|
US9428567B2
(en)
|
2010-12-22 |
2016-08-30 |
The Board Of Trustees Of The Leland Stanford Junior University |
Antagonists of interleukin-2 receptor
|
|
KR102437522B1
(ko)
*
|
2012-05-25 |
2022-08-26 |
셀렉티스 |
면역요법을 위한 동종이형 및 면역억제제 저항성인 ｔ 세포의 조작 방법
|
|
EP2934532B1
(en)
|
2012-12-20 |
2019-10-23 |
Purdue Research Foundation |
Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
|
|
EP2948544A4
(en)
|
2013-01-28 |
2016-08-03 |
St Jude Childrens Res Hospital |
CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES
|
|
EP4303232A3
(en)
|
2013-02-15 |
2024-04-17 |
The Regents of The University of California |
Chimeric antigen receptor and methods of use thereof
|
|
WO2014151960A2
(en)
|
2013-03-14 |
2014-09-25 |
Bellicum Pharmaceuticals, Inc. |
Methods for controlling t cell proliferation
|
|
EP2970426B1
(en)
|
2013-03-15 |
2019-08-28 |
Michael C. Milone |
Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
|
|
WO2015017214A1
(en)
|
2013-07-29 |
2015-02-05 |
Bluebird Bio, Inc. |
Multipartite signaling proteins and uses thereof
|
|
CN105722860A
(zh)
|
2013-09-24 |
2016-06-29 |
梅迪塞纳医疗股份有限公司 |
白介素-2融合蛋白及其应用
|
|
UA129760C2
(uk)
|
2013-12-17 |
2025-07-30 |
Дженентек, Інк. |
Анти-cd3 антитіло та спосіб його застосування
|
|
US10287354B2
(en)
|
2013-12-20 |
2019-05-14 |
Novartis Ag |
Regulatable chimeric antigen receptor
|
|
ES2701846T3
(es)
*
|
2014-01-14 |
2019-02-26 |
Cellectis |
Receptor de antígeno quimérico que usa dominios de reconocimiento de antígenos derivados de pez cartilaginoso
|
|
US10934346B2
(en)
|
2014-02-14 |
2021-03-02 |
Bellicum Pharmaceuticals, Inc. |
Modified T cell comprising a polynucleotide encoding an inducible stimulating molecule comprising MyD88, CD40 and FKBP12
|
|
US20170081411A1
(en)
*
|
2014-03-15 |
2017-03-23 |
Novartis Ag |
Regulatable chimeric antigen receptor
|
|
GB201405845D0
(en)
*
|
2014-04-01 |
2014-05-14 |
Ucl Business Plc |
Signalling system
|
|
AU2015244039B2
(en)
|
2014-04-07 |
2021-10-21 |
Novartis Ag |
Treatment of cancer using anti-CD19 chimeric antigen receptor
|
|
RU2763795C2
(ru)
|
2014-04-23 |
2022-01-11 |
Джуно Терапьютикс, Инк. |
Способы выделения, культивирования и генетической инженерии популяций клеток иммунной системы для адоптивной терапии
|
|
WO2015164815A1
(en)
|
2014-04-24 |
2015-10-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Superagonists, partial agonists and antagonists of interleukin-2
|
|
AU2015259877B2
(en)
|
2014-05-15 |
2021-02-25 |
National University Of Singapore |
Modified natural killer cells and uses thereof
|
|
ES2928000T3
(es)
*
|
2014-06-06 |
2022-11-14 |
Memorial Sloan Kettering Cancer Center |
Receptores de antígeno quimérico dirigidos a mesotelina y usos de los mismos
|
|
US11542488B2
(en)
|
2014-07-21 |
2023-01-03 |
Novartis Ag |
Sortase synthesized chimeric antigen receptors
|
|
TWI750110B
(zh)
|
2014-07-21 |
2021-12-21 |
瑞士商諾華公司 |
使用人類化抗-ｂｃｍａ嵌合抗原受體治療癌症
|
|
WO2016014530A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Combinations of low, immune enhancing. doses of mtor inhibitors and cars
|
|
ES2781175T3
(es)
|
2014-07-31 |
2020-08-31 |
Novartis Ag |
Subconjunto optimizado de células T que contienen un receptor de antígeno quimérico
|
|
WO2016033331A1
(en)
*
|
2014-08-28 |
2016-03-03 |
Bioatla, Llc |
Conditionally active chimeric antigen receptors for modified t-cells
|
|
US11111288B2
(en)
|
2014-08-28 |
2021-09-07 |
Bioatla, Inc. |
Conditionally active chimeric antigen receptors for modified t-cells
|
|
EP2990416B1
(en)
|
2014-08-29 |
2018-06-20 |
GEMoaB Monoclonals GmbH |
Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders
|
|
GB201415347D0
(en)
*
|
2014-08-29 |
2014-10-15 |
Ucl Business Plc |
Signalling system
|
|
US10888608B2
(en)
|
2014-09-02 |
2021-01-12 |
Bellicum Pharmaceuticals, Inc. |
Costimulation of chimeric antigen receptors by MyD88 and CD40 polypeptides
|
|
ES2777305T5
(en)
|
2014-09-04 |
2025-09-30 |
Cellectis |
Trophoblast glycoprotein (5t4, tpbg) specific chimeric antigen receptors for cancer immunotherapy
|
|
KR20250067191A
(ko)
*
|
2014-09-17 |
2025-05-14 |
노파르티스 아게 |
입양 면역요법을 위한 키메라 수용체에 의한 세포독성 세포의 표적화
|
|
JP2017532325A
(ja)
*
|
2014-10-03 |
2017-11-02 |
イエール ユニバーシティ |
抗癌療法のための自然免疫系の改変
|
|
JP2017531430A
(ja)
*
|
2014-10-07 |
2017-10-26 |
セレクティスＣｅｌｌｅｃｔｉｓ |
Ｃａｒによって誘導される免疫細胞の活性を調節するための方法
|
|
KR20170068504A
(ko)
|
2014-10-08 |
2017-06-19 |
노파르티스 아게 |
키메라 항원 수용체 요법에 대한 치료 반응성을 예측하는 바이오마커 및 그의 용도
|
|
US10201606B2
(en)
|
2014-11-26 |
2019-02-12 |
Miltenyi Biotec Gmbh |
Combination immunotherapy of antigen-recognizing receptors and hematopoietic cells for the treatment of diseases
|
|
SG10202103475XA
(en)
*
|
2014-12-02 |
2021-05-28 |
Prospect Chartercare Rwmc Llc |
Methods and compositons for treating cancer
|
|
EP3227324A4
(en)
|
2014-12-05 |
2018-08-29 |
Memorial Sloan Kettering Cancer Center |
Antibodies targeting g-protein coupled receptor and methods of use
|
|
SI3227339T1
(sl)
*
|
2014-12-05 |
2022-02-28 |
Memorial Sloan-Kettering Cancer Center |
Himerni antigenski receptorji, ki ciljajo na receptor, povezan z G-proteinom, in njihova uporaba
|
|
HK1245326A1
(zh)
|
2014-12-12 |
2018-08-24 |
Voyager Therapeutics, Inc. |
用於生产scaav的组合物和方法
|
|
EP4400516A1
(en)
|
2014-12-15 |
2024-07-17 |
The Regents of the University of California |
Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20
|
|
HK1245827B
(en)
*
|
2014-12-15 |
2020-06-19 |
Board Of Regents Of The University Of Texas System |
Methods for controlled activation or elimination of therapeutic cells
|
|
EP3234120B1
(en)
|
2014-12-15 |
2025-09-03 |
The Regents of the University of California |
Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing
|
|
US20190054117A1
(en)
*
|
2014-12-19 |
2019-02-21 |
Novartis Ag |
Dimerization switches and uses thereof
|
|
EP3233903B1
(en)
*
|
2014-12-19 |
2020-12-09 |
ETH Zürich |
Chimeric antigen receptors and methods of use
|
|
EP3237436B1
(en)
|
2014-12-24 |
2019-05-01 |
Aadigen, Llc |
Peptides and nanoparticles for intracellular delivery of molecules
|
|
CA3197849A1
(en)
|
2014-12-29 |
2016-07-07 |
Novartis Ag |
Methods of making chimeric antigen receptor-expressing cells
|
|
GB201501936D0
(en)
|
2015-02-05 |
2015-03-25 |
Ucl Business Plc |
Signalling system
|
|
GB201503133D0
(en)
|
2015-02-24 |
2015-04-08 |
Ucl Business Plc And Syncona Partners Llp |
Chimeric protein
|
|
JP7237449B2
(ja)
|
2015-02-27 |
2023-03-13 |
アイセル・ジーン・セラピューティクス・エルエルシー |
血液系腫瘍を標的としたキメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法
|
|
US10195272B2
(en)
|
2015-03-02 |
2019-02-05 |
The Nemours Foundation |
Adoptive t-cell therapy using FcεRI-based chimeric antigen receptors for treating IgE-mediated allergic diseases
|
|
GB201504840D0
(en)
*
|
2015-03-23 |
2015-05-06 |
Ucl Business Plc |
Chimeric antigen receptor
|
|
US11261232B2
(en)
|
2015-04-02 |
2022-03-01 |
Memorial Sloan Kettering Cancer Center |
TNFRSF14 / HVEM proteins and methods of use thereof
|
|
MX2017012939A
(es)
|
2015-04-08 |
2018-05-22 |
Novartis Ag |
Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19.
