IL63410A - 4,5-diaryl(heteroaryl)imidazole alkanoic(cycloalkanoic)-acid derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

4,5-diaryl(heteroaryl)imidazole alkanoic(cycloalkanoic)-acid derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL63410A
IL63410A IL63410A IL6341081A IL63410A IL 63410 A IL63410 A IL 63410A IL 63410 A IL63410 A IL 63410A IL 6341081 A IL6341081 A IL 6341081A IL 63410 A IL63410 A IL 63410A
Authority
IL
Israel
Prior art keywords
cycloalkanoic
alkanoic
diaryl
heteroaryl
imidazole
Prior art date
Application number
IL63410A
Other languages
English (en)
Other versions
IL63410A0 (en
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Priority to IL72665A priority Critical patent/IL72665A/xx
Publication of IL63410A0 publication Critical patent/IL63410A0/xx
Priority to IL8472665A priority patent/IL72665A0/xx
Publication of IL63410A publication Critical patent/IL63410A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/26—Radicals substituted by carbon atoms having three bonds to hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
IL63410A 1980-07-25 1981-07-24 4,5-diaryl(heteroaryl)imidazole alkanoic(cycloalkanoic)-acid derivatives,their preparation and pharmaceutical compositions containing them IL63410A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL72665A IL72665A (en) 1980-07-25 1981-07-24 4,5-diaryl(heteroaryl)oxazole alkanoic(cycloalkanoic)acid derivatives,their preparation and pharmaceutical compositions containing them
IL8472665A IL72665A0 (en) 1980-07-25 1984-08-13 4,5-diaryl(heteroaryl)oxazole alkanoic(cycloalkanoic)-acid derivatives,their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH571580 1980-07-25

Publications (2)

Publication Number Publication Date
IL63410A0 IL63410A0 (en) 1981-10-30
IL63410A true IL63410A (en) 1986-04-29

Family

ID=4298165

Family Applications (1)

Application Number Title Priority Date Filing Date
IL63410A IL63410A (en) 1980-07-25 1981-07-24 4,5-diaryl(heteroaryl)imidazole alkanoic(cycloalkanoic)-acid derivatives,their preparation and pharmaceutical compositions containing them

Country Status (23)

