LV11177B - Novel pharmaceutical product - Google Patents

Novel pharmaceutical product Download PDF

Info

Publication number
LV11177B
LV11177B LVP-95-284A LV950284A LV11177B LV 11177 B LV11177 B LV 11177B LV 950284 A LV950284 A LV 950284A LV 11177 B LV11177 B LV 11177B
Authority
LV
Latvia
Prior art keywords
benzo
benzoyl
piperidinoethoxy
hydroxy
reaction
Prior art date
Application number
LVP-95-284A
Other languages
English (en)
Latvian (lv)
Other versions
LV11177A (lv
Inventor
Elizabeth S Labell
Wayne D Luke
John Mc Mcgill
Randal S Miller
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26976194&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LV11177(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/308,325 external-priority patent/US5629425A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of LV11177A publication Critical patent/LV11177A/xx
Publication of LV11177B publication Critical patent/LV11177B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LVP-95-284A 1994-09-19 1995-09-18 Novel pharmaceutical product LV11177B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/308,325 US5629425A (en) 1994-09-19 1994-09-19 Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
US42791495A 1995-04-26 1995-04-26

Publications (2)

Publication Number Publication Date
LV11177A LV11177A (lv) 1996-04-20
LV11177B true LV11177B (en) 1996-08-20

Family

ID=26976194

Family Applications (2)

Application Number Title Priority Date Filing Date
LVP-95-285A LV11178B (en) 1994-09-19 1995-09-18 Synthesis of 3-£4-(2-aminoethoxy) benzoyl|-2-aryl-6-hydroxybenzo £b| thiophenes
LVP-95-284A LV11177B (en) 1994-09-19 1995-09-18 Novel pharmaceutical product

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LVP-95-285A LV11178B (en) 1994-09-19 1995-09-18 Synthesis of 3-£4-(2-aminoethoxy) benzoyl|-2-aryl-6-hydroxybenzo £b| thiophenes

Country Status (51)

