JP6018640B2 - 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム - Google Patents

疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム Download PDF

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JP6018640B2
JP6018640B2 JP2014538963A JP2014538963A JP6018640B2 JP 6018640 B2 JP6018640 B2 JP 6018640B2 JP 2014538963 A JP2014538963 A JP 2014538963A JP 2014538963 A JP2014538963 A JP 2014538963A JP 6018640 B2 JP6018640 B2 JP 6018640B2
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phe
analgesic composition
dry powder
peptide
seq
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JP2014530914A5 (ja
JP2014530914A (ja
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レオーネ−ベイ、アンドレア
エー ホーフテン、リチャード
エー ホーフテン、リチャード
ジェイ ガーネリ、ジョセフ
ジェイ ガーネリ、ジョセフ
ダブリュ ストーウェル、グレイソン
ダブリュ ストーウェル、グレイソン
Original Assignee
マンカインド コーポレイション
マンカインド コーポレイション
トリー パインズ インスティチュート フォー モレキュラー スタディーズ
トリー パインズ インスティチュート フォー モレキュラー スタディーズ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
JP2014538963A 2011-10-24 2012-10-24 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム Expired - Fee Related JP6018640B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161550860P 2011-10-24 2011-10-24
US61/550,860 2011-10-24
PCT/US2012/061749 WO2013063160A1 (en) 2011-10-24 2012-10-24 Methods and compositions for treating pain

Related Child Applications (1)

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JP2016135940A Division JP6165300B2 (ja) 2011-10-24 2016-07-08 合成ペプチド及び乾燥粉末薬剤輸送システム

Publications (3)

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JP2014530914A JP2014530914A (ja) 2014-11-20
JP2014530914A5 JP2014530914A5 (ja) 2015-04-30
JP6018640B2 true JP6018640B2 (ja) 2016-11-02

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JP2014538963A Expired - Fee Related JP6018640B2 (ja) 2011-10-24 2012-10-24 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム
JP2016135940A Expired - Fee Related JP6165300B2 (ja) 2011-10-24 2016-07-08 合成ペプチド及び乾燥粉末薬剤輸送システム

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US (3) US9233159B2 (forum.php)
EP (1) EP2776053A1 (forum.php)
JP (2) JP6018640B2 (forum.php)
KR (1) KR20140095483A (forum.php)
CN (1) CN103945859A (forum.php)
AU (1) AU2012328885B2 (forum.php)
BR (1) BR112014009686A2 (forum.php)
CA (1) CA2852536A1 (forum.php)
HK (2) HK1201475A1 (forum.php)
IN (1) IN2014DN03093A (forum.php)
MX (1) MX2014004983A (forum.php)
WO (1) WO2013063160A1 (forum.php)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12022617B2 (en) 2021-04-20 2024-06-25 Gecko Robotics, Inc. Inspection robots with a payload engagement device
US12050202B2 (en) 2021-04-22 2024-07-30 Gecko Robotics, Inc. Robotic systems for surface inspection with simultaneous measurements at multiple orientations
US12061484B2 (en) 2016-12-23 2024-08-13 Gecko Robotics, Inc. Inspection robot having adjustable resolution

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
ATE385193T1 (de) 2002-03-20 2008-02-15 Mannkind Corp Inhalationsgerät
PL1786784T3 (pl) 2004-08-20 2011-04-29 Mannkind Corp Kataliza syntezy diketopiperazyn
BR122019022692B1 (pt) 2004-08-23 2023-01-10 Mannkind Corporation Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo
JP5167133B2 (ja) 2005-09-14 2013-03-21 マンカインド コーポレイション 結晶性微粒子表面に対する活性薬剤の親和性の増大に基づく薬物処方の方法
JP5599975B2 (ja) 2006-02-22 2014-10-01 マンカインド コーポレイション ジケトピペラジン及び活性薬剤を含有する微粒子の製剤特性の改善方法
CA3153292A1 (en) 2008-06-13 2009-12-17 Mannkind Corporation A dry powder inhaler and system for drug delivery
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CN103751892B (zh) 2008-06-20 2017-03-01 曼金德公司 用于对吸入工作进行实时描绘的交互式设备和方法
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
JP5667095B2 (ja) 2009-03-11 2015-02-12 マンカインド コーポレイション 吸入器の抵抗を測定するための装置、システムおよび方法
MY186975A (en) 2009-06-12 2021-08-26 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
JP5784622B2 (ja) 2009-11-03 2015-09-24 マンカインド コーポレ−ション 吸入活動をシミュレートするための装置及び方法
CN102985125A (zh) 2010-06-21 2013-03-20 曼金德公司 干粉药物输送系统和方法
KR101940832B1 (ko) 2011-04-01 2019-01-21 맨카인드 코포레이션 의약 카트리지용 블리스터 패키지
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
HK1201475A1 (en) 2011-10-24 2015-09-04 Mannkind Corporation Methods and compositions for treating pain
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
JP6523247B2 (ja) 2013-03-15 2019-05-29 マンカインド コーポレイション 微結晶性ジケトピペラジン粒子の製造方法および乾燥粉末組成物の製造方法
KR102465025B1 (ko) 2013-07-18 2022-11-09 맨카인드 코포레이션 열-안정성 건조 분말 약제학적 조성물 및 방법
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
CN115991678B (zh) * 2021-10-20 2025-05-23 上海惠永药物研究有限公司 一种二酮基哌嗪类化合物、制备方法及其应用
US20250032483A1 (en) * 2021-12-03 2025-01-30 Icahn School Of Medicine At Mount Sinai Compositions and methods for treating pain
CN115990152B (zh) * 2022-12-09 2024-12-24 上海市第十人民医院 支链氨基酸在糖尿病神经病理性疼痛诊断和治疗中的应用
WO2024226545A2 (en) * 2023-04-26 2024-10-31 Woolwich Sciences Llc Molecules and methods of use thereof
WO2025040658A1 (en) 2023-08-21 2025-02-27 Medizinische Universität Wien Selective cyclized peptide kappa-opioid receptor agonists
WO2025040657A1 (en) 2023-08-21 2025-02-27 Medizinische Universität Wien Selective cyclized peptide kappa-opioid receptor antagonists

Family Cites Families (1115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB475440A (en) 1935-09-23 1937-11-19 Mine Safety Appliances Co Improvements in or relating to apparatus for determining the flow resistance of breathing apparatus elements
US2549303A (en) 1949-04-20 1951-04-17 Bristol Lab Inc Inhaler for crystalline pencilllin or the like
BE509861A (forum.php) 1952-03-13
US2754276A (en) 1953-02-12 1956-07-10 Du Pont Cellular compositions utilizing dinitrosopentamethylene-tetramine as the blowing agent
US3337740A (en) 1962-02-13 1967-08-22 Deering Milliken Res Corp Process for separating acrylic acid from impurities
US4187129A (en) 1962-05-14 1980-02-05 Aerojet-General Corporation Gelled mechanically stable high energy fuel composition containing metal platelets
FR1451293A (fr) 1964-05-18 1966-01-07 Entoleter Matière composite et son procédé de préparation
US3407203A (en) 1965-03-22 1968-10-22 Union Carbide Corp Novel process for the preparation of diketopiperazines
US3669113A (en) 1966-03-07 1972-06-13 Fisons Ltd Inhalation device
US3518340A (en) 1968-04-15 1970-06-30 Dow Corning Method of forming silicone rubber drug carriers
US3622053A (en) 1969-12-10 1971-11-23 Schering Corp Aerosol inhaler with flip-up nozzle
US3673698A (en) 1970-11-25 1972-07-04 Albert S Guerard Process for freeze drying with carbon dioxide
BE794951A (fr) 1972-02-03 1973-05-29 Parke Davis & Co Conditionnement soluble dans l'eau
US3873651A (en) 1972-05-12 1975-03-25 Atomic Energy Commission Freeze drying method for preparing radiation source material
US3823843A (en) 1972-10-26 1974-07-16 Lilly Co Eli Locking capsule
US3856142A (en) 1973-01-24 1974-12-24 Mine Safety Appliances Co Inhalant package
FR2224175B1 (forum.php) 1973-04-04 1978-04-14 Isf Spa
US3980074A (en) 1973-07-18 1976-09-14 Beecham Group Limited Device for the administration of powders
GB1479283A (en) 1973-07-23 1977-07-13 Bespak Industries Ltd Inhaler for powdered medicament
GB1459488A (en) 1974-03-19 1976-12-22 Wyeth John & Brother Ltd Piperazinedione derivatives
IT1017153B (it) 1974-07-15 1977-07-20 Isf Spa Apparecchio per inalazioni
US4018619A (en) 1974-09-23 1977-04-19 Iu Technology Corporation Highly activated mixtures for constructing load bearing surfaces and method of making the same
US4005711A (en) 1975-01-13 1977-02-01 Syntex Puerto Rico, Inc. Inhalation device
DE2502251A1 (de) 1975-01-17 1976-07-22 Schering Ag Vorrichtung zur inhalation pulverfoermiger feststoffe
US4040536A (en) 1975-05-05 1977-08-09 R. P. Scherer Corporation Locking hard gelatin capsule
JPS528096A (en) 1975-06-09 1977-01-21 Nat Distillers Chem Corp Method for resisting agglomeration of ethyleneevinyl acetate copolymers
US4153689A (en) 1975-06-13 1979-05-08 Takeda Chemical Industries, Ltd. Stable insulin preparation for nasal administration
US3998226A (en) 1975-09-22 1976-12-21 Edward G. Gomez Inhalation device for encapsulated concentrates
GB1509979A (en) 1975-11-28 1978-05-10 Fisons Ltd Pharmaceutical compositions containing aspirin or indomethacin
US4102953A (en) 1976-05-25 1978-07-25 The United States Of America As Represented By The Secretary Of The Navy Method for making extruded, solventless, composite-modified double base propellant
USD252707S (en) 1977-01-03 1979-08-21 Joel Besnard Inhaler
GB1598081A (en) 1977-02-10 1981-09-16 Allen & Hanburys Ltd Inhaler device for dispensing medicaments
US4171000A (en) 1977-03-23 1979-10-16 Uhle Klaus P Smoking device
IE46865B1 (en) 1977-04-29 1983-10-19 Allen & Hanburys Ltd Device for dispensing medicaments
US4148308A (en) 1977-05-31 1979-04-10 Sayer William J Mouthpiece with a tongue retractor
US4110240A (en) 1977-07-29 1978-08-29 Wyrough And Loser, Inc. Coprecipitation process
US4091077A (en) 1977-08-12 1978-05-23 The United States Of America As Represented By The United States Department Of Energy Process for recovering filler from polymer
US4211769A (en) 1977-08-24 1980-07-08 Takeda Chemical Industries, Ltd. Preparations for vaginal administration
US4268460A (en) 1977-12-12 1981-05-19 Warner-Lambert Company Nebulizer
CA1113044A (en) 1977-12-16 1981-11-24 J. Paul Leblond Personal repellant device
US4356167A (en) 1978-01-27 1982-10-26 Sandoz, Inc. Liposome drug delivery systems
US4175556A (en) 1978-04-07 1979-11-27 Freezer Winthrop J Inhaler with flow-through cap
US4196196A (en) 1978-06-19 1980-04-01 Tiholiz Ivan C Divalen/monovalent bipolar cation therapy for enhancement of tissue perfusion and reperfusion in disease states
US4168002A (en) 1978-08-03 1979-09-18 Crosby Leslie O Multiple-seed package card
US4272398A (en) 1978-08-17 1981-06-09 The United States Of America As Represented By The Secretary Of Agriculture Microencapsulation process
DE2840442C2 (de) 1978-09-16 1982-02-11 C.H. Boehringer Sohn, 6507 Ingelheim Verwendung des Diketopiperazins L-Leu-L-Trp als Geschmacksstoff für Getränke mit bitterer Geschmacksrichtung
DE2849493C2 (de) 1978-11-15 1982-01-14 Carl Heyer Gmbh, Inhalationstechnik, 5427 Bad Ems In der Hand zu haltender Aerosolspender
USD269463S (en) 1978-12-08 1983-06-21 Fisons Limited Container for a medicinal inhaler
JPS5837833Y2 (ja) 1979-04-27 1983-08-26 凸版印刷株式会社 アンプル収納容器
JPS6034925B2 (ja) 1979-07-31 1985-08-12 帝人株式会社 持続性鼻腔用製剤およびその製造法
US4407525A (en) 1979-10-04 1983-10-04 Gao Gesellschaft Fur Automation Und Organisation Mbh Identification card with hallmark for authentication by incident and transmitted light
GB2072536B (en) 1980-03-25 1983-12-07 Malem H Nebuliser
US4289759A (en) 1980-06-23 1981-09-15 Ortho Pharmaceutical Corporation Immunoregulatory diketopiperazine compounds
EP0055537B1 (en) 1980-12-12 1984-12-05 Combi Co., Ltd. Inhaler
US4900730A (en) 1981-01-14 1990-02-13 Toyo Jozo Co., Ltd. Preparation which promotes the absorption of peptides
GB2092136B (en) 1981-01-17 1985-06-05 Mitsui Toatsu Chemicals Production of n-substituted amide compounds
JPS58140026A (ja) 1982-01-14 1983-08-19 Toyo Jozo Co Ltd 吸収性良好な製剤
IT1220979B (it) 1981-06-04 1990-06-21 Lofarma Farma Lab Capsule contenenti un allergene e procedimento per la loro preparazione
DE3274065D1 (de) 1981-07-08 1986-12-11 Draco Ab Powder inhalator
SE438261B (sv) 1981-07-08 1985-04-15 Draco Ab Anvendning i dosinhalator av ett perforerat membran
US5260306A (en) 1981-07-24 1993-11-09 Fisons Plc Inhalation pharmaceuticals
USD276654S (en) 1981-09-15 1984-12-04 Aktiebolaget Draco Medical aerosol inhalation device
KR890000664B1 (ko) 1981-10-19 1989-03-22 바리 안소니 뉴우샘 미분된 베클로메타손 디프로피오네이트 일수화물의 제조방법
US4659696A (en) 1982-04-30 1987-04-21 Takeda Chemical Industries, Ltd. Pharmaceutical composition and its nasal or vaginal use
US4483922A (en) 1982-05-14 1984-11-20 Amf Inc. Inactivation of enzymes
US4526804A (en) 1982-08-30 1985-07-02 Ball Corporation Method for providing sheet metal stock with finely divided powder
US4487327A (en) 1982-12-21 1984-12-11 Grayson Robert E Locking capsule
JPS59163313A (ja) 1983-03-09 1984-09-14 Teijin Ltd 経鼻投与用ペプチドホルモン類組成物
US4481139A (en) * 1983-04-13 1984-11-06 Board Of Regents, The University Of Texas System Peptide antagonists of substance P
AU90762S (en) 1983-06-29 1985-08-15 Glaxo Group Ltd Inhaler
US4581020A (en) 1983-07-18 1986-04-08 Trimedyne, Inc. Medication delivery device and system for percutaneous administration of medication
GB8325529D0 (en) 1983-09-23 1983-10-26 Lilly Industries Ltd Medicinal forms
CH661878A5 (de) 1983-11-04 1987-08-31 Warner Lambert Co Kapsel-dosierungsformen.
US4671954A (en) * 1983-12-13 1987-06-09 University Of Florida Microspheres for incorporation of therapeutic substances and methods of preparation thereof
USD295321S (en) 1984-03-13 1988-04-19 Glaxo Group Limited Inhaler container for a medical aerosol
JPS60248618A (ja) 1984-05-24 1985-12-09 Nippon Zoki Pharmaceut Co Ltd ジペプチドを含有する潰瘍治療剤
US4927555A (en) 1984-08-13 1990-05-22 Colgate-Palmolive Company Process for making thixotropic detergent compositions
USD288852S (en) 1984-08-29 1987-03-17 Aruman Co., Ltd. Disposable inhaler
US4757066A (en) 1984-10-15 1988-07-12 Sankyo Company Limited Composition containing a penem or carbapenem antibiotic and the use of the same
IE58468B1 (en) 1984-10-25 1993-09-22 Warner Lambert Co Method for sealing capsules and capsule
US4592348A (en) 1984-12-17 1986-06-03 Waters Iv William C Aerosol inhaler
US4946828A (en) 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
SE448277B (sv) 1985-04-12 1987-02-09 Draco Ab Indikeringsanordning vid en doseringsanordning for lekemedel
JPS6320301Y2 (forum.php) 1985-04-18 1988-06-06
US5462927A (en) * 1985-04-30 1995-10-31 The Administrators Of The Tulane Educational Fund Peptides aiding nerve regeneration
US5785989A (en) 1985-05-01 1998-07-28 University Utah Research Foundation Compositions and methods of manufacturing of oral dissolvable medicaments
US4615817A (en) 1985-05-17 1986-10-07 Mccoy Frederic C Additives containing polytetrafluoroethylene for making stable lubricants
CA1318730C (en) 1985-05-30 1993-06-01 C. Edward Capes Method of separating carbonaceous components from particulate coal containing inorganic solids and apparatus therefor
US5098590A (en) 1988-02-04 1992-03-24 Colgate Palmolive Co. Thixotropic aqueous automatic dishwasher detergent compositions with improved stability
GR861995B (en) 1985-07-30 1986-11-04 Glaxo Group Ltd Devices for administering medicaments to patients
AT384552B (de) 1985-08-01 1987-12-10 Hurka Wilhelm Inhalationsgeraet zur dosierung und verteilung von festkoerpern in die atemluft
US4624861A (en) 1985-09-05 1986-11-25 Gte Products Corporation Rare earth oxysulfide phosphors and processes for creating same
US4742156A (en) * 1985-09-30 1988-05-03 Mcneilab, Inc. Peptide antagonists of neurokinin B and opthalmic solutions containing them
PT83613B (en) 1985-10-28 1988-11-21 Lilly Co Eli Process for the selective chemical removal of a protein amino-terminal residue
EP0248051A1 (en) 1985-11-29 1987-12-09 FISONS plc Pharmaceutical composition including sodium cromoglycate
LU86258A1 (fr) 1986-01-21 1987-09-03 Rech Dermatologiques C I R D S Composes benzamido aromatique,leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique
SE453566B (sv) 1986-03-07 1988-02-15 Draco Ab Anordning vid pulverinhalatorer
US4849227A (en) 1986-03-21 1989-07-18 Eurasiam Laboratories, Inc. Pharmaceutical compositions
USD304975S (en) 1986-04-14 1989-12-12 Mark Movitz Portable ball container
US5120712A (en) 1986-05-05 1992-06-09 The General Hospital Corporation Insulinotropic hormone
US5118666A (en) 1986-05-05 1992-06-02 The General Hospital Corporation Insulinotropic hormone
US6849708B1 (en) 1986-05-05 2005-02-01 The General Hospital Corporation Insulinotropic hormone and uses thereof
US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
US4926852B1 (en) 1986-06-23 1995-05-23 Univ Johns Hopkins Medication delivery system phase one
USD301273S (en) 1986-07-10 1989-05-23 Leonard G Darin Hand held fly suction device
JPS6320301A (ja) 1986-07-11 1988-01-28 Dainichi Color & Chem Mfg Co Ltd キトサン微小粒体
US5042975A (en) 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
WO1988001165A1 (en) 1986-08-11 1988-02-25 Innovata Biomed Limited Pharmaceutical formulations comprising microcapsules
WO1988001213A1 (en) 1986-08-18 1988-02-25 Clinical Technologies Associates, Inc. Delivery systems for pharmacological agents
USRE35862E (en) 1986-08-18 1998-07-28 Emisphere Technologies, Inc. Delivery systems for pharmacological agents encapsulated with proteinoids
ATE76311T1 (de) 1986-08-19 1992-06-15 Genentech Inc Einrichtung und dispersion zum intrapulmonalen eingeben von polypeptidwuchsstoffen und zytokinen.
