JP6523164B2 - フラクトオリゴ糖とケルセチン配糖体とを含有する組成物 - Google Patents
フラクトオリゴ糖とケルセチン配糖体とを含有する組成物 Download PDFInfo
- Publication number
- JP6523164B2 JP6523164B2 JP2015513728A JP2015513728A JP6523164B2 JP 6523164 B2 JP6523164 B2 JP 6523164B2 JP 2015513728 A JP2015513728 A JP 2015513728A JP 2015513728 A JP2015513728 A JP 2015513728A JP 6523164 B2 JP6523164 B2 JP 6523164B2
- Authority
- JP
- Japan
- Prior art keywords
- quercetin glycoside
- oral composition
- quercetin
- ratio
- fructooligosaccharide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- REFJWTPEDVJJIY-UHFFFAOYSA-N quercetin Natural products C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 title claims description 68
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 title claims description 63
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 title claims description 63
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 title claims description 63
- 235000005875 quercetin Nutrition 0.000 title claims description 63
- 229960001285 quercetin Drugs 0.000 title claims description 63
- 229930182470 glycoside Natural products 0.000 title claims description 62
- -1 quercetin glycoside Chemical class 0.000 title claims description 62
- 239000000203 mixture Substances 0.000 title claims description 61
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 title claims description 31
- 229940107187 fructooligosaccharide Drugs 0.000 title claims description 31
- 239000000463 material Substances 0.000 claims description 35
- 235000019658 bitter taste Nutrition 0.000 claims description 33
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical class OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 25
- 235000013325 dietary fiber Nutrition 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 20
- 239000008187 granular material Substances 0.000 claims description 19
- 235000005493 rutin Nutrition 0.000 claims description 14
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 claims description 13
- 244000269722 Thea sinensis Species 0.000 claims description 13
- 230000000694 effects Effects 0.000 claims description 13
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 claims description 13
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 claims description 13
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical group O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 claims description 13
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 claims description 13
- 229960004555 rutoside Drugs 0.000 claims description 13
- 230000006870 function Effects 0.000 claims description 10
- 240000007124 Brassica oleracea Species 0.000 claims description 9
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 claims description 9
- 235000012905 Brassica oleracea var viridis Nutrition 0.000 claims description 8
- 230000003078 antioxidant effect Effects 0.000 claims description 8
- 235000009569 green tea Nutrition 0.000 claims description 8
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 claims description 7
- 235000017647 Brassica oleracea var italica Nutrition 0.000 claims description 7
- 235000002678 Ipomoea batatas Nutrition 0.000 claims description 7
- 244000017020 Ipomoea batatas Species 0.000 claims description 7
- 241000209140 Triticum Species 0.000 claims description 7
- 235000021307 Triticum Nutrition 0.000 claims description 7
- 238000010521 absorption reaction Methods 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 235000003434 Sesamum indicum Nutrition 0.000 claims description 6
- 230000006872 improvement Effects 0.000 claims description 6
