KR850002754A - 삼-치환 옥사졸 유도체의 제조방법 - Google Patents

삼-치환 옥사졸 유도체의 제조방법

Info

Publication number
KR850002754A
KR850002754A KR1019840005970A KR840005970A KR850002754A KR 850002754 A KR850002754 A KR 850002754A KR 1019840005970 A KR1019840005970 A KR 1019840005970A KR 840005970 A KR840005970 A KR 840005970A KR 850002754 A KR850002754 A KR 850002754A
Authority
KR
South Korea
Prior art keywords
oxazole derivatives
substituted oxazole
preparing tri
tri
preparing
Prior art date
Application number
KR1019840005970A
Other languages
English (en)
Other versions
KR850000911B1 (ko
Inventor
살만 알프레드
Original Assignee
시바-가이기 에이지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 시바-가이기 에이지 filed Critical 시바-가이기 에이지
Priority to KR1019840005970A priority Critical patent/KR850000911B1/ko
Publication of KR850002754A publication Critical patent/KR850002754A/ko
Application granted granted Critical
Publication of KR850000911B1 publication Critical patent/KR850000911B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/26—Radicals substituted by carbon atoms having three bonds to hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
KR1019840005970A 1980-07-25 1984-09-27 삼-치환 옥사졸 유도체의 제조방법 KR850000911B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019840005970A KR850000911B1 (ko) 1980-07-25 1984-09-27 삼-치환 옥사졸 유도체의 제조방법

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH571580 1980-07-25
CH5715/80-5 1980-07-25
KR1019810002709A KR850000883B1 (ko) 1980-07-25 1981-07-25 삼-치환 이미다졸 유도체의 제조방법
KR1019840005970A KR850000911B1 (ko) 1980-07-25 1984-09-27 삼-치환 옥사졸 유도체의 제조방법

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1019810002709A Division KR850000883B1 (ko) 1980-07-25 1981-07-25 삼-치환 이미다졸 유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR850002754A true KR850002754A (ko) 1985-05-15
KR850000911B1 KR850000911B1 (ko) 1985-06-27

Family

ID=4298165

Family Applications (13)

Application Number Title Priority Date Filing Date
KR1019810002709A KR850000883B1 (ko) 1980-07-25 1981-07-25 삼-치환 이미다졸 유도체의 제조방법
KR1019840005970A KR850000911B1 (ko) 1980-07-25 1984-09-27 삼-치환 옥사졸 유도체의 제조방법
KR1019840005969A KR850000891B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005968A KR850000890B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005963A KR850000886B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005971A KR850000892B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005960A KR850000873B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005962A KR850000885B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005961A KR850000884B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005972A KR850001064B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005965A KR850000888B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005966A KR850000889B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005964A KR850000887B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1019810002709A KR850000883B1 (ko) 1980-07-25 1981-07-25 삼-치환 이미다졸 유도체의 제조방법

Family Applications After (11)

Application Number Title Priority Date Filing Date
KR1019840005969A KR850000891B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005968A KR850000890B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005963A KR850000886B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005971A KR850000892B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005960A KR850000873B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005962A KR850000885B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005961A KR850000884B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005972A KR850001064B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005965A KR850000888B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005966A KR850000889B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법
KR1019840005964A KR850000887B1 (ko) 1980-07-25 1984-09-27 삼-치환 이미다졸 유도체의 제조방법

Country Status (23)

Country Link
US (1) US4447431A (ko)
EP (1) EP0045081B1 (ko)
JP (1) JPS5756466A (ko)
KR (13) KR850000883B1 (ko)
AR (1) AR230269A1 (ko)
AT (1) ATE17349T1 (ko)
AU (2) AU7340481A (ko)
CA (1) CA1175431A (ko)
DD (2) DD201677A5 (ko)
DE (1) DE3173434D1 (ko)
DK (1) DK331881A (ko)
ES (8) ES8301472A1 (ko)
FI (1) FI812326L (ko)
GB (1) GB2080805B (ko)
GR (1) GR75287B (ko)
IE (1) IE52071B1 (ko)
IL (1) IL63410A (ko)
NO (1) NO812542L (ko)
NZ (1) NZ197828A (ko)
PL (8) PL237005A1 (ko)
PT (1) PT73424B (ko)
SU (8) SU1235454A3 (ko)
ZA (1) ZA815078B (ko)