|
|
WO2016168773A2
(en)
*
|
2015-04-15 |
2016-10-20 |
The California Institute For Biomedical Research |
Optimized pne-based chimeric receptor t cell switches and uses thereof
|
|
SG11201708516YA
(en)
|
2015-04-17 |
2017-11-29 |
David Maxwell Barrett |
Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
|
|
GB201507119D0
(en)
*
|
2015-04-27 |
2015-06-10 |
Ucl Business Plc |
Nucleic Acid Construct
|
|
GB201507111D0
(en)
*
|
2015-04-27 |
2015-06-10 |
Ucl Business Plc |
Nucleic acid construct
|
|
GB201507115D0
(en)
*
|
2015-04-27 |
2015-06-10 |
Ucl Business Plc |
Nucleic Acid Construct
|
|
EP3294773A1
(en)
|
2015-05-15 |
2018-03-21 |
The General Hospital Corporation |
Antagonistic anti-tumor necrosis factor receptor superfamily antibodies
|
|
CN107995913B
(zh)
|
2015-05-18 |
2022-02-11 |
T细胞受体治疗公司 |
使用融合蛋白对tcr重编程的组合物和方法
|
|
TWI833684B
(zh)
|
2015-06-25 |
2024-03-01 |
美商生物細胞基因治療有限公司 |
嵌合抗原受體（ｃａｒ）、組合物及其使用方法
|
|
US11173179B2
(en)
|
2015-06-25 |
2021-11-16 |
Icell Gene Therapeutics Llc |
Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof
|
|
AU2016297014B2
(en)
*
|
2015-07-21 |
2021-06-17 |
Novartis Ag |
Methods for improving the efficacy and expansion of immune cells
|
|
GB201513540D0
(en)
|
2015-07-31 |
2015-09-16 |
King S College London |
Therapeutic agents
|
|
KR102011789B1
(ko)
*
|
2015-08-05 |
2019-08-19 |
주식회사 셀랩메드 |
키메라 항원 수용체 및 키메라 항원 수용체가 발현된 t 세포
|
|
WO2017024318A1
(en)
|
2015-08-06 |
2017-02-09 |
Dana-Farber Cancer Institute, Inc. |
Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses
|
|
EP3331913A1
(en)
*
|
2015-08-07 |
2018-06-13 |
Novartis AG |
Treatment of cancer using chimeric cd3 receptor proteins
|
|
EP3341410B1
(en)
|
2015-08-24 |
2021-06-02 |
Cellectis |
Chimeric antigen receptors with integrated controllable functions
|
|
US11649435B2
(en)
*
|
2015-08-28 |
2023-05-16 |
The Trustees Of The University Of Pennsylvania |
Methods and compositions for cells expressing a chimeric intracellular signaling molecule
|
|
IL293963A
(en)
*
|
2015-09-01 |
2022-08-01 |
Univ California |
Modular polypeptide libraries and methods for their preparation and use
|
|
JP6905163B2
(ja)
|
2015-09-03 |
2021-07-21 |
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア |
サイトカイン放出症候群を予測するバイオマーカー
|
|
CA2999037A1
(en)
|
2015-09-23 |
2017-03-30 |
Cytoimmune Therapeutics, LLC |
Flt3 directed car cells for immunotherapy
|
|
US12241053B2
(en)
|
2015-10-09 |
2025-03-04 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
WO2017075465A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
|
|
WO2017075451A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
|
|
DK3368571T5
(da)
|
2015-10-30 |
2024-09-30 |
Univ California |
Transformerende, vækstfaktor-beta-responsive polypeptider og fremgangsmåder til anvendelse deraf
|
|
AU2016355178B9
(en)
|
2015-11-19 |
2019-05-30 |
Massachusetts Institute Of Technology |
Lymphocyte antigen CD5-like (CD5L)-interleukin 12B (p40) heterodimers in immunity
|
|
EP3377523A4
(en)
*
|
2015-11-19 |
2019-06-19 |
The Regents of The University of California |
CONDITIONALLY REPRIMATABLE IMMUNOCELL RECEPTORS AND METHOD FOR USE THEREOF
|
|
EP3380602A4
(en)
*
|
2015-11-23 |
2019-09-25 |
Trustees of Boston University |
METHOD AND COMPOSITIONS RELATED TO CHIMERIC ANTIGEN RECEPTORS
|
|
RU2729116C2
(ru)
|
2015-12-16 |
2020-08-04 |
Гритстоун Онколоджи, Инк. |
Идентификация, производство и применение неоантигенов
|
|
EP3184548A1
(en)
|
2015-12-23 |
2017-06-28 |
Miltenyi Biotec GmbH |
Chimeric antigen receptor with cytokine receptor activating or blocking domain
|
|
SG11201805449PA
(en)
|
2015-12-28 |
2018-07-30 |
Novartis Ag |
Methods of making chimeric antigen receptor -expressing cells
|
|
JP7068169B2
(ja)
*
|
2016-01-08 |
2022-05-16 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
条件付活性ヘテロ二量体ポリペプチド及びその使用方法
|
|
WO2017123559A2
(en)
|
2016-01-11 |
2017-07-20 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric proteins and methods of regulating gene expression
|
|
ES2875747T3
(es)
|
2016-01-11 |
2021-11-11 |
Univ Leland Stanford Junior |
Proteínas quiméricas y métodos de inmunoterapia
|
|
CN105567640A
(zh)
*
|
2016-01-27 |
2016-05-11 |
苏州佰通生物科技有限公司 |
一种嵌合抗原受体脂肪干细胞及其制备方法
|
|
GB201602571D0
(en)
*
|
2016-02-12 |
2016-03-30 |
Autolus Ltd |
Signalling system
|
|
GB201602563D0
(en)
|
2016-02-12 |
2016-03-30 |
Autolus Ltd |
Signalling system
|
|
US10871490B2
(en)
|
2016-02-29 |
2020-12-22 |
Multenyi Biotec, gmbH |
Assay for detection of chimeric antigen receptor T cells
|
|
WO2017172981A2
(en)
*
|
2016-03-29 |
2017-10-05 |
University Of Southern California |
Chimeric antigen receptors targeting cancer
|
|
CA3018253A1
(en)
*
|
2016-03-31 |
2017-10-05 |
University Of Southern California |
A highly sensitive and specific luciferase based reporter assay for antigen detection
|
|
CN109414455B
(zh)
|
2016-04-01 |
