MX369545B - Receptor de antígeno químerico y métodos para usarlo. - Google Patents
Receptor de antígeno químerico y métodos para usarlo.Info
- Publication number
- MX369545B MX369545B MX2015010522A MX2015010522A MX369545B MX 369545 B MX369545 B MX 369545B MX 2015010522 A MX2015010522 A MX 2015010522A MX 2015010522 A MX2015010522 A MX 2015010522A MX 369545 B MX369545 B MX 369545B
- Authority
- MX
- Mexico
- Prior art keywords
- car
- antigen receptor
- chimeric antigen
- methods
- present disclosure
- Prior art date
Links
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 title abstract 6
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
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- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
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- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
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- A61K39/464468—Mesothelin [MSLN]
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07—ORGANIC CHEMISTRY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12N9/90—Isomerases (5.)
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- C12Y502/01—Cis-trans-Isomerases (5.2.1)
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the structure of the chimeric antigen receptor [CAR]
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- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K2319/00—Fusion polypeptide
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
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- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a un receptor de antígeno quimérico (CAR) condicionalmente activo y heterodimérico, y un ácido nucleico que comprende una secuencia de nucleótidos que codifica el CAR. La presente descripción proporciona células genéticamente modificadas para producir el CAR. Un CAR de la presente descripción se puede utilizar en varios métodos, que también se proporcionan.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361765585P | 2013-02-15 | 2013-02-15 | |
PCT/US2014/016527 WO2014127261A1 (en) | 2013-02-15 | 2014-02-14 | Chimeric antigen receptor and methods of use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015010522A MX2015010522A (es) | 2016-06-23 |
MX369545B true MX369545B (es) | 2019-11-12 |
Family
ID=51354582
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015010522A MX369545B (es) | 2013-02-15 | 2014-02-14 | Receptor de antígeno químerico y métodos para usarlo. |
MX2019013498A MX2019013498A (es) | 2013-02-15 | 2015-08-14 | Receptor de antigeno quimerico y metodos para usarlo. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019013498A MX2019013498A (es) | 2013-02-15 | 2015-08-14 | Receptor de antigeno quimerico y metodos para usarlo. |
Country Status (21)
Country | Link |
---|---|
US (9) | US20150368342A1 (es) |
EP (5) | EP3613439B1 (es) |
JP (5) | JP6450690B2 (es) |
KR (5) | KR102332790B1 (es) |
CN (2) | CN110423282B (es) |
AU (5) | AU2014216130B2 (es) |
CA (1) | CA2901115A1 (es) |
CY (1) | CY1122386T1 (es) |
DK (2) | DK2956175T3 (es) |
ES (3) | ES2758227T3 (es) |
HK (2) | HK1218625A1 (es) |
HR (1) | HRP20192123T1 (es) |
HU (2) | HUE047487T2 (es) |
IL (3) | IL272279B2 (es) |
LT (2) | LT2956175T (es) |
MX (2) | MX369545B (es) |
NO (1) | NO2929995T3 (es) |
PL (3) | PL3300745T3 (es) |
PT (3) | PT3613439T (es) |
SI (2) | SI3613439T1 (es) |
WO (1) | WO2014127261A1 (es) |
Families Citing this family (263)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2655409A4 (en) | 2010-12-22 | 2015-07-01 | Univ Leland Stanford Junior | SUPERAGONISTS AND ANTAGONISTS OF INTERLEUKIN-2 |
EP3279315A3 (en) * | 2012-05-25 | 2018-02-28 | Cellectis | Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells |
SG11201505858VA (en) | 2013-01-28 | 2015-09-29 | St Jude Childrens Res Hospital | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
US20150368342A1 (en) | 2013-02-15 | 2015-12-24 | The Regents Of The University Of California | Chimeric antigen receptor and methods of use thereof |
US9944690B2 (en) | 2013-03-14 | 2018-04-17 | Bellicum Pharmaceuticals, Inc. | Methods for controlling T cell proliferation |
EP2970426B1 (en) * | 2013-03-15 | 2019-08-28 | Michael C. Milone | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
DK3027204T3 (da) * | 2013-07-29 | 2022-04-19 | 2Seventy Bio Inc | Flerdelte signaleringsproteiner og anvendelser deraf |
CN105722860A (zh) | 2013-09-24 | 2016-06-29 | 梅迪塞纳医疗股份有限公司 | 白介素-2融合蛋白及其应用 |
PE20210648A1 (es) | 2013-12-17 | 2021-03-26 | Genentech Inc | Anticuerpos anti-cd3 y metodos de uso |
JP6793902B2 (ja) * | 2013-12-20 | 2020-12-02 | ノバルティス アーゲー | 調節可能キメラ抗原受容体 |
ES2701846T3 (es) | 2014-01-14 | 2019-02-26 | Cellectis | Receptor de antígeno quimérico que usa dominios de reconocimiento de antígenos derivados de pez cartilaginoso |
EP3104866A4 (en) | 2014-02-14 | 2017-08-02 | Bellicum Pharmaceuticals, Inc. | Methods for activating t cells using an inducible chimeric polypeptide |
US20170081411A1 (en) * | 2014-03-15 | 2017-03-23 | Novartis Ag | Regulatable chimeric antigen receptor |
GB201405845D0 (en) | 2014-04-01 | 2014-05-14 | Ucl Business Plc | Signalling system |
CN107075482B (zh) | 2014-04-07 | 2021-03-16 | 诺华股份有限公司 | 使用抗cd19嵌合抗原受体治疗癌症 |
CN106659757B (zh) | 2014-04-24 | 2022-01-28 | 利兰斯坦福初级大学董事会 | 白介素2的超级激动剂、部分激动剂和拮抗剂 |
US10428305B2 (en) | 2014-05-15 | 2019-10-01 | National University Of Singapore | Modified natural killer cells that express IL15 and uses thereof |
WO2015188141A2 (en) * | 2014-06-06 | 2015-12-10 | Memorial Sloan-Kettering Cancer Ceneter | Mesothelin-targeted chimeric antigen receptors and uses thereof |
JP2017528433A (ja) | 2014-07-21 | 2017-09-28 | ノバルティス アーゲー | 低い免疫増強用量のmTOR阻害剤とCARの組み合わせ |
US11542488B2 (en) | 2014-07-21 | 2023-01-03 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
EP3174546B1 (en) | 2014-07-31 | 2019-10-30 | Novartis AG | Subset-optimized chimeric antigen receptor-containing t-cells |