DE3639836A1 (de) 1986-11-21 1988-06-01 Sigrid Bechter Mundstueck fuer ein inhalationsgeraet
KR890003520Y1 (ko) 1986-12-20 1989-05-27 주식회사 서흥캅셀 의약용 캅셀
US4861627A (en) 1987-05-01 1989-08-29 Massachusetts Institute Of Technology Preparation of multiwall polymeric microcapsules
US4981295A (en) 1987-05-11 1991-01-01 City Of Hope Respiratory training using feedback
US6645504B1 (en) 1987-06-24 2003-11-11 Autoimmune Inc. Bystander suppression of type I diabetes by oral administration of glucagon
DE3727894A1 (de) 1987-08-21 1989-03-02 Stephan Dieter Kapsel fuer pharmazeutisch wirksame inhaltsstoffe einer droge
GB8723846D0 (en) 1987-10-10 1987-11-11 Danbiosyst Ltd Bioadhesive microsphere drug delivery system
US4887722A (en) 1987-12-11 1989-12-19 Greenward Sr Edward H Method for beneficiating by carbonaceous refuse
DE3801326A1 (de) 1988-01-19 1989-07-27 Asea Brown Boveri Verfahren zur herstellung einer keramiksuspension
US4981625A (en) 1988-03-14 1991-01-01 California Institute Of Technology Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops
GB8813338D0 (en) 1988-06-06 1988-07-13 Osprey Metals Ltd Powder production
USD316902S (en) 1988-09-02 1991-05-14 Hoelfing H Curt Meter hose inhaler reservoir
GB8821287D0 (en) 1988-09-12 1988-10-12 Ici Plc Device
EP0360340A1 (en) 1988-09-19 1990-03-28 Akzo N.V. Composition for nasal administration containing a peptide
USD321570S (en) 1988-09-30 1991-11-12 Blasdell Richard J Inhaler
EP0363060B1 (en) 1988-10-04 1994-04-27 The Johns Hopkins University Aerosol inhaler
US4984158A (en) 1988-10-14 1991-01-08 Hillsman Dean Metered dose inhaler biofeedback training and evaluation system
JPH02104531A (ja) 1988-10-14 1990-04-17 Toyo Jozo Co Ltd 経鼻投与用生理活性ペプチド組成物
JPH02115154A (ja) 1988-10-25 1990-04-27 Kao Corp イミド化合物及びその用途
USD326517S (en) 1988-10-27 1992-05-26 Glaxo Group Limited Inhalator
JP2692742B2 (ja) 1988-11-30 1997-12-17 株式会社ツムラ 新規なリグナン類
US5006343A (en) 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
US5075027A (en) 1989-02-06 1991-12-24 Colgate Palmolive Co. Thixotropic aqueous scented automatic dishwasher detergent compositions
US5514646A (en) 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
IT1228460B (it) 1989-02-23 1991-06-19 Phidea S R L Inalatore monouso con capsula pre-forata
IT1228459B (it) 1989-02-23 1991-06-19 Phidea S R L Inalatore con svuotamento regolare e completo della capsula.
US4983402A (en) 1989-02-24 1991-01-08 Clinical Technologies Associates, Inc. Orally administerable ANF
SE466684B (sv) 1989-03-07 1992-03-23 Draco Ab Anordning vid en inhalator samt foerfarande foer att med anordningen registrera medicinering med inhalator
US5358734A (en) 1989-03-30 1994-10-25 Gte Products Corporation Process for producing a blue emitting lamp phosphor
US5215739A (en) 1989-04-05 1993-06-01 Toko Yakuhin Kogyo Kabushiki Kaisha Spray gel base and spray gel preparation using thereof
US5067500A (en) 1989-04-24 1991-11-26 Philip Morris Incorporated Container for additive materials for smoking articles
US4991605A (en) 1989-04-24 1991-02-12 Philip Morris Incorporated Container for additive materials for smoking articles
AU643435B2 (en) 1989-04-28 1993-11-18 Riker Laboratories, Inc. Dry powder inhalation device
GB8909891D0 (en) 1989-04-28 1989-06-14 Riker Laboratories Inc Device
US5019400A (en) 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
DE69005800T2 (de) 1989-05-01 1994-05-19 Alkermes Inc Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekülen.
US5017383A (en) 1989-08-22 1991-05-21 Taisho Pharmaceutical Co., Ltd. Method of producing fine coated pharmaceutical preparation
GB8919131D0 (en) 1989-08-23 1989-10-04 Riker Laboratories Inc Inhaler
US5270305A (en) 1989-09-08 1993-12-14 Glaxo Group Limited Medicaments
GB8921222D0 (en) 1989-09-20 1989-11-08 Riker Laboratories Inc Medicinal aerosol formulations
DK544589D0 (da) 1989-11-01 1989-11-01 Novo Nordisk As Manuel betjent apparat til dispensering af en forudbestemt maengde af et pulverformet stof
WO1991006287A1 (en) 1989-11-06 1991-05-16 Enzytech, Inc. Protein microspheres and methods of using them
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5105291A (en) 1989-11-20 1992-04-14 Ricoh Company, Ltd. Liquid crystal display cell with electrodes of substantially amorphous metal oxide having low resistivity
AU6774790A (en) 1989-12-06 1991-06-13 Canon Kabushiki Kaisha Package for ink jet cartridge
USD331106S (en) 1989-12-30 1992-11-17 Ing. Erich Pfeiffer Gmbh & Co. Kg Single use inhaler
GB9001635D0 (en) 1990-01-24 1990-03-21 Ganderton David Aerosol carriers
US5545618A (en) 1990-01-24 1996-08-13 Buckley; Douglas I. GLP-1 analogs useful for diabetes treatment
US5201308A (en) 1990-02-14 1993-04-13 Newhouse Michael T Powder inhaler
UA26230A (uk) 1990-03-02 1999-07-19 Глексо Груп Лімітед Іhгалятор для спільhого використаhhя з лікувальhим блоком і лікувальhий блок
US6536427B2 (en) 1990-03-02 2003-03-25 Glaxo Group Limited Inhalation device
SK280967B6 (sk) 1990-03-02 2000-10-09 Glaxo Group Limited Inhalačný prístroj
US5615670A (en) 1990-03-07 1997-04-01 Fisons Plc Powder inhaler with centrifugal force used to meter powder
IT1240750B (it) 1990-04-12 1993-12-17 Chiesi Farma Spa Dispositivo per la somministrazione di sostanze medicamentose in polvere
JPH05963A (ja) 1990-04-13 1993-01-08 Toray Ind Inc ポリペプチド類組成物
US5328464A (en) 1990-04-24 1994-07-12 Science Incorporated Closed drug delivery system
USD338268S (en) 1990-05-04 1993-08-10 Omron Corporation Heating inhaler
WO1991016882A1 (en) 1990-05-08 1991-11-14 Liposome Technology, Inc. Direct spray-dried drug/lipid powder composition
NZ238489A (en) 1990-06-14 1995-09-26 Rhone Poulenc Rorer Ltd Inhaler with capsule in swirling chamber: capsule pierced in chamber
DE4021263C2 (de) 1990-07-04 1996-04-11 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung für Medien
GB9015522D0 (en) 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler
US5443841A (en) 1992-06-15 1995-08-22 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US5451410A (en) 1993-04-22 1995-09-19 Emisphere Technologies, Inc. Modified amino acids for encapsulating active agents
US5693338A (en) 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5541155A (en) 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US6331318B1 (en) 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US5629020A (en) 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5447728A (en) 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5578323A (en) 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
JPH04103585A (ja) 1990-08-24 1992-04-06 Nisshin Flour Milling Co Ltd ピロリジン環を有する化合物
US5074418A (en) 1990-09-12 1991-12-24 Pitney Bowes Inc. Ink replenishing system transport and storage container
SE9002895D0 (sv) 1990-09-12 1990-09-12 Astra Ab Inhalation devices for dispensing powders i
EP0503031B1 (en) 1990-09-26 1998-04-01 Pharmachemie B.V. Inhaler devices provided with a reservoir for several doses of medium for inhaling, transporting device, whirl chamber
US5170801A (en) 1990-10-02 1992-12-15 Glaxo Inc. Medical capsule device actuated by radio-frequency (rf) signal
FR2667509B1 (fr) 1990-10-04 1995-08-25 Valois Inhalateur a poudre, dispositif de conditionnement de microdoses de poudre sous forme de bandes adaptees a etre utilisees dans un inhalateur a poudre, et procede de fabrication de ces bandes.
IL99699A (en) 1990-10-10 2002-04-21 Autoimmune Inc Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
GB9024760D0 (en) 1990-11-14 1991-01-02 Riker Laboratories Inc Inhalation device and medicament carrier
US5124291A (en) 1990-11-15 1992-06-23 The Standard Oil Company Method for deagglomerating and re-exposing catalyst in a fluid bed reactor
GB9026191D0 (en) 1990-12-01 1991-01-16 Harris Pharma Ltd Breath actuated dispensing device
GB9027234D0 (en) 1990-12-15 1991-02-06 Harris Pharma Ltd An inhalation device
WO1992011050A1 (en) 1990-12-17 1992-07-09 Minnesota Mining And Manufacturing Company Inhaler
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
GB2253200A (en) 1991-02-01 1992-09-02 Harris Pharma Ltd Inhalation apparatus and fracturable capsule for use therewith
WO1992014449A1 (en) 1991-02-20 1992-09-03 Nova Pharmaceutical Corporation Controlled release microparticulate delivery system for proteins
US5208998A (en) 1991-02-25 1993-05-11 Oyler Jr James R Liquid substances freeze-drying systems and methods
DE69430303T2 (de) 1991-03-05 2002-11-28 Aradigm Corp Verfahren und vorrichtung zur korrektur eines nullsignals eines drucksensors fur einen durchflussmesser
US5404871A (en) 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
US5394866A (en) 1991-03-05 1995-03-07 Aradigm Corporation Automatic aerosol medication delivery system and methods
USD338062S (en) 1991-03-06 1993-08-03 Innovata Biomed Limited Inhaler
USD347057S (en) 1991-03-14 1994-05-17 Technosystem Limited Inhaler
US5797391A (en) 1991-03-28 1998-08-25 Rhone-Poulenc Rorer Limited Inhaler
US5413804A (en) 1991-04-23 1995-05-09 Cacique, Inc. Process for making whey-derived fat substitute product and products thereof
US5244653A (en) 1991-05-01 1993-09-14 Isp Chemicals Inc. Glycine anhydride dimethylol as a biocide and preservative
US6060069A (en) 1991-05-20 2000-05-09 Dura Pharmaceuticals, Inc. Pulmonary delivery of pharmaceuticals
US6055980A (en) 1991-05-20 2000-05-02 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5327883A (en) 1991-05-20 1994-07-12 Dura Pharmaceuticals, Inc. Apparatus for aerosolizing powdered medicine and process and using
US5492112A (en) 1991-05-20 1996-02-20 Dura Pharmaceuticals, Inc. Dry powder inhaler
FR2676929B1 (fr) 1991-05-30 1994-02-11 Aerosols Bouchage Ste Fse Inhalateur de poudres.
CA2070061C (en) 1991-06-07 2004-02-10 Shigeyuki Takama Physiologically active polypeptide-containing pharmaceutical composition
IT1248059B (it) 1991-06-14 1995-01-05 Miat Spa Insufflatore multidose per farmaci in polvere
EP0592540B1 (en) 1991-07-02 2000-01-26 Inhale, Inc. Method and device for delivering aerosolized medicaments
US6681767B1 (en) 1991-07-02 2004-01-27 Nektar Therapeutics Method and device for delivering aerosolized medicaments
US5203768A (en) 1991-07-24 1993-04-20 Alza Corporation Transdermal delivery device
US5337740A (en) 1991-08-01 1994-08-16 New England Pharmaceuticals, Inc. Inhalation devices
GB9116610D0 (en) 1991-08-01 1991-09-18 Danbiosyst Uk Preparation of microparticles
US5139878A (en) 1991-08-12 1992-08-18 Allied-Signal Inc. Multilayer film constructions
ES2089474T3 (es) 1991-08-16 1996-10-01 Sandoz Ltd Inhalador para la administracion de sustancias en polvo.
US5287850A (en) 1991-08-20 1994-02-22 Habley Medical Technology Corporation Timing and velocity controlled powered pharmaceutical inhaler
US6119688A (en) 1991-08-26 2000-09-19 3M Innovative Properties Company Powder dispenser
USD337636S (en) 1991-09-12 1993-07-20 Devilbiss Health Care, Inc. Ultrasonic medicament nebulizer
US5167506A (en) 1991-10-24 1992-12-01 Minnesota Mining And Manufacturing Company Inhalation device training system
USD348100S (en) 1991-10-29 1994-06-21 Fisons Plc Medicament inhaler
USD350602S (en) 1991-11-01 1994-09-13 Rhone-Poulenc Rorer Limited Combined dry powder inhaler and cap
US6063910A (en) 1991-11-14 2000-05-16 The Trustees Of Princeton University Preparation of protein microparticles by supercritical fluid precipitation
USD350821S (en) 1991-11-18 1994-09-20 Smithkline Beecham P.L.C. Oral inhaler
SE9103572D0 (sv) 1991-11-29 1991-11-29 Astra Ab Organic salts of n,n'-diacetyl cystine
USD340975S (en) 1991-12-02 1993-11-02 Thayer Medical Corporation Combined expansion chamber metered dose inhaler dispenser and adaptor
US5338837A (en) 1991-12-13 1994-08-16 The Trustees Of Princeton University Glycosylated steroid derivatives for transport across biological membranes and process for making same
DE4211475A1 (de) 1991-12-14 1993-06-17 Asta Medica Ag Pulverinhalator
GB2262452B (en) 1991-12-19 1995-12-20 Minnesota Mining & Mfg Inhalation device
JP3121080B2 (ja) 1991-12-19 2000-12-25 アール・ピー・シーラー コーポレイション カプセル封入用溶液
US5363842A (en) 1991-12-20 1994-11-15 Circadian, Inc. Intelligent inhaler providing feedback to both patient and medical professional
US5525519A (en) 1992-01-07 1996-06-11 Middlesex Sciences, Inc. Method for isolating biomolecules from a biological sample with linear polymers
US5320094A (en) 1992-01-10 1994-06-14 The Johns Hopkins University Method of administering insulin
DE69306755T2 (de) 1992-01-21 1997-04-10 Stanford Res Inst Int Verbessertes verfahren zur herstellung von mikronisierter polypeptidarzneimitteln
DE9209050U1 (de) 1992-02-13 1992-10-01 Schrader, Barthold von, 2400 Travemünde Inhalationseinrichtung
US5476093A (en) 1992-02-14 1995-12-19 Huhtamaki Oy Device for more effective pulverization of a powdered inhalation medicament
US5469971A (en) 1992-02-26 1995-11-28 Estee Lauder Inc. Method and apparatus for deagglomerating powder
EP0558879B1 (en) 1992-03-04 1997-05-14 Astra Aktiebolag Disposable inhaler
US5639441A (en) 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
US5352461A (en) 1992-03-11 1994-10-04 Pharmaceutical Discovery Corporation Self assembling diketopiperazine drug delivery system
DK36392D0 (da) 1992-03-19 1992-03-19 Novo Nordisk As Anvendelse af kemisk forbindelse
USD348929S (en) 1992-04-03 1994-07-19 Norton Healthcare Limited Medicament inhaler
CA2096302A1 (en) 1992-05-15 1993-11-16 David Kilis Air flow controller and recording system
USD344796S (en) 1992-06-11 1994-03-01 Schering Corporation Combined inhaler and cover
USD344797S (en) 1992-06-11 1994-03-01 Schering Corporation Combined inhaler and cover
USD345013S (en) 1992-06-11 1994-03-08 Schering Corporation Combined inhaler and cover
USD350193S (en) 1992-06-11 1994-08-30 Schering Corporation Combined inhaler and cover
WO1993025193A1 (en) 1992-06-12 1993-12-23 Teijin Limited Pharmaceutical preparation for intra-airway administration
US5811127A (en) 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5394868A (en) 1992-06-25 1995-03-07 Schering Corporation Inhalation device for powdered medicaments
GB9213874D0 (en) 1992-06-30 1992-08-12 Fisons Plc Process to novel medicament form
US6509006B1 (en) 1992-07-08 2003-01-21 Inhale Therapeutic Systems, Inc. Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
JP3413876B2 (ja) 1992-07-08 2003-06-09 セイコーエプソン株式会社 半導体装置
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
GB9214819D0 (en) 1992-07-13 1992-08-26 Minnesota Mining & Mfg Valve assemblies
GB9216038D0 (en) 1992-07-28 1992-09-09 Bespak Plc Dispensing apparatus for powdered medicaments
GB2269992A (en) 1992-08-14 1994-03-02 Rh Ne Poulenc Rorer Limited Powder inhalation formulations
US5239993A (en) 1992-08-26 1993-08-31 Glaxo Inc. Dosage inhalator providing optimized compound inhalation trajectory
GB2270293A (en) 1992-09-05 1994-03-09 Medix Ltd Drug dispensing system
USD348928S (en) 1992-09-21 1994-07-19 Schering Corporation Inhaler
US5333106A (en) 1992-10-09 1994-07-26 Circadian, Inc. Apparatus and visual display method for training in the power use of aerosol pharmaceutical inhalers
AU5171293A (en) 1992-10-14 1994-05-09 Regents Of The University Of Colorado, The Ion-pairing of drugs for improved efficacy and delivery
ES2127837T3 (es) 1992-10-19 1999-05-01 Dura Pharma Inc Inhalador para polvo seco.