- 230000000968 intestinal effect Effects 0.000 claims description 6
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims description 5
- 240000006891 Artemisia vulgaris Species 0.000 claims description 5
- 240000003259 Brassica oleracea var. botrytis Species 0.000 claims description 5
- 240000000249 Morus alba Species 0.000 claims description 5
- 235000008708 Morus alba Nutrition 0.000 claims description 5
- 244000000231 Sesamum indicum Species 0.000 claims description 5
- 239000008280 blood Substances 0.000 claims description 5
- 210000004369 blood Anatomy 0.000 claims description 5
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 5
- 239000011707 mineral Substances 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 206010010774 Constipation Diseases 0.000 claims description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 102000051366 Glycosyltransferases Human genes 0.000 claims description 4
- 108700023372 Glycosyltransferases Proteins 0.000 claims description 4
- OVSQVDMCBVZWGM-IDRAQACASA-N Hirsutrin Natural products O([C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1)C1=C(c2cc(O)c(O)cc2)Oc2c(c(O)cc(O)c2)C1=O OVSQVDMCBVZWGM-IDRAQACASA-N 0.000 claims description 4
- FVQOMEDMFUMIMO-UHFFFAOYSA-N Hyperosid Natural products OC1C(O)C(O)C(CO)OC1OC1C(=O)C2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 FVQOMEDMFUMIMO-UHFFFAOYSA-N 0.000 claims description 4
- LUJAXSNNYBCFEE-UHFFFAOYSA-N Quercetin 3,7-dimethyl ether Natural products C=1C(OC)=CC(O)=C(C(C=2OC)=O)C=1OC=2C1=CC=C(O)C(O)=C1 LUJAXSNNYBCFEE-UHFFFAOYSA-N 0.000 claims description 4
- PUTDIROJWHRSJW-UHFFFAOYSA-N Quercitrin Natural products CC1OC(Oc2cc(cc(O)c2O)C3=CC(=O)c4c(O)cc(O)cc4O3)C(O)C(O)C1O PUTDIROJWHRSJW-UHFFFAOYSA-N 0.000 claims description 4
- OXGUCUVFOIWWQJ-XIMSSLRFSA-N acanthophorin B Natural products O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-XIMSSLRFSA-N 0.000 claims description 4
- 208000007502 anemia Diseases 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- GXMWXESSGGEWEM-UHFFFAOYSA-N isoquercitrin Natural products OCC(O)C1OC(OC2C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)c(O)c4)C(O)C1O GXMWXESSGGEWEM-UHFFFAOYSA-N 0.000 claims description 4
- 230000000291 postprandial effect Effects 0.000 claims description 4
- OVSQVDMCBVZWGM-QSOFNFLRSA-N quercetin 3-O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-QSOFNFLRSA-N 0.000 claims description 4
- OEKUVLQNKPXSOY-UHFFFAOYSA-N quercetin 3-O-beta-D-glucopyranosyl(1->3)-alpha-L-rhamnopyranosyl(1->6)-beta-d-galactopyranoside Natural products OC1C(O)C(C(O)C)OC1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OEKUVLQNKPXSOY-UHFFFAOYSA-N 0.000 claims description 4
- QPHXPNUXTNHJOF-UHFFFAOYSA-N quercetin-7-O-beta-L-rhamnopyranoside Natural products OC1C(O)C(O)C(C)OC1OC1=CC(O)=C2C(=O)C(O)=C(C=3C=C(O)C(O)=CC=3)OC2=C1 QPHXPNUXTNHJOF-UHFFFAOYSA-N 0.000 claims description 4
- OXGUCUVFOIWWQJ-HQBVPOQASA-N quercitrin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-HQBVPOQASA-N 0.000 claims description 4
- 206010003210 Arteriosclerosis Diseases 0.000 claims description 3
- 241000186000 Bifidobacterium Species 0.000 claims description 3
- 208000007882 Gastritis Diseases 0.000 claims description 3
- 208000007107 Stomach Ulcer Diseases 0.000 claims description 3
- 208000011775 arteriosclerosis disease Diseases 0.000 claims description 3
- 230000003908 liver function Effects 0.000 claims description 3
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 230000004913 activation Effects 0.000 claims description 2