ES2913865T3 (es) * | 2014-08-28 | 2022-06-06 | Bioatla Inc | Receptores de antígeno quimérico condicionalmente activos para células T modificadas |
US11111288B2 (en) | 2014-08-28 | 2021-09-07 | Bioatla, Inc. | Conditionally active chimeric antigen receptors for modified t-cells |
GB201415347D0 (en) * | 2014-08-29 | 2014-10-15 | Ucl Business Plc | Signalling system |
ES2688035T3 (es) | 2014-08-29 | 2018-10-30 | Gemoab Monoclonals Gmbh | Receptor de antígeno universal que expresa células inmunes para direccionamiento de antígenos múltiples diversos, procedimiento para fabricación del mismo y utilización del mismo para tratamiento de cáncer, infecciones y enfermedades autoinmunes |
EP3189148A4 (en) | 2014-09-02 | 2018-05-02 | Bellicum Pharmaceuticals, Inc. | Costimulation of chimeric antigen receptors by myd88 and cd40 polypeptides |
US10759868B2 (en) | 2014-09-04 | 2020-09-01 | Cellectis | Trophoblast glycoprotein (5T4, TPBG) specific chimeric antigen receptors for cancer immunotherapy |
EP3967709A1 (en) | 2014-09-17 | 2022-03-16 | Novartis AG | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
US20170218036A1 (en) * | 2014-10-03 | 2017-08-03 | Yale University | Innate immune system modification for anticancer therapy |
CA2963327A1 (en) * | 2014-10-07 | 2016-04-14 | Cellectis | Method for modulating car-induced immune cells activity |
WO2016057705A1 (en) | 2014-10-08 | 2016-04-14 | Novartis Ag | Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof |
EP3025719B1 (en) | 2014-11-26 | 2018-09-26 | Miltenyi Biotec GmbH | Combination immunotherapy of antigen-recognizing receptors and hematopoietic cells for the treatment of diseases |
BR112017011771A2 (pt) * | 2014-12-02 | 2018-07-10 | Prospect Chartercare Rwmc Llc | métodos e composições para o tratamento de câncer |
PT3227339T (pt) | 2014-12-05 | 2022-01-14 | Eureka Therapeutics Inc | Recetores de antigénio quiméricos que têm como alvo o recetor 4 acoplado a proteína g e utilizações dos mesmos |
RU2725819C2 (ru) | 2014-12-05 | 2020-07-06 | Мемориал Слоан-Кеттеринг Кэнсер Сентер | Антитела, нацеленные на рецептор, связанный с g-белками, и способы их применения |
US11697825B2 (en) | 2014-12-12 | 2023-07-11 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scAAV |
ES2743232T3 (es) * | 2014-12-15 | 2020-02-18 | Bellicum Pharmaceuticals Inc | Métodos para la activación o eliminación controlada de células terapéuticas |
ES2857052T3 (es) | 2014-12-19 | 2021-09-28 | Eth Zuerich | Receptores de antígenos quiméricos y métodos de uso |
WO2016098078A2 (en) * | 2014-12-19 | 2016-06-23 | Novartis Ag | Dimerization switches and uses thereof |
JP6768664B2 (ja) | 2014-12-24 | 2020-10-14 | アーディジェン, エルエルシー | 分子の細胞内送達のためのペプチドおよびナノ粒子 |
TW201631152A (zh) | 2014-12-29 | 2016-09-01 | 諾華公司 | 製造嵌合抗原受體-表現細胞之方法 |
GB201501936D0 (en) | 2015-02-05 | 2015-03-25 | Ucl Business Plc | Signalling system |
GB201503133D0 (en) | 2015-02-24 | 2015-04-08 | Ucl Business Plc And Syncona Partners Llp | Chimeric protein |
JP7237449B2 (ja) | 2015-02-27 | 2023-03-13 | アイセル・ジーン・セラピューティクス・エルエルシー | 血液系腫瘍を標的としたキメラ抗体受容体(CARs)の構成およびその使用方法 |
US10195272B2 (en) | 2015-03-02 | 2019-02-05 | The Nemours Foundation | Adoptive t-cell therapy using FcεRI-based chimeric antigen receptors for treating IgE-mediated allergic diseases |
GB201504840D0 (en) * | 2015-03-23 | 2015-05-06 | Ucl Business Plc | Chimeric antigen receptor |
WO2016161415A2 (en) * | 2015-04-02 | 2016-10-06 | Memorial Sloan Kettering Cancer Center | Tnfrsf14/ hvem proteins and methods of use thereof |
CN114958764A (zh) | 2015-04-08 | 2022-08-30 | 诺华股份有限公司 | Cd20疗法、cd22疗法和与cd19嵌合抗原受体(car)表达细胞的联合疗法 |
EP3283113A4 (en) * | 2015-04-15 | 2018-12-05 | The California Institute for Biomedical Research | Optimized pne-based chimeric receptor t cell switches and uses thereof |
EP3283619B1 (en) | 2015-04-17 | 2023-04-05 | Novartis AG | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
GB201507119D0 (en) * | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic Acid Construct |
GB201507111D0 (en) * | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic acid construct |
GB201507115D0 (en) * | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic Acid Construct |
DK3447075T3 (da) | 2015-05-15 | 2023-11-13 | Massachusetts Gen Hospital | Antagonistiske antistoffer af antitumornekrosefaktorreceptor-superfamilien |
JP2018515123A (ja) | 2015-05-18 | 2018-06-14 | ティーシーアール2 セラピューティクス インク. | 融合タンパク質を用いたtcrの再プログラミングのための組成物及び方法 |
US11173179B2 (en) | 2015-06-25 | 2021-11-16 | Icell Gene Therapeutics Llc | Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof |
CN115058395A (zh) * | 2015-06-25 | 2022-09-16 | 美商生物细胞基因治疗有限公司 | 嵌合抗原受体(car)、组合物及其使用方法 |
US10829735B2 (en) * | 2015-07-21 | 2020-11-10 | The Trustees Of The University Of Pennsylvania | Methods for improving the efficacy and expansion of immune cells |
GB201513540D0 (en) | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
MX2018001502A (es) * | 2015-08-05 | 2018-08-01 | Yoo Young Pharm Co Ltd | Receptor de antigeno quimerico y celulas t en las cuales se expresa el receptor de antigeno quimerico. |
CA2995036A1 (en) | 2015-08-06 | 2017-02-09 | Dana-Farber Cancer Institute, Inc. | Tunable endogenous protein degradation |
US11667691B2 (en) * | 2015-08-07 | 2023-06-06 | Novartis Ag | Treatment of cancer using chimeric CD3 receptor proteins |
MX2018001533A (es) | 2015-08-24 | 2018-03-15 | Cellectis | Receptores de antigeno quimerico con funciones controlables integradas. |
KR20240056636A (ko) | 2015-09-01 | 2024-04-30 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 모듈 폴리펩타이드 라이브러리 및 이의 제조 및 사용 방법 |
WO2017040930A2 (en) | 2015-09-03 | 2017-03-09 | The Trustees Of The University Of Pennsylvania | Biomarkers predictive of cytokine release syndrome |
EP3569244A1 (en) | 2015-09-23 | 2019-11-20 | CytoImmune Therapeutics, LLC | Flt3 directed car cells for immunotherapy |
