KR101343676B1 - 메이탠시노이드 화합물 - Google Patents
메이탠시노이드 화합물 Download PDFInfo
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- KR101343676B1 KR101343676B1 KR1020127004142A KR20127004142A KR101343676B1 KR 101343676 B1 KR101343676 B1 KR 101343676B1 KR 1020127004142 A KR1020127004142 A KR 1020127004142A KR 20127004142 A KR20127004142 A KR 20127004142A KR 101343676 B1 KR101343676 B1 KR 101343676B1
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- conjugate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50990103P | 2003-10-10 | 2003-10-10 | |
US60/509,901 | 2003-10-10 | ||
US10/960,602 | 2004-10-08 | ||
US10/960,602 US8088387B2 (en) | 2003-10-10 | 2004-10-08 | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
PCT/US2004/030917 WO2005037992A2 (en) | 2003-10-10 | 2004-10-12 | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020067006874A Division KR20060130552A (ko) | 2003-10-10 | 2004-10-12 | 비절단성 링커를 통해 연결된 세포결합물질 메이탠시노이드접합체를 사용한 특정세포집단 표적화 방법, 상기 접합체및 상기 접합체 생산방법 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020137020144A Division KR101476082B1 (ko) | 2003-10-10 | 2004-10-12 | 메이탠시노이드 화합물 |
Publications (2)
Publication Number | Publication Date |
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KR20120034800A KR20120034800A (ko) | 2012-04-12 |
KR101343676B1 true KR101343676B1 (ko) | 2013-12-20 |
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Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020137020144A KR101476082B1 (ko) | 2003-10-10 | 2004-10-12 | 메이탠시노이드 화합물 |
KR1020067006874A KR20060130552A (ko) | 2003-10-10 | 2004-10-12 | 비절단성 링커를 통해 연결된 세포결합물질 메이탠시노이드접합체를 사용한 특정세포집단 표적화 방법, 상기 접합체및 상기 접합체 생산방법 |
KR1020137023561A KR101573124B1 (ko) | 2003-10-10 | 2004-10-12 | 비절단성 링커를 통해 연결된 세포결합물질 메이탠시노이드 접합체, 및 상기 접합체 생산방법 |
KR1020127004142A KR101343676B1 (ko) | 2003-10-10 | 2004-10-12 | 메이탠시노이드 화합물 |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
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KR1020137020144A KR101476082B1 (ko) | 2003-10-10 | 2004-10-12 | 메이탠시노이드 화합물 |
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WO2005037992A2 (en) | 2003-10-10 | 2005-04-28 | Immunogen, Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
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