KR850000883B1 - 삼-치환 이미다졸 유도체의 제조방법 - Google Patents

삼-치환 이미다졸 유도체의 제조방법 Download PDF

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Publication number
KR850000883B1
KR850000883B1 KR1019810002709A KR810002709A KR850000883B1 KR 850000883 B1 KR850000883 B1 KR 850000883B1 KR 1019810002709 A KR1019810002709 A KR 1019810002709A KR 810002709 A KR810002709 A KR 810002709A KR 850000883 B1 KR850000883 B1 KR 850000883B1
Authority
KR
South Korea
Prior art keywords
phenyl
pyridyl
imidazol
oxido
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019810002709A
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English (en)
Korean (ko)
Other versions
KR830006230A (ko
Inventor
살만 알프레드
Original Assignee
시바-가이기 에이지
아놀드 자일러, 에른스트 알테르
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 시바-가이기 에이지, 아놀드 자일러, 에른스트 알테르 filed Critical 시바-가이기 에이지
Publication of KR830006230A publication Critical patent/KR830006230A/ko
Priority to KR1019840005962A priority Critical patent/KR850000885B1/ko
Priority to KR1019840005966A priority patent/KR850000889B1/ko
Priority to KR1019840005964A priority patent/KR850000887B1/ko
Priority to KR1019840005963A priority patent/KR850000886B1/ko
Priority to KR1019840005970A priority patent/KR850000911B1/ko
Priority to KR1019840005969A priority patent/KR850000891B1/ko
Priority to KR1019840005965A priority patent/KR850000888B1/ko
Priority to KR1019840005968A priority patent/KR850000890B1/ko
Priority to KR1019840005960A priority patent/KR850000873B1/ko
Priority to KR1019840005972A priority patent/KR850001064B1/ko
Priority to KR1019840005971A priority patent/KR850000892B1/ko
Priority to KR1019840005961A priority patent/KR850000884B1/ko
Application granted granted Critical
Publication of KR850000883B1 publication Critical patent/KR850000883B1/ko
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/26—Radicals substituted by carbon atoms having three bonds to hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
KR1019810002709A 1980-07-25 1981-07-25 삼-치환 이미다졸 유도체의 제조방법 Expired KR850000883B1 (ko)

Priority Applications (12)

Application Number Priority Date Filing Date Title
KR1019840005965A KR850000888B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005968A KR850000890B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005964A KR850000887B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005963A KR850000886B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005970A KR850000911B1 (ko) 1980-07-25 1984-09-27 삼-치환 옥사졸 유도체의 제조방법
KR1019840005969A KR850000891B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005962A KR850000885B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005966A KR850000889B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005960A KR850000873B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005972A KR850001064B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005971A KR850000892B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005961A KR850000884B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH5715/80-5 1980-07-25
CH571580 1980-07-25

Related Child Applications (12)

Application Number Title Priority Date Filing Date
KR1019840005961A Division KR850000884B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005970A Division KR850000911B1 (ko) 1980-07-25 1984-09-27 삼-치환 옥사졸 유도체의 제조방법
KR1019840005960A Division KR850000873B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005966A Division KR850000889B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005964A Division KR850000887B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005962A Division KR850000885B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005972A Division KR850001064B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005971A Division KR850000892B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005963A Division KR850000886B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005965A Division KR850000888B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005968A Division KR850000890B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005969A Division KR850000891B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR830006230A KR830006230A (ko) 1983-09-20
KR850000883B1 true KR850000883B1 (ko) 1985-06-26

Family

ID=4298165

Family Applications (13)

Application Number Title Priority Date Filing Date
KR1019810002709A Expired KR850000883B1 (ko) 1980-07-25 1981-07-25 삼-치환 이미다졸 유도체의 제조방법
KR1019840005964A Expired KR850000887B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005970A Expired KR850000911B1 (ko) 1980-07-25 1984-09-27 삼-치환 옥사졸 유도체의 제조방법
KR1019840005962A Expired KR850000885B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005968A Expired KR850000890B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005972A Expired KR850001064B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005971A Expired KR850000892B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005963A Expired KR850000886B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005961A Expired KR850000884B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005965A Expired KR850000888B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005960A Expired KR850000873B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005969A Expired KR850000891B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005966A Expired KR850000889B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법