US20190255107A1 (en) | 2015-10-09 | 2019-08-22 | The Brigham And Women's Hospital, Inc. | Modulation of novel immune checkpoint targets |
WO2017075465A1 (en) | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3 |
WO2017075451A1 (en) | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1 |
EP3377523A4 (en) * | 2015-11-19 | 2019-06-19 | The Regents of The University of California | IMMUNITY CELL RECEIVERS REPRESSIBLE UNDER CONDITIONS AND METHODS OF USING THE SAME |
AU2016355178B9 (en) | 2015-11-19 | 2019-05-30 | Massachusetts Institute Of Technology | Lymphocyte antigen CD5-like (CD5L)-interleukin 12B (p40) heterodimers in immunity |
WO2017091546A1 (en) * | 2015-11-23 | 2017-06-01 | Trustees Of Boston University | Methods and compositions relating to chimeric antigen receptors |
IL305238A (en) | 2015-12-16 | 2023-10-01 | Gritstone Bio Inc | Identification of neoantigens, preparation, and use |
EP3184548A1 (en) | 2015-12-23 | 2017-06-28 | Miltenyi Biotec GmbH | Chimeric antigen receptor with cytokine receptor activating or blocking domain |
MX2018008416A (es) * | 2016-01-08 | 2019-11-11 | Univ California | Polipéptidos heterodímericos condicionalmente activos y métodos para su uso. |
CA3009194A1 (en) | 2016-01-11 | 2017-07-20 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric proteins and methods of regulating gene expression |
CN108463229B (zh) | 2016-01-11 | 2023-10-17 | 斯坦福大学托管董事会 | 嵌合蛋白和免疫治疗方法 |
CN105567640A (zh) * | 2016-01-27 | 2016-05-11 | 苏州佰通生物科技有限公司 | 一种嵌合抗原受体脂肪干细胞及其制备方法 |
GB201602571D0 (en) * | 2016-02-12 | 2016-03-30 | Autolus Ltd | Signalling system |
GB201602563D0 (en) | 2016-02-12 | 2016-03-30 | Autolus Ltd | Signalling system |
US10871490B2 (en) | 2016-02-29 | 2020-12-22 | Multenyi Biotec, gmbH | Assay for detection of chimeric antigen receptor T cells |
EP3436070A4 (en) * | 2016-03-29 | 2019-11-27 | University of Southern California | CHIMERIC ANTIGENIC RECEPTORS TARGETING CANCER |
EP3436037A4 (en) * | 2016-03-31 | 2019-12-04 | University of Southern California | HIGHLY SENSITIVE AND SPECIFIC LUCIFERASE-BASED REPORTER TEST FOR ANTIGEN DETECTION |
CU20180121A7 (es) | 2016-04-01 | 2019-05-03 | Kite Pharma Inc | Receptores de antígenos quiméricos y células t |
NZ746925A (en) | 2016-04-01 | 2023-06-30 | Amgen Inc | Chimeric receptors to flt3 and methods of use thereof |
CN109641008B (zh) | 2016-04-01 | 2021-03-23 | 凯德药业股份有限公司 | 嵌合受体及其方法和用途 |
CA3019135A1 (en) | 2016-04-01 | 2017-10-05 | Kite Pharma, Inc. | Bcma binding molecules and methods of use thereof |
WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
US11976116B2 (en) | 2016-04-14 | 2024-05-07 | 2Seventy Bio, Inc. | Salvage chimeric antigen receptor systems |
WO2017180989A2 (en) | 2016-04-15 | 2017-10-19 | Memorial Sloan Kettering Cancer Center | Transgenic t cell and chimeric antigen receptor t cell compositions and related methods |
PT3455261T (pt) | 2016-05-13 | 2022-11-11 | Bioatla Llc | Anticorpos anti-ror2, fragmentos de anticorpo, seus imunoconjugados e suas utilizações |
WO2017210617A2 (en) | 2016-06-02 | 2017-12-07 | Porter, David, L. | Therapeutic regimens for chimeric antigen receptor (car)- expressing cells |
JP7114490B2 (ja) | 2016-06-24 | 2022-08-08 | アイセル・ジーン・セラピューティクス・エルエルシー | キメラ抗体受容体(CARs)の構成およびその使用方法 |
US11384156B2 (en) | 2016-07-25 | 2022-07-12 | The Nemours Foundation | Adoptive T-cell therapy using EMPD-specific chimeric antigen receptors for treating IgE-mediated allergic diseases |
CN109715668A (zh) | 2016-08-02 | 2019-05-03 | T细胞受体治疗公司 | 用于使用融合蛋白进行tcr重编程的组合物和方法 |
WO2018027197A1 (en) | 2016-08-04 | 2018-02-08 | Memorial Sloan-Kettering Cancer Center | Cancer antigen targets and uses thereof |
WO2018045034A1 (en) * | 2016-08-30 | 2018-03-08 | Promab Biotechnologies, Inc. | Chimeric antigen receptors having gitr intracellular domain as co-stimulatory domain |
US20180064758A1 (en) * | 2016-09-05 | 2018-03-08 | Ucl Business Plc | Chimeric antigen receptor |
CN107793483B (zh) * | 2016-09-06 | 2019-08-23 | 伍志强 | 嵌合抗原受体及其基因和重组表达载体、carmsln-nkt细胞及其制备方法和应用 |
US20190262399A1 (en) | 2016-09-07 | 2019-08-29 | The Broad Institute, Inc. | Compositions and methods for evaluating and modulating immune responses |
US10683355B2 (en) | 2016-09-16 | 2020-06-16 | Kissei Pharmaceutical Co., Ltd. | Genetically-modified cells and method for producing same |
EP3757120B8 (en) * | 2016-10-04 | 2022-06-15 | Precision Biosciences, Inc. | Co-stimulatory domains for use in genetically-modified cells |
TW202340473A (zh) | 2016-10-07 | 2023-10-16 | 瑞士商諾華公司 | 利用嵌合抗原受體之癌症治療 |
EP3445787B1 (en) | 2016-10-07 | 2020-12-02 | TCR2 Therapeutics Inc. | Compositions and methods for t-cell receptors reprogramming using fusion proteins |
US20200016202A1 (en) | 2016-10-07 | 2020-01-16 | The Brigham And Women's Hospital, Inc. | Modulation of novel immune checkpoint targets |
CA3041284A1 (en) * | 2016-10-20 | 2018-04-26 | Celgene Corporation | Cereblon-based heterodimerizable chimeric antigen receptors |
CA3044593A1 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
CN107058315B (zh) * | 2016-12-08 | 2019-11-08 | 上海优卡迪生物医药科技有限公司 | 敲减人PD-1的siRNA、重组表达CAR-T载体及其构建方法和应用 |
CN110191955B (zh) | 2016-12-13 | 2024-05-31 | 西雅图儿童医院(Dba西雅图儿童研究所) | 在体外和体内对工程化的细胞中表达的化学物质诱导的信号传导复合物进行外源性药物激活的方法 |
US20200095301A1 (en) | 2016-12-14 | 2020-03-26 | The Board Of Trustees Of The Leland Stanford Junior University | Il-13 superkine: immune cell targeting constructs and methods of use thereof |
AU2018207300B2 (en) * | 2017-01-10 | 2023-08-24 | The General Hospital Corporation | T cells expressing a chimeric antigen receptor |
CN107573419A (zh) * | 2017-01-24 | 2018-01-12 | 深圳市体内生物医药科技有限公司 | 一种增强t细胞抗肿瘤活性的核酸分子 |
US11649288B2 (en) | 2017-02-07 | 2023-05-16 | Seattle Children's Hospital | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
WO2018148440A1 (en) * | 2017-02-08 | 2018-08-16 | Dana-Farber Cancer Institute, Inc. | Regulating chimeric antigen receptors |
