MX2011013455A - Diseño de moleculas de fc de anticuerpo estables y libres de agregacion a traves del diseño de la interfase del dominio de ch3. - Google Patents
Diseño de moleculas de fc de anticuerpo estables y libres de agregacion a traves del diseño de la interfase del dominio de ch3.Info
- Publication number
- MX2011013455A MX2011013455A MX2011013455A MX2011013455A MX2011013455A MX 2011013455 A MX2011013455 A MX 2011013455A MX 2011013455 A MX2011013455 A MX 2011013455A MX 2011013455 A MX2011013455 A MX 2011013455A MX 2011013455 A MX2011013455 A MX 2011013455A
- Authority
- MX
- Mexico
- Prior art keywords
- molecules
- stable
- design
- free antibody
- domain interface
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a métodos para incrementar la estabilidad y reducir la agregación en composiciones que comprenden moléculas de Fc de anticuerpo y a una composición que comprende estas moléculas. Ciertas sustituciones de aminoácidos en el dominio de CH3 dan por resultado una estabilidad incrementada y una agregación reducida de las composiciones que contienen polipéptidos que comprenden un dominio de CH3, por ejemplo, un anticuerpo o proteína de fusión de Fc.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22383109P | 2009-07-08 | 2009-07-08 | |
PCT/US2010/040471 WO2011005621A1 (en) | 2009-07-08 | 2010-06-29 | Design of stable and aggregation free antibody fc molecules through ch3 domain interface engineering |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2011013455A true MX2011013455A (es) | 2012-02-13 |
Family
ID=43429484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011013455A MX2011013455A (es) | 2009-07-08 | 2010-06-29 | Diseño de moleculas de fc de anticuerpo estables y libres de agregacion a traves del diseño de la interfase del dominio de ch3. |
Country Status (7)
Country | Link |
---|---|
US (1) | US9308258B2 (es) |
EP (1) | EP2451840B1 (es) |
JP (1) | JP2012532608A (es) |
AU (1) | AU2010270844A1 (es) |
CA (1) | CA2766166A1 (es) |
MX (1) | MX2011013455A (es) |
WO (1) | WO2011005621A1 (es) |
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WO2011047383A1 (en) | 2009-10-16 | 2011-04-21 | Oncomed Pharmaceuticals, Inc. | Therapeutic combination and methods of treatment with a dll4 antagonist and an anti-hypertensive agent |
CA2806252C (en) | 2010-07-29 | 2019-05-14 | Xencor, Inc. | Antibodies with modified isoelectric points |
US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
AU2011325833C1 (en) | 2010-11-05 | 2017-07-13 | Zymeworks Bc Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
ES2707580T3 (es) | 2011-09-23 | 2019-04-04 | Oncomed Pharm Inc | Agentes de unión a VEGF/DLL4 y usos de los mismos |
US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
CA2854233C (en) | 2011-11-04 | 2020-05-12 | Zymeworks Inc. | Stable heterodimeric antibody design with mutations in the fc domain |
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WO2014084508A1 (ko) * | 2012-11-27 | 2014-06-05 | (주)알테오젠 | 단백질과 Fc 도메인을 융합한 융합 단백질의 안정화용 조성물 |
US9914785B2 (en) | 2012-11-28 | 2018-03-13 | Zymeworks Inc. | Engineered immunoglobulin heavy chain-light chain pairs and uses thereof |
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US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
EP3620473A1 (en) | 2013-01-14 | 2020-03-11 | Xencor, Inc. | Novel heterodimeric proteins |
US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
EP2945969A1 (en) | 2013-01-15 | 2015-11-25 | Xencor, Inc. | Rapid clearance of antigen complexes using novel antibodies |
US9161966B2 (en) | 2013-01-30 | 2015-10-20 | Ngm Biopharmaceuticals, Inc. | GDF15 mutein polypeptides |
