EA202190304A1 - Химерные рецепторы к steap1 и способы их применения - Google Patents

Химерные рецепторы к steap1 и способы их применения

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Publication number
EA202190304A1
EA202190304A1 EA202190304A EA202190304A EA202190304A1 EA 202190304 A1 EA202190304 A1 EA 202190304A1 EA 202190304 A EA202190304 A EA 202190304A EA 202190304 A EA202190304 A EA 202190304A EA 202190304 A1 EA202190304 A1 EA 202190304A1
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Prior art keywords
steap1
methods
chimeric receptors
application
antigen
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EA202190304A
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English (en)
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Оливье Нолан-Стево
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Эмджен Инк.
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Application filed by Эмджен Инк. filed Critical Эмджен Инк.
Publication of EA202190304A1 publication Critical patent/EA202190304A1/ru

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Abstract

В соответствии с настоящим изобретением раскрыты антигенсвязывающие молекулы, химерные рецепторы и сконструированные иммунные клетки, связывающиеся с STEAP1. Настоящее изобретение также относится к векторам, композициям и способам лечения и/или выявления с использованием антигенсвязывающих молекул и сконструированных иммунных клеток, связывающих STEAP1.
EA202190304A 2018-07-18 2019-07-17 Химерные рецепторы к steap1 и способы их применения EA202190304A1 (ru)

Applications Claiming Priority (2)

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US201862700178P 2018-07-18 2018-07-18
PCT/US2019/042245 WO2020018695A1 (en) 2018-07-18 2019-07-17 Chimeric receptors to steap1 and methods of use thereof

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EA202190304A1 true EA202190304A1 (ru) 2022-01-21

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US (1) US20210277148A1 (ru)
EP (1) EP3823993A1 (ru)
JP (1) JP7459046B2 (ru)
KR (1) KR20210033025A (ru)
CN (1) CN112771080A (ru)
AR (1) AR117950A1 (ru)
AU (1) AU2019307607A1 (ru)
BR (1) BR112021000914A2 (ru)
CA (1) CA3106653A1 (ru)
CL (1) CL2021000136A1 (ru)
CO (1) CO2021000660A2 (ru)
CR (1) CR20210091A (ru)
EA (1) EA202190304A1 (ru)
IL (1) IL280238A (ru)
JO (1) JOP20210011A1 (ru)
MA (1) MA53167A (ru)
MX (1) MX2021000617A (ru)
PE (1) PE20210315A1 (ru)
PH (1) PH12021550120A1 (ru)
SG (1) SG11202100464UA (ru)
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Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202019473A (zh) 2018-07-02 2020-06-01 美商安進公司 抗steap1抗原結合蛋白
WO2023091954A2 (en) * 2021-11-19 2023-05-25 The Trustees Of The University Of Pennsylvania Engineered pan-leukocyte antigen cd45 to facilitate car t cell therapy
WO2023154890A2 (en) * 2022-02-11 2023-08-17 Fred Hutchinson Cancer Center Chimeric antigen receptors binding steap1
GB202208119D0 (en) * 2022-06-01 2022-07-13 Univ Oslo Hf Anti-steap1 car