US11850262B2 (en) | 2017-02-28 | 2023-12-26 | Purdue Research Foundation | Compositions and methods for CAR T cell therapy |
TW201837175A (zh) | 2017-03-13 | 2018-10-16 | 美商凱特製藥公司 | 用於黑色素瘤之嵌合抗原受體及其用途 |
KR102624509B1 (ko) | 2017-03-27 | 2024-01-12 | 싱가포르국립대학교 | 자연 살해 세포의 ex vivo 확장 및 활성화를 위한 자극성 세포주 |
CN117384929A (zh) | 2017-03-27 | 2024-01-12 | 新加坡国立大学 | 一种编码由细胞表达的嵌合受体的多核苷酸 |
JOP20180027A1 (ar) | 2017-03-28 | 2019-01-30 | Cell Design Labs Inc | بوليبيبتيدات مخلطة و طرق لتغيير موضع الغشاء فيها |
US20200101108A1 (en) * | 2017-03-31 | 2020-04-02 | The Board Of Trustees Of The Le-Land Standford Junior University | Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling |
US11963966B2 (en) | 2017-03-31 | 2024-04-23 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating ovarian tumors |
US11913075B2 (en) | 2017-04-01 | 2024-02-27 | The Broad Institute, Inc. | Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer |
EP3610266A4 (en) | 2017-04-12 | 2021-04-21 | Massachusetts Eye and Ear Infirmary | TUMOR SIGNATURE OF METASTASIS, COMPOSITIONS OF SUBSTANCES AND USES THEREOF |
KR20240059648A (ko) | 2017-04-19 | 2024-05-07 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 조작된 항원 수용체를 발현하는 면역 세포 |
JOP20180042A1 (ar) | 2017-04-24 | 2019-01-30 | Kite Pharma Inc | نطاقات ربط مولد ضد متوافقة مع البشر وطرق الاستخدام |
AU2018265242B2 (en) * | 2017-05-12 | 2024-01-18 | Cellectis | Protease based switch chimeric antigen receptors for safer cell immunotherapy |
JP7132249B2 (ja) * | 2017-05-15 | 2022-09-06 | オートラス リミテッド | キメラ抗原受容体(car)を含む細胞 |
CN107141356B (zh) * | 2017-06-07 | 2020-03-13 | 胜武(北京)生物科技有限公司 | 一种光诱导二聚体型嵌合抗原受体 |
WO2019060174A1 (en) * | 2017-09-22 | 2019-03-28 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | CHIMERIC ANTIGENIC RECEPTORS WITH ENHANCED NFKB SIGNALING |
EP3638218A4 (en) | 2017-06-14 | 2021-06-09 | The Broad Institute, Inc. | COMPOSITIONS AND METHOD OF TARGETING COMPLEMENTING COMPONENT 3 FOR INHIBITION OF TUMOR GROWTH |
CA3067909A1 (en) | 2017-06-19 | 2018-12-27 | Medicenna Therapeutics Inc. | Uses and methods for il-2 superagonists, agonists, and fusions thereof |
US11325957B2 (en) | 2017-06-19 | 2022-05-10 | Cell Design Labs, Inc. | Methods and compositions for reducing the immunogenicity of chimeric notch receptors |
CN107446937B (zh) * | 2017-09-05 | 2020-12-25 | 深圳华云生物技术有限公司 | 嵌合抗原受体及其表达基因、光控调节的嵌合抗原受体修饰的t细胞及其应用 |
JP7382310B2 (ja) * | 2017-09-06 | 2023-11-16 | カリフォルニア インスティチュート オブ テクノロジー | シグナリング及び抗原提示の2機能性レセプター(sabr) |
CN109504697A (zh) * | 2017-09-15 | 2019-03-22 | 上海恒润达生生物科技有限公司 | 一种靶向人源化mesothelin的嵌合抗原受体的方法和用途 |
CN109553686A (zh) * | 2017-09-26 | 2019-04-02 | 南京安吉生物科技有限公司 | 一种新型可调控的双嵌合抗原受体t细胞及其构建方法和应用 |
GB201715918D0 (en) * | 2017-09-29 | 2017-11-15 | Tc Biopharm Ltd | Modified CAR-T |
KR20200087143A (ko) | 2017-10-10 | 2020-07-20 | 그릿스톤 온콜로지, 인코포레이티드 | 핫스팟을 이용한 신생항원 동정 |
WO2019084055A1 (en) | 2017-10-23 | 2019-05-02 | Massachusetts Institute Of Technology | CLASSIFICATION OF GENETIC VARIATION FROM UNICELLULAR TRANSCRIPTOMS |
KR20200069358A (ko) | 2017-10-25 | 2020-06-16 | 노파르티스 아게 | 키메라 항원 수용체 발현 세포의 제조 방법 |
WO2019094983A1 (en) | 2017-11-13 | 2019-05-16 | The Broad Institute, Inc. | Methods and compositions for treating cancer by targeting the clec2d-klrb1 pathway |
WO2019099707A1 (en) | 2017-11-16 | 2019-05-23 | Kite Pharma, Inc | Modified chimeric antigen receptors and methods of use |
CN111630602A (zh) | 2017-11-22 | 2020-09-04 | 磨石肿瘤生物技术公司 | 减少新抗原的接合表位呈递 |
US20210070831A1 (en) * | 2017-12-14 | 2021-03-11 | Celyad S.A. | Pooling signaling and costimulatory domains in flexible car design |
EP3723787A4 (en) * | 2017-12-14 | 2021-09-01 | Bluebird Bio, Inc. | DARIC INTERLEUKIN RECEPTORS |
EP3502130A1 (en) | 2017-12-20 | 2019-06-26 | St. Anna Kinderkrebsforschung | Ligand regulated protein-protein interaction system |
WO2019122188A1 (en) | 2017-12-20 | 2019-06-27 | St. Anna Kinderkrebsforschung | Ligand regulated protein-protein interaction system |
US20190194617A1 (en) * | 2017-12-22 | 2019-06-27 | Cell Design Labs, Inc. | Single- and multi-chain chimeric antigen receptors |
EP4083192A1 (en) | 2017-12-22 | 2022-11-02 | Fate Therapeutics, Inc. | Enhanced immune effector cells and use thereof |
US11994512B2 (en) | 2018-01-04 | 2024-05-28 | Massachusetts Institute Of Technology | Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity |
CN111542547B (zh) | 2018-01-04 | 2024-02-13 | 美天施生物科技有限两合公司 | 对bdca2抗原具有特异性的嵌合抗原受体 |
TW201940182A (zh) | 2018-01-22 | 2019-10-16 | 美商安德賽特公司 | Car t 細胞之使用方法 |
CN108017717B (zh) | 2018-01-24 | 2019-08-16 | 首都医科大学宣武医院 | 一种用于体外高效定向扩增的嵌合抗原受体及其应用 |
PE20211116A1 (es) * | 2018-02-08 | 2021-06-23 | Genentech Inc | Moleculas biespecificas de union al antigeno y metodos de uso |
WO2019157496A1 (en) * | 2018-02-12 | 2019-08-15 | University Of Florida Researchfoundation, Inc. | Fviii chimeric antigen receptor tregs for tolerance induction in hemophilia a |
JP2021513839A (ja) | 2018-02-16 | 2021-06-03 | カイト ファーマ インコーポレイテッドKite Pharma, Inc | 改変された多能性幹細胞並びに製造方法及び使用方法 |
EP3759491A1 (en) * | 2018-03-01 | 2021-01-06 | H. Hoffnabb-La Roche Ag | Specificity assay for novel target antigen binding moieties |
US11813292B2 (en) * | 2018-03-12 | 2023-11-14 | Immunity Bio, Inc. | Use of CD33CAR modified high affinity NK cells (t-haNK) to reduce myeloid-derived suppressor cells suppressor activity (or reduce negative impact on NK cell activity) |
KR20200127250A (ko) | 2018-03-29 | 2020-11-10 | 페이트 세러퓨틱스, 인코포레이티드 | 조작된 면역 효과기 세포 및 이의 용도 |
AU2019247830A1 (en) * | 2018-04-06 | 2020-10-22 | The Regents Of The University Of California | Trans-antigen targeting in heterogeneous cancers and methods of use thereof |
KR20210018797A (ko) | 2018-04-10 | 2021-02-18 | 암젠 인크 | Dll3에 대한 키메라 수용체 및 이의 사용 방법 |
CN108410908B (zh) * | 2018-04-12 | 2021-08-03 | 吉林大学 | 一种利用植物激素ga及小分子物质pac调节细胞通路的方法 |
US20210113615A1 (en) * | 2018-04-13 | 2021-04-22 | Ludwig Institute For Cancer Research Ltd. | Heterodimeric inactivatable chimeric antigen receptors |