- 230000001906 cholesterol absorption Effects 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 238000013329 compounding Methods 0.000 claims description 2
- 235000005911 diet Nutrition 0.000 claims description 2
- 230000037213 diet Effects 0.000 claims description 2
- 201000005917 gastric ulcer Diseases 0.000 claims description 2
- 230000003871 intestinal function Effects 0.000 claims description 2
- 230000001629 suppression Effects 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
- 241000251557 Ascidiacea Species 0.000 claims 1
- 241000222455 Boletus Species 0.000 claims 1
- 244000025254 Cannabis sativa Species 0.000 claims 1
- 240000007643 Phytolacca americana Species 0.000 claims 1
- 235000009074 Phytolacca americana Nutrition 0.000 claims 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 claims 1
- 239000000843 powder Substances 0.000 description 23
- 230000009471 action Effects 0.000 description 15
- 239000011230 binding agent Substances 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 102000004190 Enzymes Human genes 0.000 description 12
- 108090000790 Enzymes Proteins 0.000 description 12
- 235000013305 food Nutrition 0.000 description 12
- 238000005469 granulation Methods 0.000 description 11
- 230000003179 granulation Effects 0.000 description 11
- 239000000047 product Substances 0.000 description 9
- 241000196324 Embryophyta Species 0.000 description 8
- 238000001727 in vivo Methods 0.000 description 8
- 239000000796 flavoring agent Substances 0.000 description 7
- 235000019634 flavors Nutrition 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 7
- 240000005979 Hordeum vulgare Species 0.000 description 6
- 235000007340 Hordeum vulgare Nutrition 0.000 description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 6
- 230000036541 health Effects 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 235000013616 tea Nutrition 0.000 description 6
- 229940088594 vitamin Drugs 0.000 description 6
- 239000011782 vitamin Substances 0.000 description 6
- 229930003231 vitamin Natural products 0.000 description 6
- 235000013343 vitamin Nutrition 0.000 description 6
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 5
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 5
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 description 5
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 5
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 229920001542 oligosaccharide Polymers 0.000 description 5
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 5
- PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 description 4
- 244000291564 Allium cepa Species 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 150000001746 carotenes Chemical class 0.000 description 4
- 235000005473 carotenes Nutrition 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 230000000873 masking effect Effects 0.000 description 4
- 235000010755 mineral Nutrition 0.000 description 4
- 239000011812 mixed powder Substances 0.000 description 4
- 150000002482 oligosaccharides Chemical class 0.000 description 4
- 238000004806 packaging method and process Methods 0.000 description 4
- 235000019629 palatability Nutrition 0.000 description 4
- 235000013311 vegetables Nutrition 0.000 description 4
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 3
- 240000008620 Fagopyrum esculentum Species 0.000 description 3
- 235000009419 Fagopyrum esculentum Nutrition 0.000 description 3
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 3
- 102000019197 Superoxide Dismutase Human genes 0.000 description 3
