MX2013015323A - Polipeptidos de fusion de serpina y metodos de uso de los mismos. - Google Patents

Polipeptidos de fusion de serpina y metodos de uso de los mismos.

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Publication number
MX2013015323A
MX2013015323A MX2013015323A MX2013015323A MX2013015323A MX 2013015323 A MX2013015323 A MX 2013015323A MX 2013015323 A MX2013015323 A MX 2013015323A MX 2013015323 A MX2013015323 A MX 2013015323A MX 2013015323 A MX2013015323 A MX 2013015323A
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MX
Mexico
Prior art keywords
polypeptide
derived
methods
molecules
amino acid
Prior art date
Application number
MX2013015323A
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English (en)
Other versions
MX356517B (es
Inventor
Brendan P Eckelman
John C Timmer
Peter L Nguy
Grant B Guenther
Quinn Deveraux
Original Assignee
Inhibrx Llc
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Publication date
Application filed by Inhibrx Llc filed Critical Inhibrx Llc
Publication of MX2013015323A publication Critical patent/MX2013015323A/es
Publication of MX356517B publication Critical patent/MX356517B/es

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
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    • C07K16/241—Tumor Necrosis Factors
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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Abstract

Esta invención se relaciona con moléculas, particularmente polipéptidos, más particularmente proteínas de fusión que incluyen un polipéptido de serpina o una secuencia de aminoácidos que se deriva de una serpina y un segundo polipéptido que comprende al menos uno de los siguientes: un polipéptido Fc o una secuencia de aminoácidos que se deriva de un polipéptido Fc; un polipéptido dirigido a una citosina o una secuencia derivada de un polipéptido dirigido a citosina; un dominio WAP que contiene polipéptido o una secuencia derivada de un polipéptido que contiene WAP; y un polipéptido de albúmina o una secuencia de aminoácidos que se deriva de un polipéptido de albúmina de suero; esta invención también se relaciona con métodos para usar dichas moléculas en una variedad de indicaciones terapéuticas y diagnósticas, así como métodos para producir dichas moléculas.
MX2013015323A 2011-06-28 2012-06-28 Polipéptidos de fusión de serpina y métodos de uso de los mismos. MX356517B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161502055P 2011-06-28 2011-06-28
US201161570394P 2011-12-14 2011-12-14
US201161577204P 2011-12-19 2011-12-19
US201261638168P 2012-04-25 2012-04-25
PCT/US2012/044730 WO2013003641A2 (en) 2011-06-28 2012-06-28 Serpin fusion polypeptides and methods of use thereof

Publications (2)

Publication Number Publication Date
MX2013015323A true MX2013015323A (es) 2014-06-23
MX356517B MX356517B (es) 2018-06-01

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MX2013015323A MX356517B (es) 2011-06-28 2012-06-28 Polipéptidos de fusión de serpina y métodos de uso de los mismos.

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EP (2) EP2726092B1 (es)
JP (4) JP2014523900A (es)
KR (5) KR102084944B1 (es)
CN (3) CN103917563A (es)
AU (4) AU2012275287B2 (es)
BR (1) BR112013033799A2 (es)
CA (2) CA3132298A1 (es)
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HR (1) HRP20191652T1 (es)
HU (1) HUE046156T2 (es)
IL (3) IL312872A (es)
IN (1) IN2013MN02441A (es)
LT (1) LT2726092T (es)
ME (1) ME03473B (es)
MX (1) MX356517B (es)
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PL (1) PL2726092T3 (es)
PT (1) PT2726092T (es)
RS (1) RS59368B1 (es)
RU (5) RU2642310C2 (es)
SG (2) SG10201601621PA (es)
SI (1) SI2726092T1 (es)
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WO (1) WO2013003641A2 (es)

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US9938353B2 (en) 2011-06-24 2018-04-10 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
US10400029B2 (en) * 2011-06-28 2019-09-03 Inhibrx, Lp Serpin fusion polypeptides and methods of use thereof
CN103917563A (zh) * 2011-06-28 2014-07-09 英伊布里克斯有限责任公司 丝氨酸蛋白酶抑制蛋白融合多肽及其使用方法
JP2014528913A (ja) * 2011-06-28 2014-10-30 インヒブルクス リミティド ライアビリティ カンパニー Ｗａｐドメイン融合ポリペプチド及びその使用方法
CA2896951A1 (en) * 2012-01-10 2013-07-18 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
WO2013156054A1 (en) * 2012-04-16 2013-10-24 Universität Stuttgart The igm and ige heavy chain domain 2 as covalently linked homodimerization modules for the generation of fusion proteins with dual specificity
KR101509020B1 (ko) * 2013-05-22 2015-04-14 (주)입디 알파 1 안티트립신 융합 분자에 대한 조성물, 방법 및 용도
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TW201613981A (en) 2014-07-23 2016-04-16 Inova Diagnostics Inc Compositions and methods for the diagnosis of rheumatoid arthritis
IL308589A (en) * 2014-10-27 2024-01-01 Inhibrx Inc Serpin-fused polypeptides and methods of using them
US20160130324A1 (en) * 2014-10-31 2016-05-12 Shire Human Genetic Therapies, Inc. C1 Inhibitor Fusion Proteins and Uses Thereof
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