US11945878B2 (en) | 2018-04-18 | 2024-04-02 | Abclon Inc. | Switch molecule and switchable chimeric antigen receptor |
US11957695B2 (en) | 2018-04-26 | 2024-04-16 | The Broad Institute, Inc. | Methods and compositions targeting glucocorticoid signaling for modulating immune responses |
EP3784259A4 (en) | 2018-04-27 | 2021-12-29 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | Rapamycin resistant cells |
US20210060071A1 (en) * | 2018-04-27 | 2021-03-04 | The Trustees Of The University Of Pennsylvania | Chimeric Antigen Receptor T Regulatory Cells for the Treatment of Atherosclerosis |
CN108715616A (zh) * | 2018-04-27 | 2018-10-30 | 上海恒润达生生物科技有限公司 | 靶向人源化间皮素的嵌合抗原受体方法和用途 |
EP3788369A1 (en) | 2018-05-01 | 2021-03-10 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
US20210213063A1 (en) | 2018-05-25 | 2021-07-15 | Novartis Ag | Combination therapy with chimeric antigen receptor (car) therapies |
CN112533943B (zh) | 2018-06-01 | 2024-03-05 | 利兰斯坦福初级大学董事会 | Il-13/il-4超级因子:免疫细胞靶向性构建体及其使用方法 |
WO2019232542A2 (en) | 2018-06-01 | 2019-12-05 | Massachusetts Institute Of Technology | Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients |
CN110577604A (zh) * | 2018-06-07 | 2019-12-17 | 亘喜生物科技(上海)有限公司 | 携带gitr共刺激信号靶向egfr的嵌合抗原受体t细胞 |
CN112203725A (zh) | 2018-06-13 | 2021-01-08 | 诺华股份有限公司 | Bcma嵌合抗原受体及其用途 |
KR20210025525A (ko) | 2018-06-22 | 2021-03-09 | 카이트 파마 인코포레이티드 | 키메라 막횡단 단백질 및 그의 용도 |
CN110669138A (zh) * | 2018-07-02 | 2020-01-10 | 中国药科大学 | 一种双嵌合抗原受体、t细胞及其构建方法与应用 |
CA3105658A1 (en) | 2018-07-13 | 2020-01-16 | The Regents Of The University Of California | Retrotransposon-based delivery vehicle and methods of use thereof |
CN112771080A (zh) | 2018-07-18 | 2021-05-07 | 美国安进公司 | 针对steap1的嵌合受体及其使用方法 |
CA3108657A1 (en) | 2018-08-09 | 2020-02-13 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
EP3844265A2 (en) | 2018-08-31 | 2021-07-07 | Novartis AG | Methods of making chimeric antigen receptor-expressing cells |
BR112021003305A2 (pt) | 2018-08-31 | 2021-05-25 | Novartis Ag | métodos para produzir células que expressam receptor de antígeno quimérico |
CN112823166A (zh) * | 2018-09-07 | 2021-05-18 | 生物蛋白有限公司 | 用于修饰的t细胞的条件活性嵌合抗原受体 |
WO2020069405A1 (en) | 2018-09-28 | 2020-04-02 | Novartis Ag | Cd22 chimeric antigen receptor (car) therapies |
EP3856782A1 (en) | 2018-09-28 | 2021-08-04 | Novartis AG | Cd19 chimeric antigen receptor (car) and cd22 car combination therapies |
US20210382068A1 (en) | 2018-10-02 | 2021-12-09 | Dana-Farber Cancer Institute, Inc. | Hla single allele lines |
EP3632460A1 (en) | 2018-10-05 | 2020-04-08 | St. Anna Kinderkrebsforschung | A group of chimeric antigen receptors (cars) |
EP3632461A1 (en) | 2018-10-05 | 2020-04-08 | St. Anna Kinderkrebsforschung | A group of chimeric antigen receptors (cars) |
CA3109747A1 (en) | 2018-10-05 | 2020-04-09 | St. Anna Kinderkrebsforschung | A group of chimeric antigen receptors (cars) |
KR20210072797A (ko) * | 2018-10-05 | 2021-06-17 | 세인트 안나 킨더크렙스포르슝 | 키메라 항원 수용체(car) 그룹 |
GB201816839D0 (en) * | 2018-10-16 | 2018-11-28 | Glaxosmithkline Ip Dev Ltd | Novel control switch |
WO2020081730A2 (en) | 2018-10-16 | 2020-04-23 | Massachusetts Institute Of Technology | Methods and compositions for modulating microenvironment |
EP3891185A2 (en) | 2018-12-05 | 2021-10-13 | F. Hoffmann-La Roche AG | Diagnostic methods and compositions for cancer immunotherapy |
WO2020118305A1 (en) * | 2018-12-07 | 2020-06-11 | The Trustees Of Columbia University In The City Of New York | Muc4 car-t cells for treating cancer |
JP7386382B2 (ja) | 2018-12-12 | 2023-11-27 | カイト ファーマ インコーポレイテッド | キメラ抗原受容体及びt細胞受容体並びに使用方法 |
US20220062394A1 (en) | 2018-12-17 | 2022-03-03 | The Broad Institute, Inc. | Methods for identifying neoantigens |
WO2020141106A1 (en) | 2019-01-03 | 2020-07-09 | Kemijski Institut | Engineered externally regulated artificial transcription regulatory system based on engineered nfat |
US11739156B2 (en) | 2019-01-06 | 2023-08-29 | The Broad Institute, Inc. Massachusetts Institute of Technology | Methods and compositions for overcoming immunosuppression |
EP3914268A1 (en) | 2019-01-23 | 2021-12-01 | Miltenyi Biotec B.V. & Co. KG | A combination of compositions for elimination and enhanced engraftment of hematopoietic stem cells in the bone marrow of a subject |
MX2021010441A (es) | 2019-03-01 | 2021-09-21 | Allogene Therapeutics Inc | Receptores antigenicos quimericos y agentes de union dirigidos a dll3. |
KR20210137085A (ko) * | 2019-03-05 | 2021-11-17 | 엔카르타, 인크. | Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도 |
WO2020186101A1 (en) | 2019-03-12 | 2020-09-17 | The Broad Institute, Inc. | Detection means, compositions and methods for modulating synovial sarcoma cells |
EP3942023A1 (en) | 2019-03-18 | 2022-01-26 | The Broad Institute, Inc. | Compositions and methods for modulating metabolic regulators of t cell pathogenicity |
WO2020201527A1 (en) | 2019-04-04 | 2020-10-08 | Umc Utrecht Holding B.V. | Modified immune receptor constructs |
WO2020210678A1 (en) | 2019-04-12 | 2020-10-15 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
KR20220004028A (ko) | 2019-04-26 | 2022-01-11 | 알로젠 테라퓨틱스 인코포레이티드 | 동종 car t 세포를 제조하는 방법 |
KR20220004076A (ko) | 2019-04-26 | 2022-01-11 | 알로젠 테라퓨틱스 인코포레이티드 | 리툭시맙-내성 키메라 항원 수용체 및 이의 용도 |
WO2020223571A1 (en) | 2019-05-01 | 2020-11-05 | Juno Therapeutics, Inc. | Cells expressing a chimeric receptor from a modified cd247 locus, related polynucleotides and methods |
CN114025788A (zh) | 2019-05-01 | 2022-02-08 | 朱诺治疗学股份有限公司 | 从经修饰的tgfbr2基因座表达重组受体的细胞、相关多核苷酸和方法 |
KR20220017914A (ko) | 2019-05-07 | 2022-02-14 | 그라셀 바이오테크놀로지스 (상하이) 컴퍼니, 리미티드 | Bcma를 표적으로 하는 조작된 면역 세포 및 그의 용도 |
EP3964238A4 (en) * | 2019-05-07 | 2022-09-14 | Gracell Biotechnologies (Shanghai) Co., Ltd. | MANIPULATED IMMUNE CELL TARGETING BCMA AND USE THEREOF |