- 108010012715 Superoxide dismutase Proteins 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000002550 fecal effect Effects 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 229930003935 flavonoid Natural products 0.000 description 3
- 150000002215 flavonoids Chemical class 0.000 description 3
- 235000017173 flavonoids Nutrition 0.000 description 3
- 229910052742 iron Inorganic materials 0.000 description 3
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 3
- 229960000511 lactulose Drugs 0.000 description 3
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 244000308180 Brassica oleracea var. italica Species 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- VMBCEJXTYHMTMM-UHFFFAOYSA-N F.F.I Chemical compound F.F.I VMBCEJXTYHMTMM-UHFFFAOYSA-N 0.000 description 2
- 229920002907 Guar gum Polymers 0.000 description 2
- FLDFNEBHEXLZRX-DLQNOBSRSA-N Nystose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(O[C@@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 FLDFNEBHEXLZRX-DLQNOBSRSA-N 0.000 description 2
- 244000046101 Sophora japonica Species 0.000 description 2
- 235000010586 Sophora japonica Nutrition 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 238000007792 addition Methods 0.000 description 2
- FYGDTMLNYKFZSV-DZOUCCHMSA-N alpha-D-Glcp-(1->4)-alpha-D-Glcp-(1->4)-D-Glcp Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@H](O[C@@H]2[C@H](OC(O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-DZOUCCHMSA-N 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 235000001465 calcium Nutrition 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 235000013376 functional food Nutrition 0.000 description 2
- 239000000665 guar gum Substances 0.000 description 2
- 235000010417 guar gum Nutrition 0.000 description 2
- 229960002154 guar gum Drugs 0.000 description 2
- 235000013402 health food Nutrition 0.000 description 2
- 239000000845 maltitol Substances 0.000 description 2
- 235000010449 maltitol Nutrition 0.000 description 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 2
- 229940035436 maltitol Drugs 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- FLDFNEBHEXLZRX-UHFFFAOYSA-N nystose Natural products OC1C(O)C(CO)OC1(CO)OCC1(OCC2(OC3C(C(O)C(O)C(CO)O3)O)C(C(O)C(CO)O2)O)C(O)C(O)C(CO)O1 FLDFNEBHEXLZRX-UHFFFAOYSA-N 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 150000003305 rutin Chemical class 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 230000003639 vasoconstrictive effect Effects 0.000 description 2
- 239000005526 vasoconstrictor agent Substances 0.000 description 2
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 235000010167 Allium cepa var aggregatum Nutrition 0.000 description 1
- 240000002234 Allium sativum Species 0.000 description 1
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 description 1
- 241001105098 Angelica keiskei Species 0.000 description 1
- 235000003097 Artemisia absinthium Nutrition 0.000 description 1
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 235000007319 Avena orientalis Nutrition 0.000 description 1
- 244000075850 Avena orientalis Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 1
- 241000219198 Brassica Species 0.000 description 1
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 1
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 1
- 244000064816 Brassica oleracea var. acephala Species 0.000 description 1
- 241000219193 Brassicaceae Species 0.000 description 1
- 241000873224 Capparaceae Species 0.000 description 1