Family Applications After (12)

Application Number Title Priority Date Filing Date
KR1019840005964A Expired KR850000887B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005970A Expired KR850000911B1 (ko) 1980-07-25 1984-09-27 삼-치환 옥사졸 유도체의 제조방법
KR1019840005962A Expired KR850000885B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005968A Expired KR850000890B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005972A Expired KR850001064B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005971A Expired KR850000892B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005963A Expired KR850000886B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005961A Expired KR850000884B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005965A Expired KR850000888B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005960A Expired KR850000873B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005969A Expired KR850000891B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005966A Expired KR850000889B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법

Country Status (23)

Country Link
US (1) US4447431A (cg-RX-API-DMAC10.html)
EP (1) EP0045081B1 (cg-RX-API-DMAC10.html)
JP (1) JPS5756466A (cg-RX-API-DMAC10.html)
KR (13) KR850000883B1 (cg-RX-API-DMAC10.html)
AR (1) AR230269A1 (cg-RX-API-DMAC10.html)
AT (1) ATE17349T1 (cg-RX-API-DMAC10.html)
AU (2) AU7340481A (cg-RX-API-DMAC10.html)
CA (1) CA1175431A (cg-RX-API-DMAC10.html)
DD (2) DD201677A5 (cg-RX-API-DMAC10.html)
DE (1) DE3173434D1 (cg-RX-API-DMAC10.html)
DK (1) DK331881A (cg-RX-API-DMAC10.html)
ES (8) ES8301472A1 (cg-RX-API-DMAC10.html)
FI (1) FI812326A7 (cg-RX-API-DMAC10.html)
GB (1) GB2080805B (cg-RX-API-DMAC10.html)
GR (1) GR75287B (cg-RX-API-DMAC10.html)
IE (1) IE52071B1 (cg-RX-API-DMAC10.html)
IL (1) IL63410A (cg-RX-API-DMAC10.html)
NO (1) NO812542L (cg-RX-API-DMAC10.html)
NZ (1) NZ197828A (cg-RX-API-DMAC10.html)
PL (8) PL237000A1 (cg-RX-API-DMAC10.html)
PT (1) PT73424B (cg-RX-API-DMAC10.html)
SU (8) SU1235454A3 (cg-RX-API-DMAC10.html)
ZA (1) ZA815078B (cg-RX-API-DMAC10.html)

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FR2633291B1 (fr) * 1988-06-27 1990-09-07 Oreal Derives d'hydroxy-4 isoxazoles, leur procede de preparation et compositions cosmetiques et pharmaceutiques les contenant
US5252322A (en) * 1989-09-22 1993-10-12 The Gillette Company Skin tanning compositions containing imidazoles
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US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
US5593992A (en) * 1993-07-16 1997-01-14 Smithkline Beecham Corporation Compounds
US5670527A (en) * 1993-07-16 1997-09-23 Smithkline Beecham Corporation Pyridyl imidazole compounds and compositions
US5593991A (en) * 1993-07-16 1997-01-14 Adams; Jerry L. Imidazole compounds, use and process of making
DE69433501T2 (de) * 1993-11-08 2004-11-04 Smithkline Beecham Corp. Oxazole zur behandlung von zytokinvermittelten erkrankungen
US5723477A (en) * 1994-11-10 1998-03-03 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
US5739143A (en) * 1995-06-07 1998-04-14 Smithkline Beecham Corporation Imidazole compounds and compositions
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TR199801361T2 (xx) * 1996-01-11 1998-10-21 Smithkline Beecham Corporation Yeni ikameli imidazol bile�imleri.
US6046208A (en) * 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
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AP9700912A0 (en) 1996-01-11 1997-01-31 Smithkline Beecham Corp Novel cycloalkyl substituted imidazoles
WO1997035856A1 (en) * 1996-03-25 1997-10-02 Smithkline Beecham Corporation Novel treatment for cns injuries
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SU1235454A3 (ru) 1986-05-30
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SU1205763A3 (ru) 1986-01-15

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