US20220235340A1 (en) | 2019-05-20 | 2022-07-28 | The Broad Institute, Inc. | Novel crispr-cas systems and uses thereof |
US20220226464A1 (en) | 2019-05-28 | 2022-07-21 | Massachusetts Institute Of Technology | Methods and compositions for modulating immune responses |
JP2022534921A (ja) | 2019-05-28 | 2022-08-04 | ミルテニイ ビオテック ベー.ファー. ウント コー.カーゲー | 遺伝子改変t細胞の生成方法 |
US20220265715A1 (en) * | 2019-07-24 | 2022-08-25 | Eureka Therapeutics, Inc. | Chimeric antigen receptor t cells and uses thereof |
WO2021030627A1 (en) | 2019-08-13 | 2021-02-18 | The General Hospital Corporation | Methods for predicting outcomes of checkpoint inhibition and treatment thereof |
WO2021041922A1 (en) | 2019-08-30 | 2021-03-04 | The Broad Institute, Inc. | Crispr-associated mu transposase systems |
EP4028049A1 (en) | 2019-09-11 | 2022-07-20 | Miltenyi Biotec B.V. & Co. KG | In vitro method for transduction of t cells in the presence of malignant cells |
US11981922B2 (en) | 2019-10-03 | 2024-05-14 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment |
US11793787B2 (en) | 2019-10-07 | 2023-10-24 | The Broad Institute, Inc. | Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis |
AU2020362554A1 (en) * | 2019-10-08 | 2022-05-12 | Provincial Health Services Authority | Chimeric cytokine receptors |
US11844800B2 (en) | 2019-10-30 | 2023-12-19 | Massachusetts Institute Of Technology | Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia |
US20230053013A1 (en) * | 2019-12-03 | 2023-02-16 | University Of Massachusetts | Compositions and methods for optogenetic immunotherapy |
CN113087805A (zh) * | 2019-12-31 | 2021-07-09 | 华东师范大学 | 一种共表达免疫调节分子的嵌合抗原受体t细胞的制备及其应用 |
JP2023512452A (ja) * | 2020-01-13 | 2023-03-27 | ンカルタ・インコーポレイテッド | Bcma指向性細胞免疫療法組成物および方法 |
IL294715A (en) | 2020-01-23 | 2022-09-01 | Childrens Medical Ct Corp | Inducible t-cell differentiation from human pluripotent stem cells |
US20230100000A1 (en) | 2020-02-04 | 2023-03-30 | Miltenyi Biotec B.V. & Co. KG | Immune cell expressing adapter chimeric antigen receptor for sensing soluble antigens |
EP4104187A1 (en) | 2020-02-14 | 2022-12-21 | Novartis AG | Method of predicting response to chimeric antigen receptor therapy |
MX2022010685A (es) | 2020-02-27 | 2022-09-23 | Novartis Ag | Metodos de produccion de celulas que expresan receptores de antigeno quimericos. |
JP2023516008A (ja) | 2020-02-27 | 2023-04-17 | ノバルティス アーゲー | キメラ抗原受容体発現細胞を作製する方法 |
AU2021236226A1 (en) | 2020-03-11 | 2022-09-15 | The Trustees Of The University Of Pennsylvania | Methods and composition for gene delivery using an engineered viral particle |
CN113402612A (zh) | 2020-03-17 | 2021-09-17 | 西比曼生物科技(香港)有限公司 | 靶向cd19和cd20的联合嵌合抗原受体及其应用 |
US20230159644A1 (en) | 2020-04-17 | 2023-05-25 | City Of Hope | Flt3-targeted chimeric antigen receptor modified cells for treatment of flt3-positive malignancies |
EP3916388A1 (en) | 2020-05-27 | 2021-12-01 | Miltenyi Biotec B.V. & Co. KG | Reagents for detection of chimeric antigen receptor cells |
EP3915578A1 (en) | 2020-05-28 | 2021-12-01 | Miltenyi Biotec B.V. & Co. KG | Chimeric antigen receptor with a spacer comprising c2-set ig-like domains |
WO2021252804A1 (en) * | 2020-06-12 | 2021-12-16 | Nkarta, Inc. | Genetically modified natural killer cells for cd70-directed cancer immunotherapy |
WO2021260186A1 (en) | 2020-06-26 | 2021-12-30 | Juno Therapeutics Gmbh | Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods |
EP3964585A1 (en) | 2020-09-03 | 2022-03-09 | Miltenyi Biotec B.V. & Co. KG | Cd62l specific lentiviral vector particle for targeted transduction of t cell subsets |
WO2022049217A1 (en) | 2020-09-04 | 2022-03-10 | Miltenyi Biotec B.V. & Co. KG | System for inducible expression of an adapter in immune cells |
EP4240404A1 (en) | 2020-11-09 | 2023-09-13 | Miltenyi Biotec B.V. & Co. KG | Methods and compositions for eliminating engineered immune cells |
CN116635062A (zh) | 2020-11-13 | 2023-08-22 | 诺华股份有限公司 | 使用表达嵌合抗原受体(car)的细胞的组合疗法 |
AU2021409801A1 (en) | 2020-12-21 | 2023-06-22 | Allogene Therapeutics, Inc. | Protease-activating cd45-gate car |
EP4284822A1 (en) * | 2021-01-29 | 2023-12-06 | Outpace Bio, Inc. | Small molecule-regulated cell signaling expression system |
WO2022173703A1 (en) * | 2021-02-10 | 2022-08-18 | The Regents Of The University Of California | Immune receptors with synthetic co-stimulatory domains |
GB202104030D0 (en) * | 2021-03-23 | 2021-05-05 | Autolus Ltd | Signalling system |
US20240180969A1 (en) * | 2021-04-01 | 2024-06-06 | A2 Biotherapeutics, Inc. | Polypeptides targeting hla-a*11 and methods of use thereof |
GB202108366D0 (en) | 2021-06-11 | 2021-07-28 | Quell Therapeutics Ltd | Multichain chimeric antigen receptor |
US20230060292A1 (en) | 2021-07-26 | 2023-03-02 | Kite Pharma, Inc. | Split chimeric antigen receptors and methods of use |
WO2023044304A1 (en) * | 2021-09-15 | 2023-03-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric adaptor and kinase signaling proteins and their use in immunotherapy |
WO2023057285A1 (en) | 2021-10-06 | 2023-04-13 | Miltenyi Biotec B.V. & Co. KG | Method for targeted gene insertion into immune cells |
WO2023062113A1 (en) | 2021-10-15 | 2023-04-20 | Miltenyi Biotec B.V. & Co. KG | Method for the generation of genetically modified nk cells |
WO2023130462A1 (zh) * | 2022-01-10 | 2023-07-13 | 卡瑞济(北京)生命科技有限公司 | 靶向IL13Rα2的嵌合抗原受体及其用途 |
CN114736306B (zh) * | 2022-03-01 | 2024-04-19 | 中国科学院深圳先进技术研究院 | 一种受化学调控的蛋白酶工具及其配套底物 |
WO2023187031A1 (en) | 2022-04-01 | 2023-10-05 | Miltenyi Biotec B.V. & Co. KG | A system for drug-inducible expression of a polynucleotide |
WO2023217796A1 (en) | 2022-05-10 | 2023-11-16 | Miltenyi Biotec B.V. & Co. KG | Compositions comprising il-15, il-15 receptor alpha and the intracellular signaling domain of cd2 for immune cell therapy |
WO2023220459A1 (en) * | 2022-05-13 | 2023-11-16 | Northwestern University | Active loading of cargo entity into lipid bilayer particles using dimerization domains |