- 235000017336 Capparis spinosa Nutrition 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- DQFBYFPFKXHELB-UHFFFAOYSA-N Chalcone Natural products C=1C=CC=CC=1C(=O)C=CC1=CC=CC=C1 DQFBYFPFKXHELB-UHFFFAOYSA-N 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 240000005250 Chrysanthemum indicum Species 0.000 description 1
- 241000207782 Convolvulaceae Species 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 206010016326 Feeling cold Diseases 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 229920000926 Galactomannan Polymers 0.000 description 1
- 241001632576 Hyacinthus Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 235000000069 L-ascorbic acid Nutrition 0.000 description 1
- 239000002211 L-ascorbic acid Substances 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 1
- 244000070406 Malus silvestris Species 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 235000016357 Mirtillo rosso Nutrition 0.000 description 1
- 241000218213 Morus <angiosperm> Species 0.000 description 1
- 240000005561 Musa balbisiana Species 0.000 description 1
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 240000008881 Oenanthe javanica Species 0.000 description 1
- 240000001439 Opuntia Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 206010033546 Pallor Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 239000004373 Pullulan Substances 0.000 description 1
- 229920001218 Pullulan Polymers 0.000 description 1
- CZMRCDWAGMRECN-UHFFFAOYSA-N Rohrzucker Natural products OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O CZMRCDWAGMRECN-UHFFFAOYSA-N 0.000 description 1
- 240000007651 Rubus glaucus Species 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 235000007238 Secale cereale Nutrition 0.000 description 1
- 244000082988 Secale cereale Species 0.000 description 1
- 244000040738 Sesamum orientale Species 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- 235000021536 Sugar beet Nutrition 0.000 description 1
- 240000001717 Vaccinium macrocarpon Species 0.000 description 1
- 244000077923 Vaccinium vitis idaea Species 0.000 description 1
- 235000017606 Vaccinium vitis idaea Nutrition 0.000 description 1
- 241001464837 Viridiplantae Species 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 244000128884 Zier Kohl Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 235000021016 apples Nutrition 0.000 description 1
- 239000001138 artemisia absinthium Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000023852 carbohydrate metabolic process Effects 0.000 description 1
- 235000021256 carbohydrate metabolism Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 230000001013 cariogenic effect Effects 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 150000001789 chalcones Chemical class 0.000 description 1
- 235000005513 chalcones Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 150000004775 coumarins Chemical class 0.000 description 1
- 235000021019 cranberries Nutrition 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 235000021316 daily nutritional intake Nutrition 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- BJHIKXHVCXFQLS-UYFOZJQFSA-N fructose group Chemical group OCC(=O)[C@@H](O)[C@H](O)[C@H](O)CO BJHIKXHVCXFQLS-UYFOZJQFSA-N 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 235000021384 green leafy vegetables Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000001656 lutein Substances 0.000 description 1
- 235000012680 lutein Nutrition 0.000 description 1
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 description 1
- 229960005375 lutein Drugs 0.000 description 1
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 235000013575 mashed potatoes Nutrition 0.000 description 1
