LT3961B - Hypoglycemic compounds, process for preparing thereof and pharmaceutical compositions containing them - Google Patents

Hypoglycemic compounds, process for preparing thereof and pharmaceutical compositions containing them Download PDF

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Publication number
LT3961B
LT3961B LTIP1648A LTIP1648A LT3961B LT 3961 B LT3961 B LT 3961B LT IP1648 A LTIP1648 A LT IP1648A LT IP1648 A LTIP1648 A LT IP1648A LT 3961 B LT3961 B LT 3961B
Authority
LT
Lithuania
Prior art keywords
carbon atoms
group
phenyl
methyl
formula
Prior art date
Application number
LTIP1648A
Other languages
English (en)
Lithuanian (lt)
Inventor
Balasubramanian Golapan
Original Assignee
Boots Co Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Co Plc filed Critical Boots Co Plc
Publication of LTIP1648A publication Critical patent/LTIP1648A/xx
Publication of LT3961B publication Critical patent/LT3961B/lt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Soy Sauces And Products Related Thereto (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
LTIP1648A 1989-02-16 1993-12-21 Hypoglycemic compounds, process for preparing thereof and pharmaceutical compositions containing them LT3961B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898903592A GB8903592D0 (en) 1989-02-16 1989-02-16 Therapeutic agents

Publications (2)

Publication Number Publication Date
LTIP1648A LTIP1648A (en) 1995-07-25
LT3961B true LT3961B (en) 1996-05-27

Family

ID=10651840

Family Applications (3)

Application Number Title Priority Date Filing Date
LTIP1648A LT3961B (en) 1989-02-16 1993-12-21 Hypoglycemic compounds, process for preparing thereof and pharmaceutical compositions containing them
LTIP1647A LT3960B (en) 1989-02-16 1993-12-21 Process for preparing hypoglycemic compounds
LTIP1646A LT3958B (en) 1989-02-16 1993-12-21 Process for preparing hypoglycemic guanidine derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
LTIP1647A LT3960B (en) 1989-02-16 1993-12-21 Process for preparing hypoglycemic compounds
LTIP1646A LT3958B (en) 1989-02-16 1993-12-21 Process for preparing hypoglycemic guanidine derivatives

Country Status (26)

Country Link
US (2) US5223498A (cs)
EP (1) EP0385038B1 (cs)
JP (1) JP2545475B2 (cs)
AT (1) ATE90074T1 (cs)
BG (1) BG60557B1 (cs)
CS (1) CS277609B6 (cs)
DD (1) DD294023A5 (cs)
DE (1) DE68906880T2 (cs)
DK (1) DK640889A (cs)
ES (1) ES2055115T3 (cs)
FI (1) FI95565C (cs)
GB (1) GB8903592D0 (cs)
GE (1) GEP19981040B (cs)
HU (1) HU211571A9 (cs)
IL (1) IL92963A (cs)
LT (3) LT3961B (cs)
LV (1) LV10619B (cs)
MY (1) MY105052A (cs)
NO (1) NO177993C (cs)
PL (2) PL162960B1 (cs)
PT (1) PT92770B (cs)
RO (2) RO107945B1 (cs)
RU (3) RU1826969C (cs)
UA (2) UA27713C2 (cs)
YU (1) YU48164B (cs)
ZA (1) ZA899941B (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3766696D1 (de) * 1986-12-27 1991-01-24 Konishiroku Photo Ind Lichtempfindliches photographisches silberhalogenidmaterial.
IN172842B (cs) * 1990-05-17 1993-12-11 Boots Pharmaceuticals Limited
BR9407515A (pt) * 1993-08-12 1997-01-07 Astra Ab Composto formulação farmaceutica uso do composto processos para o tratamento de desordens neurodegenerativas ou de enxaqueca ou para a prevenção e a reversão da tolerância aos opiatos e diazepinas ou para o tratamento do vicio das drogas e para a preparação do composto
GB9418912D0 (en) * 1994-09-20 1994-11-09 Fisons Corp Pharmaceutically active compounds
AU4176396A (en) * 1994-12-08 1996-06-26 Knoll Aktiengesellschaft Use of substituted phenylamidine and phenylguanidine compounds for the treatment of cerebral and cardiac ischaemia, convulsion and sickle cell anaemia
TW397812B (en) * 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy
WO1997046515A1 (en) * 1996-06-04 1997-12-11 Chugai Seiyaku Kabushiki Kaisha Substituted benzenes having nos inhibitory effects
US6756389B2 (en) * 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6187203B1 (en) * 1998-12-01 2001-02-13 Academia Sinica Sample purification apparatus and method
US20030212116A1 (en) * 1999-12-28 2003-11-13 Toshio Niki Heterocyclic imino compounds and fungicides and insecticides for agricultural and horitcultural use
CA2421506A1 (en) * 2000-09-07 2002-03-14 Ming Wang Cyclic and acyclic amidines and pharmaceutical compositions containing them for use as progesterone receptor binding agents
PE20070182A1 (es) * 2005-07-29 2007-03-06 Wyeth Corp Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona
PE20070341A1 (es) * 2005-07-29 2007-04-13 Wyeth Corp Derivados de pirrol como moduladores del receptor de progesterona
PE20070404A1 (es) * 2005-07-29 2007-05-10 Wyeth Corp Compuestos derivados de cianopirrol-sulfonamida como moduladores del receptor de progesterona

