CR20210098A - COMPUESTOS DE PIRAZOLO[3,4-b]PIRIDINA COMO INHIBIDORES DE CINASAS TAM Y MET - Google Patents
COMPUESTOS DE PIRAZOLO[3,4-b]PIRIDINA COMO INHIBIDORES DE CINASAS TAM Y METInfo
- Publication number
- CR20210098A CR20210098A CR20210098A CR20210098A CR20210098A CR 20210098 A CR20210098 A CR 20210098A CR 20210098 A CR20210098 A CR 20210098A CR 20210098 A CR20210098 A CR 20210098A CR 20210098 A CR20210098 A CR 20210098A
- Authority
- CR
- Costa Rica
- Prior art keywords
- sup
- tam
- inhibitors
- pyrazolo
- pyridine compounds
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000020233 phosphotransferase Human genes 0.000 title abstract 2
- 150000005230 pyrazolo[3,4-b]pyridines Chemical class 0.000 title 1
- 229940125895 MET kinase inhibitor Drugs 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a compuestos de la Fórmula <strong>I</strong>: y estereoisómeros, tautómeros y sales de los mismos farmacéuticamente aceptables, en donde R<sup>1</sup>, R<sup>2</sup>, R<sup>9</sup>, X<sup>1</sup> y G son como se definen en la presente, los cuales son inhibidores de una o más cinasas TAM y/o cinasa c-Met, y son útiles en el tratamiento y prevención de enfermedades las cuales pueden ser tratadas con un inhibidor de cinasa TAM y/o un inhibidor de cinasa c-Met.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862724829P | 2018-08-30 | 2018-08-30 | |
| US201962858686P | 2019-06-07 | 2019-06-07 | |
| PCT/US2019/048701 WO2020047184A1 (en) | 2018-08-30 | 2019-08-29 | PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20210098A true CR20210098A (es) | 2021-07-01 |
Family
ID=67928919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20210098A CR20210098A (es) | 2018-08-30 | 2019-08-29 | COMPUESTOS DE PIRAZOLO[3,4-b]PIRIDINA COMO INHIBIDORES DE CINASAS TAM Y MET |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US11104676B2 (es) |
| EP (1) | EP3843850B1 (es) |
| JP (2) | JP6970859B2 (es) |
| KR (1) | KR20210049898A (es) |
| CN (1) | CN112930215A (es) |
| AU (3) | AU2019330017B2 (es) |
| BR (1) | BR112021002722A2 (es) |
| CA (1) | CA3110502C (es) |
| CL (1) | CL2021000467A1 (es) |
| CO (1) | CO2021002651A2 (es) |
| CR (1) | CR20210098A (es) |
| CU (1) | CU20210015A7 (es) |
| DO (1) | DOP2021000038A (es) |
| EC (1) | ECSP21012498A (es) |
| IL (1) | IL281127B2 (es) |
| MA (1) | MA53487A (es) |
| MX (1) | MX2021001952A (es) |
| NI (1) | NI202100007A (es) |
| PE (1) | PE20211779A1 (es) |
| PH (1) | PH12021500017A1 (es) |
| SG (1) | SG11202101148UA (es) |
| TW (1) | TW202024071A (es) |
| UY (1) | UY38349A (es) |
| WO (1) | WO2020047184A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019323455A1 (en) * | 2018-08-24 | 2021-04-01 | Transthera Sciences (Nanjing), Inc. | Novel quinoline derivative inhibitor |
| TWI817018B (zh) | 2019-06-28 | 2023-10-01 | 美商艾瑞生藥股份有限公司 | 用於治療ｂｒａｆ相關的疾病和失調症之化合物 |
| AU2020342108B2 (en) * | 2019-09-06 | 2024-03-07 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Compound having Axl and c-Met kinase inhibitory activity, preparation thereof and application thereof |