WO2023222617A1 (en) | 2022-05-16 | 2023-11-23 | Miltenyi Biotec B.V. & Co. KG | Endogenous signaling molecule activating chimeric antigen receptors and methods of generation thereof |
WO2024050325A2 (en) * | 2022-09-01 | 2024-03-07 | Sri International | Genetically engineered cd4 t-cells for in situ synthesis of proteins |
WO2024056809A1 (en) | 2022-09-15 | 2024-03-21 | Novartis Ag | Treatment of autoimmune disorders using chimeric antigen receptor therapy |
EP4342488A1 (en) | 2022-09-26 | 2024-03-27 | Miltenyi Biotec B.V. & Co. KG | Chimeric antigen receptor specific for folate receptor 1 |
WO2024077256A1 (en) | 2022-10-07 | 2024-04-11 | The General Hospital Corporation | Methods and compositions for high-throughput discovery ofpeptide-mhc targeting binding proteins |
WO2024078995A1 (en) | 2022-10-15 | 2024-04-18 | Miltenyi Biotec B.V. & Co. KG | Transduction of gammadelta t cells with pseudotyped retroviral vectors |
WO2024118593A1 (en) | 2022-11-28 | 2024-06-06 | Allogene Therapeutics Inc. | Claudin 18.2 targeting chimeric antigen receptors and binding agents and uses thereof |
WO2024124044A1 (en) | 2022-12-07 | 2024-06-13 | The Brigham And Women’S Hospital, Inc. | Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression |
Family Cites Families (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
US5906936A (en) | 1988-05-04 | 1999-05-25 | Yeda Research And Development Co. Ltd. | Endowing lymphocytes with antibody specificity |
US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
CA2052928A1 (en) * | 1990-10-15 | 1992-04-16 | John J. Siekierka | Genes encoding the human fk-506 binding protein and a.s. cerevisiae homolog, fkb1 and their expression |
KR100246529B1 (ko) | 1990-12-14 | 2000-04-01 | 스티븐 에이. 서윈. 엠.디. | 수용체 관련된 신호 변환 경로를 위한 키메라 사슬 |
TW197439B (es) | 1991-04-04 | 1993-01-01 | Ueno Pharmaceutics Applic Res Co Ltd | |
DK0648271T3 (da) | 1991-08-20 | 2003-07-21 | Us Gov Health & Human Serv | Adenovirusmedieret overførsel af gener til mave-/tarmkanal |
US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
AU3140093A (en) | 1991-11-22 | 1993-06-15 | University Of Mississippi, The | Synthesis and optical resolution of the taxol side chain and related compounds |
US5200534A (en) | 1992-03-13 | 1993-04-06 | University Of Florida | Process for the preparation of taxol and 10-deacetyltaxol |
FR2688514A1 (fr) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
WO1993023555A1 (en) | 1992-05-21 | 1993-11-25 | The Penn State Research Foundation | Cultured taxus tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds |
US5274137A (en) | 1992-06-23 | 1993-12-28 | Nicolaou K C | Intermediates for preparation of taxols |
US5294637A (en) | 1992-07-01 | 1994-03-15 | Bristol-Myers Squibb Company | Fluoro taxols |
US5202448A (en) | 1992-08-14 | 1993-04-13 | Napro Biotherapeutics, Inc. | Processes of converting taxanes into baccatin III |
CA2100808A1 (en) | 1992-10-01 | 1994-04-02 | Vittorio Farina | Deoxy paclitaxels |
FR2696464B1 (fr) | 1992-10-05 | 1994-11-10 | Rhone Poulenc Rorer Sa | Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III. |
FR2696458B1 (fr) | 1992-10-05 | 1994-11-10 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
FR2696461B1 (fr) | 1992-10-05 | 1994-11-10 | Rhone Poulenc Rorer Sa | Nouveaux dérivés d'analogues du taxol, leur préparation et les compositions qui les contiennent. |
FR2696463B1 (fr) | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé d'obtention de la désacétyl-10 baccatine III. |
FR2696462B1 (fr) | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé d'obtention de la désacétyl-10 baccatine III. |
CA2145641C (en) | 1992-12-03 | 2008-05-27 | Richard J. Gregory | Pseudo-adenovirus vectors |
US5279949A (en) | 1992-12-07 | 1994-01-18 | Board Of Trustees Operating Michigan State University | Process for the isolation and purification of taxol and taxanes from Taxus spp |
US5869337A (en) | 1993-02-12 | 1999-02-09 | President And Fellows Of Harvard College | Regulated transcription of targeted genes and other biological events |
US5830462A (en) | 1993-02-12 | 1998-11-03 | President & Fellows Of Harvard College | Regulated transcription of targeted genes and other biological events |
US5834266A (en) | 1993-02-12 | 1998-11-10 | President & Fellows Of Harvard College | Regulated apoptosis |
DE69435260D1 (de) * | 1993-02-12 | 2010-02-11 | Univ R | Regulierte transkription von zielgerichteten genen und andere biologische ereignisse |
US5310903A (en) | 1993-03-05 | 1994-05-10 | Merck & Co., Inc. | Imidazolidyl rapamycin derivatives |
DE69434486T2 (de) | 1993-06-24 | 2006-07-06 | Advec Inc. | Adenovirus vektoren für gentherapie |
US5824701A (en) | 1993-10-20 | 1998-10-20 | Enzon, Inc. | Taxane-based prodrugs |
ATE437232T1 (de) | 1993-10-25 | 2009-08-15 | Canji Inc | Rekombinanter adenoviren-vektor und verfahren zur verwendung |
US5415869A (en) | 1993-11-12 | 1995-05-16 | The Research Foundation Of State University Of New York | Taxol formulation |
US5527907A (en) | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
US5525610A (en) | 1994-03-31 | 1996-06-11 | American Home Products Corporation | 42-Epi-rapamycin and pharmaceutical compositions thereof |
US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
US6150527A (en) | 1994-08-18 | 2000-11-21 | Ariad Pharmaceuticals, Inc. | Synthetic multimerizing agents |
US6133456A (en) | 1994-08-18 | 2000-10-17 | Ariad Gene Therapeutics, Inc. | Synthetic multimerizing agents |
US20030036654A1 (en) | 1994-08-18 | 2003-02-20 | Holt Dennis A. | Synthetic multimerizing agents |
DE69526377T2 (de) | 1994-12-09 | 2002-11-07 | Microscience Ltd | Virulenzgene in der VGC2-Region von Salmonella |
US5712149A (en) | 1995-02-03 | 1998-01-27 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
KR19990022651A (ko) | 1995-06-07 | 1999-03-25 | 데이비드 엘. 버스테인 | 생물학적 사건에 대한 라파마이신 기재 조절방법 |
US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