Country Link
US (4) US6472531B1 (cs)
JP (2) JP2860071B2 (cs)
KR (2) KR100381346B1 (cs)
CN (2) CN1075069C (cs)
AP (1) AP754A (cs)
AT (2) AT502957A1 (cs)
AU (3) AU692907B2 (cs)
BE (2) BE1009626A3 (cs)
BG (1) BG62793B1 (cs)
BR (2) BR9504059A (cs)
CA (2) CA2158400C (cs)
CH (3) CH691125A5 (cs)
CO (2) CO4410190A1 (cs)
CZ (2) CZ290343B6 (cs)
DE (3) DE19534745B4 (cs)
DK (4) DK175903B1 (cs)
EE (1) EE03386B1 (cs)
EG (1) EG23763A (cs)
ES (2) ES2129293B1 (cs)
FI (2) FI112226B (cs)
FR (2) FR2724655B1 (cs)
GB (2) GB2293382B (cs)
GE (1) GEP19991821B (cs)
GR (2) GR1002709B (cs)
HK (1) HK1019009A1 (cs)
HR (2) HRP950483B1 (cs)
HU (2) HU227683B1 (cs)
IE (2) IE80883B1 (cs)
IL (3) IL115314A (cs)
IS (1) IS1788B (cs)
IT (2) IT1277601B1 (cs)
LU (2) LU88660A1 (cs)
LV (2) LV11178B (cs)
MY (1) MY116371A (cs)
NL (2) NL1001194C2 (cs)
NO (2) NO308107B1 (cs)
NZ (2) NZ280027A (cs)
OA (1) OA10406A (cs)
PE (2) PE32796A1 (cs)
PL (2) PL187686B1 (cs)
PT (2) PT101771B (cs)
RO (2) RO115260B1 (cs)
RS (2) RS49513B (cs)
SE (2) SE520721C2 (cs)
SI (2) SI9500293A (cs)
SK (1) SK283502B6 (cs)
TR (1) TR199501136A2 (cs)
TW (1) TW412534B (cs)
UA (2) UA44240C2 (cs)
UY (1) UY24040A1 (cs)
WO (1) WO1996009045A1 (cs)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE39049E1 (en) 1992-07-28 2006-03-28 Eli Lilly And Company Methods for inhibiting bone loss
USRE38968E1 (en) 1992-07-28 2006-02-07 Eli Lilly And Company Methods for inhibiting bone loss using 6-hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl-4-[2-(piperidin-1-yl) ethoxyphenylimethanone hydrochloride
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
US5478847A (en) 1994-03-02 1995-12-26 Eli Lilly And Company Methods of use for inhibiting bone loss and lowering serum cholesterol
CO4410190A1 (es) * 1994-09-19 1997-01-09 Lilly Co Eli 3-[4-(2-AMINOETOXI)-BENZOIL]-2-ARIL-6-HIDROXIBENZO [b] TIOFENO CRISTALINO
US6458811B1 (en) * 1996-03-26 2002-10-01 Eli Lilly And Company Benzothiophenes formulations containing same and methods
TR199801915T2 (xx) * 1996-03-26 1998-12-21 Eli Lilly And Company Benzotiofenler, bunlar� ihtiva eden form�lasyonlar ve y�ntemler.
ZA979720B (en) 1996-10-30 1999-04-29 Lilly Co Eli Prophylaxis of breast cancer
CA2236254A1 (en) * 1997-04-30 1998-10-30 David Warren Hoard Process for preparing benzo¬b|thiophenes
US6630453B1 (en) 1999-05-04 2003-10-07 Strakan Limited Androgen derivatives and uses thereof
AU2002230409A1 (en) * 2000-11-27 2002-06-03 Eli Lilly And Company Process for preparing 3-aryl-benzo(b)thiophenes
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
AU2003266940B2 (en) 2002-09-30 2007-02-08 A/S Gea Farmaceutisk Fabrik Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these
US6861422B2 (en) 2003-02-26 2005-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
US20060106010A1 (en) * 2003-05-27 2006-05-18 Black Larry J Methods for inhibiting bone loss
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004029784A1 (de) 2004-06-21 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
DE102004030502A1 (de) 2004-06-24 2006-01-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel
DE102004033670A1 (de) 2004-07-09 2006-02-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
US20060074088A1 (en) 2004-08-14 2006-04-06 Boehringer Ingelheim International Gmbh Dihydropteridinones for the treatment of cancer diseases
US7759485B2 (en) 2004-08-14 2010-07-20 Boehringer Ingelheim International Gmbh Process for the manufacture of dihydropteridinones
US20060035903A1 (en) 2004-08-14 2006-02-16 Boehringer Ingelheim International Gmbh Storage stable perfusion solution for dihydropteridinones
US7728134B2 (en) 2004-08-14 2010-06-01 Boehringer Ingelheim International Gmbh Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
EP1630163A1 (de) 2004-08-25 2006-03-01 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
UA91520C2 (en) 2004-09-29 2010-08-10 Баер Шеринг Фарма Акциенгезельшафт Thermodynamically stable form of tosylate
US20060068010A1 (en) * 2004-09-30 2006-03-30 Stephen Turner Method for improving the bioavailability of orally delivered therapeutics