- 235000020332 matcha tea Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 235000007686 potassium Nutrition 0.000 description 1
- 239000012254 powdered material Substances 0.000 description 1
- 230000022558 protein metabolic process Effects 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 235000012339 rape kale Nutrition 0.000 description 1
- 244000086221 rape kale Species 0.000 description 1
- 235000021013 raspberries Nutrition 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/84—Flavour masking or reducing agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/86—Addition of bitterness inhibitors
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Description
ケルセチン配糖体とは、フラボノイドの一種であるケルセチン(クエルセチンとも呼ばれる)の配糖体であり、例えば、ルチン、クエルシトリン、イソクエルシトリンなど、及びこれらの酵素処理物が挙げられる。ケルセチン配糖体は様々な生理作用を示すことが知られており、抗炎症作用、抗酸化作用、血管収縮作用、毛細血管の透過抑制作用、毛細血管壁を強くする効果、さらに細胞増殖などに関わるいくつかの酵素を阻害することが報告されている。
様物質とされる。一般に、ミカン科の植物から得ることができ、また、マメ科のエンジュ、タデ科のソバなどからも得ることができる。
本発明の組成物には、苦味成分に対して、特定の比率でフラクトオリゴ糖を配合する。ケルセチン配糖体のような苦味を有する成分は、食品として日常的に経口摂取しにくいものであるが、ケルセチン配糖体に特定の比率でフラクトオリゴ糖を混合することにより、苦味が抑制され、摂取しやすい経口組成物となる。
本発明の経口組成物は、食品、医薬品、食品用添加物等として使用することができる。本発明の組成物は、苦味を有するケルセチン配糖体を含むが、その苦味が抑制されているため、無理なく日常的に摂取することができ、いわゆる機能性食品などの食品として使用することに適する。
ケルセチン配糖体を含有する組成物において、ケルセチン配糖体の苦味を好適にマスキングするオリゴ糖について検討をおこなった。具体的には、フラクトオリゴ糖、マルトオリゴ糖、パラチノース、ラフィノース、ラクチュロース、キシロオリゴ糖、アガロオリゴ糖の、ケルセチン配糖体の苦味に対するマスキング効果を試験した。
使用した材料は以下のとおりである:
ケルセチン配糖体:サンエミックP15(登録商標)(三栄源エフ・エフ・アイ(株)製、ケルセチン配糖体15%含有)
フラクトオリゴ糖:メイオリゴP(登録商標)(粉末)((株)明治フードマテリア、フラクトオリゴ糖95%含有)
マルトオリゴ糖:パインオリゴ20(松谷化学工業(株)、マルトオリゴ糖65%含有)
パラチノース:粉末パラチノースICP(三井製糖(株)、パラチノース99%含有)
ラフィノース:ニッテンラフィノース(登録商標)(日本甜菜製糖(株)、ラフィノース98%含有)
ラクチュロース:ミルクオリゴ糖MLC−97(森永乳業(株)、ラクチュロース97%含有)
キシロオリゴ糖:キシロオリゴ95P(サントリーウエルネス(株)、キシロオリゴ糖95%含有)
アガロオリゴ糖:Takaraアガオリゴ糖(登録商標)(タカラバイオ(株)、アガロオリゴ糖85%含有)
<評価方法>
ケルセチン配糖体と各種オリゴ糖とを表1に示す重量比で配合した混合粉末を調製した。なお、表中の重量比は、使用した材料の純度から計算した各種化合物自体の重量に基づく比である。調製した混合粉末1gを7名のパネラーが水とともに経口摂取し、ケルセチン配糖体由来の苦味の強さを以下の基準にしたがって評価した。
0点:「苦味を感じない」
5点:「ケルセチン配糖体と同等の苦味を感じる」
7名のパネラーのスコアを平均し、集計した。結果を表1に示す。
ケルセチン配糖体を含有する組成物において、ケルセチン配糖体の苦味を好適にマスキングするフラクトオリゴ糖の配合割合について検討をおこなった。具体的には、実施例1でほとんどマスキング効果を示さなかったラフィノースをコントロールとして、ケルセチン配糖体に対するフラクトオリゴ糖の配合比を変化させて試験を行った。使用した材料及び評価方法は、実施例1と同じである。結果を表2に示す。
食物繊維含有素材として大麦若葉末、アシタバ末、緑茶末を用い、これにケルセチン配糖体(「サンメリンパウダーFA」(登録商標)三栄源エフ・エフ・アイ(株)製)及びマルチトールを表1に示す配合量で加えた混合粉末を、流動層造粒機(FD−LAB−1、(株)パウレック社製)内に投入して品温が40℃になるまで混合した。次いで、キシロオリゴ糖シロップ(「キシロオリゴ70」サントリー(株)製 固形分:75%、固形分中キシロオリゴ糖含量:70%)と、フラクトオリゴ糖シロップ(「メイオリゴG」(登録商標)(株)明治フードマテリア製 固形分:75%、固形分中フラクトオリゴ糖含量:55%)のそれぞれを表1に示す配合量で溶解した噴霧液を調製し、混合粉末及び噴霧液由来の全固形分量が約300gとなるように各サンプルの製造を行った。なお、表中の重量は、使用した材料の純度から計算した各種化合物自体の重量である。造粒条件は10〜30ml/分の速度で噴霧しながら5〜15分間造粒した(品温:35℃〜40℃、給気温度:65℃)。同装置で10〜20分乾燥後、造粒物を取り出して20号(目開き840μm)の篩にて篩過して顆粒を得た。
Claims (7)
- ケルセチン配糖体、フラクトオリゴ糖、および食物繊維含有素材を含む顆粒状の経口組成物であって、
該ケルセチン配糖体1に対し、該フラクトオリゴ糖5以上50以下(重量比)の割合であり、そして
該食物繊維含有素材が、アシタバ、麦若葉、緑茶、ケール、カンショ若葉、ブロッコリー、モロヘイヤ、ゴマ若葉、桑葉、ボタンボウフウ、ヨモギの1ないしそれ以上からなる、
前記経口組成物。 - 前記ケルセチン配糖体1に対する前記フラクトオリゴ糖の割合は10以上(重量比)である、請求項1に記載の経口組成物。
- 前記ケルセチン配糖体が、ルチン、クエルシトリン、イソクエルシトリン、又はこれらの糖転移酵素処理物である、請求項1または2に記載の経口組成物。
- 前記ケルセチン配糖体が、クエルシトリン、イソクエルシトリン、又はこれらの糖転移酵素処理物である、請求項1〜3のいずれか1項に記載の経口組成物。
- 動脈硬化、貧血、胃炎、胃潰瘍、便秘といった症状の予防または改善、肝機能改善、有害物質の吸着抑制、腸内環境の改善、ダイエット効果、コレステロールの吸収抑制、食後血糖値の急上昇防止、スーパーオキシドディスムターゼの活性化、ビフィズス菌増殖活性を始めとする整腸作用、大腸癌予防、ミネラル吸収促進、または抗酸化作用に基づく機能に関する表示が付されていることを特徴とする、請求項1〜4のいずれか1項に記載の経口組成物。
- ケルセチン配糖体と、フラクトオリゴ糖とを、ケルセチン配糖体1に対し、フラクトオリゴ糖5以上50以下(重量比)の割合で混合すること、
アシタバ、麦若葉、緑茶、ケール、カンショ若葉、ブロッコリー、モロヘイヤ、ゴマ若葉、桑葉、ボタンボウフウ、ヨモギの1ないしそれ以上からなる、食物繊維含有素材を配合すること、および
顆粒状に成形すること、
を含む、ケルセチン配糖体含有経口組成物の苦味を抑制する方法。 - 前記ケルセチン配糖体1に対する前記フラクトオリゴ糖の割合は10以上(重量比)である、請求項6に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013093490 | 2013-04-26 | ||