GB9526131D0 (en) | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Recombinant chimeric receptors |
US5821263A (en) | 1996-08-26 | 1998-10-13 | Bristol-Myers Squibb Company | Sulfenamide taxane derivatives |
WO1998013059A1 (en) | 1996-09-27 | 1998-04-02 | Bristol-Myers Squibb Company | Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells |
WO1998022451A1 (fr) | 1996-11-19 | 1998-05-28 | Daiichi Pharmaceutical Co., Ltd. | Derives taxol |
US5977386A (en) | 1996-12-24 | 1999-11-02 | Bristol-Myers Squibb Company | 6-thio-substituted paclitaxels |
SK182599A3 (en) | 1997-06-20 | 2000-07-11 | Baker Norton Pharma | Soluble prodrugs of paclitaxel |
US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
JPH1192468A (ja) | 1997-09-17 | 1999-04-06 | Yakult Honsha Co Ltd | 新規なタキサン誘導体 |
AU741433B2 (en) | 1997-10-08 | 2001-11-29 | Bio Research Corporation Of Yokohama | Taxoid derivatives and process for producing the same |
CA2318402A1 (en) | 1998-01-15 | 1999-07-22 | Ariad Gene Therapeutics, Inc. | Regulation of biological events using multimeric chimeric proteins |
WO2000023573A2 (en) | 1998-10-20 | 2000-04-27 | City Of Hope | Cd20-specific redirected t cells and their use in cellular immunotherapy of cd20+ malignancies |
WO2001014387A1 (en) | 1999-08-24 | 2001-03-01 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
GB9925854D0 (en) * | 1999-11-01 | 1999-12-29 | Celltech Therapeutics Ltd | Biological products |
US7514239B2 (en) | 2000-03-28 | 2009-04-07 | Amgen Inc. | Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof |
US6916846B2 (en) | 2000-05-12 | 2005-07-12 | Merck & Co. Inc. | Coumermycin analogs as chemical dimerizers of chimeric proteins |
GB0025307D0 (en) | 2000-10-16 | 2000-11-29 | Celltech Chiroscience Ltd | Biological products |
US7446179B2 (en) | 2000-11-07 | 2008-11-04 | City Of Hope | CD19-specific chimeric T cell receptor |
GB0105402D0 (en) | 2001-03-05 | 2001-04-18 | Inpharmatica Ltd | Novel proteins |
GB0105924D0 (en) | 2001-03-09 | 2001-04-25 | Microscience Ltd | Promoter |
AU2003223244A1 (en) | 2002-03-11 | 2003-09-29 | The Johns Hopkins University | Molecular switches and methods for making and using the same |
US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
US7404950B2 (en) | 2003-02-18 | 2008-07-29 | Baylor College Of Medicine | Induced activation in dendritic cell |
US20050113564A1 (en) | 2003-11-05 | 2005-05-26 | St. Jude Children's Research Hospital | Chimeric receptors with 4-1BB stimulatory signaling domain |
US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
WO2006036445A2 (en) | 2004-09-24 | 2006-04-06 | Trustees Of Dartmouth College | Chimeric nk receptor and methods for treating cancer |
US8236925B1 (en) | 2005-08-26 | 2012-08-07 | University Of Minnesota | Protein nanorings |
AT503861B1 (de) | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | Verfahren zur manipulation von t-zell-rezeptoren |
WO2011053825A2 (en) * | 2009-10-30 | 2011-05-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions and methods for the treatment or prevention of mitochondrial diseases |
PL2519543T3 (pl) | 2009-12-29 | 2016-12-30 | Białka wiążące heterodimery i ich zastosowania | |
WO2011119773A1 (en) * | 2010-03-23 | 2011-09-29 | Roeth Jeremiah F | Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof |
CA3122219A1 (en) | 2010-04-16 | 2011-10-20 | The Children's Hospital Corporation | Sustained polypeptide expression from synthetic, modified rnas and uses thereof |
US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
MX349622B (es) | 2010-09-08 | 2017-08-07 | Halozyme Inc | Metodos para evaluar e identificar o evolucionar proteinas terapeuticas condicionalmente activas. |
FR2968013A1 (fr) * | 2010-11-29 | 2012-06-01 | Cis Bio Int | Methode de retention conditionnelle d'une proteine d'interet dans le reticulum endoplasmique |
US9499629B2 (en) | 2010-12-09 | 2016-11-22 | The Trustees Of The University Of Pennsylvania | Use of chimeric antigen receptor-modified T-cells to treat cancer |
JP2014509841A (ja) * | 2011-01-18 | 2014-04-24 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 癌を治療するための組成物および方法 |
EP3279315A3 (en) | 2012-05-25 | 2018-02-28 | Cellectis | Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells |
PT2893004T (pt) | 2012-09-04 | 2019-01-21 | Cellectis | Recetor de antígeno quimérico de cadeia múltipla e utilizações do mesmo |
WO2014055657A1 (en) * | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
US20150368342A1 (en) | 2013-02-15 | 2015-12-24 | The Regents Of The University Of California | Chimeric antigen receptor and methods of use thereof |
US9944690B2 (en) | 2013-03-14 | 2018-04-17 | Bellicum Pharmaceuticals, Inc. | Methods for controlling T cell proliferation |
EP2970426B1 (en) | 2013-03-15 | 2019-08-28 | Michael C. Milone | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
ES2741308T3 (es) * | 2013-10-15 | 2020-02-10 | Scripps Research Inst | Interruptores de células T con receptores de antígenos quiméricos y usos de los mismos |
JP6793902B2 (ja) | 2013-12-20 | 2020-12-02 | ノバルティス アーゲー | 調節可能キメラ抗原受容体 |
EP3104866A4 (en) | 2014-02-14 | 2017-08-02 | Bellicum Pharmaceuticals, Inc. | Methods for activating t cells using an inducible chimeric polypeptide |
US20170081411A1 (en) * | 2014-03-15 | 2017-03-23 | Novartis Ag | Regulatable chimeric antigen receptor |
GB201405845D0 (en) | 2014-04-01 | 2014-05-14 | Ucl Business Plc | Signalling system |
CA2963327A1 (en) | 2014-10-07 | 2016-04-14 | Cellectis | Method for modulating car-induced immune cells activity |
EP3377523A4 (en) | 2015-11-19 | 2019-06-19 | The Regents of The University of California | IMMUNITY CELL RECEIVERS REPRESSIBLE UNDER CONDITIONS AND METHODS OF USING THE SAME |
MX2018008416A (es) | 2016-01-08 | 2019-11-11 | Univ California | Polipéptidos heterodímericos condicionalmente activos y métodos para su uso. |
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