JP6450690B2 - キメラ抗原受容体及びその使用方法 - Google Patents

キメラ抗原受容体及びその使用方法 Download PDF

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JP6450690B2
JP6450690B2 JP2015558159A JP2015558159A JP6450690B2 JP 6450690 B2 JP6450690 B2 JP 6450690B2 JP 2015558159 A JP2015558159 A JP 2015558159A JP 2015558159 A JP2015558159 A JP 2015558159A JP 6450690 B2 JP6450690 B2 JP 6450690B2
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amino acids
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car
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JP2016508518A (ja
JP2016508518A5 (https=
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チア−ヨン ウー
チア−ヨン ウー
ジェイムズ オウナファー
ジェイムズ オウナファー
ウェンデル エイ ． リム
ウェンデル エイ ． リム
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University of California
University of California Los Angeles UCLA
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University of California San Diego UCSD
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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JP2015558159A 2013-02-15 2014-02-14 キメラ抗原受容体及びその使用方法 Active JP6450690B2 (ja)

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Application Number Priority Date Filing Date Title
US201361765585P 2013-02-15 2013-02-15
US61/765,585 2013-02-15
PCT/US2014/016527 WO2014127261A1 (en) 2013-02-15 2014-02-14 Chimeric antigen receptor and methods of use thereof

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JP2016508518A JP2016508518A (ja) 2016-03-22
JP2016508518A5 JP2016508518A5 (https=) 2017-03-23
JP6450690B2 true JP6450690B2 (ja) 2019-01-09

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JP2018230498A Active JP6687712B2 (ja) 2013-02-15 2018-12-10 キメラ抗原受容体及びその使用方法
JP2020066759A Active JP7014843B2 (ja) 2013-02-15 2020-04-02 キメラ抗原受容体及びその使用方法
JP2022006902A Active JP7317159B2 (ja) 2013-02-15 2022-01-20 キメラ抗原受容体及びその使用方法
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JP2020066759A Active JP7014843B2 (ja) 2013-02-15 2020-04-02 キメラ抗原受容体及びその使用方法
JP2022006902A Active JP7317159B2 (ja) 2013-02-15 2022-01-20 キメラ抗原受容体及びその使用方法
JP2023116579A Active JP7676476B2 (ja) 2013-02-15 2023-07-18 キメラ抗原受容体及びその使用方法

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US (10) US20150368342A1 (https=)
EP (5) EP4303232A3 (https=)
JP (5) JP6450690B2 (https=)
KR (5) KR20210147101A (https=)
CN (2) CN110423282B (https=)
AU (5) AU2014216130B2 (https=)
CA (1) CA2901115A1 (https=)
CY (1) CY1122386T1 (https=)
DK (2) DK3300745T3 (https=)
ES (3) ES2653487T3 (https=)
HR (1) HRP20192123T1 (https=)
HU (2) HUE036250T2 (https=)
IL (3) IL272279B2 (https=)
LT (2) LT2956175T (https=)
MX (2) MX369545B (https=)
NO (1) NO2929995T3 (https=)
PL (3) PL2956175T3 (https=)
PT (3) PT3613439T (https=)
SI (2) SI3613439T1 (https=)
WO (1) WO2014127261A1 (https=)

Families Citing this family (344)

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Publication number Priority date Publication date Assignee Title
US9428567B2 (en) 2010-12-22 2016-08-30 The Board Of Trustees Of The Leland Stanford Junior University Antagonists of interleukin-2 receptor
KR102437522B1 (ko) * 2012-05-25 2022-08-26 셀렉티스 면역요법을 위한 동종이형 및 면역억제제 저항성인 ｔ 세포의 조작 방법
EP2934532B1 (en) 2012-12-20 2019-10-23 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
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