GB2123830A - Trisubstituted diazo compounds - Google Patents

Trisubstituted diazo compounds

Info

Publication number
GB2123830A
GB2123830A GB08324692A GB8324692A GB2123830A GB 2123830 A GB2123830 A GB 2123830A GB 08324692 A GB08324692 A GB 08324692A GB 8324692 A GB8324692 A GB 8324692A GB 2123830 A GB2123830 A GB 2123830A
Authority
GB
United Kingdom
Prior art keywords
diazo compounds
trisubstituted
compounds
formyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB08324692A
Other versions
GB8324692D0 (en
Inventor
Alfred Sallmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of GB8324692D0 publication Critical patent/GB8324692D0/en
Publication of GB2123830A publication Critical patent/GB2123830A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

New substituted diazo compounds, particularly compound having the general formula I <IMAGE> wherein R1 and R2 are, independently from each other, carbocyclic aryl and/or heteroaryl, A is a residual bivalent hydrocarbon and R3 is formyl or acetalised formyl, the isomers and salts thereof, particularly those which are pharmaceutically usable. The compounds having the formula (I) may be used as epidermic antiphlogistic and are produced according to known methods.
GB08324692A 1981-07-20 1982-01-25 Trisubstituted diazo compounds Withdrawn GB2123830A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28523181A 1981-07-20 1981-07-20
PCT/CH1982/000011 WO1983002611A1 (en) 1981-07-20 1982-01-25 Trisubstituted diazo compounds

Publications (2)

Publication Number Publication Date
GB8324692D0 GB8324692D0 (en) 1983-10-19
GB2123830A true GB2123830A (en) 1984-02-08

Family

ID=23093352

Family Applications (2)

Application Number Title Priority Date Filing Date
GB08324693A Expired GB2123831B (en) 1981-07-20 1982-01-22 Trisubstituted oxazo compounds
GB08324692A Withdrawn GB2123830A (en) 1981-07-20 1982-01-25 Trisubstituted diazo compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB08324693A Expired GB2123831B (en) 1981-07-20 1982-01-22 Trisubstituted oxazo compounds

Country Status (2)

Country Link
GB (2) GB2123831B (en)
WO (2) WO1983002613A1 (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6362209B1 (en) 1994-12-20 2002-03-26 Japan Tobacco Inc. Heterocyclic aromatic oxazole compounds and use thereof
US6730683B2 (en) 1997-12-19 2004-05-04 Smithkline Beecham Corporation Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
US6982270B1 (en) 1999-11-23 2006-01-03 Smithkline Beecham Corporation 3,4-dihydro-(1H)quinazolin-2-one compounds as CSBP/p38 kinase inhibitors
US7053098B1 (en) 1999-11-23 2006-05-30 Smithkline Beecham Corporation 3,4-Dihydro-(1H) quinazolin-2-one compounds as CSBP/P38 kinase inhibitors
US7053099B1 (en) 1999-11-23 2006-05-30 Smithkline Beecham Corporation 3,4-dihydro-(1H)quinazolin-2-one compounds as CSBP/p38 kinase inhibitors
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US7423042B2 (en) 2005-03-25 2008-09-09 Glaxo Group Limited Compounds
US7479558B2 (en) 2005-03-25 2009-01-20 Glaxo Group Limited Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one derivatives
US7629350B2 (en) 2002-04-19 2009-12-08 Smithkline Beecham Corporation Compounds
US7674789B2 (en) 2005-03-25 2010-03-09 Glaxo Group Limited Compounds
US7678801B2 (en) 2005-03-25 2010-03-16 Glaxo Group Limited Compounds
US7759486B2 (en) 2000-10-23 2010-07-20 Glaxosmithkline Llc 2,4,5-Trisubstituted pyrimidine compounds

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0727998B1 (en) * 1993-11-08 2004-01-21 Smithkline Beecham Corporation Oxazoles for treating cytokine mediated diseases
CZ9904452A3 (en) 1997-06-12 2002-02-13 Rhone-Poulenc Rorer Limited Imidazolyl cyclic acetals, process of their preparation, their use and pharmaceutical preparation in which the acetals are comprised

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3578671A (en) * 1967-11-06 1971-05-11 Wyeth John & Brother Ltd Oxazoles
CH561716A5 (en) * 1971-05-10 1975-05-15 Ciba Geigy Ag
GB1542315A (en) * 1976-08-13 1979-03-14 Wyeth John & Brother Ltd Process for preparing oxazoles
DK513580A (en) * 1980-01-07 1981-07-08 Du Pont METHOD FOR PREPARING 4,5-DIARYL-ALFA (POLYHALOGENALKYL) -1H-IMIDAZOL-2-METHANOLS
DD201677A5 (en) * 1980-07-25 1983-08-03 Ciba Geigy PROCESS FOR THE PREPARATION OF TRISUBSTITUTED IMIDAZOLE DERIVATIVES

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6362209B1 (en) 1994-12-20 2002-03-26 Japan Tobacco Inc. Heterocyclic aromatic oxazole compounds and use thereof
US6730683B2 (en) 1997-12-19 2004-05-04 Smithkline Beecham Corporation Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
US7053099B1 (en) 1999-11-23 2006-05-30 Smithkline Beecham Corporation 3,4-dihydro-(1H)quinazolin-2-one compounds as CSBP/p38 kinase inhibitors
US6982270B1 (en) 1999-11-23 2006-01-03 Smithkline Beecham Corporation 3,4-dihydro-(1H)quinazolin-2-one compounds as CSBP/p38 kinase inhibitors
US7053098B1 (en) 1999-11-23 2006-05-30 Smithkline Beecham Corporation 3,4-Dihydro-(1H) quinazolin-2-one compounds as CSBP/P38 kinase inhibitors
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
US7700768B2 (en) 2000-03-02 2010-04-20 Glaxosmithkline Llc Compounds
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US7629462B2 (en) 2000-03-02 2009-12-08 Smithkline Beecham Corporation Tetrasubstituted pyrimidine compounds as chemical intermediates
US8058282B2 (en) 2000-10-23 2011-11-15 Glaxosmithkline Llc 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy
US7759486B2 (en) 2000-10-23 2010-07-20 Glaxosmithkline Llc 2,4,5-Trisubstituted pyrimidine compounds
US7629350B2 (en) 2002-04-19 2009-12-08 Smithkline Beecham Corporation Compounds
US7423042B2 (en) 2005-03-25 2008-09-09 Glaxo Group Limited Compounds
US7678801B2 (en) 2005-03-25 2010-03-16 Glaxo Group Limited Compounds
US7674789B2 (en) 2005-03-25 2010-03-09 Glaxo Group Limited Compounds
US7479558B2 (en) 2005-03-25 2009-01-20 Glaxo Group Limited Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one derivatives
US8207176B2 (en) 2005-03-25 2012-06-26 Glaxo Group Limited Compounds
US8354416B2 (en) 2005-03-25 2013-01-15 Glaxo Group Limited 7,8-dihydropyrido[2,3-d]pyrimidin-4-yl substituted compounds as inhibitors of p38 kinase

Also Published As

Publication number Publication date
GB2123831B (en) 1986-01-15
GB2123831A (en) 1984-02-08
GB8324693D0 (en) 1983-10-19
WO1983002613A1 (en) 1983-08-04
WO1983002611A1 (en) 1983-08-04
GB8324692D0 (en) 1983-10-19

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)