AU121578S (en) 1992-10-22 1994-09-20 Fisons Plc An inhalation device
USD359555S (en) 1992-11-18 1995-06-20 Nippon Glaxo Limited Nasal medicine inhaler
USD352107S (en) 1992-12-10 1994-11-01 Ciba-Geigy Corporation Inhaler
USD349572S (en) 1992-12-10 1994-08-09 Schering Corporation Aerosol inhaler
US6250300B1 (en) 1992-12-11 2001-06-26 Ab Astra System for dispensing pharmaceutically active compounds
SE9203743D0 (sv) 1992-12-11 1992-12-11 Astra Ab Efficient use
ES2128550T3 (es) 1992-12-18 1999-05-16 Schering Corp Inhalador para medicamentos en polvo.
US5401516A (en) 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
US6880554B1 (en) 1992-12-22 2005-04-19 Battelle Memorial Institute Dispensing device
US6105571A (en) 1992-12-22 2000-08-22 Electrosols, Ltd. Dispensing device
US5896855A (en) 1992-12-24 1999-04-27 Rhone-Poulenc Rorer Limited Multi dose inhaler apparatus
FR2700279B1 (fr) 1993-01-14 1995-03-17 Valois Dispositif portatif pour projeter des doses d'une substance fluide à l'aide d'un flux d'air comprimé.
AU119600S (en) 1993-01-21 1994-03-07 Boehringer Ingelheim Kg Inhaler device
US5888477A (en) 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US6024090A (en) 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US7448375B2 (en) 1993-01-29 2008-11-11 Aradigm Corporation Method of treating diabetes mellitus in a patient
US6131567A (en) 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US5364838A (en) 1993-01-29 1994-11-15 Miris Medical Corporation Method of administration of insulin
US5672581A (en) 1993-01-29 1997-09-30 Aradigm Corporation Method of administration of insulin
US5441060A (en) 1993-02-08 1995-08-15 Duke University Dry powder delivery system
IL108780A (en) 1993-02-27 1999-06-20 Fisons Plc Inhalation device
US5437271A (en) 1993-04-06 1995-08-01 Minnesota Mining And Manufacturing Company Deagglomerators for dry powder inhalers
US5372128A (en) 1993-04-14 1994-12-13 Habley Medical Technology Corporation Fluidizing powder inhaler
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
ZA939608B (en) 1993-04-22 1994-08-24 Emisphere Tech Inc Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof.
ES2163444T3 (es) 1993-04-22 2002-02-01 Emisphere Tech Inc Composiciones y metodos para la administracion oral de farmacos.
US5360614A (en) 1993-04-26 1994-11-01 The Estee Corporation Method of controlling the release of carbohydrates by encapsulation and composition therefor
EP0695171B1 (en) 1993-04-28 1996-12-18 Akzo Nobel N.V. Lyospheres comprising gonadotropin
ATE176164T1 (de) 1993-05-12 1999-02-15 Teijin Ltd Vorrichtung und verfahren zur dosierten abgabe von pulverförmigen arzneistoffen
US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
US5533502A (en) 1993-05-28 1996-07-09 Vortran Medical Technology, Inc. Powder inhaler with aerosolization occurring within each individual powder receptacle
USD365876S (en) 1993-06-16 1996-01-02 Chawla Brindra P S Medicament inhaler
TW402506B (en) 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
US5506203C1 (en) 1993-06-24 2001-02-06 Astra Ab Systemic administration of a therapeutic preparation
US5747445A (en) 1993-06-24 1998-05-05 Astra Aktiebolag Therapeutic preparation for inhalation
US6632456B1 (en) 1993-06-24 2003-10-14 Astrazeneca Ab Compositions for inhalation
IS1796B (is) 1993-06-24 2001-12-31 Ab Astra Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
US6794357B1 (en) 1993-06-24 2004-09-21 Astrazeneca Ab Compositions for inhalation
US5562909A (en) 1993-07-12 1996-10-08 Massachusetts Institute Of Technology Phosphazene polyelectrolytes as immunoadjuvants
GB9314614D0 (en) 1993-07-14 1993-08-25 Minnesota Mining & Mfg Dry powder inhalers
US5371046A (en) 1993-07-22 1994-12-06 Taiwan Semiconductor Manufacturing Company Method to solve sog non-uniformity in the VLSI process
JPH0741428A (ja) 1993-07-30 1995-02-10 Teijin Ltd ペプチド、蛋白質性薬物経鼻・経肺製剤
DK0714314T3 (da) 1993-08-18 1999-06-23 Fisons Plc Inhalator med åndedrætsregulering
US5306453A (en) 1993-08-18 1994-04-26 Edward Shulman Apparatus and method of making a non-woven fabric
US5524613A (en) 1993-08-25 1996-06-11 Habley Medical Technology Corporation Controlled multi-pharmaceutical inhaler
BE1007551A3 (nl) 1993-09-24 1995-08-01 Philips Electronics Nv Werkwijze voor het in een rekenmachine automatisch herstellen van consistentie in een hierarchische objektstruktuur na een interaktie door een gebruiker en rekenmachine voorzien van zo een systeem voor automatische consistentieherstelling.
US5477285A (en) 1993-10-06 1995-12-19 Thomson Consumer Electronics, Inc. CRT developing apparatus
GB9322014D0 (en) 1993-10-26 1993-12-15 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
US5726156A (en) * 1995-03-06 1998-03-10 Trega Biosciences, Inc. Cytokine regulatory agents and methods of use in pathologies and conditions associated with altered cytokine levels
PL314485A1 (en) 1993-11-16 1996-09-16 Depotech Corp Bubbles with controllable release of active substances
EP0655237A1 (de) 1993-11-27 1995-05-31 Hoechst Aktiengesellschaft Medizinische Aerosolformulierung
USD358880S (en) 1993-12-02 1995-05-30 Tenax Corporation Dry powder inhalator
US5705483A (en) 1993-12-09 1998-01-06 Eli Lilly And Company Glucagon-like insulinotropic peptides, compositions and methods
DE4422710C1 (de) 1994-06-29 1995-09-14 Boehringer Ingelheim Kg Inhalationsgerät mit einem Elektronikmodul zur Funktionsüberwachung
US5965536A (en) * 1993-12-15 1999-10-12 Board Of Regents, The University Of Texas System Methods of inhibiting CXC intercrine molecules
ATE192341T1 (de) 1993-12-18 2000-05-15 Merck Patent Gmbh Pulverinhalator
USD357603S (en) 1993-12-20 1995-04-25 Wolff Stephen H Base for displaying or holding items
US5415162A (en) 1994-01-18 1995-05-16 Glaxo Inc. Multi-dose dry powder inhalation device
US5484606A (en) 1994-01-24 1996-01-16 The Procter & Gamble Company Process for reducing the precipitation of difficulty soluble pharmaceutical actives
PT101450B (pt) 1994-02-02 1999-11-30 Hovione Produtos Farmaceuticos Novo dispositivo para inalacao
CA2182988A1 (en) 1994-02-09 1995-08-17 Kinerton Limited Process for drying a material from solution
SE9400462D0 (sv) 1994-02-11 1994-02-11 Astra Ab Filling device
BR9507023A (pt) 1994-03-07 1997-09-23 Inhale Therapeutic Syst Processos para aerossolização de uma dose de insulina para a liberação respiratória de insulina e para preparação de uma composição de insulina e composição de insulina
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US5505194A (en) 1994-03-23 1996-04-09 Abbott Laboratories Aerosol inhalation device having slideably and rotatably connected elliptical cylinder portions
US5839429A (en) 1994-03-25 1998-11-24 Astra Aktiebolag Method and apparatus in connection with an inhaler
AU124387S (en) 1994-03-25 1995-08-11 Astra Ab Training device for an inhaler
DE59500494D1 (de) 1994-04-15 1997-09-18 Fissler Gmbh Gar- und/oder Kochgerät, welches für eine bodenseitige Zuführung von Wärmeenergie durch Wärmeleitung oder durch elektromagnetische Induktion eingerichtet ist
US6395744B1 (en) 1994-04-22 2002-05-28 Queen's University At Kingston Method and compositions for the treatment or amelioration of female sexual dysfunction
FI942196L (fi) 1994-05-11 1995-11-12 Orion Yhtymae Oy Jauheinhalaattori
AU696387B2 (en) 1994-05-18 1998-09-10 Inhale Therapeutic Systems, Inc. Methods and compositions for the dry powder formulation of interferons
WO1995031979A1 (en) 1994-05-19 1995-11-30 R.P. Scherer International Corporation Solutions of aryl or heteroaryl substituted alkanoic acids in lipophilic solvents and soft gelatin capsules containing such solutions
JP3372105B2 (ja) 1994-05-26 2003-01-27 株式会社日立ユニシアオートモティブ 吸入式投薬器
US5483954A (en) 1994-06-10 1996-01-16 Mecikalski; Mark B. Inhaler and medicated package
IL110024A (en) 1994-06-15 1998-04-05 Yissum Res Dev Co Controlled release oral drug delivery system containing hydrogel- forming polymer
USD363775S (en) 1994-06-21 1995-10-31 Rhone-Poulenc Rorer Limited Multidose dry powder inhaler
USD362500S (en) 1994-06-28 1995-09-19 Thayer Medical Corporation Medication inhaler spacer
US5641510A (en) 1994-07-01 1997-06-24 Genentech, Inc. Method for treating capsules used for drug storage
US6039208A (en) 1994-07-29 2000-03-21 Ortho Pharmaceutical Corporation Variable day start tablet dispenser
US5562231A (en) 1994-07-29 1996-10-08 Ortho Pharmaceutical Corporation Variable day start tablet dispenser
US5623724A (en) 1994-08-09 1997-04-22 Northrop Grumman Corporation High power capacitor
GB9416884D0 (en) 1994-08-20 1994-10-12 Danbiosyst Uk Drug delivery compositions
USD359153S (en) 1994-08-25 1995-06-13 Viggiano Bernard J Muffin top
US5574008A (en) 1994-08-30 1996-11-12 Eli Lilly And Company Biologically active fragments of glucagon-like insulinotropic peptide
US5547929A (en) 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
HU220472B1 (hu) 1994-09-21 2002-02-28 Inhale Therapeutic Systems Eljárás és készülék por aeroszolosítására, valamint a készülékben alkalmazott adagolócső-egység
FR2725626A1 (fr) 1994-10-18 1996-04-19 Sofab Dispositif pour l'inhalation de produits en poudre
AU4010395A (en) 1994-10-27 1996-05-23 Amgen, Inc. Compositions for increased bioavailability of orally delivered therapeutic agents
SE9404140D0 (sv) 1994-11-29 1994-11-29 Astra Ab Dose indicating device
EP0805149A4 (en) 1994-12-01 1998-03-11 Toyama Chemical Co Ltd NEW 2,3-DICETOPIPERAZINE DERIVATIVE OR SALT THEREOF
SE9404439D0 (sv) 1994-12-21 1994-12-21 Astra Ab Inhalation device
AR002009A1 (es) 1994-12-22 1998-01-07 Astra Ab Composicion farmaceutica, procedimiento para la manufactura de un polvo de proliposoma como el utilizado en dicha composicion, procedimiento para lamanufactura de dicha composicion, uso de dicha composicion farmaceutica en la manufactura de un medicamento y dispositivo inhalador de polvo seco.
US6485726B1 (en) 1995-01-17 2002-11-26 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
NZ298384A (en) 1995-01-23 1998-07-28 Direct Haler As Inhaler - single dose of particulate substance arranged in air flow passage
USD368364S (en) 1995-02-02 1996-04-02 Reitano Joseph R Inhaler case
US5901703A (en) 1995-02-06 1999-05-11 Unisia Jecs Corporation Medicine administering device for nasal cavities
US5660835A (en) 1995-02-24 1997-08-26 East Carolina University Method of treating adenosine depletion
EP0870699A3 (en) 1995-03-10 1998-10-21 Minnesota Mining And Manufacturing Company Aerosol valves
US5653961A (en) 1995-03-31 1997-08-05 Minnesota Mining And Manufacturing Company Butixocort aerosol formulations in hydrofluorocarbon propellant
US5542539A (en) 1995-04-04 1996-08-06 Ethicon Endo-Surgery, Inc. Container for quick release packages for surgical instruments
USD377215S (en) 1995-04-13 1997-01-07 Glaxo Group Limited Inhaler
US5990077A (en) 1995-04-14 1999-11-23 1149336 Ontario Inc. Glucagon-like peptide-2 and its therapeutic use
US6309671B1 (en) 1995-04-14 2001-10-30 Inhale Therapeutic Systems Stable glassy state powder formulations
US5645051A (en) 1995-04-21 1997-07-08 Dura Pharmaceuticals, Inc. Unit dose dry powder inhaler
US5622166A (en) 1995-04-24 1997-04-22 Dura Pharmaceuticals, Inc. Dry powder inhaler delivery system
US5921237A (en) 1995-04-24 1999-07-13 Dura Pharmaceuticals, Inc. Dry powder inhaler
US6428771B1 (en) 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
US5922253A (en) 1995-05-18 1999-07-13 Alkermes Controlled Therapeutics, Inc. Production scale method of forming microparticles
US5809997A (en) 1995-05-18 1998-09-22 Medtrac Technologies, Inc. Electronic medication chronolog device
US5924419A (en) 1995-05-22 1999-07-20 Kotliar; Igor K. Apparatus for passive hypoxic training and therapy
DE19519840A1 (de) 1995-05-31 1996-12-05 Kaewert Klaus Gelantinekapsel
AU128811S (en) 1995-06-06 1996-12-03 Orion Yhtymae Oy A protective cover for example a moisture protective cover for a powder inhaler
US5714007A (en) 1995-06-06 1998-02-03 David Sarnoff Research Center, Inc. Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate
US5610271A (en) 1995-06-07 1997-03-11 Torrey Pines Institute For Molecular Studies Kappa receptor selective opioid peptides
US5641861A (en) 1995-06-07 1997-06-24 Torrey Pines Institute For Molecular Studies μopioid receptor ligands: agonists and antagonists
US5919897A (en) 1995-06-07 1999-07-06 Torrey Pines Institute For Molecular Studies MU opioid receptor ligands: agonists and antagonists
US5824345A (en) 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
US6193844B1 (en) 1995-06-07 2001-02-27 Mclaughlin John R. Method for making paper using microparticles
US6357442B1 (en) 1995-06-08 2002-03-19 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIS)
US6672304B1 (en) 1995-06-08 2004-01-06 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIs)
CA2225396C (en) 1995-06-21 2003-03-25 Asta Medica Aktiengesellschaft Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments
GB9513218D0 (en) 1995-06-29 1995-09-06 Fisons Plc Inhalation device and method
DE19523516C1 (de) 1995-06-30 1996-10-31 Asta Medica Ag Inhalator zum Verabreichen von Medikamenten aus Blisterpackungen
AU131838S (en) 1995-07-01 1997-10-21 Glaxo Group Ltd Inhalation device
JP3098401B2 (ja) 1995-07-12 2000-10-16 株式会社エルティーティー研究所 経鼻投与用製剤
US5758638A (en) 1995-07-24 1998-06-02 Kreamer; Jeffry W. Indicator for a medicament inhaler
US5642727A (en) 1995-07-25 1997-07-01 David Sarnoff Research Center, Inc. Inhaler apparatus using a tribo-electric charging technique
WO1997004747A1 (en) 1995-07-27 1997-02-13 Dunn James M Drug delivery systems for macromolecular drugs
US6209538B1 (en) 1995-08-02 2001-04-03 Robert A. Casper Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
SE9502800D0 (sv) 1995-08-10 1995-08-10 Astra Ab Disposable inhaler
SE9502799D0 (sv) 1995-08-10 1995-08-10 Astra Ab Device in inhalers
JP3317823B2 (ja) 1995-08-11 2002-08-26 株式会社ユニシアジェックス 投薬器
US5690910A (en) 1995-08-18 1997-11-25 Baker Norton Pharmaceuticals, Inc. Method for treating asthma
US5980865A (en) 1995-08-18 1999-11-09 Baker Norton Pharmaceuticals, Inc. Method for treating late phase allergic reactions and inflammatory diseases
US5746197A (en) 1995-08-18 1998-05-05 Williams; Jeffery W. Extension for metered dose inhaler
US6852690B1 (en) 1995-08-22 2005-02-08 Amylin Pharmaceuticals, Inc. Method and composition for enhanced parenteral nutrition
FR2738153B1 (fr) 1995-09-04 1998-01-02 Valois Appareil d'inhalation destine a distribuer des doses precises et reproductibles de produit pulverulent
US5617844A (en) 1995-09-21 1997-04-08 King; Russell W. Aerosol medication delivery system
KR0124764Y1 (ko) 1995-09-23 1998-09-15 양주환 의약 및 식품용 하드 공 캅셀
SE9503344D0 (sv) 1995-09-27 1995-09-27 Astra Ab Inhalation device
WO1997014425A1 (en) * 1995-10-17 1997-04-24 The General Hospital Corporation Two novel genes from psoriatic epidermis: psoriastatin type i and psoriastatin type ii
US5766620A (en) 1995-10-23 1998-06-16 Theratech, Inc. Buccal delivery of glucagon-like insulinotropic peptides
US5849322A (en) 1995-10-23 1998-12-15 Theratech, Inc. Compositions and methods for buccal delivery of pharmaceutical agents
DK0861089T3 (da) 1995-11-13 2002-10-07 Medtronic Minimed Inc Metoder og sammensætninger til indgivelse af monomere proteiner
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
ATE193455T1 (de) 1995-12-07 2000-06-15 Jago Pharma Ag Inhalator zur mehrfachen dosisweisen abgabe eines pharmakologischen trockenpulvers
US7131441B1 (en) 1995-12-07 2006-11-07 Skyepharma Ag Inhaler for multiple dosed administration of a pharmacological dry powder
AP9801285A0 (en) 1996-01-03 1998-09-30 Glaxo Group Ltd Inhalation device.
