EA202190304A1 - Химерные рецепторы к steap1 и способы их применения - Google Patents
Химерные рецепторы к steap1 и способы их примененияInfo
- Publication number
- EA202190304A1 EA202190304A1 EA202190304A EA202190304A EA202190304A1 EA 202190304 A1 EA202190304 A1 EA 202190304A1 EA 202190304 A EA202190304 A EA 202190304A EA 202190304 A EA202190304 A EA 202190304A EA 202190304 A1 EA202190304 A1 EA 202190304A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- steap1
- methods
- chimeric receptors
- application
- antigen
- Prior art date
Links
- 101000628547 Homo sapiens Metalloreductase STEAP1 Proteins 0.000 title abstract 3
- 102100026712 Metalloreductase STEAP1 Human genes 0.000 title abstract 3
- 108700010039 chimeric receptor Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 210000002865 immune cell Anatomy 0.000 abstract 2
- 238000001514 detection method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464493—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; Prostatic acid phosphatase [PAP]; Prostate-specific G-protein-coupled receptor [PSGR]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70507—CD2
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70546—Integrin superfamily
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
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- A61K38/00—Medicinal preparations containing peptides
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
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- C07K2317/00—Immunoglobulins specific features
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- C07K2317/515—Complete light chain, i.e. VL + CL
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- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C07K2319/00—Fusion polypeptide
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C12N2510/00—Genetically modified cells
Abstract
В соответствии с настоящим изобретением раскрыты антигенсвязывающие молекулы, химерные рецепторы и сконструированные иммунные клетки, связывающиеся с STEAP1. Настоящее изобретение также относится к векторам, композициям и способам лечения и/или выявления с использованием антигенсвязывающих молекул и сконструированных иммунных клеток, связывающих STEAP1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862700178P | 2018-07-18 | 2018-07-18 | |
PCT/US2019/042245 WO2020018695A1 (en) | 2018-07-18 | 2019-07-17 | Chimeric receptors to steap1 and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
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EA202190304A1 true EA202190304A1 (ru) | 2022-01-21 |
Family
ID=67515138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202190304A EA202190304A1 (ru) | 2018-07-18 | 2019-07-17 | Химерные рецепторы к steap1 и способы их применения |
Country Status (23)
Country | Link |
---|---|
US (1) | US20210277148A1 (ru) |
EP (1) | EP3823993A1 (ru) |
JP (1) | JP7459046B2 (ru) |
KR (1) | KR20210033025A (ru) |
CN (1) | CN112771080A (ru) |
AR (1) | AR117950A1 (ru) |
AU (1) | AU2019307607A1 (ru) |
BR (1) | BR112021000914A2 (ru) |
CA (1) | CA3106653A1 (ru) |
CL (1) | CL2021000136A1 (ru) |
CO (1) | CO2021000660A2 (ru) |
CR (1) | CR20210091A (ru) |
EA (1) | EA202190304A1 (ru) |
IL (1) | IL280238A (ru) |
JO (1) | JOP20210011A1 (ru) |
MA (1) | MA53167A (ru) |
MX (1) | MX2021000617A (ru) |
PE (1) | PE20210315A1 (ru) |
PH (1) | PH12021550120A1 (ru) |
SG (1) | SG11202100464UA (ru) |
TW (1) | TW202019464A (ru) |
UY (1) | UY38309A (ru) |
