CN115776991A - 改进的t细胞受体-共刺激分子嵌合物 - Google Patents

改进的t细胞受体-共刺激分子嵌合物 Download PDF

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CN115776991A
CN115776991A CN202180033726.3A CN202180033726A CN115776991A CN 115776991 A CN115776991 A CN 115776991A CN 202180033726 A CN202180033726 A CN 202180033726A CN 115776991 A CN115776991 A CN 115776991A
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tcr
chain
modified
cells
constant region
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王嘉盛
虞莉
贾乐梅
刘玥
赵学强
芮魏
周志霄
刘光娜
林欣
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Tsinghua University
Bristar Immunotech Ltd
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Tsinghua University
Bristar Immunotech Ltd
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Abstract

提供一种改进的T细胞受体‑共刺激分子嵌合物，尤其涉及一种包含共刺激分子的T细胞受体(TCR)或TCR复合物、包含所述TCR或TCR复合物的T细胞以及它们的用途。

Description

PCT国内申请，说明书已公开。

Claims (65)

  1. PCT国内申请，权利要求书已公开。
CN202180033726.3A 2020-05-07 2021-05-06 改进的t细胞受体-共刺激分子嵌合物 Pending CN115776991A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN2020103777262 2020-05-07
CN202010377726 2020-05-07
CN202010449454 2020-05-25
CN2020104494542 2020-05-25
CN2020115491764 2020-12-24
CN202011549176 2020-12-24
PCT/CN2021/091897 WO2021223707A1 (zh) 2020-05-07 2021-05-06 改进的t细胞受体-共刺激分子嵌合物

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CN115776991A true CN115776991A (zh) 2023-03-10

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US (1) US20240148869A1 (zh)
EP (1) EP4159767A4 (zh)
JP (1) JP2023535229A (zh)
KR (1) KR20230060488A (zh)
CN (1) CN115776991A (zh)
CA (1) CA3187163A1 (zh)
WO (1) WO2021223707A1 (zh)

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KR20220131253A (ko) * 2019-12-30 2022-09-27 차이나 이뮤노테크 (베이징) 바이오테크놀로지 컴퍼니 리미티드 향상된 t-세포 수용체 star 및 이의 적용
CN118696123A (zh) * 2022-07-10 2024-09-24 清华大学 经修饰的免疫细胞
WO2024062138A1 (en) 2022-09-23 2024-03-28 Mnemo Therapeutics Immune cells comprising a modified suv39h1 gene
WO2024140710A1 (zh) * 2022-12-26 2024-07-04 华夏英泰（北京）生物技术有限公司 一种特异性结合lilrb4的合成t细胞受体抗原受体及其应用
CN116574748B (zh) * 2023-07-10 2023-09-12 昆明医科大学 一种用于靶向KRAS高频突变肿瘤的嵌合型nTCR-T构建方法

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