| TW202115028A (zh) * | 2019-09-24 | 2021-04-16 | 大陸商南京藥捷安康生物科技有限公司 | 雜環衍生物及其用途 |
| AU2021231435A1 (en) * | 2020-03-03 | 2022-09-22 | Array Biopharma Inc. | Methods to treat cancer using (R)-N-(3-fluoro-4-((3-((1-hydroxypropan-2-yl)amino)-1H-pyrazolo(3,4-b)pyridin-4-yl)oxy)phenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide |
| CA3214399A1 (en) * | 2021-04-09 | 2022-10-13 | Frank Perabo | Treatment of cancer with kdm4 inhibitors |
| WO2023002360A1 (en) | 2021-07-22 | 2023-01-26 | Pfizer Inc. | Solid forms and formulations of an inhibitor of tam and c-met kinases |
| IT202100022682A1 (it) * | 2021-09-01 | 2023-03-01 | Luigi Frati | Derivati pirimidinici e loro uso nel trattamento di tumori |
| CN115850301A (zh) * | 2021-09-24 | 2023-03-28 | 中山医诺维申新药研发有限公司 | 吡唑酮类化合物及其组合物和用途 |
| WO2023078408A1 (zh) * | 2021-11-05 | 2023-05-11 | 上海海和药物研究开发股份有限公司 | 含met受体酪氨酸激酶抑制剂的药物组合及应用 |
| CA3236956A1 (en) * | 2021-11-05 | 2023-05-11 | Haihe Biopharma Co., Ltd. | Solid dispersion, preparation method therefor, and solid formulation comprising same |
| US11753395B2 (en) | 2021-12-16 | 2023-09-12 | Kinnate Biopharma Inc. | Inhibitors of MET kinase |
| CN116003406B (zh) * | 2021-12-29 | 2024-01-23 | 北京鞍石生物科技有限责任公司 | 杂芳环氮氧化合物及其制备方法和应用 |
| TW202340177A (zh) | 2021-12-30 | 2023-10-16 | 美商拜歐米富士恩股份有限公司 | 作為 flt3抑制劑之吡嗪化合物 |
| CN116768868B (zh) * | 2023-08-15 | 2023-12-08 | 云南省药物研究所 | 一种哒嗪酮硫代衍生物及其制备方法和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US7173031B2 (en) | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| CA2572331A1 (en) | 2004-07-02 | 2006-02-09 | Exelixis, Inc. | C-met modulators and method of use |
| PE20061119A1 (es) | 2005-01-19 | 2006-11-27 | Aventis Pharma Sa | PIRAZOLO PIRIDINAS SUSTITUIDAS COMO INHIBIDORES DE CINASAS FAK, KDR Y Tie |
| US7723330B2 (en) | 2006-03-07 | 2010-05-25 | Array Biopharma Inc. | Heterobicyclic pyrazole compounds and methods of use |
| CN102816175B (zh) | 2011-06-09 | 2015-12-16 | 上海汇伦生命科技有限公司 | 一种杂环并吡啶酮类化合物,其中间体、制备方法和用途 |
| WO2013032797A2 (en) * | 2011-08-26 | 2013-03-07 | New Hope R & D Bioscience, Inc. | Oxetane 3,3-dicarboxamide compounds and methods of making and using same |
| BR112014006419A2 (pt) * | 2011-09-19 | 2018-08-07 | Genentech Inc | métodos para tratar um paciente com câncer, kit e artigo |
| AU2012339640B2 (en) | 2011-11-14 | 2017-01-05 | Ignyta, Inc. | Uracil derivatives as AXL and c-MET kinase inhibitors |
| TW201536291A (zh) | 2013-08-02 | 2015-10-01 | Cephalon Inc | 單獨使用ＡＸＬ／ｃＭＥＴ抑制劑或與其它藥劑組合使用以治療多種癌症之方法 |
| CA2934667A1 (en) * | 2013-12-26 | 2015-07-02 | Ignyta, Inc. | Pyrazolo[1,5-a]pyridine derivatives and methods of their use |
| WO2016004305A2 (en) | 2014-07-02 | 2016-01-07 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| WO2016016822A1 (en) | 2014-07-31 | 2016-02-04 | Novartis Ag | Combination therapy |
| GB201509338D0 (en) | 2015-05-29 | 2015-07-15 | Bergenbio As | Combination therapy |
| KR101829998B1 (ko) | 2015-11-04 | 2018-02-19 | 롬엔드하스전자재료코리아유한회사 | 착색 감광성 수지 조성물 및 이를 이용한 차광성 스페이서 |
| SI3436461T1 (sl) * | 2016-03-28 | 2024-03-29 | Incyte Corporation | Pirolotriazinske spojine kot tam-inhibitorji |