Country Link
US (1) US4447431A (xx)
EP (1) EP0045081B1 (xx)
JP (1) JPS5756466A (xx)
KR (13) KR850000883B1 (xx)
AR (1) AR230269A1 (xx)
AT (1) ATE17349T1 (xx)
AU (2) AU7340481A (xx)
CA (1) CA1175431A (xx)
DD (2) DD201677A5 (xx)
DE (1) DE3173434D1 (xx)
DK (1) DK331881A (xx)
ES (8) ES504257A0 (xx)
FI (1) FI812326L (xx)
GB (1) GB2080805B (xx)
GR (1) GR75287B (xx)
IE (1) IE52071B1 (xx)
IL (1) IL63410A (xx)
NO (1) NO812542L (xx)
NZ (1) NZ197828A (xx)
PL (8) PL237004A1 (xx)
PT (1) PT73424B (xx)
SU (8) SU1235454A3 (xx)
ZA (1) ZA815078B (xx)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2123831B (en) * 1981-07-20 1986-01-15 Ciba Geigy Ag Trisubstituted oxazo compounds
EP0084756A1 (de) * 1982-01-22 1983-08-03 Ciba-Geigy Ag Trisubstituierte Oxazaverbindungen
FR2633291B1 (fr) * 1988-06-27 1990-09-07 Oreal Derives d'hydroxy-4 isoxazoles, leur procede de preparation et compositions cosmetiques et pharmaceutiques les contenant
US5252322A (en) * 1989-09-22 1993-10-12 The Gillette Company Skin tanning compositions containing imidazoles
NZ239161A (en) * 1990-07-31 1994-01-26 Smithkline Beecham Corp Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments,
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
IL104369A0 (en) * 1992-01-13 1993-05-13 Smithkline Beecham Corp Novel compounds and compositions
US5670527A (en) * 1993-07-16 1997-09-23 Smithkline Beecham Corporation Pyridyl imidazole compounds and compositions
US5593992A (en) * 1993-07-16 1997-01-14 Smithkline Beecham Corporation Compounds
US5593991A (en) * 1993-07-16 1997-01-14 Adams; Jerry L. Imidazole compounds, use and process of making
EP0727998B1 (en) * 1993-11-08 2004-01-21 Smithkline Beecham Corporation Oxazoles for treating cytokine mediated diseases
US5723477A (en) * 1994-11-10 1998-03-03 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
US5739143A (en) * 1995-06-07 1998-04-14 Smithkline Beecham Corporation Imidazole compounds and compositions
US6369068B1 (en) 1995-06-07 2002-04-09 Smithkline Beecham Corporation Amino substituted pyrimidine containing compounds
IL118544A (en) 1995-06-07 2001-08-08 Smithkline Beecham Corp History of imidazole, the process for their preparation and the pharmaceutical preparations containing them
ZA9610687B (en) * 1995-12-22 1997-09-29 Smithkline Beecham Corp Novel synthesis.
US6046208A (en) * 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
AU715900B2 (en) * 1996-01-11 2000-02-10 Smithkline Beecham Corporation Novel substituted imidazole compounds
AP9700912A0 (en) 1996-01-11 1997-01-31 Smithkline Beecham Corp Novel cycloalkyl substituted imidazoles
ZA97175B (en) * 1996-01-11 1997-11-04 Smithkline Beecham Corp Novel substituted imidazole compounds.
US6096739A (en) * 1996-03-25 2000-08-01 Smithkline Beecham Corporation Treatment for CNS injuries
WO1998007425A1 (en) 1996-08-21 1998-02-26 Smithkline Beecham Corporation Imidazole compounds, compositions and use
US5929076A (en) * 1997-01-10 1999-07-27 Smithkline Beecham Corporation Cycloalkyl substituted imidazoles
US5965583A (en) * 1997-04-24 1999-10-12 Ortho-Mcneil Pharmaceutical, Inc. Substituted imidazoles useful in the treatment of inflammatory disease
AU7966198A (en) 1997-06-13 1998-12-30 Smithkline Beecham Corporation Novel pyrazole and pyrazoline substituted compounds
US6610695B1 (en) 1997-06-19 2003-08-26 Smithkline Beecham Corporation Aryloxy substituted pyrimidine imidazole compounds
US6562832B1 (en) 1997-07-02 2003-05-13 Smithkline Beecham Corporation Substituted imidazole compounds
AR016294A1 (es) * 1997-07-02 2001-07-04 Smithkline Beecham Corp Compuesto de imidazol sustituido, composicion farmaceutica que la contiene, su uso en la fabricacion de un medicamento y procedimiento para supreparacion
US7301021B2 (en) * 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
US6489325B1 (en) 1998-07-01 2002-12-03 Smithkline Beecham Corporation Substituted imidazole compounds
AU8381098A (en) 1997-07-02 1999-01-25 Smithkline Beecham Corporation Novel cycloalkyl substituted imidazoles
TW517055B (en) 1997-07-02 2003-01-11 Smithkline Beecham Corp Novel substituted imidazole compounds
EP1041989A4 (en) 1997-10-08 2002-11-20 Smithkline Beecham Corp NEW SUBSTITUTED CYCLOALCENYL COMPOUNDS
AR017219A1 (es) 1997-12-19 2001-08-22 Smithkline Beecham Corp Derivados de imidazol 1,4,5 sustituidos, composiciones que los comprenden, procedimiento para la preparacion de dichos derivados, uso de los derivados parala manufactura de un medicamento
JP2002516322A (ja) * 1998-05-22 2002-06-04 スミスクライン・ビーチャム・コーポレイション 新規２−アルキル置換イミダゾール化合物
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
EP1112070B1 (en) * 1998-08-20 2004-05-12 Smithkline Beecham Corporation Novel substituted triazole compounds
DE69914357T2 (de) 1998-11-04 2004-11-11 Smithkline Beecham Corp. Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine
WO2000029399A1 (en) * 1998-11-12 2000-05-25 Boehringer Ingelheim (Canada) Ltd. Antiherpes compounds
US6239279B1 (en) 1998-12-16 2001-05-29 Smithkline Beecham Corporation Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
WO2001037835A1 (en) 1999-11-22 2001-05-31 Smithkline Beecham Plc. Novel compounds
AU1782301A (en) 1999-11-23 2001-06-04 Smithkline Beecham Corporation 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p39 kinase inhibitors
WO2001038312A1 (en) 1999-11-23 2001-05-31 Smithkline Beecham Corporation 3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/p38 KINASE INHIBITORS
ES2241675T3 (es) 1999-11-23 2005-11-01 Smithkline Beecham Corporation Compuestos de 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de cspb/p38 quinasa.
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
US7235551B2 (en) * 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
DE60103136T2 (de) * 2000-03-06 2004-10-28 Smithkline Beecham Plc, Brentford Imidazolderivate als Raf-Kinase Inhibitoren
GB0005357D0 (en) 2000-03-06 2000-04-26 Smithkline Beecham Plc Compounds
EP1333833B1 (en) * 2000-10-23 2011-08-24 GlaxoSmithKline LLC Novel trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compound for the treatment of CSBP/p38 kinase mediated diseases
GB0112348D0 (en) * 2001-05-19 2001-07-11 Smithkline Beecham Plc Compounds
WO2003022837A1 (en) * 2001-09-05 2003-03-20 Smithkline Beecham P.L.C. Heterocycle-carboxamide derivatives as raf kinase inhibitors
TW200505446A (en) * 2003-01-17 2005-02-16 Fuj Isawa Pharmaceutical Co Ltd Inhibitor of cox
CA2524889A1 (en) * 2003-05-08 2004-11-18 Astellas Pharma Inc. 1,2-diarylimidazoles useful as inhibitors of cox
CN101495475A (zh) * 2005-03-25 2009-07-29 葛兰素集团有限公司 制备吡啶并[2,3-d]嘧啶-7-酮和3,4-二氢嘧啶并[4,5-d]嘧啶-2(1H)-酮衍生物的方法
AR053346A1 (es) 2005-03-25 2007-05-02 Glaxo Group Ltd Compuesto derivado de 8h -pirido (2,3-d) pirimidin -7 ona 2,4,8- trisustituida composicion farmaceutica y uso para preparar una composicion para tratamiento y profilxis de una enfermedad mediada por la quinasa csbp/ rk/p38
WO2013049272A2 (en) 2011-09-29 2013-04-04 Theraceutix, Llc Composition and method for treatment of symptoms associated with various skin conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558645A (en) * 1968-07-08 1971-01-26 Sandoz Ag 2-(4-(4',5-diphenyl - 2 - imidazolyl)-phenoxy) lower aliphatic monocarboxylic acids
CH561716A5 (xx) * 1971-05-10 1975-05-15 Ciba Geigy Ag
GB1469532A (en) * 1973-06-28 1977-04-06 Dumex Ltd As Imimdazolyl-alkanoic acid derivatives
US4372964A (en) * 1980-10-30 1983-02-08 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-1H-imidazole-2-methanols