2023-01-20 |
凯德药业股份有限公司 |
Bcma结合分子及其使用方法
|
|
PT3436079T
(pt)
|
2016-04-01 |
2021-10-06 |
Kite Pharma Inc |
Recetores de antigénios quiméricos e de células t e métodos de uso
|
|
MY210545A
(en)
|
2016-04-01 |
2025-09-30 |
Kite Pharma Inc |
Chimeric receptors to flt3 and methods of use thereof
|
|
KR20200068750A
(ko)
|
2016-04-01 |
2020-06-15 |
카이트 파마 인코포레이티드 |
키메라 수용체 및 그의 사용 방법
|
|
JP7282521B2
(ja)
|
2016-04-08 |
2023-05-29 |
パーデュー・リサーチ・ファウンデイション |
Ｃａｒ ｔ細胞療法のための方法および組成物
|
|
EP3443001B1
(en)
|
2016-04-11 |
2025-04-30 |
Obsidian Therapeutics, Inc. |
REGULATED BIOCIRCUIT SYSTEMS
|
|
WO2017180993A1
(en)
*
|
2016-04-14 |
2017-10-19 |
Bluebird Bio, Inc. |
Salvage chimeric antigen receptor systems
|
|
US11377637B2
(en)
|
2016-04-15 |
2022-07-05 |
Memorial Sloan Kettering Cancer Center |
Transgenic T cell and chimeric antigen receptor T cell compositions and related methods
|
|
CN116751298A
(zh)
|
2016-05-13 |
2023-09-15 |
生物蛋白有限公司 |
抗ror2抗体、抗体片段和它们的免疫缀合物以及其用途
|
|
US20210177896A1
(en)
|
2016-06-02 |
2021-06-17 |
Novartis Ag |
Therapeutic regimens for chimeric antigen receptor (car)- expressing cells
|
|
JP7114490B2
(ja)
|
2016-06-24 |
2022-08-08 |
アイセル・ジーン・セラピューティクス・エルエルシー |
キメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法
|
|
US11384156B2
(en)
|
2016-07-25 |
2022-07-12 |
The Nemours Foundation |
Adoptive T-cell therapy using EMPD-specific chimeric antigen receptors for treating IgE-mediated allergic diseases
|
|
EP3494138A1
(en)
|
2016-08-02 |
2019-06-12 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
|
CA3000514A1
(en)
|
2016-08-04 |
2018-02-08 |
Memorial Sloan-Kettering Cancer Center |
Cancer antigen targets and uses thereof
|
|
CN109789164B
(zh)
*
|
2016-08-30 |
2023-04-28 |
亘喜生物科技（上海）有限公司 |
具有gitr胞内结构域作为共刺激结构域的嵌合抗原受体
|
|
US20180064758A1
(en)
*
|
2016-09-05 |
2018-03-08 |
Ucl Business Plc |
Chimeric antigen receptor
|
|
CN107793483B
(zh)
*
|
2016-09-06 |
2019-08-23 |
伍志强 |
嵌合抗原受体及其基因和重组表达载体、carmsln-nkt细胞及其制备方法和应用
|
|
US20190262399A1
(en)
|
2016-09-07 |
2019-08-29 |
The Broad Institute, Inc. |
Compositions and methods for evaluating and modulating immune responses
|
|
WO2018052142A1
(ja)
|
2016-09-16 |
2018-03-22 |
キッセイ薬品工業株式会社 |
遺伝子改変細胞及びその作製方法
|
|
ES2925644T3
(es)
*
|
2016-10-04 |
2022-10-19 |
Prec Biosciences Inc |
Dominios coestimuladores para su uso en células modificadas genéticamente
|
|
EP3523331A1
(en)
|
2016-10-07 |
2019-08-14 |
Novartis AG |
Chimeric antigen receptors for the treatment of cancer
|
|
US12447213B2
(en)
|
2016-10-07 |
2025-10-21 |
The Broad Institute, Inc. |
Modulation of novel immune checkpoint targets
|
|
CA3036745A1
(en)
|
2016-10-07 |
2018-04-12 |
TCR2 Therapeutics Inc. |
Compositions and methods for t-cell receptors reprogramming using fusion proteins
|
|
WO2018075820A2
(en)
*
|
2016-10-20 |
2018-04-26 |
Celgene Corporation |
Cereblon-based heterodimerizable chimeric antigen receptors
|
|
WO2018089386A1
(en)
|
2016-11-11 |
2018-05-17 |
The Broad Institute, Inc. |
Modulation of intestinal epithelial cell differentiation, maintenance and/or function through t cell action
|
|
US11851491B2
(en)
|
2016-11-22 |
2023-12-26 |
TCR2 Therapeutics Inc. |
Compositions and methods for TCR reprogramming using fusion proteins
|
|
CN107058315B
(zh)
*
|
2016-12-08 |
2019-11-08 |
上海优卡迪生物医药科技有限公司 |
敲减人PD-1的siRNA、重组表达CAR-T载体及其构建方法和应用
|
|
JP7206214B2
(ja)
*
|
2016-12-13 |
2023-01-17 |
シアトル チルドレンズ ホスピタル （ディービーエイ シアトル チルドレンズ リサーチ インスティテュート） |
インビトロ及びインビボで操作された細胞において発現された化学誘導シグナル伝達複合体の外因性薬物活性化の方法
|
|
WO2018112266A1
(en)
|
2016-12-14 |
2018-06-21 |
The Board Of Trustees Of The Leland Stanford Junior University |
Il-13 superkine: immune cell targeting constructs and methods of use thereof
|
|
WO2018132513A1
(en)
*
|
2017-01-10 |
2018-07-19 |
The General Hospital Corporation |
T cells experessing a chimeric antigen receptor
|
|
CN107573419A
(zh)
*
|
2017-01-24 |
2018-01-12 |
深圳市体内生物医药科技有限公司 |
一种增强t细胞抗肿瘤活性的核酸分子
|
|
CN110612119B
(zh)
|
2017-02-07 |
2024-10-29 |
西雅图儿童医院（Dba西雅图儿童研究所） |
磷脂醚(ple)car t细胞肿瘤靶向(ctct)剂
|
|
CN108395482B
(zh)
|
2017-02-08 |
2021-02-05 |
西比曼生物科技（香港）有限公司 |
一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定
|
|
EP3580212A4
(en)
*
|
2017-02-08 |
2021-03-17 |
Dana Farber Cancer Institute, Inc. |
REGULATION OF CHEMERIC ANTIGEN RECEPTORS
|
|
JP7178355B2
(ja)
|
2017-02-28 |
2022-11-25 |
エンドサイト・インコーポレイテッド |
Ｃａｒ ｔ細胞療法のための組成物および方法
|
|
KR102746901B1
(ko)
*
|
2017-03-03 |
2024-12-26 |
옵시디안 테라퓨틱스, 인크. |
Cd19 조성물 및 면역요법을 위한 방법
|
|
WO2018169922A2
(en)
|
2017-03-13 |
2018-09-20 |
Kite Pharma, Inc. |
Chimeric antigen receptors for melanoma and uses thereof
|
|
KR102660336B1
(ko)
|
2017-03-27 |
2024-04-26 |
내셔널 유니버시티 오브 싱가포르 |
절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도
|
|
MX2019011570A
(es)
|
2017-03-27 |
2019-11-18 |
Nat Univ Singapore |
Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales.