| EP3490676A1 (en) | 2016-07-29 | 2019-06-05 | Eli Lilly and Company | Combination therapy with merestinib and anti-pd-l1 or anti-pd-1 inhibitors for use in the treatment of cancer |
| CN109689056A (zh) | 2016-08-01 | 2019-04-26 | 亚尼塔公司 | 用于治疗癌症的组合 |
| WO2018039275A1 (en) | 2016-08-24 | 2018-03-01 | Ignyta, Inc. | Combinations for the treatment of cancer |
| EP3541384A1 (en) | 2016-11-16 | 2019-09-25 | Eli Lilly and Company | Treatment of cancer with exon 14 skipping mutation(s) or exon 14 skipping phenotype |
| CN108250200A (zh) | 2016-12-28 | 2018-07-06 | 中国科学院上海药物研究所 | 一种具有Axl抑制活性的化合物及其制备和应用 |
| JOP20180040A1 (ar) | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
| EP3719012B1 (en) | 2017-11-24 | 2024-03-06 | Medshine Discovery Inc. | N-[4-[(2-amino-4-pyridinyl)oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinecarboxamide derivatives as c-met/axl inhibitors for the treatment of tumors |
| US11247990B1 (en) | 2017-12-07 | 2022-02-15 | Array Biopharma Inc | Bicyclic fused pyridine compounds as inhibitors of TAM kinases |
-
2019
- 2019-08-28 UY UY0001038349A patent/UY38349A/es unknown
- 2019-08-29 CU CU2021000015A patent/CU20210015A7/es unknown
- 2019-08-29 IL IL281127A patent/IL281127B2/en unknown
- 2019-08-29 TW TW108131145A patent/TW202024071A/zh unknown
- 2019-08-29 SG SG11202101148UA patent/SG11202101148UA/en unknown
- 2019-08-29 CN CN201980071473.1A patent/CN112930215A/zh active Pending
- 2019-08-29 MX MX2021001952A patent/MX2021001952A/es unknown
- 2019-08-29 MA MA053487A patent/MA53487A/fr unknown
- 2019-08-29 JP JP2021510177A patent/JP6970859B2/ja active Active
- 2019-08-29 WO PCT/US2019/048701 patent/WO2020047184A1/en active Application Filing
- 2019-08-29 PE PE2021000248A patent/PE20211779A1/es unknown
- 2019-08-29 CR CR20210098A patent/CR20210098A/es unknown
- 2019-08-29 US US16/555,432 patent/US11104676B2/en active Active
- 2019-08-29 BR BR112021002722-0A patent/BR112021002722A2/pt not_active Application Discontinuation
- 2019-08-29 KR KR1020217009262A patent/KR20210049898A/ko active IP Right Grant
- 2019-08-29 AU AU2019330017A patent/AU2019330017B2/en active Active
- 2019-08-29 CA CA3110502A patent/CA3110502C/en active Active
- 2019-08-29 EP EP19766425.3A patent/EP3843850B1/en active Active
-
2021
- 2021-02-09 NI NI202100007A patent/NI202100007A/es unknown
- 2021-02-23 EC ECSENADI202112498A patent/ECSP21012498A/es unknown
- 2021-02-23 PH PH12021500017A patent/PH12021500017A1/en unknown
- 2021-02-24 CL CL2021000467A patent/CL2021000467A1/es unknown
- 2021-02-26 DO DO2021000038A patent/DOP2021000038A/es unknown
- 2021-02-26 CO CONC2021/0002651A patent/CO2021002651A2/es unknown
- 2021-07-15 US US17/376,571 patent/US11780835B2/en active Active
- 2021-10-29 JP JP2021177253A patent/JP7337133B2/ja active Active
-
2022
- 2022-05-03 AU AU2022202946A patent/AU2022202946B2/en active Active
- 2022-08-25 AU AU2022221514A patent/AU2022221514B2/en not_active Expired - Fee Related
-
2023
- 2023-08-29 US US18/457,795 patent/US20240174666A1/en active Pending
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