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102004058337A1 (de) 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
US7439358B2 (en) 2006-02-08 2008-10-21 Boehringer Ingelheim International Gmbh Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
NZ619413A (en) 2006-05-04 2015-08-28 Boehringer Ingelheim Int Polymorphs of a dpp-iv enzyme inhibitor
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
AR062927A1 (es) 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
KR20090082399A (ko) * 2006-10-17 2009-07-30 씨아이피엘에이 엘티디. 벤조티오펜 화합물의 결정형 및 그의 제조방법
US8258291B2 (en) * 2006-10-25 2012-09-04 Mamtek International Limited Process for the preparation of sucralose by the chlorination of sugar with triphosgene (BTC)
US20080103295A1 (en) * 2006-10-25 2008-05-01 David Losan Ho Process for the preparation of sucrose-6-ester by esterification in the presence of solid superacid catalyst
DE102007032451B4 (de) 2007-07-12 2010-09-30 Icfs Gmbh Verfahren zur Herstellung von aromatischen Ketonen
WO2009015004A1 (en) * 2007-07-20 2009-01-29 King Pharmaceuticals Research And Development, Inc. Crystals of (2-amino-4,5,6,7-tetrahydrobenzo[b]thien-3-yl)(4-chlorophenyl)methanone
WO2009019205A1 (en) 2007-08-03 2009-02-12 Boehringer Ingelheim International Gmbh Crystalline form of a dihydropteridione derivative
CL2008003799A1 (es) * 2007-12-21 2009-12-18 Synthon Bv Composicion farmaceutica que comprende raloxifeno en forma de tableta de liberacion inmediata; util para el tratamiento y/o prevencion de la osteoporosis.
AR071175A1 (es) 2008-04-03 2010-06-02 Boehringer Ingelheim Int Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante
WO2009150669A1 (en) * 2008-06-09 2009-12-17 Erregierre S.P.A. Process for controlling the growth of a raloxifene hydrochloride crystal
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
BRPI0919288A2 (pt) 2008-09-10 2015-12-15 Boehring Ingelheim Internat Gmbh teriapia de combinação para tratamento de diabetes e condições relacionadas.
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CN102256976A (zh) 2008-12-23 2011-11-23 贝林格尔.英格海姆国际有限公司 有机化合物的盐形式
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
ES2437916T3 (es) 2009-07-02 2014-01-15 Synthon B.V. Composición de raloxifeno
EP2314581B1 (en) 2009-10-23 2012-07-25 Hexal AG A process for preparing benzo[b]thiophene derivatives
KR20210033559A (ko) 2009-11-27 2021-03-26 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
WO2011099942A1 (en) 2010-02-09 2011-08-18 Silverstone Pharma New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy
CN102946875A (zh) 2010-05-05 2013-02-27 贝林格尔.英格海姆国际有限公司 组合疗法
EP3124041A1 (en) 2010-06-24 2017-02-01 Boehringer Ingelheim International GmbH Diabetes therapy
US8546566B2 (en) 2010-10-12 2013-10-01 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof
IT1403083B1 (it) * 2010-10-25 2013-10-04 Fidia Farmaceutici Nuova forma polimorfa di raloxifene cloridrato
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
AU2012285904C1 (en) 2011-07-15 2017-08-31 Boehringer Ingelheim International Gmbh Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
EP2849755A1 (en) 2012-05-14 2015-03-25 Boehringer Ingelheim International GmbH A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
WO2014135834A1 (en) 2013-03-05 2014-09-12 Cipla House Oxalic acid addition salts and/or solvates of a selective estrogen receptor modulator
EP3024464A1 (en) 2013-07-26 2016-06-01 Boehringer Ingelheim International GmbH Treatment of myelodysplastic syndrome
US9526728B2 (en) 2014-02-28 2016-12-27 Boehringer Ingelheim International Gmbh Medical use of a DPP-4 inhibitor
US9867831B2 (en) 2014-10-01 2018-01-16 Boehringer Ingelheim International Gmbh Combination treatment of acute myeloid leukemia and myelodysplastic syndrome
CN104496963A (zh) * 2014-12-02 2015-04-08 千辉药业（安徽）有限责任公司 一种盐酸雷洛昔芬的制备方法
WO2017211979A1 (en) 2016-06-10 2017-12-14 Boehringer Ingelheim International Gmbh Combinations of linagliptin and metformin

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3869485A (en) * 1969-09-25 1975-03-04 Allied Chem Preparation of acid chlorides with phosgene in the presence of a catalyst
GB1456323A (en) * 1974-06-06 1976-11-24 Labaz Benzothiophenes process for preparing them and pharmaceutical compositions containing the same
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
IL65378A (en) 1981-04-03 1986-02-28 Lilly Co Eli Process for preparing 3-(4-aminoethoxybenzoyl)benzo-(b)thiophenes
ZA822247B (en) 1981-04-03 1983-11-30 Lilly Co Eli Benzothiophene compounds and process for preparing them
IL65379A0 (en) * 1981-04-03 1982-05-31 Lilly Co Eli Process for preparing acylated benzothiophenes
US4418068A (en) 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4358593A (en) * 1981-04-03 1982-11-09 Eli Lilly And Company Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
NZ200204A (en) * 1981-04-03 1985-05-31 Lilly Co Eli Benzothiophene derivatives and process for preparation
DE4117512A1 (de) * 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
US5169860A (en) * 1992-03-13 1992-12-08 Eli Lilly And Company Antitumor compositions and methods of treatment
TW383306B (en) * 1992-12-22 2000-03-01 Lilly Co Eli New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol
ZA944377B (en) 1993-06-24 1995-12-20 Lilly Co Eli Hypoglycemic agents
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5523416A (en) 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes
CO4410190A1 (es) * 1994-09-19 1997-01-09 Lilly Co Eli 3-[4-(2-AMINOETOXI)-BENZOIL]-2-ARIL-6-HIDROXIBENZO [b] TIOFENO CRISTALINO