US6026809A (en) 1996-01-25 2000-02-22 Microdose Technologies, Inc. Inhalation device
US6470884B2 (en) 1996-01-29 2002-10-29 Aventis Pharma Limited Capsule opening arrangement for use in a powder inhaler
JPH09208485A (ja) 1996-01-31 1997-08-12 Teijin Ltd ペプチド・蛋白質性薬物の水難溶性組成物
US6156114A (en) 1996-02-06 2000-12-05 E. I. Du Pont De Nemours And Company Treatment of deagglomerated particles with plasma-activated species
USD381416S (en) 1996-02-08 1997-07-22 Astra Aktiebolag Unit dose inhaler
PL185384B1 (pl) 1996-02-21 2003-04-30 Schering Corp Inhalator proszku
USD377861S (en) 1996-02-21 1997-02-11 Medport, Inc. Inhaler carrying case
CN1155368C (zh) 1996-02-27 2004-06-30 帝人株式会社 鼻腔给药的粉剂组合物
US6509313B1 (en) 1996-02-28 2003-01-21 Cornell Research Foundation, Inc. Stimulation of immune response with low doses of cytokines
US5699789A (en) 1996-03-11 1997-12-23 Hendricks; Mark R. Dry powder inhaler
JP3328132B2 (ja) 1996-03-21 2002-09-24 株式会社ユニシアジェックス 吸入式投薬器
GB9606188D0 (en) 1996-03-23 1996-05-29 Danbiosyst Uk Pollysaccharide microspheres for the pulmonary delivery of drugs
USD395499S (en) 1996-04-08 1998-06-23 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5858099A (en) 1996-04-09 1999-01-12 Sarnoff Corporation Electrostatic chucks and a particle deposition apparatus therefor
US5875776A (en) 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
ATE247948T1 (de) 1996-04-29 2003-09-15 Dura Pharma Inc Verfahren zum inhalieren trockener pulver
US5817343A (en) 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
AU132977S (en) 1996-05-17 1998-02-17 Astrazeneca Ab Container for inhaling apparatus
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US6503480B1 (en) 1997-05-23 2003-01-07 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5985309A (en) 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
USRE37053E1 (en) 1996-05-24 2001-02-13 Massachusetts Institute Of Technology Particles incorporating surfactants for pulmonary drug delivery
US6254854B1 (en) 1996-05-24 2001-07-03 The Penn Research Foundation Porous particles for deep lung delivery
JPH1053765A (ja) 1996-06-04 1998-02-24 Denso Corp スメクチック液晶組成物及び液晶セル
CA2258720A1 (en) 1996-06-05 1997-12-11 Basil Rapoport Human thyrotropin receptor compositions and use thereof
US5871010A (en) 1996-06-10 1999-02-16 Sarnoff Corporation Inhaler apparatus with modified surfaces for enhanced release of dry powders
AUPO066096A0 (en) 1996-06-26 1996-07-18 Peptide Delivery Systems Pty Ltd Oral delivery of peptides
US5769276A (en) 1996-07-10 1998-06-23 Terronics Development Corporation Powder atomizer
US5783556A (en) 1996-08-13 1998-07-21 Genentech, Inc. Formulated insulin-containing composition
AU133903S (en) 1996-08-19 1998-05-29 Orion Yhtymae Oy Inhaler device
US6277819B1 (en) 1996-08-30 2001-08-21 Eli Lilly And Company Use of GLP-1 or analogs in treatment of myocardial infarction
US6006753A (en) 1996-08-30 1999-12-28 Eli Lilly And Company Use of GLP-1 or analogs to abolish catabolic changes after surgery
JP3890099B2 (ja) 1996-09-30 2007-03-07 キヤノン株式会社 パターン認識装置及びその方法、及びそのプログラムを記憶した記憶媒体
JP3020141B2 (ja) 1996-10-07 2000-03-15 株式会社富士薬品 経鼻投与用製剤
US6532437B1 (en) 1996-10-23 2003-03-11 Cornell Research Foundation, Inc. Crystalline frap complex
UA65549C2 (uk) 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
US6441172B1 (en) 1996-11-07 2002-08-27 Torrey Pines Institute For Molecular Studies Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof
ES2290799T3 (es) 1996-11-12 2008-02-16 Novo Nordisk A/S Uso de peptidos glp-1.
DE19647947A1 (de) 1996-11-20 1998-05-28 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung für Medien
US5868774A (en) 1996-11-21 1999-02-09 Reil; Vladimir Unique cartridge and earring stud gun system
US6159360A (en) 1996-11-22 2000-12-12 Heinkel Industriezentrifugen Gmbh & Co. Invertible filter centrifuge including a solids drier
ATE215403T1 (de) 1996-12-11 2002-04-15 Earth Sciences Ltd Verfahren und vorrichtung zur verarbeitung und behandlung von partikelförmigem material
USD390651S (en) 1996-12-12 1998-02-10 Inhale Therapeutics Systems Medicament inhaler housing
GB9626263D0 (en) 1996-12-18 1997-02-05 Innovata Biomed Ltd Powder inhaler
GB9626233D0 (en) 1996-12-18 1997-02-05 Chawla Brinda P S Medicament packaging and deliveery device
GB2320489A (en) 1996-12-20 1998-06-24 Norton Healthcare Ltd Inhaler dose counter
AU6014098A (en) 1996-12-31 1998-07-31 Inhale Therapeutic Systems Aerosolized hydrophobic drug
USD397435S (en) 1997-01-03 1998-08-25 GGU Gesellschaft fuer Gesundheits-und Umweltforschung mbH Combined inhaler and cover
US5794613A (en) 1997-01-09 1998-08-18 Sepracor, Inc. Multiple-dose dispenser for dry powder inhalers
USD389238S (en) 1997-01-24 1998-01-13 Healthscan Products, Inc. Inhaler mask
WO1998033540A1 (fr) 1997-01-30 1998-08-06 Unisia Jecs Corporation Applicateur de medicament du type a aspiration
US6884435B1 (en) 1997-01-30 2005-04-26 Chiron Corporation Microparticles with adsorbent surfaces, methods of making same, and uses thereof
SE9700421D0 (sv) 1997-02-07 1997-02-07 Astra Ab Single dose inhaler I
SE9700424D0 (sv) 1997-02-07 1997-02-07 Astra Ab Powder inhaler
SE9700422D0 (sv) 1997-02-07 1997-02-07 Astra Ab Single dose inhaler II
SE9700423D0 (sv) 1997-02-07 1997-02-07 Astra Ab Disposable inhaler
JP3011898B2 (ja) 1997-02-20 2000-02-21 フォルテ グロウ メディカル株式会社 吸引器
DE19708406A1 (de) 1997-03-03 1998-09-10 Alfred Von Schuckmann Gerät zur dosierten Ausgabe von Substanzen
USD390653S (en) 1997-03-04 1998-02-10 Blasdell Richard J Inhaler
SE9700938D0 (sv) 1997-03-14 1997-03-14 Astra Ab Powder inhaler II and a method of construction thereof
SE9700937D0 (sv) 1997-03-14 1997-03-14 Astra Ab Powder inhaler I
SE9700948D0 (sv) 1997-03-14 1997-03-14 Astra Ab Powder inhaler X
SE9700940D0 (sv) 1997-03-14 1997-03-14 Astra Ab Powder inhaler IV
TW469832U (en) 1997-03-14 2001-12-21 Astra Ab Inhalation device
SE9700943D0 (sv) 1997-03-14 1997-03-14 Astra Ab Powder inhaler V
SE9700935D0 (sv) 1997-03-14 1997-03-14 Astra Ab Inhalation device
SE9700936D0 (sv) 1997-03-14 1997-03-14 Astra Ab Inhalation device
US5983105A (en) 1997-03-17 1999-11-09 Nokia Telecommunications Oy Method and receiver implemented on the rake principle
US6043214A (en) 1997-03-20 2000-03-28 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
US6006747A (en) 1997-03-20 1999-12-28 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5904139A (en) 1997-03-28 1999-05-18 Hauser; Stephen G. Breath coordinated inhaler
US8391104B2 (en) 1997-03-28 2013-03-05 Carlos De La Huerga Interactive medication container labeling
JP2002510193A (ja) 1997-03-31 2002-04-02 イーライ・リリー・アンド・カンパニー グルカゴン様ペプチド−１類似体
DE69838393T2 (de) 1997-04-01 2008-01-17 Cima Labs Inc., Eden Prairie Blisterverpackung für tabletten
CA2285457A1 (en) 1997-04-02 1998-10-08 Hoshi University Method for oral delivery of proteins
PT101988B (pt) 1997-04-04 2004-02-27 Hovione Farmaciencia Sa Sistema de orientacao e posicionamento de um objecto
USD410541S (en) 1997-06-30 1999-06-01 Novartis Ag Inhaler
SE9702796D0 (sv) 1997-07-25 1997-07-25 Pharmacia & Upjohn Ab A device at a pharmaceutical container or inhaler
CA2212430A1 (en) 1997-08-07 1999-02-07 George Volgyesi Inhalation device
GB2327895B (en) 1997-08-08 2001-08-08 Electrosols Ltd A dispensing device
US5855564A (en) 1997-08-20 1999-01-05 Aradigm Corporation Aerosol extrusion mechanism
US5846447A (en) 1997-08-26 1998-12-08 E. I. Du Pont De Nemours And Company Process for forming a dispersion of polytetrafluoroethylene
USD416085S (en) 1997-09-05 1999-11-02 Pharmacia & Upjohn Inhaler
USD417271S (en) 1997-09-10 1999-11-30 Medic-Aid Limited Drug delivery device
EP1012188B1 (de) 1997-09-12 2004-08-18 Pharis Biotec GmbH Zusammensetzung zur therapie von diabetes mellitus und fettsucht
US5848589A (en) 1997-09-18 1998-12-15 Welnetz; Robert J. Altitude mask simulator
AU135340S (en) 1997-09-24 1998-10-12 Innovata Biomed Ltd An inhaler
US6394085B1 (en) 1997-09-25 2002-05-28 Norton Healthcare Ltd. Inhaler spacer
US6073629A (en) 1997-09-25 2000-06-13 Norton Healthcare Ltd. Inhaler spacer
USD463544S1 (en) 1997-09-26 2002-09-24 1263152 Ontario Inc. Aerosol medication delivery inhaler
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
EP1019019A1 (en) 1997-10-01 2000-07-19 Flemington Pharmaceutical Corporation Buccal, polar and non-polar spray or capsule
US6228394B1 (en) 1997-10-14 2001-05-08 Boehringer Ingelheim Pharmaceuticals, Inc. Supercritical fluid extraction of mould lubricant from hard shell capsules
NZ504021A (en) 1997-10-17 2003-04-29 Systemic Pulmonary Delivery Lt Method and apparatus for delivering aerosolized medication having air discharged through air tube directly into plume of aerosolized medication
USD398992S (en) 1997-10-21 1998-09-29 Schering-Plough Healthcare Products, Inc. Nasal inhaler
ZA989744B (en) 1997-10-31 2000-04-26 Lilly Co Eli Method for administering acylated insulin.