|
|
BR102018006205A2
(pt)
|
2017-03-28 |
2021-03-23 |
Cell Design Labs, Inc. |
Polipeptídeos quiméricos e métodos de alterar a localização da membrana dos mesmos
|
|
WO2018183888A2
(en)
*
|
2017-03-31 |
2018-10-04 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling
|
|
WO2018183908A1
(en)
|
2017-03-31 |
2018-10-04 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating ovarian tumors
|
|
EP3606518A4
(en)
|
2017-04-01 |
2021-04-07 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR DETECTION AND MODULATION OF IMMUNOTHERAPY RESISTANCE GENE SIGNATURE IN CANCER
|
|
WO2018191558A1
(en)
|
2017-04-12 |
2018-10-18 |
The Broad Institute, Inc. |
Modulation of epithelial cell differentiation, maintenance and/or function through t cell action, and markers and methods of use thereof
|
|
US20200071773A1
(en)
|
2017-04-12 |
2020-03-05 |
Massachusetts Eye And Ear Infirmary |
Tumor signature for metastasis, compositions of matter methods of use thereof
|
|
WO2018195339A1
(en)
|
2017-04-19 |
2018-10-25 |
Board Of Regents, The University Of Texas System |
Immune cells expressing engineered antigen receptors
|
|
SG10201912400VA
(en)
|
2017-04-24 |
2020-02-27 |
Kite Pharma Inc |
Humanized antigen-binding domains against cd19 and methods of use
|
|
EP3622092A4
(en)
|
2017-05-11 |
2021-06-23 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS OF USE OF CD8 + TUMOR-INFILTRATING LYMPHOCYTE SUBTYPES AND GENE SIGNATURES THEREOF
|
|
JP2020519267A
(ja)
*
|
2017-05-12 |
2020-07-02 |
セレクティスＣｅｌｌｅｃｔｉｓ |
より安全な細胞免疫療法のためのプロテアーゼベースの切り替えキメラ抗原受容体
|
|
JP7132249B2
(ja)
*
|
2017-05-15 |
2022-09-06 |
オートラス リミテッド |
キメラ抗原受容体（ｃａｒ）を含む細胞
|
|
CN107141356B
(zh)
*
|
2017-06-07 |
2020-03-13 |
胜武（北京）生物科技有限公司 |
一种光诱导二聚体型嵌合抗原受体
|
|
WO2018232195A1
(en)
|
2017-06-14 |
2018-12-20 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
US11325957B2
(en)
|
2017-06-19 |
2022-05-10 |
Cell Design Labs, Inc. |
Methods and compositions for reducing the immunogenicity of chimeric notch receptors
|
|
AU2018287317B2
(en)
|
2017-06-19 |
2024-06-20 |
Medicenna Therapeutics Inc. |
Uses and methods for IL-2 superagonists, agonists, and fusions thereof
|
|
CA3287539A1
(en)
|
2017-06-21 |
2026-03-02 |
Icell Gene Therapeutics Llc |
CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS THEREOF
|
|
US12049643B2
(en)
|
2017-07-14 |
2024-07-30 |
The Broad Institute, Inc. |
Methods and compositions for modulating cytotoxic lymphocyte activity
|
|
CN107446937B
(zh)
*
|
2017-09-05 |
2020-12-25 |
深圳华云生物技术有限公司 |
嵌合抗原受体及其表达基因、光控调节的嵌合抗原受体修饰的t细胞及其应用
|
|
WO2019051001A1
(en)
*
|
2017-09-06 |
2019-03-14 |
California Institute Of Technology |
SIGNALING AND BIFUNCTIONAL RECEPTORS HAVING ANTIGENS (SABR)
|
|
CN109504697A
(zh)
*
|
2017-09-15 |
2019-03-22 |
上海恒润达生生物科技有限公司 |
一种靶向人源化mesothelin的嵌合抗原受体的方法和用途
|
|
CA3070861A1
(en)
*
|
2017-09-22 |
2019-03-28 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Chimeric antigen receptors with enhanced nfkb signaling
|
|
CN109553686A
(zh)
*
|
2017-09-26 |
2019-04-02 |
南京安吉生物科技有限公司 |
一种新型可调控的双嵌合抗原受体t细胞及其构建方法和应用
|
|
EP3687569A1
(en)
|
2017-09-29 |
2020-08-05 |
Cell Design Labs, Inc. |
Methods of making bispecific anti-cd307e and anti-bcma chimeric antigen receptors and uses of the same
|
|
GB201715918D0
(en)
*
|
2017-09-29 |
2017-11-15 |
Tc Biopharm Ltd |
Modified CAR-T
|
|
EP3695408B1
(en)
|
2017-10-02 |
2026-01-21 |
The Broad Institute, Inc. |
Medical use of cdk4/6- and checkpoint-inhibitors in phased combination, in treatment of cancer
|
|
KR20260039788A
(ko)
|
2017-10-10 |
2026-03-20 |
시애틀 프로젝트 코포레이션 |
핫스팟을 이용한 신생항원 동정
|
|
WO2019084055A1
(en)
|
2017-10-23 |
2019-05-02 |
Massachusetts Institute Of Technology |
CLASSIFICATION OF GENETIC VARIATION FROM UNICELLULAR TRANSCRIPTOMS
|
|
MX2020004229A
(es)
|
2017-10-25 |
2020-07-22 |
Novartis Ag |
Metodos de produccion de celulas que expresan receptores antigenicos quimericos.
|
|
WO2019094955A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods and compositions for targeting developmental and oncogenic programs in h3k27m gliomas
|
|
EP3710039A4
(en)
|
2017-11-13 |
2021-08-04 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER BY TARGETING THE CLEC2D-KLRB1 PATH
|
|
WO2019099707A1
(en)
|
2017-11-16 |
2019-05-23 |
Kite Pharma, Inc |
Modified chimeric antigen receptors and methods of use
|
|
CA3083097A1
(en)
|
2017-11-22 |
2019-05-31 |
Gritstone Oncology, Inc. |
Reducing junction epitope presentation for neoantigens
|
|
AU2018385699B2
(en)
*
|
2017-12-14 |
2024-08-15 |
Regeneron Pharmaceuticals, Inc. |
Daric interleukin receptors
|
|
EP3724339A2
(en)
|
2017-12-14 |
2020-10-21 |
Celyad S.A. |
Pooling signaling and costimulatory domains in flexible car design
|
|
CN118206634A
(zh)
|
2017-12-20 |
2024-06-18 |
圣安娜儿童癌症研究中心 |
配体调控的蛋白-蛋白相互作用系统
|
|
EP3502130A1
(en)
|
2017-12-20 |
2019-06-26 |
St. Anna Kinderkrebsforschung |
Ligand regulated protein-protein interaction system
|
|
CA3083779A1
(en)
|
2017-12-22 |
2019-06-27 |
Fate Therapeutics, Inc. |
Enhanced immune effector cells and use thereof
|
|
WO2019126358A1
(en)
*
|
2017-12-22 |
2019-06-27 |
Cell Design Labs, Inc. |
Single- and multi-chain chimeric antigen receptors
|
|
US11994512B2
(en)
|
2018-01-04 |
2024-05-28 |
Massachusetts Institute Of Technology |
Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
|
|
US11701387B2
(en)
|
2018-01-04 |
2023-07-18 |
Miltenyi Biotec B.V. & Co. KG |
Chimeric antigen receptor specific for BDCA2 antigen
|
|
JP7549303B2
(ja)
|
2018-01-22 |
2024-09-11 |
エンドサイト・インコーポレイテッド |
Ｃａｒ ｔ細胞の使用方法
|
|
CN108017717B
(zh)
*
|
2018-01-24 |
2019-08-16 |
首都医科大学宣武医院 |
一种用于体外高效定向扩增的嵌合抗原受体及其应用
|
|
SG11202007426XA
(en)
|
2018-02-06 |
2020-09-29 |
Seattle Childrens Hospital Dba Seattle Childrens Res Inst |
Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors
|
|
JP7475275B2
(ja)
|
2018-02-08 |
2024-04-26 |
ジェネンテック， インコーポレイテッド |
二重特異性抗原結合分子及びその使用方法
|
|
AU2019219454A1
(en)
|
2018-02-09 |
2020-08-27 |
National University Of Singapore |
Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
|
|
US20210023170A1
(en)
*
|
2018-02-12 |
2021-01-28 |
University Of Florida Research Foundation, Incorporated |
Fviii chimeric antigen receptor tregs for tolerance induction in hemophilia a
|
|
CN112534044A
(zh)
|
2018-02-16 |
2021-03-19 |
凯德药业股份有限公司 |
经修饰的多能干细胞及制备和使用方法
|
|
JP7273421B2
(ja)
|
2018-02-21 |
2023-05-15 |
ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム |
ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用
|
|
CN112105382A
(zh)
|
2018-02-23 |
2020-12-18 |
恩多塞特公司 |
用于car t细胞疗法的顺序方法
|
|
CN119851752A
(zh)
|
2018-02-27 |
2025-04-18 |
磨石生物公司 |
利用泛等位基因模型进行的新抗原鉴别
|
|
WO2019166453A1
(en)
*
|
2018-03-01 |
2019-09-06 |
F. Hoffmann-La Roche Ag |
Specificity assay for novel target antigen binding moieties
|
|
CA3092794A1
(en)
|
2018-03-01 |
2019-09-06 |
University Of Kansas |
Techniques for generating cell-based therapeutics using recombinant t cell receptor genes
|
|
CN112004829A
(zh)
*
|
2018-03-12 |
2020-11-27 |
南克维斯特公司 |
Cd33car修饰的高亲和力nk细胞(t-hank)用于降低髓系衍生的抑制细胞的抑制活性(或降低对nk细胞活性的负面影响)的用途
|
|
JP7412006B2
(ja)
*
|
2018-03-14 |
2024-01-12 |
メディジーン イミュノテラピーズ ゲーエムベーハー |
誘導性ｔ細胞レセプター及びその使用
|
|
JP7575271B2
(ja)
|
2018-03-29 |
2024-10-29 |
フェイト セラピューティクス，インコーポレイテッド |
操作された免疫エフェクター細胞およびその使用
|
|
CN112055717B
(zh)
|
2018-04-02 |
2024-04-26 |
新加坡国立大学 |
用在免疫细胞中表达的膜结合抗细胞因子非信号传导粘合剂中和人细胞因子
|
|
AU2019247830B2
(en)
*
|
2018-04-06 |
2026-02-19 |
The Regents Of The University Of California |
Trans-antigen targeting in heterogeneous cancers and methods of use thereof
|
|
CA3096202A1
(en)
|
2018-04-06 |
2019-10-10 |
The Regents Of The University Of California |
Methods of treating egfrviii expressing glioblastomas
|
|
CA3095757A1
(en)
|
2018-04-06 |
2019-10-10 |
The Regents Of The University Of California |
Methods of treating glioblastomas
|
|
CA3095920A1
(en)
|
2018-04-10 |
2019-10-17 |
Amgen Inc. |
Chimeric receptors to dll3 and methods of use thereof
|
|
CN108410908B
(zh)
*
|
2018-04-12 |
2021-08-03 |
吉林大学 |
一种利用植物激素ga及小分子物质pac调节细胞通路的方法
|
|
WO2019197676A1
(en)
*
|
2018-04-13 |
2019-10-17 |
Ludwig Institute For Cancer Research Ltd |
Heterodimeric inactivatable chimeric antigen receptors
|
|
JP7527641B2
(ja)
|
2018-04-18 |
2024-08-05 |
アブクロン・インコーポレイテッド |
スイッチ分子及びスイッチャブルキメラ抗原受容体
|
|
US11957695B2
(en)
|
2018-04-26 |
2024-04-16 |
The Broad Institute, Inc. |
Methods and compositions targeting glucocorticoid signaling for modulating immune responses
|
|
CN108715616A
(zh)
*
|
2018-04-27 |
2018-10-30 |
上海恒润达生生物科技有限公司 |
靶向人源化间皮素的嵌合抗原受体方法和用途
|
|
US12473342B2
(en)
|
2018-04-27 |
2025-11-18 |
The Trustees Of The University Of Pennsylvania |
Chimeric antigen receptor T regulatory cells for the treatment of atherosclerosis
|
|
CA3091490A1
(en)
|
2018-04-27 |
2019-10-31 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Rapamycin resistant cells
|
|
US20210396739A1
(en)
|
2018-05-01 |
2021-12-23 |
Novartis Ag |
Biomarkers for evaluating car-t cells to predict clinical outcome
|
|
IL321548A
(en)
|
2018-05-22 |
2025-08-01 |
Immunitybio Inc |
Recombinant NK cells expressing a chimeric antigen receptor (CAR) for epsilon-FC and uses thereof
|
|
EP3801769A1
(en)
|
2018-05-25 |
2021-04-14 |
Novartis AG |
Combination therapy with chimeric antigen receptor (car) therapies
|
|
WO2019232523A1
(en)
|
2018-06-01 |
2019-12-05 |
The Board Of Trustees Of The Leland Stanford Junior University |
Il-13/il-4 superkines: immune cell targeting constructs and methods of use thereof
|
|
US20210371932A1
(en)
|
2018-06-01 |
2021-12-02 |
Massachusetts Institute Of Technology |
Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
|
|
CN110577604A
(zh)
*
|
2018-06-07 |
2019-12-17 |
亘喜生物科技（上海）有限公司 |
携带gitr共刺激信号靶向egfr的嵌合抗原受体t细胞
|
|
CA3100724A1
(en)
|
2018-06-13 |
2019-12-19 |
Novartis Ag |
B-cell maturation antigen protein (bcma) chimeric antigen receptors and uses thereof
|
|
US12036240B2
(en)
|
2018-06-14 |
2024-07-16 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
TWI809130B
(zh)
|
2018-06-22 |
2023-07-21 |
美商凱特製藥公司 |
嵌合跨膜蛋白及其用途
|
|
CN110669138A
(zh)
*
|
2018-07-02 |
2020-01-10 |
中国药科大学 |
一种双嵌合抗原受体、t细胞及其构建方法与应用
|
|
JP2021530212A
(ja)
|
2018-07-13 |
2021-11-11 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California |
レトロトランスポゾンベースの送達媒体及びその使用方法
|
|
EA202190304A1
(ru)
|
2018-07-18 |
2022-01-21 |
Эмджен Инк. |
Химерные рецепторы к steap1 и способы их применения
|
|
CN113474450A
(zh)
|
2018-08-09 |
2021-10-01 |
朱诺治疗学股份有限公司 |
产生工程化细胞的方法以及所述工程化细胞的组合物
|
|
US12190997B2
(en)
|
2018-08-13 |
2025-01-07 |
Aarhus Universitet |
Genetically altered LysM receptors with altered agonist specificity and affinity
|
|
EP3844186A4
(en)
|
2018-08-29 |
2022-08-17 |
National University of Singapore |
METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
|
|
WO2020047449A2
(en)
|
2018-08-31 |
2020-03-05 |
Novartis Ag |
Methods of making chimeric antigen receptor-expressing cells
|
|
CA3109959A1
(en)
|
2018-08-31 |
2020-03-05 |
Novartis Ag |
Methods of making chimeric antigen receptor-expressing cells
|
|
EP3847191A4
(en)
*
|
2018-09-07 |
2022-06-08 |
BioAtla, Inc. |
CONDITIONALLY ACTIVE CHIMERIC ANTIGEN RECEPTORS FOR MODIFIED T-CELLS
|
|
EP3856779A1
(en)
|
2018-09-28 |
2021-08-04 |
Novartis AG |
Cd22 chimeric antigen receptor (car) therapies
|
|
WO2020069409A1
(en)
|
2018-09-28 |
2020-04-02 |
Novartis Ag |
Cd19 chimeric antigen receptor (car) and cd22 car combination therapies
|
|
WO2020072700A1
(en)
|
2018-10-02 |
2020-04-09 |
Dana-Farber Cancer Institute, Inc. |
Hla single allele lines
|
|
CN113164576A
(zh)
*
|
2018-10-05 |
2021-07-23 |
圣安娜儿童癌症研究中心 |
嵌合抗原受体(car)组
|
|
EP3632461A1
(en)
|
2018-10-05 |
2020-04-08 |
St. Anna Kinderkrebsforschung |
A group of chimeric antigen receptors (cars)
|
|
CA3112310C
(en)
*
|
2018-10-05 |
2025-05-06 |
Universitat Fur Bodenkultur Wien |
CHIMERIC ANTIGEN RECEPTOR GROUP (CAR)
|
|
EP3632460A1
(en)
|
2018-10-05 |
2020-04-08 |
St. Anna Kinderkrebsforschung |
A group of chimeric antigen receptors (cars)
|
|
US20210379057A1
(en)
|
2018-10-16 |
2021-12-09 |
Massachusetts Institute Of Technology |
Nutlin-3a for use in treating a mycobacterium tuberculosis infection
|
|
GB201816839D0
(en)
*
|
2018-10-16 |
2018-11-28 |
Glaxosmithkline Ip Dev Ltd |
Novel control switch
|
|
US12590148B2
(en)
|
2018-11-26 |
2026-03-31 |
Nkarta, Inc. |
Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
|
|
KR102943217B1
(ko)
|
2018-12-02 |
2026-03-25 |
페이트 세러퓨틱스, 인코포레이티드 |
향상된 iPSC 유래 효과기 세포를 사용한 면역요법
|
|
WO2020117952A2
(en)
|
2018-12-05 |
2020-06-11 |
Genentech, Inc. |
Diagnostic methods and compositions for cancer immunotherapy
|
|
WO2020118305A1
(en)
*
|
2018-12-07 |
2020-06-11 |
The Trustees Of Columbia University In The City Of New York |
Muc4 car-t cells for treating cancer
|
|
KR102840400B1
(ko)
|
2018-12-12 |
2025-08-04 |
카이트 파마 인코포레이티드 |
키메라 항원 수용체 및 car-t 세포 및 사용 방법
|
|
WO2020123938A1
(en)
|
2018-12-14 |
2020-06-18 |
Bluebird Bio, Inc. |
Dimerizing agent regulated immunoreceptor complexes
|
|
US12291560B2
(en)
|
2018-12-14 |
2025-05-06 |
Regeneron Pharmaceuticals, Inc. |
Dimerizing agent regulated immunoreceptor complexes
|
|
WO2020131586A2
(en)
|
2018-12-17 |
2020-06-25 |
The Broad Institute, Inc. |
Methods for identifying neoantigens
|
|
WO2020141106A1
(en)
|
2019-01-03 |
2020-07-09 |
Kemijski Institut |
Engineered externally regulated artificial transcription regulatory system based on engineered nfat
|
|
US11739156B2
(en)
|
2019-01-06 |
2023-08-29 |
The Broad Institute, Inc. Massachusetts Institute of Technology |
Methods and compositions for overcoming immunosuppression
|
|
US20220133791A1
(en)
|
2019-01-23 |
2022-05-05 |
Miltenyi Biotec B.V. & Co. KG |
A Combination of compositions for elimination and enhanced engraftment of hematopoietic stem cells in the bone marrow of a subject
|
|
WO2020180591A1
(en)
|
2019-03-01 |
2020-09-10 |
Allogene Therapeutics, Inc. |
Dll3 targeting chimeric antigen receptors and binding agents
|
|
AU2020232691B2
(en)
*
|
2019-03-05 |
2023-06-29 |
Nkarta, Inc. |
CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
|
|
WO2020186101A1
(en)
|
2019-03-12 |
2020-09-17 |
The Broad Institute, Inc. |
Detection means, compositions and methods for modulating synovial sarcoma cells
|
|
US20220142948A1
(en)
|
2019-03-18 |
2022-05-12 |
The Broad Institute, Inc. |
Compositions and methods for modulating metabolic regulators of t cell pathogenicity
|
|
EP3946382A1
(en)
|
2019-04-04 |
2022-02-09 |
UMC Utrecht Holding B.V. |
Modified immune receptor constructs
|
|
WO2020210678A1
(en)
|
2019-04-12 |
2020-10-15 |
Novartis Ag |
Methods of making chimeric antigen receptor-expressing cells
|
|
MX2021012740A
(es)
|
2019-04-17 |
2022-01-24 |
Aadigen Llc |
Péptidos y nanopartículas para entrega intracelular de moléculas.
|
|
KR20220004028A
(ko)
|
2019-04-26 |
2022-01-11 |
알로젠 테라퓨틱스 인코포레이티드 |
동종 car t 세포를 제조하는 방법
|
|
JP7664180B2
(ja)
|
2019-04-26 |
2025-04-17 |
アロジーン セラピューティクス，インコーポレイテッド |
リツキシマブ耐性キメラ抗原受容体およびその用途
|
|
EP3962519A1
(en)
|
2019-05-01 |
2022-03-09 |
Juno Therapeutics, Inc. |
Cells expressing a chimeric receptor from a modified cd247 locus, related polynucleotides and methods
|
|
AU2020265741A1
(en)
|
2019-05-01 |
2021-11-25 |
Editas Medicine, Inc. |
Cells expressing a recombinant receptor from a modified TGFBR2 Locus, related polynucleotides and methods
|
|
KR20220004751A
(ko)
|
2019-05-04 |
2022-01-11 |
인히브릭스, 인크. |
CLEC12a 결합 폴리펩타이드 및 이의 용도
|
|
CN113784733B
(zh)
*
|
2019-05-07 |
2024-09-06 |
亘喜生物科技（上海）有限公司 |
靶向bcma的工程化免疫细胞及其用途
|
|
CA3139346A1
(en)
*
|
2019-05-07 |
2020-11-12 |
Gracell Biotechnologies (Shanghai) Co., Ltd. |
Engineered immune cell targeting bcma and use thereof
|
|
US12421315B2
(en)
|
2019-05-08 |
2025-09-23 |
Regeneron Pharmaceuticals, Inc. |
CLL-1 targeted immunotherapies
|
|
US20220235340A1
(en)
|
2019-05-20 |
2022-07-28 |
The Broad Institute, Inc. |
Novel crispr-cas systems and uses thereof
|
|
CA3142108A1
(en)
|
2019-05-28 |
2020-12-03 |
Miltenyi Biotec B.V. & Co. KG |
Method for generation of genetically modified t cells
|
|
US20220226464A1
(en)
|
2019-05-28 |
2022-07-21 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating immune responses
|
|
WO2020257823A2
(en)
|
2019-06-21 |
2020-12-24 |
Kite Pharma, Inc. |
TGF-β RECEPTORS AND METHODS OF USE
|
|
US20220265715A1
(en)
*
|
2019-07-24 |
2022-08-25 |
Eureka Therapeutics, Inc. |
Chimeric antigen receptor t cells and uses thereof
|
|
WO2021030627A1
(en)
|
2019-08-13 |
2021-02-18 |
The General Hospital Corporation |
Methods for predicting outcomes of checkpoint inhibition and treatment thereof
|
|
US12421557B2
(en)
|
2019-08-16 |
2025-09-23 |
The Broad Institute, Inc. |
Methods for predicting outcomes and treating colorectal cancer using a cell atlas
|
|
WO2021041922A1
(en)
|
2019-08-30 |
2021-03-04 |
The Broad Institute, Inc. |
Crispr-associated mu transposase systems
|
|
US20220315894A1
(en)
|
2019-09-11 |
2022-10-06 |
Miltenyi Biotec B.V. & Co. KG |
Method for Transduction of T Cells in the Presence of Malignant Cells
|
|
US12297426B2
(en)
|
2019-10-01 |
2025-05-13 |
The Broad Institute, Inc. |
DNA damage response signature guided rational design of CRISPR-based systems and therapies
|
|
US12394502B2
(en)
|
2019-10-02 |
2025-08-19 |
The General Hospital Corporation |
