ES2653487T3 - Receptor de antígeno quimérico y métodos de uso del mismo - Google Patents

Receptor de antígeno quimérico y métodos de uso del mismo Download PDF

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ES2653487T3
ES2653487T3 ES14751227T ES14751227T ES2653487T3 ES 2653487 T3 ES2653487 T3 ES 2653487T3 ES 14751227 T ES14751227 T ES 14751227T ES 14751227 T ES14751227 T ES 14751227T ES 2653487 T3 ES2653487 T3 ES 2653487T3
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domain
pair
polypeptide
specific binding
antigen receptor
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Chia-Yung WU
James Onuffer
Wendell A. Lim
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University of California
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University of California
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464411—Immunoglobulin superfamily
    • A61K39/464412—CD19 or B4
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    • A61K39/464466—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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Abstract

Un receptor de antígeno quimérico (CAR) heterodimérico condicionalmente activo que comprende: a) un primer polipéptido que comprende: i) un primer miembro de un par de unión específica; ii) un primer dominio coestimulador; iii) un primer miembro de un par de dimerización; y iv) un dominio transmembrana interpuesto entre el primer miembro de un par de unión específica y el primer dominio coestimulador; y b) un segundo polipéptido que comprende: i) un dominio transmembrana; ii) un segundo dominio coestimulador; iii) un segundo miembro del par de dimerización; y iv) un dominio de señalización intracelular; o que comprende: a) un primer polipéptido que comprende: i) un primer miembro de un par de unión específica; ii) un dominio coestimulador; iii) un primer miembro de un par de dimerización; iv) un dominio transmembrana interpuesto entre el primer miembro de un par de unión específica y el dominio coestimulador; y b) un segundo polipéptido que comprende: i) un segundo miembro del par de dimerización; y ii) un dominio de señalización intracelular, en donde los miembros primero y segundo del par de dimerización forman un homodímero o un heterodímero en presencia de un agente dimerizador
ES14751227T 2013-02-15 2014-02-14 Receptor de antígeno quimérico y métodos de uso del mismo Active ES2653487T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361765585P 2013-02-15 2013-02-15
PCT/US2014/016527 WO2014127261A1 (en) 2013-02-15 2014-02-14 Chimeric antigen receptor and methods of use thereof

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ES2653487T3 true ES2653487T3 (es) 2018-02-07

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ES19188398T Active ES2868247T3 (es) 2013-02-15 2014-02-14 Receptor de antígeno quimérico y métodos de uso del mismo
ES17187293T Active ES2758227T3 (es) 2013-02-15 2014-02-14 Receptor de antígeno quimérico y métodos de uso del mismo
ES14751227T Active ES2653487T3 (es) 2013-02-15 2014-02-14 Receptor de antígeno quimérico y métodos de uso del mismo

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ES19188398T Active ES2868247T3 (es) 2013-02-15 2014-02-14 Receptor de antígeno quimérico y métodos de uso del mismo
ES17187293T Active ES2758227T3 (es) 2013-02-15 2014-02-14 Receptor de antígeno quimérico y métodos de uso del mismo

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US (9) US20150368342A1 (es)
EP (5) EP3881868B1 (es)
JP (5) JP6450690B2 (es)
KR (5) KR102132246B1 (es)
CN (2) CN110423282B (es)
AU (5) AU2014216130B2 (es)
BR (1) BR112015019640A2 (es)
CA (1) CA2901115A1 (es)
CY (1) CY1122386T1 (es)
DK (2) DK3300745T3 (es)
ES (3) ES2868247T3 (es)
HK (2) HK1218625A1 (es)
HR (1) HRP20192123T1 (es)
HU (2) HUE036250T2 (es)
IL (3) IL305629A (es)
LT (2) LT2956175T (es)
MX (2) MX369545B (es)
NO (1) NO2929995T3 (es)
PL (3) PL3300745T3 (es)
PT (3) PT3613439T (es)
SI (2) SI3300745T1 (es)
WO (1) WO2014127261A1 (es)

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ES2758227T3 (es) 2020-05-04
US20210196757A1 (en) 2021-07-01
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US20170143765A1 (en) 2017-05-25
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US20170340672A1 (en) 2017-11-30
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WO2014127261A1 (en) 2014-08-21
US11478510B2 (en) 2022-10-25
KR20230022452A (ko) 2023-02-15
US20200237824A1 (en) 2020-07-30
PL3300745T3 (pl) 2020-03-31
EP3881868B1 (en) 2023-09-27
PT2956175T (pt) 2017-12-26
ES2868247T3 (es) 2021-10-21
KR102132246B1 (ko) 2020-07-09
JP2019068822A (ja) 2019-05-09
DK3300745T3 (da) 2019-11-04
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AU2021204054A1 (en) 2021-07-08
US10632152B2 (en) 2020-04-28
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