IN188720B (forum.php) 1997-11-06 2002-11-02 Panacea Biotec Ltd
SE9704184D0 (sv) 1997-11-14 1997-11-14 Astra Ab Inhalation device
AU135120S (en) 1997-11-14 1998-09-21 Astrazeneca Ab Inhaler
US6116238A (en) 1997-12-02 2000-09-12 Dura Pharmaceuticals, Inc. Dry powder inhaler
USD412978S (en) 1997-12-02 1999-08-17 Dura Pharmaceuticals, Inc. Inhaler
USD418600S (en) 1997-12-04 2000-01-04 Charmaine Haerle Inhaler clip
EP1049486A4 (en) 1997-12-05 2006-01-04 Lilly Co Eli GLP-1 FORMULATIONS
US6192876B1 (en) 1997-12-12 2001-02-27 Astra Aktiebolag Inhalation apparatus and method
US6380357B2 (en) 1997-12-16 2002-04-30 Eli Lilly And Company Glucagon-like peptide-1 crystals
US5965701A (en) 1997-12-23 1999-10-12 Ferring Bv Kappa receptor opioid peptides
US6077940A (en) 1997-12-24 2000-06-20 Genentech, Inc. Free solution ligand interaction molecular separation method
US6358058B1 (en) 1998-01-30 2002-03-19 1263152 Ontario Inc. Aerosol dispensing inhaler training device
JP3530004B2 (ja) 1998-02-06 2004-05-24 株式会社日立ユニシアオートモティブ 吸入式投薬器
US6158431A (en) 1998-02-13 2000-12-12 Tsi Incorporated Portable systems and methods for delivery of therapeutic material to the pulmonary system
USD421800S (en) 1998-02-19 2000-03-21 Pierre Fabre Medicament Powder and compressed-air inhaler
USD412979S (en) 1998-02-27 1999-08-17 Diemolding Corporation Metered dose inhaler spacer
US7143764B1 (en) 1998-03-13 2006-12-05 Astrazeneca Ab Inhalation device
RO121834B1 (ro) 1998-03-16 2008-06-30 Inhale Therapeutic Systems, Inc. Dispozitiv pentru administrarea unui agent activ
US6998387B1 (en) 1998-03-19 2006-02-14 Amylin Pharmaceuticals, Inc. Human appetite control by glucagon-like peptide receptor binding compounds
SE9801078D0 (sv) 1998-03-27 1998-03-27 Shl Medical Ab Inhalator
AU138849S (en) 1998-03-30 1999-11-22 Astra Ab Inhaler with cap
AU138848S (en) 1998-03-30 1999-11-22 Astra Ab Inhaler with cap
AU138847S (en) 1998-03-30 1999-11-22 Astra Ab Inhaler with cap
PL343438A1 (en) 1998-04-08 2001-08-13 Lilly Co Eli Pulmonary and nasal delivery of raloxifene
WO1999052506A1 (de) 1998-04-09 1999-10-21 Axiva Gmbh Partikulärer wirkstoffträger für die pulmonale applikation
FR2777283B1 (fr) 1998-04-10 2000-11-24 Adir Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6578571B1 (en) 1998-04-20 2003-06-17 Infamed Ltd. Drug delivery device and methods therefor
GB9810126D0 (forum.php) 1998-05-13 1998-07-08 Glaxo Group Ltd
US6257233B1 (en) 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
SE9802080D0 (sv) 1998-06-11 1998-06-11 Hellstroem Pharmaceutical composition for the treatment of functional dyspepsia and/or irritable bowel syndrome and new use of substances therein
EA004538B1 (ru) 1998-06-12 2004-06-24 Амилин Фармасьютикалс, Инк. ГЛЮКАГОНОПОДОБНЫЙ ПЕПТИД-1, УЛУЧШАЮЩИЙ ОТВЕТ β-КЛЕТОК НА ГЛЮКОЗУ У СУБЪЕКТОВ С НАРУШЕНИЕМ ТОЛЕРАНТНОСТИ К ГЛЮКОЗЕ
US6152130A (en) 1998-06-12 2000-11-28 Microdose Technologies, Inc. Inhalation device with acoustic control
USD412572S (en) 1998-06-19 1999-08-03 Gray Gene W Nasal inhaler adaptor for left and right nostril
CZ300314B6 (cs) 1998-06-22 2009-04-15 Astrazeneca Ab Zarízení na vyprazdnování dutin obsahujících prášek
JP2002519366A (ja) 1998-07-07 2002-07-02 トランスダーマル・テクノロジーズ・インコーポレーテツド 医薬的に活性な作用物質を迅速かつ非刺激的に経皮送達するための組成物、およびそのような組成物の調剤法およびそれらの送達
DE19831525A1 (de) 1998-07-14 2000-01-20 Pfeiffer Erich Gmbh & Co Kg Spender für Medien
US6703381B1 (en) 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
US6087334A (en) 1998-08-21 2000-07-11 Amylin Pharmaceuticals, Inc. Anti-diabetic peptides
AU762145C (en) 1998-08-26 2005-03-17 Teijin Limited Powdery pernasal compositions
CZ2001690A3 (cs) 1998-08-28 2002-04-17 Eli Lilly And Company Způsob podávání inzulinotropních peptidů
US6720407B1 (en) 1998-08-28 2004-04-13 Eli Lilly And Company Method for administering insulinotropic peptides
CA2344383A1 (en) 1998-09-24 2000-03-30 Astrazeneca Ab Inhaler
US20020088458A1 (en) 1998-09-24 2002-07-11 Astrazeneca Ab Inhaler
GB9820886D0 (en) 1998-09-26 1998-11-18 Glaxo Group Ltd Inhalation device
GB9820937D0 (en) 1998-09-26 1998-11-18 Glaxo Group Ltd Inhalation device
US6187291B1 (en) 1998-09-28 2001-02-13 Robert Weinstein Method and device for facilitating combined aerosol and oral treatments for diabetes mellitus
USD411005S (en) 1998-09-29 1999-06-15 Pharmadesign Inc. Arthritic aid for metered dose inhaler
UA73924C2 (en) 1998-10-09 2005-10-17 Nektar Therapeutics Device for delivering active agent formulation to lungs of human patient
US6279511B1 (en) 1998-10-23 2001-08-28 Instech Laboratories, Inc. Powered multichannel infusion and monitoring system
US6263871B1 (en) 1998-10-29 2001-07-24 Richard I. Brown Mouthpiece with coupler
US6235725B1 (en) 1998-10-30 2001-05-22 Baker Norton Pharmaceuticals, Inc. Methods and compositions for the prevention of tolerance to medications
JP3747134B2 (ja) 1998-11-04 2006-02-22 キヤノン株式会社 インクジェット記録ヘッドカートリッジの保管容器
US6261594B1 (en) 1998-11-25 2001-07-17 The University Of Akron Chitosan-based nitric oxide donor compositions
US6540672B1 (en) 1998-12-09 2003-04-01 Novo Nordisk A/S Medical system and a method of controlling the system for use by a patient for medical self treatment
GB9827145D0 (en) 1998-12-09 1999-02-03 Co Ordinated Drug Dev Improvements in or relating to powders
US6375975B1 (en) 1998-12-21 2002-04-23 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary application
US6552024B1 (en) 1999-01-21 2003-04-22 Lavipharm Laboratories Inc. Compositions and methods for mucosal delivery
SE9900215D0 (sv) 1999-01-26 1999-01-26 Pharmacia & Upjohn Ab New use
JP2000217917A (ja) 1999-01-27 2000-08-08 Unisia Jecs Corp 吸入式投薬器
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
AU3409399A (en) 1999-03-05 2000-09-28 Chiesi Farmaceutici S.P.A. Improved powdery pharmaceutical compositions for inhalation
IT1309592B1 (it) 1999-03-05 2002-01-24 Chiesi Farma Spa Particelle veicolo modificate da utilizzarsi nella preparazione diformulazioni farmaceutiche sotto forma di polimeri per inalazione e
US6632258B1 (en) 1999-03-16 2003-10-14 The United States Of America As Represented By The United States Department Of Energy Coal beneficiation by gas agglomeration
US6803044B1 (en) 1999-03-24 2004-10-12 Zengen, Inc. Antimicrobial and anti-inflammatory peptides for use in human immunodeficiency virus
US6630169B1 (en) 1999-03-31 2003-10-07 Nektar Therapeutics Particulate delivery systems and methods of use
JP2002540850A (ja) 1999-04-05 2002-12-03 ファーマシューティカル ディスカバリー コーポレイション 微粉形成のための方法
USD441859S1 (en) 1999-04-06 2001-05-08 Istituto Biochimico Pavese Pharma S.P.A. Disposable dry-powder inhaler
WO2000068160A1 (en) 1999-05-07 2000-11-16 Imerys Pigments, Inc. A method of treating an aqueous suspension of kaolin
US6417920B1 (en) 1999-05-11 2002-07-09 Shimadzu Corporation Particle size analyzer based on laser diffraction method
US6514500B1 (en) 1999-10-15 2003-02-04 Conjuchem, Inc. Long lasting synthetic glucagon like peptide {GLP-!}
GB9911388D0 (en) 1999-05-18 1999-07-14 Glaxo Group Ltd Dispenser
MXPA01011660A (es) 1999-05-20 2004-04-05 Pharmasol Gmbh Adyuvante optimizado en estabilidad y biocompatibilidad (sba) para aumentar la respuesta inmune humoral y celular.
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US7919119B2 (en) 1999-05-27 2011-04-05 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
ATE248587T1 (de) 1999-06-14 2003-09-15 Baxter Int Mikrosphären mit verzögerter wirkstoffabgabe
US6644315B2 (en) 1999-06-18 2003-11-11 Saeed Ziaee Nasal mask
SE516826C2 (sv) 1999-06-18 2002-03-05 Shl Medical Ab Anordning i en inhalator med organ för aktivering och avaktivering av en kanister som svar på ett luftflöde
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
ATE372782T1 (de) 1999-06-21 2007-09-15 Lilly Co Eli Synergitische verwendung von thiazolidinedionen und glucagon-ähnlichem peptid-1 und dessen agonisten für die behandlung von nicht-insulin- abhängigen diabetes
US6858199B1 (en) 2000-06-09 2005-02-22 Advanced Inhalation Research, Inc. High efficient delivery of a large therapeutic mass aerosol
GB2353222B (en) 1999-06-23 2001-09-19 Cambridge Consultants Inhalers
USD444226S1 (en) 1999-06-24 2001-06-26 Novo Nordisk A/S Inhaler
ES2569949T3 (es) 1999-06-29 2016-05-13 Mannkind Corporation Formulaciones farmacéuticas que comprenden un péptido complejado con una dicetopiperazina
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US6606992B1 (en) 1999-06-30 2003-08-19 Nektar Therapeutics Systems and methods for aerosolizing pharmaceutical formulations
ITMI991582A1 (it) 1999-07-16 2001-01-16 Chiesi Farma Spa Polveri costituite da particelle aventi la superficie perfettamente levigata da utilizzare come veicoli per la preparazione di miscele inala
PL353026A1 (en) 1999-07-22 2003-10-06 Aventis Pharmaceuticals, Inc. Preserved pharmaceutical formulations
US7305986B1 (en) 1999-07-23 2007-12-11 Mannkind Corporation Unit dose capsules for use in a dry powder inhaler
WO2001007107A2 (en) 1999-07-23 2001-02-01 Pharmaceutical Discovery Corporation Unit dose capsules and dry powder inhaler
US7464706B2 (en) 1999-07-23 2008-12-16 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US20010036481A1 (en) 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
CN1175961C (zh) 1999-09-17 2004-11-17 株式会社新王磁材 稀土合金的切割方法和切割装置
USD438612S1 (en) 1999-09-27 2001-03-06 G-Intek Co., Ltd. Snivel inhaler
CA2390111C (en) 1999-10-06 2007-08-07 Raul Goldemann Breathing-controlled inhalation device for dry powder and method for the even distribution of said dry powder in the air
WO2001032144A1 (en) 1999-10-29 2001-05-10 Inhale Therapeutic Systems, Inc. Dry powder compositions having improved dispersivity
SE9903990D0 (sv) 1999-11-02 1999-11-02 Shl Medical Ab Inhalator with aerosolizing unit
GB9928311D0 (en) 1999-11-30 2000-01-26 Novartis Ag Organic compounds
IT1308581B1 (it) 1999-12-03 2002-01-08 Medel Italiana Srl Apparato per nebulizzare un liquido, in particolare per uso medico.
SE9904706D0 (sv) 1999-12-21 1999-12-21 Astra Ab An inhalation device
AR026914A1 (es) 1999-12-11 2003-03-05 Glaxo Group Ltd Distribuidor de medicamento
US7022674B2 (en) 1999-12-16 2006-04-04 Eli Lilly And Company Polypeptide compositions with improved stability
US7204250B1 (en) 1999-12-16 2007-04-17 Compumedics Limited Bio-mask
DE19961300A1 (de) 1999-12-18 2001-06-21 Asta Medica Ag Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator
US6669960B2 (en) 1999-12-21 2003-12-30 Rxkinetix, Inc. Particulate drug-containing products and method of manufacture
US7080642B2 (en) 1999-12-22 2006-07-25 3M Innovative Properties Company Refillable device with counting means
JP2003519175A (ja) 1999-12-30 2003-06-17 カイロン コーポレイション インターロイキン−２の肺送達のための方法
WO2001051071A2 (en) 2000-01-11 2001-07-19 Novo Nordisk A/S Transepithelial delivery of glp-1 derivatives
US6894026B1 (en) 2000-01-11 2005-05-17 Atossa Healthcare, Inc. Long-acting oxytocin analogues for the treatment and prevention of breast cancer and psychiatric disorders
AU2001231000A1 (en) 2000-01-19 2001-07-31 Pharmaceutical Discovery Corporation Dry powder formulations of antihistamine for nasal administration
EP1248594B1 (en) 2000-01-19 2005-12-14 Mannkind Corporation Multi-spike release formulation for drug delivery
US6540983B1 (en) 2000-01-25 2003-04-01 Aeropharm Technology Incorporated Medical aerosol formulation
US6443307B1 (en) 2000-01-25 2002-09-03 Michael D. Burridge Medication dispenser with an internal ejector
US6540982B1 (en) 2000-01-25 2003-04-01 Aeropharm Technology Incorporated Medical aerosol formulation
WO2001055213A2 (en) 2000-01-27 2001-08-02 Eli Lilly And Company Process for solubilizing glucagon-like peptide 1 (glp-1) compounds
US7171965B2 (en) 2000-02-01 2007-02-06 Valois S.A.S. Breath actuated dry powder inhaler and tape dose strip
US6427688B1 (en) 2000-02-01 2002-08-06 Dura Pharmaceuticals, Icn. Dry powder inhaler
USD439325S1 (en) 2000-02-08 2001-03-20 Baker Norton Pharmaceuticals, Inc. Cover for a nasal inhaler
EP1129705A1 (en) 2000-02-17 2001-09-05 Rijksuniversiteit te Groningen Powder formulation for inhalation
GB0004456D0 (en) 2000-02-26 2000-04-19 Glaxo Group Ltd Medicament dispenser
MXPA02008403A (es) 2000-02-28 2004-09-27 Vectura Ltd Mejoras en o relacionadas con el suministro de farmacos por via oral.
USD439656S1 (en) 2000-03-06 2001-03-27 Astrazeneca Uk Limited Inhaler
US6443151B1 (en) 2000-03-08 2002-09-03 Aradigm Corporation Fluid velocity-sensitive trigger mechanism
DE60129214T2 (de) 2000-03-10 2008-04-10 University Of North Carolina At Chapel Hill Trockenpulverinhalatoren, multidosistrockenpulvermedizinpackungen, kontrollsysteme und verfahren
US6608038B2 (en) 2000-03-15 2003-08-19 Novartis Ag Methods and compositions for treatment of diabetes and related conditions via gene therapy
GB0006525D0 (en) 2000-03-18 2000-05-10 Astrazeneca Uk Ltd Inhaler
GB2360218A (en) 2000-03-18 2001-09-19 Astrazeneca Uk Ltd Inhaler
GB2360216A (en) 2000-03-18 2001-09-19 Astrazeneca Uk Ltd Inhaler
US6823863B2 (en) 2000-03-18 2004-11-30 Astrazeneca Ab Inhaler
SE0000935D0 (sv) 2000-03-21 2000-03-21 Astrazeneca Ab An inhalation device
USD449684S1 (en) 2000-03-24 2001-10-23 Astrazeneca Ab Inhaler
US6432383B1 (en) 2000-03-30 2002-08-13 Generex Pharmaceuticals Incorporated Method for administering insulin
WO2001074247A2 (en) 2000-04-03 2001-10-11 Iep Pharmaceutical Devices Inc. Method for measuring changes in the airways of humans and other mammals
US6998137B2 (en) 2000-04-07 2006-02-14 Macromed, Inc. Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix
WO2001076671A2 (en) 2000-04-11 2001-10-18 Trudell Medical International Aerosol delivery apparatus with positive expiratory pressure capacity
DE10019879A1 (de) 2000-04-20 2001-10-25 Degussa Verfahren zur Herstellung von 2,5-Diketopiperazinen, neue 2,5-Diketopiperazine und deren Verwendung
MY136453A (en) 2000-04-27 2008-10-31 Philip Morris Usa Inc "improved method and apparatus for generating an aerosol"
US6447750B1 (en) 2000-05-01 2002-09-10 Aeropharm Technology Incorporated Medicinal aerosol formulation
US6468507B1 (en) 2000-05-01 2002-10-22 Aeropharm Technology, Inc. Non-aqueous aerosol formulation comprising rosiglitazone maleate, a non-aqueous carrier, and an amino acid stabilizer
USD442685S1 (en) 2000-05-02 2001-05-22 Salter Labs Medication inhaler spacer
US20010039442A1 (en) 2000-05-06 2001-11-08 Sal Gorge Headache relief device
US6948494B1 (en) 2000-05-10 2005-09-27 Innovative Devices, Llc. Medicament container with same side airflow inlet and outlet and method of use
US20020000225A1 (en) 2000-06-02 2002-01-03 Carlos Schuler Lockout mechanism for aerosol drug delivery devices
CN1141974C (zh) 2000-06-07 2004-03-17 张昊 结肠定位释放的口服生物制剂
DK1294757T3 (da) 2000-06-16 2007-03-19 Lilly Co Eli Glucagonlignende peptid 1-analoger
RU2181297C2 (ru) 2000-06-20 2002-04-20 Эпштейн Олег Ильич Способ лечения патологического синдрома и лекарственное средство
GB0015043D0 (en) 2000-06-21 2000-08-09 Glaxo Group Ltd Medicament dispenser
GB0015034D0 (en) 2000-06-21 2000-08-09 Glaxo Group Ltd Inhalation device
TWI224514B (en) 2000-06-23 2004-12-01 Norton Healthcare Ltd Dose metering system for medicament inhaler
US6562807B2 (en) 2000-06-23 2003-05-13 Novo Nordisk A/S Glucagon antagonists/inverse agonists
PE20020067A1 (es) 2000-06-23 2002-02-05 Norton Healthcare Ltd Desaglomerador para inhalador de polvo seco accionado por la respiracion
AR028746A1 (es) 2000-06-23 2003-05-21 Norton Health Care Ltd Cartucho de dosis previamente medidas para inhalador de polvo seco accionado por la respiracion, el inhalador y un metodo de provision de dosis previamente medidas de polvo seco
USD452910S1 (en) 2000-06-29 2002-01-08 Innovata Biomend Limited Inhaler
USD450117S1 (en) 2000-06-29 2001-11-06 Innovata Biomed Limited Inhaler
WO2002002560A2 (en) 2000-07-04 2002-01-10 Novo Nordisk A/S Purine-2,6-diones which are inhibitors of the enzyme dipeptidyl peptidase iv (dpp-iv)
US6363932B1 (en) 2000-07-06 2002-04-02 Clinical Technologies, Inc. Aerosol enhancement device
US6951215B1 (en) 2000-07-14 2005-10-04 Tufts University Drug delivery device for animals
US6360929B1 (en) 2000-07-17 2002-03-26 Mccarthy Madeleine Medicinal atomizing inhaler pouch/retainer
GB2364919A (en) 2000-07-21 2002-02-13 Cambridge Consultants Inhalers
WO2002011676A2 (en) 2000-08-04 2002-02-14 Dmi Biosciences, Inc. Method of using diketopiperazines and composition containing them
AU2001284697A1 (en) 2000-08-04 2002-02-18 Dmi Biosciences, Inc. Method of synthesizing diketopiperazines
SE0002822L (sv) 2000-08-04 2002-01-29 Microdrug Ag Elektropulver
PL213373B1 (pl) 2000-08-05 2013-02-28 Glaxo Group Ltd Ester S-fluorometylowy kwasu 6α,9α-difluoro-17α-(2-furanylokarboksyl)oksy-11β -hydroksy-16α-metylo-3-oksoandrosta-1,4,-dieno-17-karbotiowego, jego zastosowanie, srodek farmaceutyczny, preparat farmaceutyczny, aerozolowy preparat farmaceutyczny, sposób wytwarzania tego estru oraz zwiazki posrednie i sposób ich wytwarzania
MXPA03001092A (es) 2000-08-07 2003-09-25 Nektar Therapeutics Al Corp Polvos de proteina de haz de 4 helices secados por rocio, inhalables, que tienen agregacion minimizada.
WO2002013897A2 (en) 2000-08-14 2002-02-21 Advanced Inhalation Research, Inc. Inhalation device and method
US6704255B2 (en) 2000-08-22 2004-03-09 Ricoh Company, Ltd. Lens actuator
US6514482B1 (en) 2000-09-19 2003-02-04 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US6613308B2 (en) 2000-09-19 2003-09-02 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
CA2422941A1 (en) 2000-09-20 2003-03-19 Franco Del Bon Inhalator and pertaining atomizer
USD460173S1 (en) 2000-09-20 2002-07-09 P.A. Knowledge Limited Inhaler device
SE517225C2 (sv) 2000-09-21 2002-05-14 Microdrug Ag Optimering av en elektrostatiskt doserad inhalator för torrt pulver
SE517226C2 (sv) 2000-09-25 2002-05-14 Microdrug Ag Inhalator med luftbroms för torrt pulver
SE517228C2 (sv) 2000-09-25 2002-05-14 Microdrug Ag Inhalator för torrt pulver med andningsaktivering
GB0023653D0 (en) 2000-09-27 2000-11-08 Cambridge Consultants Device for dispensing particulate material
US7093594B2 (en) 2000-09-29 2006-08-22 Pfizer Limited Dosing device
US6756062B2 (en) 2000-11-03 2004-06-29 Board Of Regents University Of Texas System Preparation of drug particles using evaporation precipitation into aqueous solutions
KR100587237B1 (ko) 2000-11-29 2006-06-07 이토햄 가부시키가이샤 분말제제 및 그의 제조방법
GB0029562D0 (en) 2000-12-04 2001-01-17 Novartis Ag Organic compounds
USD455208S1 (en) 2000-12-05 2002-04-02 Clinical Designs Limited Inhaler
WO2002047716A2 (en) 2000-12-13 2002-06-20 Eli Lilly And Company Chronic treatment regimen using glucagon-like insulinotropic peptides
CA2432175C (en) 2000-12-21 2010-08-10 Jayne E. Hastedt Storage stable powder compositions of interleukin-4 receptor
US7077130B2 (en) 2000-12-22 2006-07-18 Chrysalis Technologies Incorporated Disposable inhaler system
US6799572B2 (en) 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
US20020141946A1 (en) 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
JP2005504715A (ja) 2000-12-29 2005-02-17 アドバンスト インハレーション リサーチ，インコーポレイテッド 持続放出特性を有する吸入用粒子
US6626173B2 (en) 2001-01-08 2003-09-30 Iep Pharmaceutical Devices Inc. Dry powder inhaler
US6644309B2 (en) 2001-01-12 2003-11-11 Becton, Dickinson And Company Medicament respiratory delivery device and method
FI20010144A0 (fi) 2001-01-24 2001-01-24 Valtion Teknillinen Menetelmä ja laite aerosolilähteiden tutkimiseksi
AUPR272901A0 (en) 2001-01-25 2001-02-22 Gainful Plan Limited Method of preparing biological materials and preparations produced using same
US20040022861A1 (en) 2001-01-30 2004-02-05 Williams Robert O. Process for production of nanoparticles and microparticles by spray freezing into liquid
WO2002067995A1 (en) 2001-02-26 2002-09-06 Council Of Scientific And Industrial Research Carrier systems comprising vitamin b12 - biodegradable micro particulate conju gates for peroral delivery of drugs, peptides/proteins and vaccines
DE60101451T2 (de) 2001-03-05 2004-10-21 Pera Ivo E Inhaliergerät zur Verteilung von in einer Kapsel enthaltenen Medikamenten in Pulverform durch die Atemwege
US6698422B2 (en) 2001-03-12 2004-03-02 Birdsong Medical Devices, Inc. Canister inhaler having a spacer and easy to operate lever mechanism and a flexible, elastic mouthpiece
US6523536B2 (en) 2001-03-12 2003-02-25 Birdsong Medical Devices, Inc. Dual-canister inhaler having a spacer and easy to operate lever mechanism
USD453264S1 (en) 2001-03-30 2002-02-05 Benjamin Acevedo, Jr. Pouch for medical inhaler
GB0108213D0 (en) 2001-04-02 2001-05-23 Glaxo Group Ltd Medicament dispenser
SE0101233L (sv) 2001-04-05 2002-10-01 Microdrug Ag Förfarande och anordning för frigörande av pulver och inhalatoranordning för administrering av medicinskt pulver
US6652838B2 (en) 2001-04-05 2003-11-25 Robert E. Weinstein Method for treating diabetes mellitus
AU2002254567B2 (en) 2001-04-11 2007-10-11 Bristol-Myers Squibb Company Amino acid complexes of C-aryl glucosides for treatment of diabetes and method
US6766799B2 (en) 2001-04-16 2004-07-27 Advanced Inhalation Research, Inc. Inhalation device
US6447751B1 (en) 2001-04-18 2002-09-10 Robert E. Weinstein Method and device for facilitating combined aerosol and oral treatments for diabetes mellitus
CA2504976C (en) 2001-04-19 2011-10-11 Technology Innovation Limited Medicament container
USD451597S1 (en) 2001-04-24 2001-12-04 G-Intek Co.,Ltd Snivel inhaler
US7232897B2 (en) 2001-04-24 2007-06-19 Harvard University, President And Fellows Of Harvard College Compositions and methods for modulating NH2-terminal Jun Kinase activity
JP4663906B2 (ja) 2001-04-26 2011-04-06 富士フイルム株式会社 セルロースアシレートフイルム
GB2375308A (en) 2001-05-10 2002-11-13 Cambridge Consultants Inhalers
EP1392383A2 (en) 2001-05-10 2004-03-03 Vectura Delivery Devices Limited Inhalers
EP1395294A4 (en) 2001-05-21 2006-01-11 Nektar Therapeutics PULMONARY ADMINISTRATION OF CHEMICALLY MODIFIED INSULIN
SE0101825D0 (sv) 2001-05-22 2001-05-22 Astrazeneca Ab An Inhalation device
AU2002308706A1 (en) 2001-06-01 2002-12-16 Eli Lilly And Company Glp-1 formulations with protracted time action
US7035294B2 (en) 2001-06-04 2006-04-25 Calix Networks, Inc. Backplane bus
EG24184A (en) 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
FI20011317A0 (fi) 2001-06-20 2001-06-20 Orion Corp Jauheinhalaattori
DE60205487T2 (de) 2001-06-22 2006-06-01 3M Innovative Properties Co., St. Paul Verfahren zur verbesserung des durchflusses einer aerosolformulierung in einem dosierventil für einen dosierinhalator
US6681768B2 (en) 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
US6614197B2 (en) 2001-06-30 2003-09-02 Motorola, Inc. Odd harmonics reduction of phase angle controlled loads
DE10136555A1 (de) 2001-07-27 2003-02-13 Boehringer Ingelheim Int Optimierte Verfahren zur Bestimmung der Aerosol-Partikelgrößenverteilung und Vorrichtung zur Durchführung derartiger Verfahren
US7414720B2 (en) 2001-07-27 2008-08-19 Herbert Wachtel Measuring particle size distribution in pharmaceutical aerosols
GB0120018D0 (en) 2001-08-16 2001-10-10 Meridica Ltd Pack containing medicament and dispensing device
IL160475A0 (en) 2001-08-22 2004-07-25 Aventis Pharma Gmbh Combination products of aryl-substituted propanolamine derivatives with other active ingredients and the use thereof
HUP0501192A3 (en) 2001-08-23 2006-06-28 Lilly Co Eli Glucagon-like peptide-1 analogs
CN1635900A (zh) 2001-08-28 2005-07-06 伊莱利利公司 Glp－1和基础胰岛素的预混合物
GB0121709D0 (en) 2001-09-07 2001-10-31 Imp College Innovations Ltd Food inhibition agent
WO2003024396A2 (en) 2001-09-17 2003-03-27 Glaxo Group Limited Dry powder medicament formulations
CN1313171C (zh) 2001-09-19 2007-05-02 埃德文特药物有限公司 吸入器
US6640050B2 (en) 2001-09-21 2003-10-28 Chrysalis Technologies Incorporated Fluid vaporizing device having controlled temperature profile heater/capillary tube
US6568390B2 (en) 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
EP1450885B1 (en) 2001-09-28 2015-04-22 Kurve Technology, Inc. Nasal nebulizer
WO2003030974A1 (en) 2001-10-08 2003-04-17 Eli Lilly And Company Portable medication inhalation kit
DK1436439T3 (da) 2001-10-16 2008-10-20 Internat Non Toxic Composites Ikke-toksiske kompositter med höj densitet, omfattende wolfram-, et andet metal- og polymerpulver
USD461239S1 (en) 2001-10-18 2002-08-06 Anna L. Cassidy Inhaler sleeve with spring clip
US7179788B2 (en) 2001-10-19 2007-02-20 Eli Lilly And Company Biphasic mixtures of GLP-1 and insulin
EP1438019A1 (en) 2001-10-24 2004-07-21 PARI GmbH Spezialisten für effektive Inhalation Kit for the preparation of a pharmaceutical composition
USD473298S1 (en) 2001-11-01 2003-04-15 Astrazeneca Ab Inhaler refill
WO2003063770A2 (en) 2001-11-07 2003-08-07 Mannkind Corporation Expression vectors encoding epitopes of target-associated antigens and methods for their design
MXPA04005865A (es) 2001-12-19 2004-09-13 Nektar Therapeutics Suministro de aminoglucosidos a los pulmones.
US6994083B2 (en) 2001-12-21 2006-02-07 Trudell Medical International Nebulizer apparatus and method
GB0130857D0 (en) 2001-12-22 2002-02-06 Glaxo Group Ltd Medicament dispenser
USD469866S1 (en) 2002-01-07 2003-02-04 Aerogen, Inc. Inhaler for dispensing medication
US20030198666A1 (en) 2002-01-07 2003-10-23 Richat Abbas Oral insulin therapy
USD471273S1 (en) 2002-01-07 2003-03-04 Aerogen, Inc. Inhaler for dispensing medication
USD479745S1 (en) 2002-01-07 2003-09-16 Aerogen, Inc. Inhaler for dispensing medications
USD474536S1 (en) 2002-01-07 2003-05-13 Aerogen, Inc. Inhaler for dispensing medications
ITMI20020078A1 (it) 2002-01-16 2003-07-16 Fabrizio Niccolai Dispositivo utilizzabile nel tratamento di affezzioni delle vie respiratorie
US6991779B2 (en) 2002-01-18 2006-01-31 Mannkind Corporation Compositions for treatment or prevention of bioterrorism
US7105489B2 (en) 2002-01-22 2006-09-12 Amylin Pharmaceuticals, Inc. Methods and compositions for treating polycystic ovary syndrome
US7258118B2 (en) 2002-01-24 2007-08-21 Sofotec Gmbh & Co, Kg Pharmaceutical powder cartridge, and inhaler equipped with same
RU2332229C2 (ru) 2002-02-20 2008-08-27 Эмисфире Текнолоджис Инк. Способ введения молекул glp-1
US6591832B1 (en) 2002-02-21 2003-07-15 Saint-Gobain Calmar Inc. Dry powder dispenser
US6830149B2 (en) 2002-03-08 2004-12-14 Musculoskeletal Transplant Foundation Package with insert for holding allograft implant to preclude lipid transfer
US7008644B2 (en) 2002-03-20 2006-03-07 Advanced Inhalation Research, Inc. Method and apparatus for producing dry particles
ATE385193T1 (de) 2002-03-20 2008-02-15 Mannkind Corp Inhalationsgerät
US20030235538A1 (en) 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
CA2453256A1 (en) 2002-04-09 2003-10-23 H. Greg Thomas Diphenhydramine tannate compositions and methods of use
UA80123C2 (en) 2002-04-09 2007-08-27 Boehringer Ingelheim Pharma Inhalation kit comprising inhalable powder of tiotropium
US20030194420A1 (en) 2002-04-11 2003-10-16 Richard Holl Process for loading a drug delivery device
USD475133S1 (en) 2002-04-18 2003-05-27 Mcluckie Lynne E. Luminescent-colored inhaler
US7316748B2 (en) 2002-04-24 2008-01-08 Wisconsin Alumni Research Foundation Apparatus and method of dispensing small-scale powders
US6830046B2 (en) 2002-04-29 2004-12-14 Hewlett-Packard Development Company, L.P. Metered dose inhaler
USD478983S1 (en) 2002-05-01 2003-08-26 Chrysalis Technologies Incorporated Inhaler
US20040151059A1 (en) 2002-05-01 2004-08-05 Roberts Ii William Leroy Deagglomerator apparatus and method
WO2003094951A1 (en) 2002-05-07 2003-11-20 Novo Nordisk A/S Soluble formulations comprising insulin aspart and insulin detemir
US6889690B2 (en) 2002-05-10 2005-05-10 Oriel Therapeutics, Inc. Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages
USD473640S1 (en) 2002-05-13 2003-04-22 Iep Pharmaceutical Devices Inc. Breath actuated inhaler
USD492769S1 (en) 2002-05-24 2004-07-06 Glaxosmithkline K.K. Lens for an inhaler
USD477665S1 (en) 2002-06-12 2003-07-22 Microdrug Ag Inhaler
US8003179B2 (en) 2002-06-20 2011-08-23 Alcan Packaging Flexible France Films having a desiccant material incorporated therein and methods of use and manufacture
AU154760S (en) 2002-06-20 2004-03-02 Astrazeneca Ab Inhaler
CA2488976C (en) 2002-06-28 2009-08-25 Advanced Inhalation Research, Inc. Inhalable epinephrine
US20060003316A1 (en) 2002-07-15 2006-01-05 John Simard Immunogenic compositions derived from poxviruses and methods of using same
GB0217198D0 (en) 2002-07-25 2002-09-04 Glaxo Group Ltd Medicament dispenser
GB0217382D0 (en) 2002-07-26 2002-09-04 Pfizer Ltd Process for making orally consumable dosage forms
USD489448S1 (en) 2002-07-31 2004-05-04 Advanced Inhalations Revolutions, Inc. Vaporization apparatus
EP1386630B1 (en) 2002-07-31 2006-05-17 CHIESI FARMACEUTICI S.p.A. Powder inhaler
US20080260838A1 (en) 2003-08-01 2008-10-23 Mannkind Corporation Glucagon-like peptide 1 (glp-1) pharmaceutical formulations
US8372804B2 (en) 2007-10-24 2013-02-12 Mannkind Corporation Delivery of active agents
US20150283213A1 (en) 2002-08-01 2015-10-08 Mannkind Corporation Method for treating hyperglycemia with glp-1
EP2409686A1 (en) 2002-08-01 2012-01-25 Mannkind Corporation Cell transport compositions and uses thereof
DE10235168A1 (de) 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
US20040038865A1 (en) 2002-08-01 2004-02-26 Mannkind Corporation Cell transport compositions and uses thereof
GB0315791D0 (en) 2003-07-07 2003-08-13 3M Innovative Properties Co Two component molded valve stems
US20040121964A1 (en) 2002-09-19 2004-06-24 Madar David J. Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
US7322352B2 (en) 2002-09-21 2008-01-29 Aventis Pharma Limited Inhaler
USD509296S1 (en) 2002-09-21 2005-09-06 Aventis Pharma Limited Inhaler
JP2004121061A (ja) 2002-10-01 2004-04-22 Sanei Gen Ffi Inc 粉末組成物の製造方法
EP1452198A4 (en) 2002-10-11 2006-11-02 Otsuka Pharma Co Ltd INHALATION DEVICE FOR POWDER
ITMO20020297A1 (it) 2002-10-16 2004-04-17 Roberto Oliva Inalatore per preparati monodose in capsule.
CN1176649C (zh) 2002-10-16 2004-11-24 上海医药工业研究院 舒马普坦干粉吸入剂及其制备方法
CA2504283A1 (en) 2002-10-31 2004-05-21 Umd, Inc. Therapeutic compositions for drug delivery to and through covering epithelia
GB0225621D0 (en) 2002-11-02 2002-12-11 Glaxo Group Ltd Medicament carrier
WO2004041338A1 (en) 2002-11-04 2004-05-21 Cambridge Consultants Limited Inhalers
USD493220S1 (en) 2002-11-06 2004-07-20 Merck Patent Gmbh Inhaler
US20080015457A1 (en) 2002-11-07 2008-01-17 Silva Carlos D Device for Monitoring Respiratory Movements
US7048098B1 (en) 2002-11-12 2006-05-23 Moradian Norick B Toroidal rotary damper apparatus
USD483860S1 (en) 2002-11-12 2003-12-16 Pari Gmbh Spezialisten Fur Effektive Inhalation Electronic inhaler and control unit
US6904907B2 (en) 2002-11-19 2005-06-14 Honeywell International Inc. Indirect flow measurement through a breath-operated inhaler
GB0227128D0 (en) 2002-11-20 2002-12-24 Glaxo Group Ltd A capsule
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
US20040138099A1 (en) 2002-11-29 2004-07-15 Draeger Eberhard Kurt Insulin administration regimens for the treatment of subjects with diabetes
AU2003285246A1 (en) 2002-12-02 2004-06-23 The Governors Of The University Of Alberta Device and method for deagglomeration of powder for inhalation
US7284553B2 (en) 2002-12-12 2007-10-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder inhaler comprising a chamber for a capsule for taking up a non-returnable capsule being filled with an active ingredient
JP4562528B2 (ja) 2002-12-13 2010-10-13 大塚製薬株式会社 経肺投与用の吸入式デバイス
WO2004054605A1 (en) 2002-12-13 2004-07-01 Otsuka Pharmaceutical Co., Ltd. Freeze-dried interferon-ϝ composition for transpulmonary administration and inhalation system therefor
WO2004056314A2 (en) 2002-12-17 2004-07-08 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of y2 receptor-binding peptides and methods for treating and preventing obesity
US6941947B2 (en) 2002-12-18 2005-09-13 Quadrant Technologies Limited Unit dose dry powder inhaler
US6962006B2 (en) 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US7185650B2 (en) 2002-12-19 2007-03-06 Arie Huber Systems and methods for determining a minimum effective dose of an inhaled drug for an individual patient at a given time
JP2006514990A (ja) 2002-12-27 2006-05-18 ディオベックス， インコーポレイテッド インスリン誘発性低血糖の予防および制御のための組成物および方法
DE10300032B3 (de) 2003-01-03 2004-05-27 E. Braun Gmbh Pulverinhalator
GB0309154D0 (en) 2003-01-14 2003-05-28 Aventis Pharma Inc Use of insulin glargine to reduce or prevent cardiovascular events in patients being treated for dysglycemia
US20040187869A1 (en) 2003-01-17 2004-09-30 Schering Corporation Training device for medicament inhalers
WO2004071490A1 (en) 2003-02-12 2004-08-26 R & P Korea Co., Ltd. Solvent system of hardly soluble drug with improved elution rate
GB0303870D0 (en) 2003-02-20 2003-03-26 Norton Healthcare Ltd Pre-metered dose magazine for breath-actuated dry powder inhaler
US20040171518A1 (en) 2003-02-27 2004-09-02 Medtronic Minimed, Inc. Compounds for protein stabilization and methods for their use
US7544656B2 (en) 2003-03-04 2009-06-09 The Technology Development Company, Ltd. Long acting injectable insulin composition and methods of making and using thereof
WO2004078236A2 (en) 2003-03-04 2004-09-16 Norton Healthcare Limited Medicament dispensing device with a display indicative of the state of an internal medicament reservoir
CA2518216C (en) 2003-03-06 2017-05-09 Emisphere Technologies, Inc. Oral insulin therapies and protocol
WO2004080482A2 (en) 2003-03-11 2004-09-23 Institut De Cardiologie De Montréal / Use of angiotensin converting enzyme (ace) inhibitors to prevent diabetes in a subject with chronic heart failure
USD499802S1 (en) 2003-04-01 2004-12-14 Chiesi Farmaceutici S.P.A. Powder inhaler
JP4542090B2 (ja) 2003-04-09 2010-09-08 ネクター セラピューティクス カプセル穿刺整合ガイドを有するエアロゾル化装置
US20040204439A1 (en) 2003-04-14 2004-10-14 Staniforth John Nicholas Composition, device, and method for treating sexual dysfunction via inhalation
EP1468935A1 (de) 2003-04-16 2004-10-20 Alcan Technology & Management Ltd. Blisterverpackung
DK2537524T3 (en) 2003-05-15 2016-10-24 Ampio Pharmaceuticals Inc The treatment of T cell mediated diseases
AU155845S (en) 2003-05-15 2004-07-13 Glaxo Group Ltd A dispensing device for example an inhaler device
AU155632S (en) 2003-05-16 2004-06-01 Henkel Kgaa Blister pack
US20070006876A1 (en) 2003-05-16 2007-01-11 University Of Alberta Add-on spacer design concept for dry-powder inhalers
GB0312007D0 (en) 2003-05-24 2003-07-02 Innovata Biomed Ltd Container
US9107831B2 (en) 2003-06-02 2015-08-18 Novartis Vaccines And Diagonstics, Inc. Immunogenic compositions containing microparticles comprising adsorbed toxoid and polysaccharide-containing antigens
US7954491B2 (en) 2003-06-13 2011-06-07 Civitas Therapeutics, Inc. Low dose pharmaceutical powders for inhalations
US20050008908A1 (en) 2003-06-27 2005-01-13 Ultracell Corporation Portable fuel cartridge for fuel cells
US7001622B1 (en) 2003-06-30 2006-02-21 Robert Berndt Composition and method for treatment and prevention of pruritis
GB0315509D0 (en) 2003-07-02 2003-08-06 Meridica Ltd Dispensing device
AU158576S (en) 2003-07-05 2006-08-22 Clinical Designs Ltd Inhaler
US7462367B2 (en) 2003-07-11 2008-12-09 Boehringer Ingelheim International Gmbh Anticholinergic powder formulations for inhalation
US8921311B2 (en) 2003-08-01 2014-12-30 Mannkind Corporation Method for treating hyperglycemia
USD569967S1 (en) 2003-08-06 2008-05-27 Meridica Limited Inhaler
US20050043247A1 (en) 2003-08-18 2005-02-24 Boehringer Ingelheim International Gmbh Spray-dried amorphous BIBN 4096, process for preparing and the use thereof as inhalative
DE10338402A1 (de) 2003-08-18 2005-03-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Sprühgetrocknetes, amorphes BIBN 4096, Verfahren zu dessen Herstellung sowie dessen Verwendung als Inhalativum
US20050056535A1 (en) 2003-09-15 2005-03-17 Makoto Nagashima Apparatus for low temperature semiconductor fabrication
DE10343668A1 (de) 2003-09-18 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Arzneimittelblister
CA2539632A1 (en) 2003-10-16 2005-04-28 Cara Therapeutics, Inc. Amide or thioamide derivatives and their use in the treatment of pain
GB2398065A (en) 2003-10-16 2004-08-11 Bespak Plc Dispensing apparatus
US20050187749A1 (en) 2003-10-24 2005-08-25 Judy Singley Method, system, and computer program for performing carbohydrate/insulin calculation based upon food weight
USD511208S1 (en) 2003-10-24 2005-11-01 Valois Sas Metered dose inhaler
US7451761B2 (en) 2003-10-27 2008-11-18 Oriel Therapeutics, Inc. Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances
US7377277B2 (en) 2003-10-27 2008-05-27 Oriel Therapeutics, Inc. Blister packages with frames and associated methods of fabricating dry powder drug containment systems
WO2005044173A1 (en) 2003-10-27 2005-05-19 Oriel Therapeutics, Inc. Blister packages and associated methods of fabricating dry powder drug containment systems
US20050147581A1 (en) 2003-11-19 2005-07-07 The Board Of Trustees Of The University Of Illinois Macromolecular drug complexes having improved stability and therapeutic use of the same
CA2450837A1 (en) 2003-11-25 2005-05-25 University Of New Brunswick Induction magnetometer
SE0303269L (sv) 2003-12-03 2005-06-04 Microdrug Ag Medicinsk produkt
GB0329884D0 (en) 2003-12-23 2004-01-28 Glaxo Group Ltd Method
US7192919B2 (en) 2004-01-07 2007-03-20 Stelios Tzannis Sustained release compositions for delivery of pharmaceutical proteins
US20070027063A1 (en) 2004-01-12 2007-02-01 Mannkind Corporation Method of preserving the function of insulin-producing cells
ES2584867T3 (es) 2004-01-12 2016-09-29 Mannkind Corporation Un método que reduce los niveles séricos de proinsulina en diabéticos de tipo 2
JP4601627B2 (ja) 2004-01-16 2010-12-22 バイオデル， インコーポレイテッド 舌下薬物送達デバイス
DE102004006450B4 (de) 2004-02-05 2012-09-27 Ing. Erich Pfeiffer Gmbh Dosiervorrichtung
DE102004008141A1 (de) 2004-02-19 2005-09-01 Abbott Gmbh & Co. Kg Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren
USD512777S1 (en) 2004-02-19 2005-12-13 Chrysalis Technologies Incorporated Inhaler
MXPA06009516A (es) 2004-02-24 2007-03-26 Microdose Technologies Inc Inhalador con sensor de flujo direccional.
JP4708369B2 (ja) 2004-02-24 2011-06-22 マイクロドース セラピューテクス，インコーポレイテッド 合成ジェットに基づく薬剤投与装置
DK1740154T3 (da) 2004-03-12 2009-08-31 Biodel Inc Insulinsammensætninger med forbedret absorption
ITMO20040060A1 (it) 2004-03-18 2004-06-18 Roberto Oliva Inalatore per preparati in polvere
USD515696S1 (en) 2004-03-19 2006-02-21 Innovata Biomed Limited Inhaler
JP4792457B2 (ja) 2004-03-26 2011-10-12 ユニヴァーシタ’デグリ ステュディ ディ パルマ 高度に呼吸に適したインスリンのマイクロ粒子
WO2005098435A2 (en) * 2004-04-05 2005-10-20 Universite Bordeaux 2 Peptides and peptidomimetics binding to cd23
USD533268S1 (en) 2004-04-18 2006-12-05 Bahram Olfati Inhaler
BRPI0509348A (pt) 2004-04-21 2007-09-11 Innovata Biomed Ltd inalador
WO2005102428A1 (en) 2004-04-23 2005-11-03 The Governors Of The University Of Alberta Enhanced drug delivery for inhaled aerosols
HUE026152T2 (en) 2004-04-23 2016-05-30 Philip Morris Products Sa Aerosol Generator and Method for Aerosol Production
USD527817S1 (en) 2004-05-13 2006-09-05 Novartis Ag Inhaler
GB0410712D0 (en) 2004-05-13 2004-06-16 Novartis Ag Organic compounds
US20050265927A1 (en) 2004-05-17 2005-12-01 Yale University Intranasal delivery of nucleic acid molecules
PE20060070A1 (es) 2004-05-19 2006-02-18 Cipla Ltd Dispositivo inhalador de medicamentos
USD529604S1 (en) 2004-05-28 2006-10-03 Quadrant Technologies Limited Dry powder inhaler
USD548833S1 (en) 2004-05-28 2007-08-14 Quadrant Technologies Limited Dry powder inhaler
RU2006145654A (ru) 2004-06-07 2008-07-20 Медерио Аг (Ch) Защита дозированного лекарства, предназначенного для ингаляции
SE528190C2 (sv) 2004-06-07 2006-09-19 Mederio Ag Inhalator
NZ552029A (en) * 2004-06-25 2009-01-31 Takeda Pharmaceutical Metastin derivatives and use thereof
US20060000469A1 (en) 2004-07-02 2006-01-05 Tseng Daniel C Nebulizing apparatus for medical use with improved nozzle positioning structure
US7850619B2 (en) 2004-07-23 2010-12-14 Intercure Ltd. Apparatus and method for breathing pattern determination using a non-contact microphone
CA2574398C (en) 2004-07-26 2010-05-18 1355540 Ontario Inc. Powder inhaler featuring reduced compaction
WO2006017688A2 (en) 2004-08-03 2006-02-16 Biorexis Pharmaceutical Corporation Combination therapy using transferrin fusion proteins comprising glp-1
PL1786784T3 (pl) 2004-08-20 2011-04-29 Mannkind Corp Kataliza syntezy diketopiperazyn
US20060099269A1 (en) 2004-08-23 2006-05-11 Mannkind Corporation Pulmonary delivery of inhibitors of phosphodiesterase type 5
BR122019022692B1 (pt) 2004-08-23 2023-01-10 Mannkind Corporation Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo
GB0419849D0 (en) 2004-09-07 2004-10-13 Pfizer Ltd Pharmaceutical combination
US8210171B2 (en) 2004-09-13 2012-07-03 Oriel Therapeutics, Inc. Tubular dry powder drug containment systems, associated inhalers and methods
USD537936S1 (en) 2004-09-15 2007-03-06 Glaxo Group Limited Cap with an extension, particularly for a dust cap of a metered dose inhaler
USD537522S1 (en) 2004-09-15 2007-02-27 Glaxo Group Limited Telescopic strap, particularly for a dust cap of a metered dose inhaler
RU2448977C2 (ru) * 2004-09-16 2012-04-27 Зе Риджентс Оф Зи Юнивесити Оф Кэлифонье Обладающий способностью облегчать по меньшей мере один симптом воспалительного состояния пептид, содержащая его фармацевтическая композиция и способ лечения атеросклероза с их помощью
USD518170S1 (en) 2004-09-28 2006-03-28 Vectura, Ltd. Inhaler
KR20070073865A (ko) 2004-10-06 2007-07-10 베링거 인겔하임 인터내셔날 게엠베하 분배장치, 저장장치 및 분말 분배 방법
US7469696B2 (en) 2004-10-13 2008-12-30 Hewlett-Packard Development Company, L.P. Thermal drop generator
USD515924S1 (en) 2004-11-01 2006-02-28 Warner-Lambert Company Llc Blister card
DE102005033398A1 (de) 2004-11-10 2006-05-11 Alfred Von Schuckmann Inhalier-Gerät
CA2589118A1 (en) 2004-12-03 2006-06-08 Mederio Ag A medical product comprising a glucagon-like peptide medicament intended for pulmonary inhalation
SE0402976L (sv) 2004-12-03 2006-06-04 Mederio Ag Medicinsk produkt
GB0427028D0 (en) 2004-12-09 2005-01-12 Cambridge Consultants Dry powder inhalers
US20060130838A1 (en) 2004-12-20 2006-06-22 Lee Yong Y Data logger for monitoring asthmatic conditions
BRPI0519241A2 (pt) 2004-12-22 2009-01-06 Centocor Inc agonistas, composiÇÕes, mÉtodos e usos de glp-1
JP2008526893A (ja) 2005-01-10 2008-07-24 マンカインド コーポレイション 肺における吸入可能なインスリンの自然増加を最少化するための方法及び組成物
US20060165756A1 (en) 2005-01-27 2006-07-27 Catani Steven J Method for weight management
USD538423S1 (en) 2005-02-04 2007-03-13 Berube-White Panda bear inhaler
GB0503738D0 (en) 2005-02-23 2005-03-30 Optinose As Powder delivery devices
US20060219242A1 (en) 2005-03-30 2006-10-05 Boehringer Ingelheim International Method for the Administration of an Anticholinergic by Inhalation
JP4656397B2 (ja) 2005-03-31 2011-03-23 株式会社吉野工業所 粉体用容器
CN100431634C (zh) 2005-04-04 2008-11-12 陈庆堂 干粉气溶胶化吸入器
US7762953B2 (en) 2005-04-20 2010-07-27 Adidas Ag Systems and methods for non-invasive physiological monitoring of non-human animals
US7694676B2 (en) 2005-04-22 2010-04-13 Boehringer Ingelheim Gmbh Dry powder inhaler
CA2604225A1 (en) 2005-04-27 2006-11-02 Baxter International Inc. Surface-modified microparticles and methods of forming and using the same
US7219664B2 (en) 2005-04-28 2007-05-22 Kos Life Sciences, Inc. Breath actuated inhaler
CA2606493A1 (en) 2005-05-02 2006-11-09 Astrazeneca Ab An arrangement and a method for opening a cavity, a medical package and a dispensing device
USD544093S1 (en) 2005-06-02 2007-06-05 Bang & Olufsen A/S Inhaler
CN101198362B (zh) 2005-06-17 2014-03-12 威斯康星校友研究基金会 在癌症化疗和放疗时保护细胞的局部血管收缩剂制品和方法
WO2007007110A1 (en) 2005-07-13 2007-01-18 Cipla Limited Inhaler device
US8763605B2 (en) 2005-07-20 2014-07-01 Manta Devices, Llc Inhalation device
USD550835S1 (en) 2005-07-22 2007-09-11 Omron Healthcare Co., Ltd. Atomizer for inhaler
DK1915171T3 (da) 2005-08-01 2013-12-09 Mannkind Corp Fremgangsmåde til bevarelse af funktionen af insulin-producerende celler
AU2006278571B2 (en) 2005-08-05 2011-11-24 3M Innovative Properties Company Compositions exhibiting improved flowability
WO2007024953A1 (en) 2005-08-25 2007-03-01 Oriel Therapeutics, Inc. Drug containment systems with sticks, related kits, dry powder inhalers and methods
WO2008048234A2 (en) 2005-08-26 2008-04-24 North Carolina State University Inhaler system for targeted maximum drug-aerosol delivery
WO2007025177A2 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
JP2007061281A (ja) 2005-08-30 2007-03-15 Hitachi Ltd 吸入量測定システム
WO2007030706A1 (en) 2005-09-08 2007-03-15 New England Medical Center Hospitals, Inc. Fragments of the glucagon-like peptide-i and uses thereof
JP5167133B2 (ja) 2005-09-14 2013-03-21 マンカインド コーポレイション 結晶性微粒子表面に対する活性薬剤の親和性の増大に基づく薬物処方の方法
USD540671S1 (en) 2005-09-21 2007-04-17 The Procter & Gamble Company Cap for product dispenser
WO2007041481A1 (en) 2005-09-29 2007-04-12 Biodel, Inc. Rapid acting and prolonged acting insulin preparations
US20070074989A1 (en) 2005-09-30 2007-04-05 Musculoskeletal Transplant Foundation Container for lyophilization and storage of tissue
GB0520794D0 (en) 2005-10-12 2005-11-23 Innovata Biomed Ltd Inhaler
ITMI20051999A1 (it) 2005-10-21 2007-04-22 Eratech S R L Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita'
USD566549S1 (en) 2005-10-26 2008-04-15 Reckitt Benckiser (Uk) Limited Cap
WO2007053946A1 (en) 2005-11-09 2007-05-18 Conjuchem Biotechnologies Inc. Method of treating diabetes and/or obesity with reduced nausea side effects using an insulinotropic peptide conjugated to albumin
AR058290A1 (es) 2005-12-12 2008-01-30 Glaxo Group Ltd Dispensador de medicamento
AR058289A1 (es) 2005-12-12 2008-01-30 Glaxo Group Ltd Colector para ser usado en dispensador de medicamento
ES2390286T3 (es) 2005-12-16 2012-11-08 Nektar Therapeutics Conjugados poliméricos de GLP-1
KR101501780B1 (ko) 2006-01-24 2015-03-16 넥스바이오, 인코퍼레이티드 고분자 미소 구체들의 조제를 위한 기술
USD557798S1 (en) 2006-01-25 2007-12-18 Valois S.A.S. Inhaler
US7390949B2 (en) 2006-02-01 2008-06-24 Wanne, Inc. Saxophone and clarinet mouthpiece cap
GB0602897D0 (en) 2006-02-13 2006-03-22 Jagotec Ag Improvements In Or Relating To Dry Powder Inhaler Devices
CA2642638A1 (en) 2006-02-14 2007-08-23 Battelle Memorial Institute Accurate metering system
AU2007221366B2 (en) 2006-02-22 2012-08-23 Msd Italia S.R.L. Oxyntomodulin derivatives
JP5599975B2 (ja) 2006-02-22 2014-10-01 マンカインド コーポレイション ジケトピペラジン及び活性薬剤を含有する微粒子の製剤特性の改善方法
DE102006010089A1 (de) 2006-02-24 2007-10-18 Aha-Kunststofftechnik Gmbh Trockenpulver-Inhalator
USD541151S1 (en) 2006-03-20 2007-04-24 The Procter & Gamble Company Cap for product dispenser
US8037880B2 (en) 2006-04-07 2011-10-18 The University Of Western Ontario Dry powder inhaler
WO2007121256A2 (en) 2006-04-12 2007-10-25 Biodel, Inc. Rapid acting and long acting insulin combination formulations
EP1844806A1 (de) 2006-04-13 2007-10-17 Boehringer Ingelheim Pharma GmbH Medikamenten-Ausgabevorrichtung, Medikamentenmagazin dafür, und Verfahren zur Entnahme eines Medikaments aus einer Medikamentenkammer
EP1844809A1 (de) 2006-04-13 2007-10-17 Boehringer Ingelheim Pharma GmbH & Co. KG Medikamentenmagazin für einen Inhalator, sowie Mehrdosispulverinhalator
CN104288756A (zh) 2006-04-14 2015-01-21 曼金德公司 高血糖素样肽1(glp-1)药物制剂
US20070243216A1 (en) 2006-04-14 2007-10-18 Stanley Kepka Stable solutions of prostaglandin and uses of same
GR1005620B (el) 2006-05-09 2007-09-03 Βελτιωση συσκευης εισπνοων ξηρης σκονης
WO2007129515A1 (ja) 2006-05-10 2007-11-15 S.K.I. Net, Inc. 小動物用麻酔システム
DE102006021978A1 (de) 2006-05-10 2007-11-15 Robert Bosch Gmbh Vorrichtung und Verfahen zum Verstärken eines Blisters
PT103481B (pt) 2006-05-16 2008-08-01 Hovione Farmaciencia S A Inalador de uso simples e método de inalação
GB0611659D0 (en) 2006-06-13 2006-07-19 Cambridge Consultants Dry powder inhalers
GB0611656D0 (en) 2006-06-13 2006-07-19 Cambridge Consultants Dry powder inhalers
ZA200810777B (en) 2006-06-16 2009-11-25 Cipla Ltd Improved dry powder inhaler
EP2035068A1 (en) 2006-06-27 2009-03-18 Brin Tech International Limited Inhaler
BRPI0713056A2 (pt) 2006-06-27 2012-04-17 Otsuka Pharma Co Ltd inalador de pó
GB0613161D0 (en) 2006-06-30 2006-08-09 Novartis Ag Organic Compounds
CN2917673Y (zh) 2006-07-06 2007-07-04 兴安药业有限公司 一种胶囊型干粉吸入器
WO2008008021A1 (en) 2006-07-14 2008-01-17 Astrazeneca Ab Inhalation system and delivery device for the administration of a drug in the form of dry powder.
