GB2123831B - Trisubstituted oxazo compounds - Google Patents

Trisubstituted oxazo compounds

Info

Publication number
GB2123831B
GB2123831B GB08324693A GB8324693A GB2123831B GB 2123831 B GB2123831 B GB 2123831B GB 08324693 A GB08324693 A GB 08324693A GB 8324693 A GB8324693 A GB 8324693A GB 2123831 B GB2123831 B GB 2123831B
Authority
GB
United Kingdom
Prior art keywords
oxazo
trisubstituted
compounds
trisubstituted oxazo
oxazo compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08324693A
Other versions
GB8324693D0 (en
GB2123831A (en
Inventor
Alfred Sallmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of GB8324693D0 publication Critical patent/GB8324693D0/en
Publication of GB2123831A publication Critical patent/GB2123831A/en
Application granted granted Critical
Publication of GB2123831B publication Critical patent/GB2123831B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
GB08324693A 1981-07-20 1982-01-22 Trisubstituted oxazo compounds Expired GB2123831B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28523181A 1981-07-20 1981-07-20
PCT/CH1982/000009 WO1983002613A1 (en) 1981-07-20 1982-01-22 Trisubstituted oxazo compounds

Publications (3)

Publication Number Publication Date
GB8324693D0 GB8324693D0 (en) 1983-10-19
GB2123831A GB2123831A (en) 1984-02-08
GB2123831B true GB2123831B (en) 1986-01-15

Family

ID=23093352

Family Applications (2)

Application Number Title Priority Date Filing Date
GB08324693A Expired GB2123831B (en) 1981-07-20 1982-01-22 Trisubstituted oxazo compounds
GB08324692A Withdrawn GB2123830A (en) 1981-07-20 1982-01-25 Trisubstituted diazo compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB08324692A Withdrawn GB2123830A (en) 1981-07-20 1982-01-25 Trisubstituted diazo compounds

Country Status (2)

Country Link
GB (2) GB2123831B (en)
WO (2) WO1983002613A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69433501T2 (en) 1993-11-08 2004-11-04 Smithkline Beecham Corp. OXAZOLES FOR TREATING CYTOKINE MEDIATED DISEASES
JP2636819B2 (en) 1994-12-20 1997-07-30 日本たばこ産業株式会社 Oxazole-based heterocyclic aromatic compounds
PL199893B1 (en) 1997-06-12 2008-11-28 Rhone Poulenc Rorer Ltd Imidazolyl-cyclic acetals
US6335340B1 (en) 1997-12-19 2002-01-01 Smithkline Beecham Corporation compounds of heteroaryl substituted imidazole, their pharmaceutical compositons and uses
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
JP2003528043A (en) 1999-11-23 2003-09-24 スミスクライン・ビーチャム・コーポレイション 3,4-Dihydro- (1H) quinazolin-2-one compounds as CSBP / p38 kinase inhibitors
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
ATE281439T1 (en) 1999-11-23 2004-11-15 Smithkline Beecham Corp 3,4-DIHYDRO-(1H)CHINAZOLINE-2-ONE COMPOUNDS AS CSBP/P38 KINASE INHIBITORS
US7053098B1 (en) 1999-11-23 2006-05-30 Smithkline Beecham Corporation 3,4-Dihydro-(1H) quinazolin-2-one compounds as CSBP/P38 kinase inhibitors
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
CA2426654C (en) 2000-10-23 2010-12-21 Smithkline Beecham Corporation 2,4,8-trisubstituted-8h-pyrido[2,3-d}pyrimidin-7-one compounds
CN1646131A (en) 2002-04-19 2005-07-27 史密丝克莱恩比彻姆公司 Novel compounds
MX2007012951A (en) 2005-03-25 2008-01-11 Glaxo Group Ltd Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one derivatives.
JP2008535822A (en) 2005-03-25 2008-09-04 グラクソ グループ リミテッド New compounds
PE20061351A1 (en) 2005-03-25 2007-01-14 Glaxo Group Ltd 8H-PYRID [2,3-d] PYRIMIDIN-7-ONA 2,4,8-TRISUSTITUTED COMPOUNDS AS CSBP / RK / p38 KINASE INHIBITORS
PE20100741A1 (en) 2005-03-25 2010-11-25 Glaxo Group Ltd COMPOUNDS DERIVED FROM 3,4-DIHYDROPYRIMIDE [4,5-d] PYRIMIDIN-2 (1H) -ONE AS KINASE INHIBITORS p38

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3578671A (en) * 1967-11-06 1971-05-11 Wyeth John & Brother Ltd Oxazoles
CH561716A5 (en) * 1971-05-10 1975-05-15 Ciba Geigy Ag
GB1542315A (en) * 1976-08-13 1979-03-14 Wyeth John & Brother Ltd Process for preparing oxazoles
DK513580A (en) * 1980-01-07 1981-07-08 Du Pont METHOD FOR PREPARING 4,5-DIARYL-ALFA (POLYHALOGENALKYL) -1H-IMIDAZOL-2-METHANOLS
GR75287B (en) * 1980-07-25 1984-07-13 Ciba Geigy Ag

Also Published As

Publication number Publication date
GB2123830A (en) 1984-02-08
GB8324693D0 (en) 1983-10-19
WO1983002613A1 (en) 1983-08-04
GB2123831A (en) 1984-02-08
GB8324692D0 (en) 1983-10-19
WO1983002611A1 (en) 1983-08-04

Similar Documents

Publication Publication Date Title
GB2094299B (en) Oxazolidines
GB2111488B (en) 1-oxa- and 1-thia-spirocyclic compounds
DE3269405D1 (en) Ammonium compounds
CS564581A2 (en) Zpusob vyroby racemickych nebo opticky aktivnich 5-substituovanych oxazolidin-2,4-dionu
JPS57150694A (en) Compound
GB2123831B (en) Trisubstituted oxazo compounds
PT75620A (en) Novel compounds
ZA824579B (en) Active compounds
DE3268037D1 (en) Epoxy compounds
GB2101580B (en) Allophanoylpiperazine compounds
GB2097003B (en) Phosporus-containing compounds
PT74377A (en) Novel compounds
GB2098604B (en) 3-substituted-2-azetidinone compounds
JPS57163384A (en) Benzopyranoimidazole compounds
GB2098593B (en) Isoxazoles
GB2106519B (en) Aminooxazolyl compounds
GB2111999B (en) Trihydroxyvitamin d3 compounds
GB2104889B (en) Phenethylpiperidine compounds
DE3268818D1 (en) Acaricide compounds
DE3260771D1 (en) Pyridothienopyridazine compounds
GB2096998B (en) Dioxaazabicyclic compounds
ZA825525B (en) Novel compounds
ZA828688B (en) Novel compounds
AU8002282A (en) Trisubstituted oxazo compounds
ZA829329B (en) Novel compounds

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee