BR112019022512A2 - Compostos de heteroarila bicíclica fundida 6-6 e seu uso como inibidores de lats - Google Patents

Compostos de heteroarila bicíclica fundida 6-6 e seu uso como inibidores de lats Download PDF

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BR112019022512A2
BR112019022512A2 BR112019022512-9A BR112019022512A BR112019022512A2 BR 112019022512 A2 BR112019022512 A2 BR 112019022512A2 BR 112019022512 A BR112019022512 A BR 112019022512A BR 112019022512 A2 BR112019022512 A2 BR 112019022512A2
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inhibitors
lath
heteroaryl compounds
present
stereoisomer
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BR112019022512-9A
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English (en)
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Behnke Dirk
Berenshteyn Frada
Hao Xueshi
Hoffman Timothy
Jin Qihui
Lacoste Arnaud
Lee Cameron
Liu Jun
Liu Yahu
Klaus Maibaum Juergen
Mo Tingting
Pan Jianfeng
Qu Xin
Tchorz Jan
Feng Xie Yun
Yan Shanshan
Zou Yefen
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Novartis Ag
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

a presente invenção refere-se a compostos de heteroarila bicíclicos 6-6 fundidos da fórmula a2 ou a1 e seu uso como inibidores de lats, ou um sal, estereoisômero ou composição farmacêutica dos mesmos; em que as variáveis são conforme definido no presente documento (a1 e a2). a2 a1 a presente invenção refere-se adicionalmente a um método de inibição de lats em uma população de células que usa um composto de fórmula a1, ou um sal, estereoisômero ou composição farmacêutica do mesmo. a presente invenção fornece adicionalmente um método para fabricar compostos da invenção e seus usos terapêuticos. a invenção fornece adicionalmente métodos para seu preparo, para seu uso médico, para seu uso no tratamento e gerenciamento de doenças ou distúrbios.
BR112019022512-9A 2017-04-28 2018-04-26 Compostos de heteroarila bicíclica fundida 6-6 e seu uso como inibidores de lats BR112019022512A2 (pt)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201762491573P 2017-04-28 2017-04-28
US201762491484P 2017-04-28 2017-04-28
US201762491475P 2017-04-28 2017-04-28
US201762491526P 2017-04-28 2017-04-28
US62/491,526 2017-04-28
US62/491,475 2017-04-28
US62/491,484 2017-04-28
US62/491,573 2017-04-28
US201862650232P 2018-03-29 2018-03-29
US62/650,232 2018-03-29
PCT/IB2018/052919 WO2018198077A2 (en) 2017-04-28 2018-04-26 6-6 fused bicyclic heteroaryl compounds and their use as lats inhibitors

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BR112019022512A2 true BR112019022512A2 (pt) 2020-06-16

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US (2) US11458138B2 (pt)
EP (1) EP3615537B1 (pt)
JP (2) JP7247102B2 (pt)
KR (1) KR20190142776A (pt)
CN (3) CN114703144A (pt)
AU (2) AU2018260495B2 (pt)
BR (1) BR112019022512A2 (pt)
CA (1) CA3056906A1 (pt)
CL (1) CL2019003049A1 (pt)
CO (1) CO2019011873A2 (pt)
CR (1) CR20190483A (pt)
CU (2) CU20200080A7 (pt)
DO (1) DOP2019000273A (pt)
EC (1) ECSP19076732A (pt)
IL (2) IL269293B (pt)
JO (1) JOP20190257A1 (pt)
MA (1) MA49285A (pt)
MX (1) MX2019012756A (pt)
PE (1) PE20200292A1 (pt)
PH (1) PH12019502436A1 (pt)
SG (1) SG11201908615RA (pt)
TW (1) TW201843140A (pt)
UY (1) UY37703A (pt)
WO (1) WO2018198077A2 (pt)

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