KR20190141666A - 항-axl 항체-약물 접합체로의 병용 요법 - Google Patents

항-axl 항체-약물 접합체로의 병용 요법 Download PDF

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KR20190141666A
KR20190141666A KR1020197030286A KR20197030286A KR20190141666A KR 20190141666 A KR20190141666 A KR 20190141666A KR 1020197030286 A KR1020197030286 A KR 1020197030286A KR 20197030286 A KR20197030286 A KR 20197030286A KR 20190141666 A KR20190141666 A KR 20190141666A
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cancer
composition
agent
kit
axl
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Inventor
파트리치우스 헨드리쿠스 코르넬리스 반 버켈
젠스 뷔스너
존 하아틀리
프란체스카 자마치
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에이디씨 테라퓨틱스 에스에이
메드임뮨 리미티드
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Priority claimed from GBGB1706228.2A external-priority patent/GB201706228D0/en
Priority claimed from GBGB1706230.8A external-priority patent/GB201706230D0/en
Priority claimed from GBGB1706229.0A external-priority patent/GB201706229D0/en
Priority claimed from GBGB1706231.6A external-priority patent/GB201706231D0/en
Priority claimed from GBGB1706223.3A external-priority patent/GB201706223D0/en
Priority claimed from GBGB1706226.6A external-priority patent/GB201706226D0/en
Priority claimed from GBGB1706225.8A external-priority patent/GB201706225D0/en
Priority claimed from GBGB1706227.4A external-priority patent/GB201706227D0/en
Priority claimed from GBGB1706224.1A external-priority patent/GB201706224D0/en
Application filed by 에이디씨 테라퓨틱스 에스에이, 메드임뮨 리미티드 filed Critical 에이디씨 테라퓨틱스 에스에이
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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