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US77978A (en) 1868-05-19 Improvement in low-water indicators
US672015A (en) 1900-10-05 1901-04-16 Alfred Schlatter Automatic switch for groups of transformers.
CA372219A (en) 1938-03-01 Kienzle Fritz Perforating device

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD81857A (cs) *
GB861527A (en) * 1958-05-16 1961-02-22 Ici Ltd New salts of penicillins
US3622596A (en) * 1960-10-14 1971-11-23 A Wander Sa Dr Carbanilide compounds
CH459172A (de) * 1961-09-11 1968-07-15 Wander Ag Dr A Verfahren zur Herstellung mehrbasischer Verbindungen
US3867448A (en) * 1962-03-08 1975-02-18 Ciba Geigy Ag Trifluoromethylphenyl-formamadines and acetamidines
BE639393A (cs) * 1962-10-30
US3320229A (en) * 1963-08-26 1967-05-16 Stauffer Chemical Co Complexes of guanidines with completely halogenated acetones
US3479437A (en) * 1963-08-26 1969-11-18 Stauffer Chemical Co Guanidine complexes as fungicides
US3636219A (en) * 1964-03-02 1972-01-18 Du Pont Anticholinergic compositions containing certain thiazolines or imidazolines
US3399211A (en) * 1964-03-10 1968-08-27 Merck & Co Inc Production of 2-aryl-4(5)-nitroimidazoles
US3479401A (en) * 1966-06-28 1969-11-18 Merck & Co Inc Guanidinoaryl and guanidinomethylaryl compounds
DE1670274A1 (de) * 1966-10-31 1970-07-16 Boehringer Sohn Ingelheim Neues Verfahren zur Herstellung von 2-Arylamino-1,3-diazacycloalkenen-(2)
IL30281A (en) * 1967-07-11 1971-12-29 Chinoin Gyogyszer Es Vegyeszet Amidine history and process for their preparation
US4013676A (en) * 1970-06-13 1977-03-22 Bayer Aktiengesellschaft Aminophenylamidines, their production and their pharmaceutical use
US4018814A (en) * 1970-06-13 1977-04-19 Bayer Aktiengesellschaft Aromatic amides and carbomates of phenylamidines
US3925471A (en) * 1970-06-13 1975-12-09 Bayer Ag Aminophenylamidines their production and their medicinal use
DE2029297A1 (de) * 1970-06-13 1971-12-30 Farbenfabriken Bayer Ag, 5090 Leverkusen Neue Aminophenyl-cycloamidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE2029298C3 (de) * 1970-06-13 1980-04-17 Bayer Ag, 5090 Leverkusen Aminophenylamidine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US3925470A (en) * 1970-06-13 1975-12-09 Bayer Ag Aminophenylamidines, their production and their medicinal use
US3903302A (en) * 1970-06-13 1975-09-02 Bayer Ag Aminophenylamidines as anthelmintic agents
US3911010A (en) * 1970-06-13 1975-10-07 Bayer Ag Aminophenylamidines, their production and their pharmaceutical use
US3911014A (en) * 1970-06-13 1975-10-07 Bayer Ag Aminophenylamidines, their production and their medicinal use
DE2029299C3 (de) * 1970-06-13 1980-08-21 Bayer Ag, 5090 Leverkusen Neue Aminophenylamidine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US3919315A (en) * 1970-06-13 1975-11-11 Bayer Ag New aminophenylamidines, their production and their medicinal use
US3996247A (en) * 1970-06-13 1976-12-07 Bayer Aktiengesellschaft Substituted 4-aminophenylamidines
US3923888A (en) * 1970-06-13 1975-12-02 Bayer Ag Aminophenylamidines, their production and their medicinal use
US3911013A (en) * 1970-06-13 1975-10-07 Bayer Ag New aminophenylamidines, their production and their medicinal use
FR2098352A7 (en) * 1970-07-13 1972-03-10 Fahlberg List Veb Hydroxyguanidines - with selective herbicidal activity