Also Published As

Publication number Publication date
FI121424B (fi) 2010-11-15
LV11178B (en) 1996-08-20
US6399778B1 (en) 2002-06-04
IL115314A (en) 2000-02-29
MY116371A (en) 2004-01-31
CZ240295A3 (en) 1996-04-17
SI9500292A (en) 1996-06-30
LU88661A1 (fr) 1996-07-15
SK283502B6 (sk) 2003-08-05
UY24040A1 (es) 1996-03-07
CZ290343B6 (cs) 2002-07-17
PT101770B (pt) 1997-04-30
SE9503213D0 (sv) 1995-09-15
ES2109882B1 (es) 1998-08-16
CH691478A5 (de) 2001-07-31
DK175887B1 (da) 2005-05-23
SE9503213L (sv) 1996-03-20
YU61395A (sh) 1998-09-18
ATA154295A (de) 2000-12-15
DE19534744A1 (de) 1996-03-21
GB2293602B (en) 1998-05-06
PL310518A1 (en) 1996-04-01
CO4410190A1 (es) 1997-01-09
IE80883B1 (en) 1999-05-19
IS1788B (is) 2001-11-28
AU691955B2 (en) 1998-05-28
DE19549755B4 (de) 2005-05-04
NL1001194C2 (nl) 1997-04-04
JPH08193081A (ja) 1996-07-30
US5731327A (en) 1998-03-24
BE1009626A3 (fr) 1997-06-03
ITMI951935A0 (it) 1995-09-15
FI112226B (fi) 2003-11-14
NO308107B1 (no) 2000-07-24
PE14796A1 (es) 1996-05-19
GB2293382B (en) 1998-08-19
GB9519028D0 (en) 1995-11-15
SE9503214D0 (sv) 1995-09-15
NO313996B1 (no) 2003-01-13
YU61495A (sh) 1998-05-15
FR2732020B1 (fr) 1997-11-14
PL310517A1 (en) 1996-04-01
HRP950482A2 (en) 1998-02-28
ES2129293A1 (es) 1999-06-01
EE9700055A (et) 1997-08-15
FI954403A0 (fi) 1995-09-18
GR1002709B (el) 1997-06-04
IL115315A (en) 1999-09-22
ES2109882A1 (es) 1998-01-16
DK175903B1 (da) 2005-06-06
IL115314A0 (en) 1996-05-14
NO953657D0 (no) 1995-09-15
AU3173095A (en) 1996-04-04
CA2158399A1 (en) 1996-03-20
AT502957A1 (de) 2007-06-15
BR9504060A (pt) 1996-09-24
PE32796A1 (es) 1996-08-07
EG23763A (en) 2007-08-08
FR2724655B1 (fr) 1997-11-14
DK2797A (da) 1997-01-09
BG62793B1 (bg) 2000-08-31
SE9503214L (sv) 1996-03-20
CH691125A5 (de) 2001-04-30
DK102895A (da) 1996-03-20
KR960010637A (ko) 1996-04-20
FI954402A0 (fi) 1995-09-18
DK175897B1 (da) 2005-05-30
BE1009625A3 (fr) 1997-06-03
HU9502721D0 (en) 1995-11-28
FI954403A (fi) 1996-03-20
HU9502723D0 (en) 1995-11-28
PT101770A (pt) 1996-04-30
SK23397A3 (en) 1997-08-06
CN1068324C (zh) 2001-07-11
CZ292007B6 (cs) 2003-07-16
TW412534B (en) 2000-11-21
TR199501136A2 (tr) 1996-06-21
JP2860071B2 (ja) 1999-02-24
NZ280027A (en) 1997-05-26
KR100367376B1 (ko) 2003-03-06
GR1002697B (el) 1997-05-22
DE19534745B4 (de) 2004-06-09
GEP19991821B (en) 1999-11-05
HRP950483B1 (en) 2003-02-28
AT407988B (de) 2001-07-25
IT1277602B1 (it) 1997-11-11
FR2732020A1 (fr) 1996-09-27
PL182450B1 (pl) 2002-01-31
KR100381346B1 (ko) 2004-04-13
NL1001196A1 (nl) 1996-03-19
PT101771A (pt) 1996-04-30
CZ240395A3 (en) 1996-04-17
PT101771B (pt) 1997-04-30
DK102795A (da) 1996-03-20
ITMI951936A0 (it) 1995-09-15
DE19534745A1 (de) 1996-04-04
AP754A (en) 1999-07-22
GB2293602A (en) 1996-04-03
UA44240C2 (uk) 2002-02-15
CH691594A5 (de) 2001-08-31
HK1019009A1 (en) 2000-01-14
SE520721C2 (sv) 2003-08-12
NL1001194A1 (nl) 1996-03-19
LU88660A1 (fr) 1996-07-15
NO953658D0 (no) 1995-09-15
FI954402A (fi) 1996-03-20
JPH08176147A (ja) 1996-07-09
IS4446A (is) 1997-03-18
RO115260B1 (ro) 1999-12-30
IE950722A1 (en) 1996-03-20
IL125283A (en) 2001-06-14
RS49513B (sr) 2006-10-27
CN1127253A (zh) 1996-07-24
KR960010634A (ko) 1996-04-20
CN1132205A (zh) 1996-10-02
HU227683B1 (en) 2011-11-28
HRP950483A2 (en) 1997-10-31
HUT74178A (en) 1996-11-28
IT1277601B1 (it) 1997-11-11
CA2158400A1 (en) 1996-03-20
HRP950482B1 (en) 2007-04-30
ES2129293B1 (es) 2000-01-16
SI9500293A (en) 1996-06-30
AU3173195A (en) 1996-04-04
AU692907B2 (en) 1998-06-18
IE950721A1 (en) 1996-03-20
FR2724655A1 (fr) 1996-03-22
BG101242A (en) 1998-03-31
DK175886B1 (da) 2005-05-23
US20020173645A1 (en) 2002-11-21
IL115315A0 (en) 1995-12-31
WO1996009045A1 (en) 1996-03-28
ITMI951936A1 (it) 1997-03-15
RS49578B (sr) 2007-04-10
US6472531B1 (en) 2002-10-29
LV11177A (lv) 1996-04-20
EE03386B1 (et) 2001-04-16
GB9519032D0 (en) 1995-11-15
HU225417B1 (en) 2006-11-28
AU3718695A (en) 1996-04-09
CA2158399C (en) 2001-03-20
LV11178A (lv) 1996-04-20
DK2897A (da) 1997-01-09
HUT75033A (en) 1997-03-28
OA10406A (en) 2001-12-05
AP9700938A0 (en) 1997-04-30
NO953658L (no) 1996-03-20
NO953657L (no) 1996-03-20
UA42716C2 (uk) 2001-11-15
NL1001196C2 (nl) 1997-04-04
BR9504059A (pt) 1996-09-24
ITMI951935A1 (it) 1997-03-15
CN1075069C (zh) 2001-11-21
NZ280028A (en) 1997-05-26
GB2293382A (en) 1996-03-27
CO4410191A1 (es) 1997-01-09
RO115259B1 (ro) 1999-12-30
PL187686B1 (pl) 2004-09-30
CA2158400C (en) 2006-10-24
SE509265C2 (sv) 1998-12-21

Similar Documents

Publication Publication Date Title
AP754A (en) Antiestrogenic benzothiophenyl compounds.
US5629425A (en) Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
US6008377A (en) Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxy-benzo[B]thiophenes