Also Published As

Publication number Publication date
PL236997A1 (en) 1983-01-03
NZ197828A (en) 1985-11-08
KR850002746A (ko) 1985-05-15
ES514583A0 (es) 1983-05-16
US4447431A (en) 1984-05-08
AU5655586A (en) 1986-09-11
KR850002753A (ko) 1985-05-15
KR850002748A (ko) 1985-05-15
SU1138023A3 (ru) 1985-01-30
ES8306124A1 (es) 1983-05-16
IE811680L (en) 1982-01-25
ES8306119A1 (es) 1983-05-16
IL63410A0 (en) 1981-10-30
GB2080805A (en) 1982-02-10
IE52071B1 (en) 1987-06-10
KR850001064B1 (ko) 1985-07-25
KR850000890B1 (ko) 1985-06-26
SU1145928A3 (ru) 1985-03-15
EP0045081A2 (de) 1982-02-03
KR850000889B1 (ko) 1985-06-26
PL237002A1 (en) 1983-02-28
JPS5756466A (en) 1982-04-05
KR850000911B1 (ko) 1985-06-27
KR850002754A (ko) 1985-05-15
ES8306123A1 (es) 1983-05-16
FI812326L (fi) 1982-01-26
SU1205763A3 (ru) 1986-01-15
PL237005A1 (en) 1983-02-28
DD201677A5 (de) 1983-08-03
ES514585A0 (es) 1983-07-01
KR830006230A (ko) 1983-09-20
AR230269A1 (es) 1984-03-01
SU1205764A3 (ru) 1986-01-15
PT73424B (en) 1983-06-20
CA1175431A (en) 1984-10-02
KR850002752A (ko) 1985-05-15
GB2080805B (en) 1984-03-07
EP0045081B1 (de) 1986-01-08
ES514579A0 (es) 1983-05-16
SU1235454A3 (ru) 1986-05-30
KR850000887B1 (ko) 1985-06-26
ATE17349T1 (de) 1986-01-15
KR850002745A (ko) 1985-05-15
PL237003A1 (en) 1983-02-28
KR850000888B1 (ko) 1985-06-26
SU1152520A3 (en) 1985-04-23
PL237004A1 (en) 1983-02-28
KR850000885B1 (ko) 1985-06-26
DK331881A (da) 1982-01-26
KR850002744A (ko) 1985-05-15
ES514581A0 (es) 1983-05-16
KR850000883B1 (ko) 1985-06-26
ES8301472A1 (es) 1982-12-01
KR850002756A (ko) 1985-05-15
GR75287B (xx) 1984-07-13
ES514580A0 (es) 1983-05-16
KR850002755A (ko) 1985-05-15
KR850002747A (ko) 1985-05-15
DD202554A5 (de) 1983-09-21
ES8306122A1 (es) 1983-05-16
EP0045081A3 (en) 1982-04-07
ES8307245A1 (es) 1983-07-01
ZA815078B (en) 1982-07-28
KR850000886B1 (ko) 1985-06-26
KR850002749A (ko) 1985-05-15
KR850000892B1 (ko) 1985-06-26
ES8306121A1 (es) 1983-05-16
PL135822B1 (en) 1985-12-31
ES514584A0 (es) 1983-05-16
PL232352A1 (xx) 1982-12-20
AU7340481A (en) 1982-01-28
SU1169534A3 (ru) 1985-07-23
DE3173434D1 (en) 1986-02-20
SU1227112A3 (ru) 1986-04-23
KR850002750A (ko) 1985-05-15
PT73424A (en) 1981-08-01
KR850000873B1 (ko) 1985-06-22
PL237001A1 (en) 1983-02-28
ES514582A0 (es) 1983-05-16
PL237000A1 (en) 1983-02-28
ES8306120A1 (es) 1983-05-16
KR850000884B1 (ko) 1985-06-26
ES504257A0 (es) 1982-12-01
KR850000891B1 (ko) 1985-06-26
NO812542L (no) 1982-01-26

