EA202091588A1 - Способ получения аминопиримидина и его промежуточных продуктов - Google Patents

Способ получения аминопиримидина и его промежуточных продуктов

Info

Publication number
EA202091588A1
EA202091588A1 EA202091588A EA202091588A EA202091588A1 EA 202091588 A1 EA202091588 A1 EA 202091588A1 EA 202091588 A EA202091588 A EA 202091588A EA 202091588 A EA202091588 A EA 202091588A EA 202091588 A1 EA202091588 A1 EA 202091588A1
Authority
EA
Eurasian Patent Office
Prior art keywords
intermediate products
aminopyrimidine
obtaining
formula
new
Prior art date
Application number
EA202091588A
Other languages
English (en)
Inventor
Мэтью Питерсон
Кевин Лу
Брэдли Морган
Дэвид Морганс
Тору Фукуяма
Original Assignee
Сайтокинетикс, Инкорпорейтид
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сайтокинетикс, Инкорпорейтид filed Critical Сайтокинетикс, Инкорпорейтид
Publication of EA202091588A1 publication Critical patent/EA202091588A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/20—Preparation of carboxylic acid nitriles by dehydration of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Согласно настоящему изобретению предложен новый и улучшенный способ получения аминопиримидинового соединения формулы (1)или его соли. Кроме того, предложены соединения формулы (1B) и формулы (1D), которые представляют собой новые промежуточные продукты, используемые в указанном способе, а также способы их получения.
EA202091588A 2017-12-26 2018-12-26 Способ получения аминопиримидина и его промежуточных продуктов EA202091588A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762610302P 2017-12-26 2017-12-26
PCT/US2018/067500 WO2019133605A1 (en) 2017-12-26 2018-12-26 Process for the preparation of an amino-pyrimidine and intermediates thereof

Publications (1)

Publication Number Publication Date
EA202091588A1 true EA202091588A1 (ru) 2021-01-18

Family

ID=67068143

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202091588A EA202091588A1 (ru) 2017-12-26 2018-12-26 Способ получения аминопиримидина и его промежуточных продуктов

Country Status (15)

Country Link
US (1) US11142516B2 (ru)
EP (1) EP3732166A4 (ru)
JP (1) JP7209726B2 (ru)
KR (1) KR20200109314A (ru)
CN (1) CN112236415B (ru)
AU (1) AU2018397684B2 (ru)
BR (1) BR112020013020A2 (ru)
CA (1) CA3087051A1 (ru)
EA (1) EA202091588A1 (ru)
IL (1) IL275655B2 (ru)
MA (1) MA51432A (ru)
MX (1) MX2020006704A (ru)
PH (1) PH12020550983A1 (ru)
SG (1) SG11202006085PA (ru)
WO (1) WO2019133605A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111848423B (zh) * 2019-04-30 2022-10-14 尚科生物医药（上海）有限公司 3-氧代环丁基氨基甲酸叔丁酯的制备方法
MX2021015468A (es) * 2019-06-27 2022-01-24 Cytokinetics Inc Polimorfos de 1-(2-((((trans)-3-fluoro-1-(3-fluoropiridin-2-il)cic lobutil)metil)amino)pirimidin-5-il)-1h-pirrol-3-carboxamida.
WO2024064745A1 (en) * 2022-09-21 2024-03-28 Cytokinetics, Incorporated Synthesis of reldesemtiv

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006001958A2 (en) * 2004-05-21 2006-01-05 Merck & Co., Inc. Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity
KR20120011093A (ko) 2007-05-09 2012-02-06 화이자 인코포레이티드 치환된 헤테로사이클릭 유도체 및 조성물 및 항균제로서의 이의 약학적 용도
WO2011133920A1 (en) 2010-04-23 2011-10-27 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081626A1 (es) * 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
SG11201701019UA (en) * 2014-09-09 2017-03-30 Astellas Pharma Inc Novel pharmaceutical composition for prevention and/or treatment of urinary incontinence

Also Published As

Publication number Publication date
IL275655B2 (en) 2023-07-01
AU2018397684B2 (en) 2023-09-07
KR20200109314A (ko) 2020-09-22
EP3732166A4 (en) 2021-09-01
JP7209726B2 (ja) 2023-01-20
BR112020013020A2 (pt) 2020-11-24
IL275655A (en) 2020-08-31
MA51432A (fr) 2020-11-04
US11142516B2 (en) 2021-10-12
CA3087051A1 (en) 2019-07-04
IL275655B1 (en) 2023-03-01
JP2021508702A (ja) 2021-03-11
PH12020550983A1 (en) 2021-03-22
CN112236415B (zh) 2023-11-14
AU2018397684A1 (en) 2020-07-16
US20210061786A1 (en) 2021-03-04
EP3732166A1 (en) 2020-11-04
WO2019133605A1 (en) 2019-07-04
SG11202006085PA (en) 2020-07-29
MX2020006704A (es) 2020-09-14
CN112236415A (zh) 2021-01-15

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