WO (1) | WO2020018695A1 (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW202019473A (zh) | 2018-07-02 | 2020-06-01 | 美商安進公司 | 抗steap1抗原結合蛋白 |
WO2023091954A2 (en) * | 2021-11-19 | 2023-05-25 | The Trustees Of The University Of Pennsylvania | Engineered pan-leukocyte antigen cd45 to facilitate car t cell therapy |
WO2023154890A2 (en) * | 2022-02-11 | 2023-08-17 | Fred Hutchinson Cancer Center | Chimeric antigen receptors binding steap1 |
GB202208119D0 (en) * | 2022-06-01 | 2022-07-13 | Univ Oslo Hf | Anti-steap1 car |
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AR106199A1 (es) * | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | Moléculas de unión a antígeno biespecíficas activadoras de células t |
GB201518136D0 (en) * | 2015-10-14 | 2015-11-25 | Glaxosmithkline Ip Dev Ltd | Novel chimeric antigen receptors |
MX2019006374A (es) | 2016-12-02 | 2019-09-11 | Univ Southern California | Receptores inmunes sinteticos y metodos de usos de ellos. |
TW202019473A (zh) * | 2018-07-02 | 2020-06-01 | 美商安進公司 | 抗steap1抗原結合蛋白 |
-
2019
- 2019-07-17 JO JOP/2021/0011A patent/JOP20210011A1/ar unknown
- 2019-07-17 JP JP2021502538A patent/JP7459046B2/ja active Active
- 2019-07-17 SG SG11202100464UA patent/SG11202100464UA/en unknown
- 2019-07-17 AU AU2019307607A patent/AU2019307607A1/en active Pending
- 2019-07-17 CR CR20210091A patent/CR20210091A/es unknown
- 2019-07-17 PE PE2021000076A patent/PE20210315A1/es unknown
- 2019-07-17 MA MA053167A patent/MA53167A/fr unknown
- 2019-07-17 US US17/260,977 patent/US20210277148A1/en active Pending
- 2019-07-17 KR KR1020217004607A patent/KR20210033025A/ko unknown
- 2019-07-17 CN CN201980060357.XA patent/CN112771080A/zh active Pending
- 2019-07-17 CA CA3106653A patent/CA3106653A1/en active Pending
- 2019-07-17 EA EA202190304A patent/EA202190304A1/ru unknown
- 2019-07-17 MX MX2021000617A patent/MX2021000617A/es unknown
- 2019-07-17 BR BR112021000914-0A patent/BR112021000914A2/pt unknown
- 2019-07-17 WO PCT/US2019/042245 patent/WO2020018695A1/en active Application Filing
- 2019-07-17 EP EP19749064.2A patent/EP3823993A1/en active Pending
- 2019-07-18 TW TW108125431A patent/TW202019464A/zh unknown
- 2019-07-18 AR ARP190102027A patent/AR117950A1/es unknown
- 2019-07-19 UY UY0001038309A patent/UY38309A/es unknown
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2021
- 2021-01-15 PH PH12021550120A patent/PH12021550120A1/en unknown
- 2021-01-18 IL IL280238A patent/IL280238A/en unknown
- 2021-01-18 CL CL2021000136A patent/CL2021000136A1/es unknown
- 2021-01-22 CO CONC2021/0000660A patent/CO2021000660A2/es unknown
Also Published As
Publication number | Publication date |
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AU2019307607A1 (en) | 2021-02-11 |
PH12021550120A1 (en) | 2021-10-04 |
MX2021000617A (es) | 2021-04-13 |
US20210277148A1 (en) | 2021-09-09 |
TW202019464A (zh) | 2020-06-01 |
SG11202100464UA (en) | 2021-02-25 |
JP7459046B2 (ja) | 2024-04-01 |
AR117950A1 (es) | 2021-09-08 |
JOP20210011A1 (ar) | 2021-01-17 |
WO2020018695A1 (en) | 2020-01-23 |
PE20210315A1 (es) | 2021-02-16 |
CR20210091A (es) | 2021-03-24 |
CN112771080A (zh) | 2021-05-07 |
EP3823993A1 (en) | 2021-05-26 |
MA53167A (fr) | 2021-05-26 |
KR20210033025A (ko) | 2021-03-25 |
BR112021000914A2 (pt) | 2021-04-13 |
JP2021530233A (ja) | 2021-11-11 |
CA3106653A1 (en) | 2020-01-23 |
CO2021000660A2 (es) | 2021-01-29 |
UY38309A (es) | 2020-01-31 |
IL280238A (en) | 2021-03-01 |
CL2021000136A1 (es) | 2021-06-11 |
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