JP2013093490 | 2013-04-26 | ||
PCT/JP2014/061045 WO2014175180A1 (ja) | 2013-04-26 | 2014-04-18 | フラクトオリゴ糖とケルセチン配糖体とを含有する組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2014175180A1 JPWO2014175180A1 (ja) | 2017-02-23 |
JP6523164B2 true JP6523164B2 (ja) | 2019-05-29 |
Family
ID=51791758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015513728A Active JP6523164B2 (ja) | 2013-04-26 | 2014-04-18 | フラクトオリゴ糖とケルセチン配糖体とを含有する組成物 |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP2990042A4 (ja) |
JP (1) | JP6523164B2 (ja) |
CN (1) | CN105120878A (ja) |
HK (1) | HK1214970A1 (ja) |
TW (1) | TWI666021B (ja) |
WO (1) | WO2014175180A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102364023B1 (ko) * | 2021-04-29 | 2022-02-17 | 주식회사 셀로닉스 | 첨가물을 사용하지 않는 과립제형의 프락토올리고당 프리바이오틱스 제조방법 |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104887724B (zh) * | 2015-05-07 | 2018-12-18 | 同济大学 | 圆果种黄麻种子提取物的制备方法及应用 |
CN104857038B (zh) * | 2015-05-07 | 2018-10-26 | 同济大学 | 长果种黄麻种子提取物的制备方法及应用 |
JP6723529B2 (ja) * | 2015-07-14 | 2020-07-15 | 株式会社東洋新薬 | ホップ葉含有飲食用組成物 |
JP6974818B2 (ja) * | 2016-11-30 | 2021-12-01 | 株式会社東洋新薬 | 組成物 |
JP6969717B2 (ja) * | 2017-07-21 | 2021-11-24 | 株式会社東洋新薬 | 組成物 |
JP7171602B2 (ja) * | 2017-11-08 | 2022-11-15 | アサヒグループホールディングス株式会社 | アッカーマンシア・ムシニフィラ増殖材 |
JP2019201629A (ja) * | 2018-05-17 | 2019-11-28 | 大正製薬株式会社 | 固形物 |
CN109288819B (zh) * | 2018-09-13 | 2021-11-19 | 华南理工大学 | 一种含槲皮素和益生因子的结肠靶向纳米纤维膜及其制备方法和应用 |
JP6620323B1 (ja) * | 2018-09-28 | 2019-12-18 | 株式会社東洋新薬 | 経口組成物 |
CN113453563A (zh) * | 2019-02-20 | 2021-09-28 | 三得利控股株式会社 | 含有蛋白质的口服组合物及含有蛋白质的口服组合物的风味改善方法 |
WO2020174382A1 (en) * | 2019-02-28 | 2020-09-03 | Tata Chemicals Limited | A granular composition comprising fenugreek extract |
JP2021166544A (ja) * | 2019-10-23 | 2021-10-21 | 株式会社東洋新薬 | 経口組成物 |
CN115023150B (zh) * | 2019-12-17 | 2024-04-26 | 三得利控股株式会社 | 硫酸软骨素合成促进用组合物 |
JP2021063139A (ja) * | 2021-01-28 | 2021-04-22 | 株式会社東洋新薬 | 食物の胃からの排出遅延剤 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59154935A (ja) | 1983-02-25 | 1984-09-04 | Mitsui Toatsu Chem Inc | アシタバ粉末の製造方法 |
JPH02231057A (ja) | 1989-03-03 | 1990-09-13 | Sanmi Shoji Kk | あしたば粉末の製造方法 |
JPH0710898A (ja) | 1993-06-24 | 1995-01-13 | Sanei Gen F F I Inc | 水難溶性フラボノイドの改質方法 |
JP2544302B2 (ja) | 1994-03-04 | 1996-10-16 | ミナト製薬株式会社 | 麦若葉粉末の製造方法 |
JP2000103746A (ja) * | 1994-10-27 | 2000-04-11 | Takeda Chem Ind Ltd | 成形物およびその製造方法 |
US6426099B1 (en) * | 1997-12-03 | 2002-07-30 | Renew Life, Inc. | Herbal formulation for rebuilding intestinal bacteria |
JP2001112435A (ja) | 1999-10-18 | 2001-04-24 | Binshiyoo:Kk | 大麦の若葉及び若草の全草を原料とする天然色素の製造法 |
JP3430126B2 (ja) | 2000-06-21 | 2003-07-28 | 株式会社東洋新薬 | 麦若葉末の製造方法 |
JP2002058449A (ja) | 2000-08-22 | 2002-02-26 | Toyo Shinyaku:Kk | 麦若葉末の製造方法 |
JP3437539B2 (ja) | 2000-09-18 | 2003-08-18 | 株式会社東洋新薬 | ケールの乾燥粉末の製造方法 |
JP3430142B2 (ja) | 2000-10-10 | 2003-07-28 | 株式会社東洋新薬 | ケール乾燥粉末の製造方法 |
JP2002119245A (ja) | 2000-10-16 | 2002-04-23 | Toyo Shinyaku:Kk | ケール乾燥粉末の製造方法 |
JP2002119239A (ja) | 2000-10-16 | 2002-04-23 | Toyo Shinyaku:Kk | ケール乾燥粉末の製造方法 |
JP2002125612A (ja) | 2000-10-26 | 2002-05-08 | Toyo Shinyaku:Kk | ケール乾燥粉末の製造方法 |
JP2002186445A (ja) | 2000-12-21 | 2002-07-02 | Toyo Shinyaku:Kk | ケール乾燥粉末の製造方法 |
JP2002218945A (ja) | 2001-01-25 | 2002-08-06 | Toyo Shinyaku:Kk | 食物繊維含有食品およびその成型方法ならびに成型方法に用いる結合剤 |
US6368617B1 (en) * | 2001-05-15 | 2002-04-09 | Reliv' International, Inc. | Dietary supplement |
JP2003000178A (ja) | 2001-06-20 | 2003-01-07 | Toyo Shinyaku:Kk | 麦若葉末の製造方法 |
JP3560939B2 (ja) | 2001-07-02 | 2004-09-02 | 株式会社京都栄養化学研究所 | 麦類若葉粉末の製造方法およびその麦類若葉粉末を含有してなる食品 |