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3785186T2 (de) 1986-09-02 1993-07-15 Enzon Lab Inc Bindungsmolekuele mit einzelpolypeptidkette.
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US6319494B1 (en) 1990-12-14 2001-11-20 Cell Genesys, Inc. Chimeric chains for receptor-associated signal transduction pathways
IL104570A0 (en) 1992-03-18 1993-05-13 Yeda Res & Dev Chimeric genes and cells transformed therewith
US5834266A (en) 1993-02-12 1998-11-10 President & Fellows Of Harvard College Regulated apoptosis
US5869337A (en) 1993-02-12 1999-02-09 President And Fellows Of Harvard College Regulated transcription of targeted genes and other biological events
US5830462A (en) 1993-02-12 1998-11-03 President & Fellows Of Harvard College Regulated transcription of targeted genes and other biological events
US20030036654A1 (en) 1994-08-18 2003-02-20 Holt Dennis A. Synthetic multimerizing agents
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
AU757698C (en) * 1998-06-01 2004-04-08 Agensys, Inc. Novel serpentine transmembrane antigens expressed in human cancers and uses thereof
US6410319B1 (en) * 1998-10-20 2002-06-25 City Of Hope CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
KR20030032922A (ko) 2000-02-24 2003-04-26 싸이트 테라피스 인코포레이티드 세포의 동시 자극 및 농축
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US7446190B2 (en) * 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
US20100196336A1 (en) 2006-05-23 2010-08-05 Dongsu Park Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods
PT2845866T (pt) * 2006-10-27 2017-08-09 Genentech Inc Anticorpos e imunoconjugados e utilizações dos mesmos
WO2011146862A1 (en) 2010-05-21 2011-11-24 Bellicum Pharmaceuticals, Inc. Methods for inducing selective apoptosis
PT3214091T (pt) 2010-12-09 2019-01-11 Univ Pennsylvania Utilização de células t modificadas por recetor de antigénio quimérico para tratar o cancro
AU2012209103B2 (en) 2011-01-26 2015-12-03 Takeda Pharmaceutical Company Limited Methods and compositions for the synthesis of multimerizing agents
BR112013024395B1 (pt) 2011-03-23 2021-10-26 Fred Hutchinson Cancer Research Center Composições adotivas de imunoterapia celular e método para fabricação da dita composição
EP2906684B8 (en) 2012-10-10 2020-09-02 Sangamo Therapeutics, Inc. T cell modifying compounds and uses thereof
CN110423282B (zh) 2013-02-15 2023-09-08 加利福尼亚大学董事会 嵌合抗原受体及其使用方法
SG11201506974XA (en) 2013-03-14 2015-10-29 Bellicum Pharmaceuticals Inc Methods for controlling t cell proliferation
WO2014165818A2 (en) * 2013-04-05 2014-10-09 T Cell Therapeutics, Inc. Compositions and methods for preventing and treating prostate cancer
JP6546160B2 (ja) * 2013-06-10 2019-07-17 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド 腫瘍細胞による免疫抑制を低下させるための方法および組成物
CA2956667A1 (en) 2013-07-29 2015-02-05 Bluebird Bio, Inc. Multipartite signaling proteins and uses thereof
EP3087101A4 (en) 2013-12-20 2017-12-06 Novartis AG Regulatable chimeric antigen receptor
ES2767423T3 (es) * 2014-01-13 2020-06-17 Hope City Receptores de antígenos quiméricos (CARS) con mutaciones en la región del espaciador Fc y métodos para su uso
RU2016130349A (ru) * 2014-01-24 2018-03-01 Дженентек, Инк. Способы применения антител против steap1 и иммуноконъюгатов
CN111849912B (zh) 2014-02-14 2024-03-15 贝里坤制药股份有限公司 用诱导型嵌合多肽活化t细胞的方法
JP2017524365A (ja) 2014-08-12 2017-08-31 アントフロゲネシス コーポレーション リンパ節のb細胞領域、皮膚、または腸管にホーミングするように操作されたcar−t細胞
JP7146397B2 (ja) 2014-11-17 2022-10-04 アディセット バイオ, インコーポレイテッド 改変γδT細胞
WO2016205176A1 (en) * 2015-06-15 2016-12-22 Genentech, Inc. Antibodies and immunoconjugates
AR106199A1 (es) * 2015-10-02 2017-12-20 Hoffmann La Roche Moléculas de unión a antígeno biespecíficas activadoras de células t
GB201518136D0 (en) * 2015-10-14 2015-11-25 Glaxosmithkline Ip Dev Ltd Novel chimeric antigen receptors
MX2019006374A (es) 2016-12-02 2019-09-11 Univ Southern California Receptores inmunes sinteticos y metodos de usos de ellos.
TW202019473A (zh) * 2018-07-02 2020-06-01 美商安進公司 抗steap1抗原結合蛋白

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PH12021550120A1 (en) 2021-10-04
MX2021000617A (es) 2021-04-13
US20210277148A1 (en) 2021-09-09
TW202019464A (zh) 2020-06-01
SG11202100464UA (en) 2021-02-25
JP7459046B2 (ja) 2024-04-01
AR117950A1 (es) 2021-09-08
JOP20210011A1 (ar) 2021-01-17
WO2020018695A1 (en) 2020-01-23
PE20210315A1 (es) 2021-02-16
CR20210091A (es) 2021-03-24
CN112771080A (zh) 2021-05-07
EP3823993A1 (en) 2021-05-26
MA53167A (fr) 2021-05-26
KR20210033025A (ko) 2021-03-25
BR112021000914A2 (pt) 2021-04-13
JP2021530233A (ja) 2021-11-11
CA3106653A1 (en) 2020-01-23
CO2021000660A2 (es) 2021-01-29
UY38309A (es) 2020-01-31
IL280238A (en) 2021-03-01
CL2021000136A1 (es) 2021-06-11

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