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FR2633291B1 (fr) * 1988-06-27 1990-09-07 Oreal Derives d'hydroxy-4 isoxazoles, leur procede de preparation et compositions cosmetiques et pharmaceutiques les contenant
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US5723477A (en) * 1994-11-10 1998-03-03 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
US6369068B1 (en) 1995-06-07 2002-04-09 Smithkline Beecham Corporation Amino substituted pyrimidine containing compounds
US5739143A (en) * 1995-06-07 1998-04-14 Smithkline Beecham Corporation Imidazole compounds and compositions
US5658903A (en) * 1995-06-07 1997-08-19 Smithkline Beecham Corporation Imidazole compounds, compositions and use
ZA9610687B (en) * 1995-12-22 1997-09-29 Smithkline Beecham Corp Novel synthesis.
JP2000503302A (ja) * 1996-01-11 2000-03-21 スミスクライン・ビーチャム・コーポレイション 新規置換イミダゾール化合物
US6046208A (en) * 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
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EP0956018A4 (en) 1996-08-21 2000-01-12 Smithkline Beecham Corp IMIDAZOLE COMPOUNDS, COMPOSITIONS CONTAINING THEM AND THEIR USE
US5929076A (en) * 1997-01-10 1999-07-27 Smithkline Beecham Corporation Cycloalkyl substituted imidazoles
AU7138298A (en) * 1997-04-24 1998-11-13 Ortho-Mcneil Corporation, Inc. Substituted imidazoles useful in the treatment of inflammatory diseases
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US6610695B1 (en) 1997-06-19 2003-08-26 Smithkline Beecham Corporation Aryloxy substituted pyrimidine imidazole compounds
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TW517055B (en) 1997-07-02 2003-01-11 Smithkline Beecham Corp Novel substituted imidazole compounds
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AR016294A1 (es) * 1997-07-02 2001-07-04 Smithkline Beecham Corp Compuesto de imidazol sustituido, composicion farmaceutica que la contiene, su uso en la fabricacion de un medicamento y procedimiento para supreparacion
EP1041989A4 (en) 1997-10-08 2002-11-20 Smithkline Beecham Corp NEW SUBSTITUTED CYCLOALCENYL COMPOUNDS
WO1999032121A1 (en) 1997-12-19 1999-07-01 Smithkline Beecham Corporation Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses
KR20010025087A (ko) * 1998-05-22 2001-03-26 스튜어트 알. 수터 신규한 2-알킬 치환된 이미다졸 화합물
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
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US6239279B1 (en) 1998-12-16 2001-05-29 Smithkline Beecham Corporation Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
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US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
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US7235551B2 (en) * 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
WO2001066539A1 (en) * 2000-03-06 2001-09-13 Smithkline Beecham P.L.C. Imidazol derivatives as raf kinase inhibitors
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CH561718A5 (ko) * 1971-05-10 1975-05-15 Ciba Geigy Ag
GB1469532A (en) * 1973-06-28 1977-04-06 Dumex Ltd As Imimdazolyl-alkanoic acid derivatives
US4372964A (en) * 1980-10-30 1983-02-08 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-1H-imidazole-2-methanols

Also Published As

Publication number Publication date
KR850000891B1 (ko) 1985-06-26
KR850002752A (ko) 1985-05-15
KR850000889B1 (ko) 1985-06-26
ATE17349T1 (de) 1986-01-15
PL237005A1 (en) 1983-02-28
KR850000890B1 (ko) 1985-06-26
IL63410A0 (en) 1981-10-30
GR75287B (ko) 1984-07-13
DD201677A5 (de) 1983-08-03
PL236997A1 (en) 1983-01-03
EP0045081A2 (de) 1982-02-03
ZA815078B (en) 1982-07-28
US4447431A (en) 1984-05-08
SU1235454A3 (ru) 1986-05-30
KR850002744A (ko) 1985-05-15
ES514585A0 (es) 1983-07-01
NO812542L (no) 1982-01-26
AU7340481A (en) 1982-01-28
SU1205763A3 (ru) 1986-01-15
KR850000885B1 (ko) 1985-06-26
SU1205764A3 (ru) 1986-01-15
CA1175431A (en) 1984-10-02
KR850000887B1 (ko) 1985-06-26
KR850000892B1 (ko) 1985-06-26
KR850002747A (ko) 1985-05-15
ES514581A0 (es) 1983-05-16
GB2080805A (en) 1982-02-10
ES504257A0 (es) 1982-12-01
ES8306124A1 (es) 1983-05-16
ES8306123A1 (es) 1983-05-16
AR230269A1 (es) 1984-03-01
KR850000884B1 (ko) 1985-06-26
ES514583A0 (es) 1983-05-16
ES514579A0 (es) 1983-05-16
KR850002756A (ko) 1985-05-15
ES8306121A1 (es) 1983-05-16
PL135822B1 (en) 1985-12-31
SU1145928A3 (ru) 1985-03-15
KR850000886B1 (ko) 1985-06-26
PL237003A1 (en) 1983-02-28
ES8306119A1 (es) 1983-05-16
PL232352A1 (ko) 1982-12-20
ES8306122A1 (es) 1983-05-16
PT73424B (en) 1983-06-20
PL237004A1 (en) 1983-02-28
ES514582A0 (es) 1983-05-16
SU1169534A3 (ru) 1985-07-23
PL237000A1 (en) 1983-02-28
KR850002749A (ko) 1985-05-15
SU1227112A3 (ru) 1986-04-23
PL237002A1 (en) 1983-02-28
AU5655586A (en) 1986-09-11
DE3173434D1 (en) 1986-02-20
EP0045081B1 (de) 1986-01-08
KR850002746A (ko) 1985-05-15
JPS5756466A (en) 1982-04-05
PL237001A1 (en) 1983-02-28
ES514584A0 (es) 1983-05-16
NZ197828A (en) 1985-11-08
KR850002753A (ko) 1985-05-15
KR850000883B1 (ko) 1985-06-26
KR850002750A (ko) 1985-05-15
KR850000888B1 (ko) 1985-06-26
GB2080805B (en) 1984-03-07
DD202554A5 (de) 1983-09-21
ES514580A0 (es) 1983-05-16
KR850002745A (ko) 1985-05-15
IE52071B1 (en) 1987-06-10
PT73424A (en) 1981-08-01
FI812326L (fi) 1982-01-26
SU1138023A3 (ru) 1985-01-30
ES8306120A1 (es) 1983-05-16
ES8301472A1 (es) 1982-12-01
ES8307245A1 (es) 1983-07-01
IL63410A (en) 1986-04-29
KR850000911B1 (ko) 1985-06-27
SU1152520A3 (en) 1985-04-23
KR830006230A (ko) 1983-09-20
KR850000873B1 (ko) 1985-06-22
DK331881A (da) 1982-01-26
KR850002748A (ko) 1985-05-15
EP0045081A3 (en) 1982-04-07
IE811680L (en) 1982-01-25
KR850001064B1 (ko) 1985-07-25
KR850002755A (ko) 1985-05-15

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