MX2020008237A - Inhibidores de 2,3,4,5-tetrahidro-1h-pirido[4,3-b]indol de cgas para tratar enfermedades autoinflamatorias. - Google Patents

Inhibidores de 2,3,4,5-tetrahidro-1h-pirido[4,3-b]indol de cgas para tratar enfermedades autoinflamatorias.

Info

Publication number
MX2020008237A
MX2020008237A MX2020008237A MX2020008237A MX2020008237A MX 2020008237 A MX2020008237 A MX 2020008237A MX 2020008237 A MX2020008237 A MX 2020008237A MX 2020008237 A MX2020008237 A MX 2020008237A MX 2020008237 A MX2020008237 A MX 2020008237A
Authority
MX
Mexico
Prior art keywords
cgas
pyrido
tetrahydro
autoinflammatory diseases
treating
Prior art date
Application number
MX2020008237A
Other languages
English (en)
Inventor
Taku Kamei
Thomas Tuschl
Michael Miller
Jumpei Aida
Toshihiro Imaeda
Yasutomi Asano
Dinshaw Patel
J Fraser Glickman
Rei Okamoto
Shogo Hashizume
Mayako Michino
Takanobu Kuroita
Lodoe Lama
Daisuke Tomita
Original Assignee
Univ Rockefeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rockefeller filed Critical Univ Rockefeller
Publication of MX2020008237A publication Critical patent/MX2020008237A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Se describen 1-(3,4-dihidro-1H-pirido[4,3-b]indol-2(5H)- il)-2-hidroxietanonas. Los compuestos son inhibidores de cGAS humano en los tipos de células que producen interferón. De esta manera son útiles como agentes terapéuticos para tratar enfermedades autoinmunitarias relacionadas con cGAS en humano. (VER FORMULA).
MX2020008237A 2018-02-05 2019-02-05 Inhibidores de 2,3,4,5-tetrahidro-1h-pirido[4,3-b]indol de cgas para tratar enfermedades autoinflamatorias. MX2020008237A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862626466P 2018-02-05 2018-02-05
PCT/US2019/016673 WO2019153002A1 (en) 2018-02-05 2019-02-05 2,3,4,5-tetrahydro-1h-pyrido[4, 3-b]indole inhibitors of cgas for treating autoinflammatory diseases

Publications (1)

Publication Number Publication Date
MX2020008237A true MX2020008237A (es) 2020-09-25

Family

ID=67479548

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020008237A MX2020008237A (es) 2018-02-05 2019-02-05 Inhibidores de 2,3,4,5-tetrahidro-1h-pirido[4,3-b]indol de cgas para tratar enfermedades autoinflamatorias.

Country Status (7)

Country Link
US (1) US11414422B2 (es)
EP (1) EP3749293B1 (es)
JP (1) JP7286679B2 (es)
BR (1) BR112020016008A2 (es)
IL (1) IL276501A (es)
MX (1) MX2020008237A (es)
WO (1) WO2019153002A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019153002A1 (en) 2018-02-05 2019-08-08 Lama Lodoe 2,3,4,5-tetrahydro-1h-pyrido[4, 3-b]indole inhibitors of cgas for treating autoinflammatory diseases
US20220185812A1 (en) 2019-03-13 2022-06-16 The Rockefeller University INHIBITORS OF cGAS FOR TREATING AUTOINFLAMMATORY DISEASES AND CANCER METASTASIS
EP4136074A1 (en) * 2020-04-16 2023-02-22 F. Hoffmann-La Roche AG Indazole derivatives
US20230227411A1 (en) * 2020-04-16 2023-07-20 Hoffmann-La Roche Inc. Benzimidazole Derivatives
JP2023521470A (ja) * 2020-04-16 2023-05-24 エフ． ホフマン－ラ ロシュ アーゲー スルファモイルアミド誘導体
US20230348398A1 (en) * 2020-04-16 2023-11-02 Hoffmann-La Roche Inc. Benzimidazole derivatives
WO2021209473A1 (en) * 2020-04-16 2021-10-21 F. Hoffmann-La Roche Ag Biphenyl derivatives
CN112010732B (zh) * 2020-09-10 2023-07-28 内蒙古永太化学有限公司 一种3,5-二氯-4-氟溴苯化合物的制备方法
CA3196153A1 (en) * 2020-09-24 2022-03-31 Ventus Therapeutics U.S., Inc. Pyrido[4,3-b]indole derivatives and their use as pharmaceuticals
JP2024502258A (ja) * 2020-12-22 2024-01-18 ノバルティス アーゲー Ｃｇａｓに関連する状態の処置に有用なインドール誘導体
WO2023154962A1 (en) 2022-02-14 2023-08-17 Subhash Sinha Cgas inhibitors and uses thereof
WO2023183275A1 (en) 2022-03-22 2023-09-28 Ventus Therapeutics U.S., Inc. Hexahydropyrido[4,3-b]indolyl ketone derivatives useful as cgas modulators
US20230391786A1 (en) 2022-06-02 2023-12-07 Eli Lilly And Company cGAS INHIBITORS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2007139634A (ru) * 2007-10-25 2009-04-27 Сергей Олегович Бачурин (RU) Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения
US8741919B2 (en) * 2009-04-29 2014-06-03 Medivation Technologies, Inc. Pyrido[4,3-B]indoles and methods of use
CN101857594B (zh) * 2010-06-18 2013-04-03 南方医科大学 一种四氢吡啶并吲哚类化合物及其制备方法和应用
CN109475565B (zh) * 2016-04-05 2021-11-02 免疫传感器公司 cGAS拮抗剂化合物
WO2017216279A1 (en) * 2016-06-16 2017-12-21 F. Hoffmann-La Roche Ag Heteroaryl estrogen receptor modulators and uses thereof
WO2019153002A1 (en) 2018-02-05 2019-08-08 Lama Lodoe 2,3,4,5-tetrahydro-1h-pyrido[4, 3-b]indole inhibitors of cgas for treating autoinflammatory diseases

Also Published As

Publication number Publication date
JP7286679B2 (ja) 2023-06-05
US20210155625A1 (en) 2021-05-27
JP2021515804A (ja) 2021-06-24
EP3749293B1 (en) 2022-03-30
EP3749293A4 (en) 2021-09-01
WO2019153002A1 (en) 2019-08-08
US11414422B2 (en) 2022-08-16
EP3749293A1 (en) 2020-12-16
IL276501A (en) 2020-09-30
BR112020016008A2 (pt) 2020-12-15

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