JP2003033164A (ja) | 2001-07-24 | 2003-02-04 | Sanei Gen Ffi Inc | 香味劣化抑制方法及び香味劣化抑制剤 |
JP2003079339A (ja) | 2001-09-10 | 2003-03-18 | Takuo Mori | 健康栄養補助食品の製法 |
JP2003334046A (ja) | 2002-05-21 | 2003-11-25 | Yoshio Yamamoto | 大麦若葉及び/又はケールを含有する粉末飲料並びに飲料 |
JP2006335648A (ja) * | 2005-05-31 | 2006-12-14 | Suntory Ltd | オリゴ糖溶液を用いて粒状経口組成物を製造する方法 |
CN102105154B (zh) * | 2008-07-30 | 2013-03-27 | 三得利控股株式会社 | 含有含硫酸软骨素的水系溶剂提取物以及槲皮素糖苷的口服给药用制剂 |
CN101341949B (zh) * | 2008-08-25 | 2010-09-08 | 中国农业大学 | 一种杂粮咀嚼片及其制备方法 |
KR101334926B1 (ko) * | 2011-01-27 | 2013-12-02 | 임실군 | 쿼세틴이 함유된 발효유 제조방법 |
JP2013068545A (ja) * | 2011-09-22 | 2013-04-18 | Kirin Holdings Co Ltd | 生体内におけるポリフェノールの抗酸化活性の判定方法 |
-
2014
- 2014-04-18 JP JP2015513728A patent/JP6523164B2/ja active Active
- 2014-04-18 CN CN201480022219.XA patent/CN105120878A/zh active Pending
- 2014-04-18 EP EP14787556.1A patent/EP2990042A4/en not_active Withdrawn
- 2014-04-18 WO PCT/JP2014/061045 patent/WO2014175180A1/ja active Application Filing
- 2014-04-23 TW TW103114678A patent/TWI666021B/zh active
-
2016
- 2016-03-16 HK HK16103064.7A patent/HK1214970A1/zh unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102364023B1 (ko) * | 2021-04-29 | 2022-02-17 | 주식회사 셀로닉스 | 첨가물을 사용하지 않는 과립제형의 프락토올리고당 프리바이오틱스 제조방법 |
Also Published As
Publication number | Publication date |
---|---|
EP2990042A4 (en) | 2016-12-07 |
EP2990042A1 (en) | 2016-03-02 |
CN105120878A (zh) | 2015-12-02 |
JPWO2014175180A1 (ja) | 2017-02-23 |
TW201519894A (zh) | 2015-06-01 |
WO2014175180A1 (ja) | 2014-10-30 |
TWI666021B (zh) | 2019-07-21 |
HK1214970A1 (zh) | 2016-08-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6523164B2 (ja) | フラクトオリゴ糖とケルセチン配糖体とを含有する組成物 | |
JP7391017B2 (ja) | ステビオール配糖体溶解度エンハンサー | |
RU2317731C2 (ru) | Композиция для получения напитков моментального приготовления | |
JP2009517385A (ja) | 高効能甘味料を用いた医薬組成物 | |
JP2008099682A (ja) | 機能性素材及び/又はエキス含有組成物 | |
FI107014B (fi) | Terveysravintovalmiste | |
WO2010013551A1 (ja) | 水抽出コンドロイチン硫酸とケルセチン配糖体を含有する経口投与用製剤 | |
JP2006045212A (ja) | 特定のキナ酸誘導体を含有する経口用組成物 | |
JP4820288B2 (ja) | 食物繊維を含有する健康食品の製造方法 | |
CN111295101B (zh) | 口服甜味剂组合物和方法 | |
JP2006335648A (ja) | オリゴ糖溶液を用いて粒状経口組成物を製造する方法 | |
JP5442243B2 (ja) | 腎障害抑制剤 | |
CN110831445A (zh) | 粉末食品及其制造方法、以及粉末食品的黑芥子酶活性促进方法 | |
JP2010265251A (ja) | 血流促進改善剤 | |
JPWO2005112665A1 (ja) | 甘藷茎葉加工物含有組成物 | |
JP2006290782A (ja) | 抗浮腫組成物 | |
JP4688555B2 (ja) | アシタバとキトサンまたはその誘導体とを含有する血中低密度リポ蛋白低下剤 | |
JP2016138070A (ja) | Glp−1分泌促進剤 | |
KR101359859B1 (ko) | 다당류를 함유하는 조성물 | |
WO2008108817A1 (en) | Nutritional supplement with oleuropein | |
JP2009084198A (ja) | アルドースレダクターゼ阻害剤 | |
KR20170076496A (ko) | 용해성이 개선된 안정한 무정형 쿠르큐미노이드 고체분산체 조성물 및 이의 제조방법 | |
JP5324943B2 (ja) | 流動層造粒による粒状食品組成物の製造方法 | |
JP2011152105A (ja) | アルキルフェノール系化合物排泄促進用食品 | |
JP2021094020A (ja) | 飲食用組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170417 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20170417 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20171222 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20180220 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180419 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180817 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20181005 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190225 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190301 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20190328 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20190425 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6523164 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |