 (es)
CA (1) CA3170121A1 (es)
MX (1) MX2022009572A (es)
WO (1) WO2021158936A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4380562A1 (en) * 2021-08-02 2024-06-12 The Rockefeller University Pyrrolopyridine-3- and 4-carboxamide compositions and methods for cellular proliferation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2888848B1 (fr) * 2005-07-22 2007-09-28 Sanofi Aventis Sa Derives de n-(arylalkyl)-1h-pyrrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique
JP2009531274A (ja) * 2005-12-07 2009-09-03 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド キナーゼ阻害性ピロロピリジン化合物
PE20081581A1 (es) * 2006-12-21 2008-11-12 Plexxikon Inc COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
TWI667233B (zh) * 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
GB201602854D0 (en) * 2016-02-18 2016-04-06 Mission Therapeutics Ltd Novel compounds
JOP20190257A1 (ar) * 2017-04-28 2019-10-28 Novartis Ag مركبات أريل غير متجانسة ثنائية الحلقة مندمجة 6-6 واستخدامها كمثبطات lats

Also Published As

Publication number Publication date
CA3170121A1 (en) 2021-08-12
US20230137893A1 (en) 2023-05-04
CN115515579A (zh) 2022-12-23
JP2023512823A (ja) 2023-03-29
EP4100008A1 (en) 2022-12-14
AU2021215925A1 (en) 2022-09-08
EP4100008A4 (en) 2024-02-07
WO2021158936A1 (en) 2021-08-12

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