Method for predicting HLA-binding peptides using protein structural features
|
|
US12195725B2
(en)
|
2019-10-03 |
2025-01-14 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for modulating and detecting tissue specific TH17 cell pathogenicity
|
|
US11981922B2
(en)
|
2019-10-03 |
2024-05-14 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
|
|
US11793787B2
(en)
|
2019-10-07 |
2023-10-24 |
The Broad Institute, Inc. |
Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis
|
|
WO2021068068A1
(en)
*
|
2019-10-08 |
2021-04-15 |
Provincial Health Services Authority |
Chimeric cytokine receptors
|
|
US11844800B2
(en)
|
2019-10-30 |
2023-12-19 |
Massachusetts Institute Of Technology |
Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
|
|
EP4069728A4
(en)
*
|
2019-12-03 |
2023-12-27 |
University of Massachusetts |
Compositions and methods for optogenetic immunotherapy
|
|
KR20220122656A
(ko)
|
2019-12-06 |
2022-09-02 |
주노 쎄러퓨티크스 인코퍼레이티드 |
Ｇｐｒｃ5ｄ-표적화 결합 도메인에 대한 항-이디오타입 항체 및 관련 조성물 및 방법
|
|
CN113087805A
(zh)
*
|
2019-12-31 |
2021-07-09 |
华东师范大学 |
一种共表达免疫调节分子的嵌合抗原受体t细胞的制备及其应用
|
|
WO2021146147A1
(en)
*
|
2020-01-13 |
2021-07-22 |
Nkarta, Inc. |
Bcma-directed cellular immunotherapy compositions and methods
|
|
AU2021211713A1
(en)
|
2020-01-23 |
2022-08-25 |
The Children's Medical Center Corporation |
Stroma-free T cell differentiation from human pluripotent stem cells
|
|
US12165747B2
(en)
|
2020-01-23 |
2024-12-10 |
The Broad Institute, Inc. |
Molecular spatial mapping of metastatic tumor microenvironment
|
|
AU2021217003A1
(en)
|
2020-02-04 |
2022-09-15 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Anti-dinitrophenol chimeric antigen receptors
|
|
EP4100027A1
(en)
|
2020-02-04 |
2022-12-14 |
Miltenyi Biotec B.V. & Co. KG |
Immune cell expressing adapter chimeric antigen receptor for sensing soluble antigens
|
|
KR20210103975A
(ko)
*
|
2020-02-14 |
2021-08-24 |
(주)이뮤노텍바이오팜코리아 |
외부에서 도입된 세포 신호 조절 인자를 과발현하는 면역 세포 및 이들의 용도
|
|
EP4104187A1
(en)
|
2020-02-14 |
2022-12-21 |
Novartis AG |
Method of predicting response to chimeric antigen receptor therapy
|
|
KR20220146530A
(ko)
|
2020-02-27 |
2022-11-01 |
노파르티스 아게 |
키메라 항원 수용체-발현 세포의 제조 방법
|
|
KR20220147109A
(ko)
|
2020-02-27 |
2022-11-02 |
노파르티스 아게 |
키메라 항원 수용체 발현 세포의 제조 방법
|
|
CA3171066A1
(en)
|
2020-03-11 |
2021-09-16 |
Saar GILL |
Methods and composition for gene delivery using an engineered viral particle
|
|
CN113402612A
(zh)
|
2020-03-17 |
2021-09-17 |
西比曼生物科技（香港）有限公司 |
靶向cd19和cd20的联合嵌合抗原受体及其应用
|
|
KR20230004680A
(ko)
|
2020-04-17 |
2023-01-06 |
시티 오브 호프 |
Flt3-양성 악성 종양의 치료를 위한 flt3-표적화된 키메라 항원 수용체 변형 세포
|
|
KR102931002B1
(ko)
*
|
2020-05-07 |
2026-02-24 |
브리스타 이뮤노테크 리미티드 |
개선된 t 세포 수용체-공동자극 분자 키메라
|
|
EP3916388A1
(en)
|
2020-05-27 |
2021-12-01 |
Miltenyi Biotec B.V. & Co. KG |
Reagents for detection of chimeric antigen receptor cells
|
|
US12286465B2
(en)
|
2020-05-28 |
2025-04-29 |
Miltenyi Biotec B.V. & Co. KG |
Chimeric antigen receptor with a spacer comprising C2-set Ig-like domains
|
|
WO2021252804A1
(en)
*
|
2020-06-12 |
2021-12-16 |
Nkarta, Inc. |
Genetically modified natural killer cells for cd70-directed cancer immunotherapy
|
|
AU2021292695A1
(en)
|
2020-06-19 |
2023-02-02 |
Fate Therapeutics, Inc. |
Combining iPSC-derived effector cell types for immunotherapy use
|
|
EP4171616A1
(en)
|
2020-06-26 |
2023-05-03 |
Juno Therapeutics GmbH |
Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods
|
|
WO2022040454A1
(en)
*
|
2020-08-20 |
2022-02-24 |
A2 Biotherapeutics, Inc. |
Compositions and methods for treating mesothelin positive cancers
|
|
EP3964585A1
(en)
|
2020-09-03 |
2022-03-09 |
Miltenyi Biotec B.V. & Co. KG |
Cd62l specific lentiviral vector particle for targeted transduction of t cell subsets
|
|
WO2022049217A1
(en)
|
2020-09-04 |
2022-03-10 |
Miltenyi Biotec B.V. & Co. KG |
System for inducible expression of an adapter in immune cells
|
|
KR20230100732A
(ko)
|
2020-11-04 |
2023-07-05 |
제넨테크, 인크. |
항-cd20/항-cd3 이중특이성 항체의 피하 투여
|
|
CA3196539A1
(en)
|
2020-11-04 |
2022-05-12 |
Chi-Chung Li |
Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies
|
|
AU2021374594B2
(en)
|
2020-11-04 |
2026-03-05 |
Genentech, Inc. |
Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies and anti-cd79b antibody drug conjugates
|
|
US20230405047A1
(en)
|
2020-11-09 |
2023-12-21 |
Miltenyi Biotec B.V. & Co. KG |
Methods and compositions for eliminating engineered immune cells
|
|
KR20230107617A
(ko)
|
2020-11-13 |
2023-07-17 |
노파르티스 아게 |
키메라 항원 수용체(car)-발현 세포를 사용한 병용 요법
|
|
WO2022115492A1
(en)
|
2020-11-24 |
2022-06-02 |
Lyell Immunopharma, Inc. |
Methods for making, compositions comprising, and methods of using rejuvenated t cells
|
|
WO2022140388A1
(en)
|
2020-12-21 |
2022-06-30 |
Allogene Therapeutics, Inc. |
Protease-activating cd45-gate car
|
|
CA3209126A1
(en)
*
|
2021-01-29 |
2022-08-04 |
Outpace Bio, Inc. |
Small molecule-regulated cell signaling expression system
|
|
AR124837A1
(es)
|
2021-02-09 |
2023-05-10 |
Millennium Pharm Inc |
Métodos y composiciones para congelar y descongelar células de mamíferos
|
|
US20240115608A1
(en)
*
|
2021-02-10 |
2024-04-11 |
The Regents Of The University Of California |
Immune receptors with synthetic co-stimulatory domains
|
|
AU2022227686A1
(en)
|
2021-02-25 |
2023-07-27 |
Lyell Immunopharma, Inc. |
Ror1 targeting chimeric antigen receptor
|
|
GB202104030D0
(en)
*
|
2021-03-23 |
2021-05-05 |
Autolus Ltd |
Signalling system
|
|
EP4313102A4
(en)
*
|
2021-04-01 |
2025-02-26 |
A2 Biotherapeutics, Inc. |
POLYPEPTIDES TARGETING HLA-A*11 AND METHODS OF USE THEREOF
|
|
US12291575B2
(en)
|
2021-05-14 |
2025-05-06 |
Genentech, Inc. |
Methods for treatment of CD20-positive proliferative disorder with mosunetuzumab and polatuzumab vedotin