GB1311913A (en) * 1970-09-05 1973-03-28 Fahlberg List Veb Herbicidal hydroxyguanidines
DE2350696A1 (de) * 1972-10-12 1974-04-18 Ciba Geigy Ag Neue ester
US3965176A (en) * 1973-06-20 1976-06-22 Schering Corporation Novel substituted amidines
IL44905A (en) * 1973-06-25 1977-03-31 Ciba Geigy Ag N-alkyl-n-(n-alkylformimidoyl)-n'-phenylformamidine derivatives their preparation and use in pest control
SE7411169L (sv) * 1974-09-04 1976-03-05 Wander Ag Dr A Forfarande for framstellning av nya organiska foreningar
JPS51118832A (en) * 1975-04-09 1976-10-19 Sumitomo Chem Co Ltd A non-medical antibacterial, 3-pyridyl substituted guanidine
US4211867A (en) * 1976-03-19 1980-07-08 Mcneil Laboratories, Incorporated Nitrogen heterocyclic carboximidamide compounds
DE2626128A1 (de) * 1976-06-11 1977-12-22 Beiersdorf Ag N-substituierte benzimidazolin-2-one und verfahren zu deren herstellung
US4414211A (en) * 1978-09-18 1983-11-08 Mcneilab, Inc. Heterocyclic derivatives of guanidine
US4182865A (en) * 1978-09-18 1980-01-08 Mcneil Laboratories, Inc. Diaza-cyclic derivatives of guanidine
DE2848786C3 (de) * 1978-11-10 1981-05-21 Ibm Deutschland Gmbh, 7000 Stuttgart Schaltungsanordnung für die Synchronisierung der Auftrittszeitpunkte von Druckhammeraufschlag mit dem Eintreffen der Drucktype an der Druckstelle
AU5263779A (en) * 1978-11-29 1980-05-29 Beecham Group Limited Derivatives of thiazolidin-2-ylidene and oxazolidin-2-ylidene with hypoglycaemic acitivity
US4247705A (en) * 1979-02-06 1981-01-27 A. H. Robins Company, Inc. 4-Substituted 2-iminoimidazolidine compounds
ZA801680B (en) * 1979-04-03 1981-03-25 Fujisawa Pharmaceutical Co 2-imidazoline derivatives,process for the preparation thereof and the pharmaceutical composition of the same
ZA802161B (en) * 1979-04-11 1981-04-29 Ciba Geigy Ag Guanidines,processes for producing them,and pharmaceutical preparations containing sucn compounds
IN150250B (cs) * 1979-04-16 1982-08-28 Ciba Geigy India Ltd
DE3066911D1 (en) * 1979-04-21 1984-04-19 Beecham Group Plc Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions containing them
US4342764A (en) * 1979-05-29 1982-08-03 Ciba-Geigy Corporation Guanidine compounds, pharmaceutical compositions and use
JPS55160764A (en) * 1979-05-29 1980-12-13 Ciba Geigy Ag Guanidine* its manufacture and pharmaceutic medicine containing same
DD144919A1 (de) * 1979-07-20 1980-11-12 Rainer Beckert Verfahren zur herstellung von 2,5-diaryl-3,4-diarylimino-1,2,5-thiadiazolidin-s-oxiden
JPS5618969A (en) * 1979-07-24 1981-02-23 Toyama Chem Co Ltd Novel 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative, its acid addition salt, and their preparation
US4340609A (en) * 1980-01-02 1982-07-20 William H. Rorer, Inc. Amidinourea derivative veterinary compositions for suppression of parasitemia
US4287201A (en) * 1980-03-03 1981-09-01 Merck & Co., Inc. Anovulatory method and chicken feed compositions
US4281004A (en) * 1980-03-31 1981-07-28 Pfizer Inc. Phenylguanidine therapeutic agents
DE3168754D1 (en) * 1980-07-09 1985-03-21 Beecham Group Plc Clonidine derivatives useful in the treatment of diarrhoea
US4348406A (en) * 1980-10-20 1982-09-07 Schering Corporation Novel guanidine derivatives
US4735959A (en) * 1981-01-10 1988-04-05 Dr. Karl Thomae Gmbh Carboxylic acid amides and pharmaceutical compositions containing them
DE3225188A1 (de) * 1982-07-06 1984-01-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue phenylessigsaeurederivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3100575A1 (de) * 1981-01-10 1982-09-02 Dr. Karl Thomae Gmbh, 7950 Biberach "neue benzoesaeuren, ihre herstellung und ihre verwendung als arzneimittel"
EP0070084A3 (en) * 1981-04-24 1983-02-16 Beecham Group Plc Imidazoline derivatives
US4461904A (en) * 1981-11-20 1984-07-24 Alcon Laboratories, Inc. 2-(Trisubstituted phenylimino)-imidazolines
EP0099017B1 (de) * 1982-07-06 1988-03-02 Dr. Karl Thomae GmbH Neue Phenylessigsäure-Derivate, ihre Herstellung und diese Verbindungen enthaltende Arzneimittel
US4533739A (en) * 1982-10-12 1985-08-06 G. D. Searle & Co. 2-[(Aminophenyl and amidophenyl)amino]-1-azacycloalkanes having antidiarrheal activity
FR2539417A1 (fr) * 1983-01-13 1984-07-20 Rhone Poulenc Sante Nouveaux pyrrolo-1, 2 heterocycles, leur preparation et les medicaments qui les contiennent
MA20003A1 (fr) * 1983-01-13 1984-10-01 Rhone Poulenc Sante Nouveaux derives de pyrrole orthocondense utiles pour la preparation de nouveaux produits et leurs preparation
SU1114674A1 (ru) * 1983-02-08 1984-09-23 Предприятие П/Я Р-6913 Способ получени гидрохлоридов производных @ , @ -дифенил бензамидина
GB8304593D0 (en) * 1983-02-18 1983-03-23 Beecham Group Plc Amidines
US4861879A (en) * 1983-02-28 1989-08-29 Janssen Pharmaceutica N.V. [[4-[4-Phenyl-1-piperazinyl)phenoxymethyl]-1-3-dioxolan-2-yl]-methyl]-1H-imidazoles and 1H-1,2,4-triazoles
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
US4735942A (en) * 1984-01-09 1988-04-05 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]-methyl]-1H-imidazoles and 1H-1,2,4-triazoles having antimicrobial properties
FR2549049B1 (fr) * 1983-07-13 1986-06-20 Chauvin Blache Lab Nouvelles amidines, leur procede de preparation et leur application therapeutique
US4723029A (en) * 1983-09-23 1988-02-02 Schering Corporation Organic acid-substituted guanidine anthelmintics
US4701447A (en) * 1983-09-23 1987-10-20 Schering Corporation N-((2-nitro)phenyl)-N' (organic acid) guanidine anthelmintics
JPS60100559A (ja) * 1983-11-05 1985-06-04 Morishita Seiyaku Kk ２−アニリノ−１，６−ジヒドロ−６−オキソ−５−ピリミジンカルボン酸誘導体，その製法及び該化合物を含有する抗アレルギ−剤
US4579951A (en) * 1984-03-19 1986-04-01 G. D. Searle & Co. Substituted (azacycloalk-2-yl)iminophenols and esters thereof
US4560690A (en) * 1984-04-30 1985-12-24 Pfizer Inc. 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents
EP0164204A1 (en) * 1984-05-12 1985-12-11 FISONS plc Novel pharmaceutically useful pyrimidines
HU192986B (en) * 1984-05-23 1987-08-28 Egyt Gyogyszervegyeszeti Gyar Process for production of imidasodiline derivatives
US4656270A (en) * 1985-03-15 1987-04-07 Mcneilab, Inc. Process for producing guanidines such as linogliride
US4693850A (en) * 1985-03-15 1987-09-15 Mcneilab, Inc. Methane sulfonic acid derivatives
DE3518917A1 (de) * 1985-05-25 1986-11-27 Bayer Ag, 5090 Leverkusen Substituierte benzochinolizine, verfahren zur herstellung und ihre verwendung in arzneimitteln
DE3529692A1 (de) * 1985-08-20 1987-02-26 Bayer Ag Verwendung von lactamamiden als leistungsfoerderer bei tieren
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles
ATE135699T1 (de) * 1986-01-13 1996-04-15 American Cyanamid Co 4,5,6-substituierte 2-pyrimidinamine
GB8602025D0 (en) 1986-01-28 1986-03-05 Reid M Orthopaedic trolley