KR101993714B1 (ko) | 2013-01-30 | 2019-06-28 | 엔지엠 바이오파마슈티컬스, 아이엔씨. | 대사 장애를 치료하는데 이용하기 위한 조성물과 방법 |
US10519242B2 (en) | 2013-03-15 | 2019-12-31 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
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US10106624B2 (en) | 2013-03-15 | 2018-10-23 | Xencor, Inc. | Heterodimeric proteins |
AU2014232416B2 (en) | 2013-03-15 | 2017-09-28 | Xencor, Inc. | Modulation of T Cells with Bispecific Antibodies and FC Fusions |
AU2014357292B2 (en) | 2013-11-27 | 2020-06-25 | Zymeworks Bc Inc. | Bispecific antigen-binding constructs targeting HER2 |
CN111410691B (zh) | 2014-03-28 | 2024-02-13 | Xencor公司 | 结合至cd38和cd3的双特异性抗体 |
AP2016009663A0 (en) | 2014-07-30 | 2016-12-31 | Ngm Biopharmaceuticals Inc | Compositions and methods of use for treating metabolic disorders |
US9821059B2 (en) | 2014-10-17 | 2017-11-21 | Alteogen Inc. | Composition for stabilizing protein and pharmaceutical formulation comprising the same |
TN2017000113A1 (en) | 2014-10-31 | 2018-07-04 | Ngm Biopharmaceuticals Inc | Compositions and methods of use for treating metabolic disorders |
ES2808153T3 (es) | 2014-10-31 | 2021-02-25 | Mereo Biopharma 5 Inc | Terapia de combinación para tratamiento de enfermedad |
LT3223845T (lt) | 2014-11-26 | 2021-08-25 | Xencor, Inc. | Heterodimeriniai antikūnai, kurie suriša cd3 ir cd20 |
US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
WO2016086196A2 (en) | 2014-11-26 | 2016-06-02 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cd38 |
EP3237449A2 (en) | 2014-12-22 | 2017-11-01 | Xencor, Inc. | Trispecific antibodies |
WO2016141387A1 (en) | 2015-03-05 | 2016-09-09 | Xencor, Inc. | Modulation of t cells with bispecific antibodies and fc fusions |
IL244857B (en) * | 2015-04-02 | 2020-11-30 | The Israel Inst Of Biological Resesrch Iibr | A fusion protein of acetylcholinesterase and the fc region |
AU2016312259B2 (en) | 2015-08-26 | 2018-12-06 | Bison Therapeutics Inc. | Multispecific antibody platform and related methods |
WO2017053705A1 (en) | 2015-09-23 | 2017-03-30 | Oncomed Pharmaceuticals, Inc. | Methods and compositions for treatment of cancer |
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KR20200014379A (ko) | 2017-06-05 | 2020-02-10 | 얀센 바이오테크 인코포레이티드 | 비대칭 ch2-ch3 영역 돌연변이를 갖는 조작된 다중특이성 항체 및 다른 다량체 단백질 |
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CN112437777A (zh) | 2018-04-18 | 2021-03-02 | Xencor股份有限公司 | 包含IL-15/IL-15RA Fc融合蛋白和TIM-3抗原结合结构域的靶向TIM-3的异源二聚体融合蛋白 |
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EP2643353A1 (en) * | 2010-11-24 | 2013-10-02 | Novartis AG | Multispecific molecules |
CN102558355B (zh) * | 2011-12-31 | 2015-02-25 | 苏州康宁杰瑞生物科技有限公司 | 基于电荷网络的异二聚体fc改造方法及异二聚体蛋白的制备方法 |
-
2010
- 2010-06-29 AU AU2010270844A patent/AU2010270844A1/en not_active Abandoned
- 2010-06-29 WO PCT/US2010/040471 patent/WO2011005621A1/en active Application Filing
- 2010-06-29 MX MX2011013455A patent/MX2011013455A/es not_active Application Discontinuation
- 2010-06-29 JP JP2012519577A patent/JP2012532608A/ja active Pending
- 2010-06-29 US US13/382,876 patent/US9308258B2/en active Active
- 2010-06-29 CA CA2766166A patent/CA2766166A1/en not_active Abandoned
- 2010-06-29 EP EP10797631.8A patent/EP2451840B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2010270844A1 (en) | 2011-12-22 |
US9308258B2 (en) | 2016-04-12 |
EP2451840B1 (en) | 2018-12-26 |
EP2451840A1 (en) | 2012-05-16 |
US20120116057A1 (en) | 2012-05-10 |
CA2766166A1 (en) | 2011-01-13 |
EP2451840A4 (en) | 2014-01-22 |
JP2012532608A (ja) | 2012-12-20 |
WO2011005621A1 (en) | 2011-01-13 |
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Legal Events
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FA | Abandonment or withdrawal |