|
|
WO2022261061A1
(en)
|
2021-06-08 |
2022-12-15 |
Kite Pharma, Inc. |
Gpc3 binding molecules
|
|
GB202108366D0
(en)
|
2021-06-11 |
2021-07-28 |
Quell Therapeutics Ltd |
Multichain chimeric antigen receptor
|
|
WO2023009989A1
(en)
|
2021-07-26 |
2023-02-02 |
Kite Pharma, Inc. |
Split chimeric antigen receptors and methods of use
|
|
WO2023021494A1
(en)
|
2021-08-20 |
2023-02-23 |
Rudd Christopher E |
Compositions and methods for anti-virus chimeric antigen receptor
|
|
WO2023044304A1
(en)
*
|
2021-09-15 |
2023-03-23 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Chimeric adaptor and kinase signaling proteins and their use in immunotherapy
|
|
WO2023057285A1
(en)
|
2021-10-06 |
2023-04-13 |
Miltenyi Biotec B.V. & Co. KG |
Method for targeted gene insertion into immune cells
|
|
AU2022366987A1
(en)
|
2021-10-14 |
2024-05-16 |
Arsenal Biosciences, Inc. |
Immune cells having co-expressed shrnas and logic gate systems
|
|
WO2023062113A1
(en)
|
2021-10-15 |
2023-04-20 |
Miltenyi Biotec B.V. & Co. KG |
Method for the generation of genetically modified nk cells
|
|
WO2023130462A1
(zh)
*
|
2022-01-10 |
2023-07-13 |
卡瑞济(北京)生命科技有限公司 |
靶向IL13Rα2的嵌合抗原受体及其用途
|
|
CN114736306B
(zh)
*
|
2022-03-01 |
2024-04-19 |
中国科学院深圳先进技术研究院 |
一种受化学调控的蛋白酶工具及其配套底物
|
|
WO2023187031A1
(en)
|
2022-04-01 |
2023-10-05 |
Miltenyi Biotec B.V. & Co. KG |
A system for drug-inducible expression of a polynucleotide
|
|
CA3247010A1
(en)
|
2022-04-08 |
2023-10-12 |
Ono Pharmaceutical Co., Ltd. |
CHIMERIC ANTIGEN RECEPTOR FOR TUMOR TARGETING
|
|
EP4504914A4
(en)
|
2022-04-08 |
2026-04-29 |
Fate Therapeutics Inc |
Cells having solid tumor targeting backbone and use thereof
|
|
WO2023217796A1
(en)
|
2022-05-10 |
2023-11-16 |
Miltenyi Biotec B.V. & Co. KG |
Compositions comprising il-15, il-15 receptor alpha and the intracellular signaling domain of cd2 for immune cell therapy
|
|
WO2023220459A1
(en)
*
|
2022-05-13 |
2023-11-16 |
Northwestern University |
Active loading of cargo entity into lipid bilayer particles using dimerization domains
|
|
US20250339464A1
(en)
|
2022-05-16 |
2025-11-06 |
Miltenyi Biotec B.V. & Co. KG |
Endogenous signaling molecule activating chimeric antigen receptors and methods of generation thereof
|
|
EP4580642A2
(en)
*
|
2022-09-01 |
2025-07-09 |
SRI International |
Genetically engineered cd4 t-cells for in situ synthesis of proteins
|
|
EP4587047A1
(en)
|
2022-09-15 |
2025-07-23 |
Novartis AG |
Treatment of autoimmune disorders using chimeric antigen receptor therapy
|
|
EP4342488A1
(en)
|
2022-09-26 |
2024-03-27 |
Miltenyi Biotec B.V. & Co. KG |
Chimeric antigen receptor specific for folate receptor 1
|
|
WO2024077256A1
(en)
|
2022-10-07 |
2024-04-11 |
The General Hospital Corporation |
Methods and compositions for high-throughput discovery ofpeptide-mhc targeting binding proteins
|
|
EP4602171A1
(en)
|
2022-10-15 |
2025-08-20 |
Miltenyi Biotec B.V. & Co. KG |
Transduction of gammadelta t cells with pseudotyped retroviral vectors
|
|
KR102834479B1
(ko)
*
|
2022-11-04 |
2025-07-16 |
한국과학기술연구원 |
형광공명에너지전이 기반 car 활성 센싱용 바이오센서 및 그의 용도
|
|
TW202440623A
(zh)
|
2022-11-28 |
2024-10-16 |
美商艾洛基因醫療公司 |
靶向密連蛋白１８﹒２之嵌合抗原受體及結合劑以及其用途
|
|
WO2024124044A1
(en)
|
2022-12-07 |
2024-06-13 |
The Brigham And Women’S Hospital, Inc. |
Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression
|
|
WO2024158800A2
(en)
*
|
2023-01-24 |
2024-08-02 |
Ginkgo Bioworks, Inc. |
Immune cell stimulatory sequences
|
|
WO2024182539A1
(en)
|
2023-02-28 |
2024-09-06 |
Lyell Immunopharma, Inc. |
Methods of culturing reprogrammed cells
|
|
CA3278900A1
(en)
|
2023-03-31 |
2024-10-03 |
AbelZeta Inc. |
BISPECIFIC CHIMERIC ANTIGENIC RECEPTORS TARGETING CD20 AND BCMA
|
|
KR20260005358A
(ko)
|
2023-04-27 |
2026-01-09 |
밀테니 비오텍 비.브이. & 씨오. 케이지 |
항-cd3 디스플레이를 갖는 슈도타이핑된 레트로바이러스 벡터 입자
|
|
KR20260005359A
(ko)
|
2023-04-27 |
2026-01-09 |
밀테니 비오텍 비.브이. & 씨오. 케이지 |
개 디스템퍼 바이러스의 외피 단백질로 슈도타이핑된 레트로바이러스 벡터 입자
|
|
EP4470555A1
(en)
|
2023-05-31 |
2024-12-04 |
Miltenyi Biotec B.V. & Co. KG |
Anti-tag chimeric antigen receptors with specificity for mutated peptides derived from human fgfr2
|
|
EP4471067A1
(en)
|
2023-06-01 |
2024-12-04 |
Miltenyi Biotec B.V. & Co. KG |
A chemically inducible heterodimerizing system and a method for generation thereof
|
|
WO2025008108A1
(en)
|
2023-07-06 |
2025-01-09 |
Miltenyi Biotec B.V. & Co. KG |
Immune cell expressing chimeric antigen receptor and transgenic t cell receptor
|
|
WO2025059533A1
(en)
|
2023-09-13 |
2025-03-20 |
The Broad Institute, Inc. |
Crispr enzymes and systems
|
|
WO2025078492A1
(en)
|
2023-10-13 |
2025-04-17 |
Miltenyi Biotec B.V. & Co. KG |
Cd3-targeted nipah-pseudotyped lentiviral vector particles
|
|
EP4545963A1
(en)
|
2023-10-26 |
2025-04-30 |
Miltenyi Biotec B.V. & Co. KG |
Method for selecting antigen recognizing moieties having specificity for a target structure
|
|
WO2025097055A2
(en)
|
2023-11-02 |
2025-05-08 |
The Broad Institute, Inc. |
Compositions and methods of use of t cells in immunotherapy
|
|
WO2025117544A1
(en)
|
2023-11-29 |
2025-06-05 |
The Broad Institute, Inc. |
Engineered omega guide molecule and iscb compositions, systems, and methods of use thereof
|
|
WO2025224123A1
(en)
|
2024-04-25 |
2025-10-30 |
Miltenyi Biotec B.V. & Co. KG |
Chimeric antigen receptors specific for fibroblast activation protein
|
|
WO2025252325A1
(en)
|
2024-06-06 |
2025-12-11 |
Miltenyi Biotec B.V. & Co. KG |
A human protein scaffold library based on the pdz3 domain of the tight junction protein zo-1
|
|
WO2025252326A1
(en)
|
2024-06-06 |
2025-12-11 |
Miltenyi Biotec B.V. & Co. KG |
A human protein scaffold library based on the n-terminal domain of human fact complex subunit ssrp1
|