KR101343676B1 - 메이탠시노이드 화합물 - Google Patents

메이탠시노이드 화합물 Download PDF

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KR101343676B1
KR101343676B1 KR1020127004142A KR20127004142A KR101343676B1 KR 101343676 B1 KR101343676 B1 KR 101343676B1 KR 1020127004142 A KR1020127004142 A KR 1020127004142A KR 20127004142 A KR20127004142 A KR 20127004142A KR 101343676 B1 KR101343676 B1 KR 101343676B1
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conjugate
cell
antibody
smcc
linker
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KR1020127004142A
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Korean (ko)
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KR20120034800A (ko
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리타 스티브스
라비 체리
에이. 블라터 윌터
씨. 위드디슨 웨인
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이뮤노젠 아이엔씨
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    • C07ORGANIC CHEMISTRY
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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KR1020127004142A 2003-10-10 2004-10-12 메이탠시노이드 화합물 KR101343676B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US50990103P 2003-10-10 2003-10-10
US60/509,901 2003-10-10
US10/960,602 2004-10-08
US10/960,602 US8088387B2 (en) 2003-10-10 2004-10-08 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
PCT/US2004/030917 WO2005037992A2 (en) 2003-10-10 2004-10-12 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates

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