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US77978A (en) 1868-05-19 Improvement in low-water indicators
CA372219A (en) 1938-03-01 Kienzle Fritz Perforating device
US672015A (en) 1900-10-05 1901-04-16 Alfred Schlatter Automatic switch for groups of transformers.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KADISH AK ET AL.: "A new and rapid method for determination of glucose by measurement of rate of oxygen consumption", CLIN CHEM., 1963, pages 116 - 131

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FI95565C (fi) 1996-02-26
US5223498A (en) 1993-06-29
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LTIP1648A (en) 1995-07-25
ES2055115T3 (es) 1994-08-16
RO105807B1 (ro) 1992-12-30
LT3960B (en) 1996-05-27
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GEP19981040B (en) 1998-09-25
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PT92770B (pt) 1995-12-29
BG60557B1 (bg) 1995-08-28
CS743389A3 (en) 1992-03-18
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FI95565B (fi) 1995-11-15
NO177993B (no) 1995-09-25
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UA27713C2 (uk) 2000-10-16
NO895023D0 (no) 1989-12-14
RU1826969C (ru) 1993-07-07
YU248589A (en) 1992-02-20
RU1797610C (ru) 1993-02-23
ATE90074T1 (de) 1993-06-15
ZA899941B (en) 1991-02-27
UA19156A (uk) 1997-12-25
PL162960B1 (pl) 1994-01-31
HU211571A9 (en) 1995-12-28
PT92770A (pt) 1990-08-31
DE68906880D1 (de) 1993-07-08
LV10619A (lv) 1995-04-20
YU48164B (sh) 1997-07-31
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US5373008A (en) 1994-12-13
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RU2052452C1 (ru) 1996-01-20
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FI895956A0 (fi) 1989-12-13
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