Similar Documents

Publication Publication Date Title
IL63410A (en) 4,5-diaryl(heteroaryl)imidazole alkanoic(cycloalkanoic)-acid derivatives,their preparation and pharmaceutical compositions containing them
IL63576A0 (en) Imidazole derivatives,their manufacture and pharmaceutical compositions containing them
IL64315A (en) 1-sulfo-oxoazetidine derivatives,their production and pharmaceutical compositions containing them
IL66501A0 (en) Benzazepine-2-one derivatives,their manufacture and pharmaceutical compositions containing them
DE3267350D1 (en) 5,6,7-trinor-4,8-inter-m-phenylene pgi derivatives and pharmaceutical compositions containing them
IL57178A (en) 1,3,4-triazole derivatives,their preparation and pharmaceutical compositions containing them
IL64345A (en) Substituted phenoxypropanolamine derivatives,process for the production thereof and pharmaceutical compositions containing the same
IL65076A (en) 3,4-dihydro-5h-2,3-benzo-diazepine derivatives,their preparation and pharmaceutical compositions containing them
DE3161260D1 (en) Imidazole derivatives, process for their preparation and pharmaceutical compositions thereof
IL62039A0 (en) Imidazoline derivative,processes for the preparation thereof and pharmaceutical compositions containing the same
DE3275296D1 (en) Azabicyclo-(3,3,1)-nonylbenzamide derivatives, processes for their preparation, and pharmaceutical compositions containing them
DE3270202D1 (en) 3,5-di-tert-butylstyrene derivatives, processes for their preparations, and pharmaceutical compositions containing them
IL57040A (en) Imidazole derivatives,their preparation and pharmaceutical compositions containing them
ZA818867B (en) Pyrazoloindazole derivatives,process for preparing the same,and pharmaceutical compositions containing the same
IL62229A (en) 3-substituted-5-amino-1,2,4-triazole derivatives,their preparation and pharmaceutical compositions containing them
DE3173130D1 (en) Amino-1,2,4-triazole derivatives, processes for their preparation and pharmaceutical compositions containing them
ZA792044B (en) Substituted 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof,and pharmaceutical compositions containing them
DE3165733D1 (en) Pyrimidone derivatives, processes for their preparation and pharmaceutical compositions containing them
IL86269A0 (en) Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL62747A (en) 2-guanidinothiazole derivatives,process for the preparation thereof and pharmaceutical compositions comprising the same
IL67715A0 (en) 3,3-dialkyl-and 3,3-alkylene-indoline derivatives,their production and pharmaceutical compositions containing them
DE3268215D1 (en) Pyrrolidinone derivatives, their preparation and pharmaceutical compositions containing them
IL62605A (en) 2-isoxazol-4-yl-3-aminoethyl-1h-indole derivatives,their production and pharmaceutical compositions containing them
IL61897A0 (en) 1,2,3-triazole derivatives,their production and pharmaceutical compositions containing them
IL72665A0 (en) 4,5-diaryl(heteroaryl)oxazole alkanoic(cycloalkanoic)-acid derivatives,their preparation and pharmaceutical compositions containing them