JP6775422B2 - Ｃｄ３８及びｃｄ３に結合する二重特異性抗体 - Google Patents

Ｃｄ３８及びｃｄ３に結合する二重特異性抗体 Download PDF

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JP6775422B2
JP6775422B2 JP2016559176A JP2016559176A JP6775422B2 JP 6775422 B2 JP6775422 B2 JP 6775422B2 JP 2016559176 A JP2016559176 A JP 2016559176A JP 2016559176 A JP2016559176 A JP 2016559176A JP 6775422 B2 JP6775422 B2 JP 6775422B2
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JP2017511130A (ja
JP2017511130A5 (Direct
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マシュー ジェイ． バーネット，
マシュー ジェイ． バーネット，
スン ワイ． チュー，
スン ワイ． チュー，
グレゴリー ムーア，
グレゴリー ムーア，
ジョン デジャルレ，
ジョン デジャルレ，
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Xencor Inc
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Xencor Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2016559176A 2014-03-28 2015-03-30 Ｃｄ３８及びｃｄ３に結合する二重特異性抗体 Active JP6775422B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461972172P 2014-03-28 2014-03-28
US61/972,172 2014-03-28
US201462025931P 2014-07-17 2014-07-17
US201462025974P 2014-07-17 2014-07-17
US62/025,931 2014-07-17
US62/025,974 2014-07-17
PCT/US2015/023411 WO2015149077A1 (en) 2014-03-28 2015-03-30 Bispecific antibodies that bind to cd38 and cd3

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020169262A Division JP7273016B2 (ja) 2014-03-28 2020-10-06 Ｃｄ３８及びｃｄ３に結合する二重特異性抗体

Publications (3)

Publication Number Publication Date
JP2017511130A JP2017511130A (ja) 2017-04-20
JP2017511130A5 JP2017511130A5 (Direct) 2018-05-24
JP6775422B2 true JP6775422B2 (ja) 2020-10-28

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JP2016559176A Active JP6775422B2 (ja) 2014-03-28 2015-03-30 Ｃｄ３８及びｃｄ３に結合する二重特異性抗体
JP2020169262A Active JP7273016B2 (ja) 2014-03-28 2020-10-06 Ｃｄ３８及びｃｄ３に結合する二重特異性抗体
JP2023012047A Pending JP2023052766A (ja) 2014-03-28 2023-01-30 Ｃｄ３８及びｃｄ３に結合する二重特異性抗体

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JP2020169262A Active JP7273016B2 (ja) 2014-03-28 2020-10-06 Ｃｄ３８及びｃｄ３に結合する二重特異性抗体
JP2023012047A Pending JP2023052766A (ja) 2014-03-28 2023-01-30 Ｃｄ３８及びｃｄ３に結合する二重特異性抗体

Country Status (32)

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US (3) US9822186B2 (Direct)
EP (3) EP3699195A3 (Direct)
JP (3) JP6775422B2 (Direct)
KR (3) KR102327996B1 (Direct)
CN (2) CN106471009B (Direct)
AP (1) AP2016009475A0 (Direct)
AU (2) AU2015237184B2 (Direct)
BR (1) BR112016022385A2 (Direct)
CA (1) CA2943621A1 (Direct)
CL (1) CL2016002460A1 (Direct)
CR (1) CR20160506A (Direct)
CY (1) CY1123236T1 (Direct)
DK (1) DK3122781T3 (Direct)
EA (1) EA201691925A1 (Direct)
ES (1) ES2775431T3 (Direct)
HR (1) HRP20200164T1 (Direct)
HU (1) HUE048734T2 (Direct)
IL (1) IL248007B (Direct)
LT (1) LT3122781T (Direct)
ME (1) ME03666B (Direct)
MX (2) MX385936B (Direct)
PE (1) PE20161431A1 (Direct)
PH (1) PH12016501908A1 (Direct)
PL (1) PL3122781T3 (Direct)
PT (1) PT3122781T (Direct)
RS (1) RS59907B1 (Direct)
SG (2) SG11201607983YA (Direct)
SI (1) SI3122781T1 (Direct)
SM (1) SMT202000141T1 (Direct)
TN (1) TN2017000532A1 (Direct)
UA (1) UA119167C2 (Direct)
WO (1) WO2015149077A1 (Direct)

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