AP754A - Antiestrogenic benzothiophenyl compounds. - Google Patents

Antiestrogenic benzothiophenyl compounds. Download PDF

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Publication number
AP754A
AP754A APAP/P/1997/000938A AP9700938A AP754A AP 754 A AP754 A AP 754A AP 9700938 A AP9700938 A AP 9700938A AP 754 A AP754 A AP 754A
Authority
AP
ARIPO
Prior art keywords
reaction
benzoyl
benzo
crystalline
compound
Prior art date
Application number
APAP/P/1997/000938A
Other languages
English (en)
Other versions
AP9700938A0 (en
Inventor
Elizabeth Smith Labell
Wayne Douglas Luke
Mcgill, (Iii) John Neil
Randal Scot Miller
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26976194&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP754(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/308,325 external-priority patent/US5629425A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AP9700938A0 publication Critical patent/AP9700938A0/xx
Application granted granted Critical
Publication of AP754A publication Critical patent/AP754A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
APAP/P/1997/000938A 1994-09-19 1995-09-19 Antiestrogenic benzothiophenyl compounds. AP754A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/308,325 US5629425A (en) 1994-09-19 1994-09-19 Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
US42791495A 1995-04-26 1995-04-26
PCT/US1995/011872 WO1996009045A1 (en) 1994-09-19 1995-09-19 Antiestrogenic benzothiophenyl compounds

Publications (2)

Publication Number Publication Date
AP9700938A0 AP9700938A0 (en) 1997-04-30
AP754A true AP754A (en) 1999-07-22

Family

ID=26976194

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1997/000938A AP754A (en) 1994-09-19 1995-09-19 Antiestrogenic benzothiophenyl compounds.

Country Status (51)

Country Link
US (4) US5731327A (cs)
JP (2) JP2860071B2 (cs)
KR (2) KR100381346B1 (cs)
CN (2) CN1075069C (cs)
AP (1) AP754A (cs)
AT (2) AT502957A1 (cs)
AU (3) AU691955B2 (cs)
BE (2) BE1009625A3 (cs)
BG (1) BG62793B1 (cs)
BR (2) BR9504060A (cs)
CA (2) CA2158399C (cs)
CH (3) CH691594A5 (cs)
CO (2) CO4410190A1 (cs)
CZ (2) CZ290343B6 (cs)
DE (3) DE19549755B4 (cs)
DK (4) DK175903B1 (cs)
EE (1) EE03386B1 (cs)
EG (1) EG23763A (cs)
ES (2) ES2129293B1 (cs)
FI (2) FI121424B (cs)
FR (2) FR2724655B1 (cs)
GB (2) GB2293602B (cs)
GE (1) GEP19991821B (cs)
GR (2) GR1002697B (cs)
HK (1) HK1019009A1 (cs)
HR (2) HRP950483B1 (cs)
HU (2) HU225417B1 (cs)
IE (2) IE950722A1 (cs)
IL (3) IL125283A (cs)
IS (1) IS1788B (cs)
IT (2) IT1277601B1 (cs)
LU (2) LU88660A1 (cs)
LV (2) LV11177B (cs)
MY (1) MY116371A (cs)
NL (2) NL1001194C2 (cs)
NO (2) NO313996B1 (cs)
NZ (2) NZ280027A (cs)
OA (1) OA10406A (cs)
PE (2) PE14796A1 (cs)
PL (2) PL187686B1 (cs)
PT (2) PT101771B (cs)
RO (2) RO115259B1 (cs)
RS (2) RS49513B (cs)
SE (2) SE509265C2 (cs)
SI (2) SI9500292A (cs)
SK (1) SK283502B6 (cs)
TR (1) TR199501136A2 (cs)
TW (1) TW412534B (cs)
UA (2) UA42716C2 (cs)
UY (1) UY24040A1 (cs)
WO (1) WO1996009045A1 (cs)

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US6458811B1 (en) 1996-03-26 2002-10-01 Eli Lilly And Company Benzothiophenes formulations containing same and methods
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US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
US20060074088A1 (en) 2004-08-14 2006-04-06 Boehringer Ingelheim International Gmbh Dihydropteridinones for the treatment of cancer diseases
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US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
EP3517539B1 (en) 2011-07-15 2022-12-14 Boehringer Ingelheim International GmbH Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
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WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
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JP2016525532A (ja) 2013-07-26 2016-08-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 骨髄異形成症候群の処置
JP6615109B2 (ja) 2014-02-28 2019-12-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｄｐｐ−４阻害薬の医学的使用
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EP0635264A2 (en) * 1993-06-24 1995-01-25 Eli Lilly And Company Antiestrogens as hypoglycemic agents

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Also Published As

Publication number Publication date
HRP950482A2 (en) 1998-02-28
SE520721C2 (sv) 2003-08-12
RO115260B1 (ro) 1999-12-30
SI9500292A (en) 1996-06-30
NO313996B1 (no) 2003-01-13
YU61495A (sh) 1998-05-15
PT101770A (pt) 1996-04-30
AT407988B (de) 2001-07-25
PT101770B (pt) 1997-04-30
NL1001196C2 (nl) 1997-04-04
RS49578B (sr) 2007-04-10
FI121424B (fi) 2010-11-15
UA42716C2 (uk) 2001-11-15
IE80883B1 (en) 1999-05-19
CZ290343B6 (cs) 2002-07-17
EE9700055A (et) 1997-08-15
NL1001194C2 (nl) 1997-04-04
BR9504059A (pt) 1996-09-24
LV11178A (lv) 1996-04-20
CH691594A5 (de) 2001-08-31
BR9504060A (pt) 1996-09-24
LV11177B (en) 1996-08-20
CH691125A5 (de) 2001-04-30
TW412534B (en) 2000-11-21
HK1019009A1 (en) 2000-01-14
DK175887B1 (da) 2005-05-23
FR2732020A1 (fr) 1996-09-27
NZ280028A (en) 1997-05-26
SE509265C2 (sv) 1998-12-21
KR960010634A (ko) 1996-04-20
HU227683B1 (en) 2011-11-28
IL115315A0 (en) 1995-12-31
MY116371A (en) 2004-01-31
DK102795A (da) 1996-03-20
AT502957A1 (de) 2007-06-15
CN1068324C (zh) 2001-07-11
JPH08176147A (ja) 1996-07-09
IL115314A0 (en) 1996-05-14
PT101771B (pt) 1997-04-30
ES2129293A1 (es) 1999-06-01
CA2158399A1 (en) 1996-03-20
GEP19991821B (en) 1999-11-05
NL1001194A1 (nl) 1996-03-19
CN1075069C (zh) 2001-11-21
ES2109882B1 (es) 1998-08-16
US20020173645A1 (en) 2002-11-21
NO953658D0 (no) 1995-09-15
ITMI951936A1 (it) 1997-03-15
FR2724655A1 (fr) 1996-03-22
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