US8900555B2 (en) 2006-07-27 2014-12-02 Nektar Therapeutics Insulin derivative formulations for pulmonary delivery
US8637521B2 (en) 2006-08-04 2014-01-28 Manus Pharmaceuticals (Canada) Ltd. Substituted piperazin-2,5-diones and their use as multifunctional bioactive compounds
GB0616299D0 (en) 2006-08-16 2006-09-27 Cambridge Consultants Drug Capsules for dry power inhalers
DE102006038206A1 (de) 2006-08-16 2008-02-21 Siemens Ag Verfahren zur Entfernung von in gelöster Form vorliegenden Fremdstoffen aus Abwasser
US20080066739A1 (en) 2006-09-20 2008-03-20 Lemahieu Edward Methods and systems of delivering medication via inhalation
US20080108574A1 (en) 2006-09-27 2008-05-08 Braincells, Inc. Melanocortin receptor mediated modulation of neurogenesis
PL2064228T3 (pl) 2006-11-10 2013-01-31 Cara Therapeutics Inc Syntetyczne amidy peptydowe
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
US8236766B2 (en) 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
CA2667335A1 (en) 2006-11-10 2008-05-22 Proveris Scientific Corporation Automated nasal spray pump testing
US7713937B2 (en) 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US7824014B2 (en) 2006-12-05 2010-11-02 Canon Kabushiki Kaisha Head substrate, printhead, head cartridge, and printing apparatus
USD549111S1 (en) 2006-12-06 2007-08-21 Eveready Battery Company, Inc. Zinc-air hearing aid battery package
USD548619S1 (en) 2006-12-06 2007-08-14 Eveready Battery Company, Inc. Zinc-air hearing aid battery package
USD548618S1 (en) 2006-12-06 2007-08-14 Eveready Battery Company, Inc. Zinc-air hearing aid battery package
ATE540717T1 (de) 2006-12-22 2012-01-15 Almirall Sa Inhalationsvorrichtung für arzneimittel in pulverform
WO2008092864A1 (en) 2007-01-29 2008-08-07 Novo Nordisk A/S Method and devices for aerosolizing a drug formulation
US8172817B2 (en) 2007-01-31 2012-05-08 Allegiance Corporation Liquid collection system and related methods
WO2008101017A2 (en) 2007-02-15 2008-08-21 Indiana Unversity Research And Technology Corporation Glucagon/glp-1 receptor co-agonists
US8196576B2 (en) 2007-02-28 2012-06-12 Microdose Therapeutx, Inc. Inhaler
WO2009005546A1 (en) 2007-03-05 2009-01-08 Board of Governors for Higher Education, State of Rhode Island and the Providence Plantations High efficiency mouthpiece/adaptor for inhalers
JP2008212436A (ja) 2007-03-06 2008-09-18 Canon Inc 吸入装置
US8146745B2 (en) 2007-03-09 2012-04-03 Cardpak, Inc. Environmentally separable packaging device with attaching base
GB0704928D0 (en) 2007-03-14 2007-04-25 Cambridge Consultants Dry powder inhalers
JP2011505925A (ja) 2007-04-11 2011-03-03 スター ライフ サイエンシーズ コーポレイション 移動性の動物用の非侵襲性フォトプレチスモグラフィセンサプラットフォーム
JP4417400B2 (ja) 2007-04-16 2010-02-17 アンリツ株式会社 はんだ検査ライン集中管理システム、及びそれに用いられる管理装置
WO2008133908A2 (en) 2007-04-23 2008-11-06 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
JP2010527914A (ja) 2007-04-26 2010-08-19 クォーク ファーマシューティカルズ インコーポレーティッド 呼吸器系への抑制性核酸分子の治療的送達
USD577815S1 (en) 2007-04-30 2008-09-30 Sun Pharma Advanced Research Company Limited Inhaler
USD583463S1 (en) 2007-04-30 2008-12-23 Sun Pharma Advanced Research Company Limited Inhaler
CN101980739B (zh) 2007-04-30 2013-06-26 太阳医药高级研发有限公司 吸入装置
US7669597B2 (en) 2007-05-16 2010-03-02 Mystic Pharmaceuticals, Inc. Combination unit dose dispensing containers
EP1992378A1 (en) 2007-05-16 2008-11-19 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device
USD579550S1 (en) 2007-06-07 2008-10-28 Novartis Ag Inhaler
EP2164509A1 (en) 2007-06-08 2010-03-24 Massachusetts Institute of Technology Igf for the treatment of rett syndrome and synaptic disorders
EA201000046A1 (ru) 2007-06-21 2011-02-28 Кара Терапеутикс, Инк. Замещенные имидазогетероциклы
WO2009009013A2 (en) 2007-07-06 2009-01-15 Manta Devices, Llc Inhalation devices for storing and delivering medicament
WO2009046072A1 (en) 2007-10-02 2009-04-09 Baxter International Inc Dry powder inhaler
EP2048112A1 (en) 2007-10-09 2009-04-15 Kemira Kemi AB Use of a nozzle for manufacturing sodium percarbonate
US8785396B2 (en) * 2007-10-24 2014-07-22 Mannkind Corporation Method and composition for treating migraines
KR101736502B1 (ko) 2007-10-24 2017-05-16 맨카인드 코포레이션 Ｇｌｐ-1에 의한 유해 효과의 예방 방법
WO2009055030A2 (en) 2007-10-25 2009-04-30 Nektar Therapeutics Powder conditioning of unit dose drug packages
GB0721394D0 (en) 2007-10-31 2007-12-12 Vectura Group Plc Compositions for trating parkinson's disease
CA2704997C (en) 2007-11-06 2016-05-24 3M Innovative Properties Company Medicinal inhalation devices and components thereof
CN101317821B (zh) 2007-11-15 2012-01-04 陈晓东 适用于肺部给药的超细干粉颗粒及其制备方法
EP2060268A1 (en) 2007-11-15 2009-05-20 Novo Nordisk A/S Pharmaceutical compositions for pulmonary or nasal delivery of peptides
USD594753S1 (en) 2007-12-14 2009-06-23 The Procter & Gamble Company Blister card
EP2534957B1 (en) 2007-12-14 2015-05-27 AeroDesigns, Inc Delivering aerosolizable products
WO2009082341A1 (en) 2007-12-20 2009-07-02 Astrazeneca Ab Device and method for deaggregating powder 854
US7584846B2 (en) 2007-12-21 2009-09-08 S.C. Johnson & Son, Inc. Shaped packaging for a refill
EP2252268A1 (en) 2008-02-01 2010-11-24 Vectura Limited Pulmonary formulations of triptans
GB0802028D0 (en) 2008-02-05 2008-03-12 Dunne Stephen T Powder inhaler flow regulator
USD614045S1 (en) 2008-02-22 2010-04-20 Ima Safe S.R.L. Blister packaging
PL2254629T3 (pl) 2008-03-27 2016-06-30 Mannkind Corp Układ inhalatora suchego proszku
US20110034385A1 (en) 2008-04-07 2011-02-10 National Institute Of Immunology Compositions Useful for the Treatment of Diabetes and Other Chronic Disorder
DE102008023376A1 (de) 2008-05-13 2009-11-19 Alfred Von Schuckmann Spender für in einer gesonderten Verpackung enthaltenen, pulverförmigen Massen
JP5727927B2 (ja) 2008-05-15 2015-06-03 ノバルティス アーゲー フルオロキノロンの肺送達
USD597418S1 (en) 2008-05-22 2009-08-04 Wm. Wrigley Jr. Company Blister card
USD598785S1 (en) 2008-05-22 2009-08-25 Wm. Wrigley Jr. Company Blister card
USD604833S1 (en) 2008-06-13 2009-11-24 Mannkind Corporation Dry powder inhaler
USD614760S1 (en) 2008-06-13 2010-04-27 Mannkind Corporation Dry powder inhaler
USD605753S1 (en) 2008-06-13 2009-12-08 Mannkind Corporation Cartridge for a dry powder inhaler
USD597657S1 (en) 2008-06-13 2009-08-04 Mannkind Corporation Dry powder inhaler
USD605752S1 (en) 2008-06-13 2009-12-08 Mannkind Corporation Dry powder inhaler
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
USD635241S1 (en) 2008-06-13 2011-03-29 Mannkind Corporation Dry powder inhaler
USD613849S1 (en) 2008-06-13 2010-04-13 Mannkind Corporation Cartridge for a dry powder inhaler
USD604832S1 (en) 2008-06-13 2009-11-24 Mannkind Corporation Cartridge for a dry powder inhaler
CA3153292A1 (en) 2008-06-13 2009-12-17 Mannkind Corporation A dry powder inhaler and system for drug delivery
CN103751892B (zh) 2008-06-20 2017-03-01 曼金德公司 用于对吸入工作进行实时描绘的交互式设备和方法
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
USD635242S1 (en) 2008-12-01 2011-03-29 Mannkind Corporation Dry powder inhaler
USD629506S1 (en) 2008-12-01 2010-12-21 Mannkind Corporation Dry powder inhaler
USD629888S1 (en) 2008-12-01 2010-12-28 Mannkind Corporation Dry powder inhaler
USD629505S1 (en) 2008-12-01 2010-12-21 Mannkind Corporation Dry powder inhaler
USD629886S1 (en) 2008-12-01 2010-12-28 Mannkind Corporation Dry powder inhaler
USD629887S1 (en) 2008-12-01 2010-12-28 Mannkind Corporation Dry powder inhaler
USD635243S1 (en) 2008-12-01 2011-03-29 Mannkind Corporation Dry powder inhaler
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2862854A1 (en) 2008-12-29 2015-04-22 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
MX2011007371A (es) 2009-01-08 2011-09-06 Mannkind Corp Metodo para tratar la hiperglucemia con la molecula.
US8550074B2 (en) 2009-01-15 2013-10-08 Manta Devices, Llc Delivery device and related methods
AU2010221254B2 (en) 2009-03-04 2014-04-03 Mannkind Corporation An improved dry powder drug delivery system
JP5667095B2 (ja) 2009-03-11 2015-02-12 マンカインド コーポレイション 吸入器の抵抗を測定するための装置、システムおよび方法
MX2011009682A (es) 2009-03-18 2011-10-17 Mannkind Corp Adaptador de inhalador para un aparato de difraccion de laser y metodo para medir la distribucion de tamaño de particula.
GB0907425D0 (en) * 2009-04-29 2009-06-10 Glaxo Group Ltd Compounds
USD626836S1 (en) 2009-04-30 2010-11-09 Bryce Lien Bottle cap
USD628090S1 (en) 2009-05-07 2010-11-30 Mccormick & Company, Incorporated Seasoning package
USD620375S1 (en) 2009-05-11 2010-07-27 Mcneil-Ppc, Inc. Blister
MY159925A (en) 2009-05-21 2017-02-15 Microdose Therapeutx Inc Rotary cassette system for dry powder inhaler
PL3111926T3 (pl) 2009-05-29 2020-06-29 Pearl Therapeutics, Inc. Kompozycje, sposoby i układy do dostarczania dwóch lub większej liczby środków czynnych do układu oddechowego
MY186975A (en) 2009-06-12 2021-08-26 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
ES2751107T3 (es) 2009-06-12 2020-03-30 Mannkind Corp Micropartículas de dicetopiperazina con contenido de isómeros definido
US9180263B2 (en) 2009-07-01 2015-11-10 Microdose Therapeutx, Inc. Laboratory animal pulmonary dosing device
US8642548B2 (en) 2009-08-07 2014-02-04 Mannkind Corporation Val (8) GLP-1 composition and method for treating functional dyspepsia and/or irritable bowel syndrome
WO2011031564A2 (en) 2009-08-27 2011-03-17 Stc.Unm Methods and systems for dosing and coating inhalation powders onto carrier particles
IT1395945B1 (it) 2009-09-30 2012-11-02 Oliva Inalatore perfezionato per preparati in polvere
USD647195S1 (en) 2009-10-09 2011-10-18 Vectura Delivery Devices Limited Inhaler having cover
USD647196S1 (en) 2009-10-09 2011-10-18 Vectura Delivery Devices Limited Inhaler having cover
JP5784622B2 (ja) 2009-11-03 2015-09-24 マンカインド コーポレ−ション 吸入活動をシミュレートするための装置及び方法
USD650295S1 (en) 2009-11-13 2011-12-13 Avidiamed Gmbh Blister pack for pharmaceuticals
AU2010336338B2 (en) 2009-12-23 2015-02-19 Map Pharmaceuticals, Inc. Enhanced eductor design
WO2011082328A1 (en) * 2009-12-31 2011-07-07 Stealth Peptides International, Inc. Methods for performing a coronary artery bypass graft procedure
AU332056S (en) 2010-01-08 2010-08-04 Teva Pharma Ireland Inhaler
US7804404B1 (en) 2010-06-08 2010-09-28 Callaway Golf Company Circuit for transmitting a RFID signal
USD641076S1 (en) 2010-03-26 2011-07-05 Oriel Therapeutics, Inc. Dry powder inhaler
PT105065B (pt) 2010-04-26 2012-07-31 Hovione Farmaciencia S A Um inalador simples de cápsulas
GB201006901D0 (en) 2010-04-26 2010-06-09 Sagentia Ltd Device for monitoring status and use of an inhalation or nasal drug delivery device
USD645954S1 (en) 2010-05-21 2011-09-27 Consort Medical Plc Mechanical dosage counter apparatus
USD636867S1 (en) 2010-06-14 2011-04-26 Mannkind Corporation Dry powder inhaler
USD636868S1 (en) 2010-06-14 2011-04-26 Mannkind Corporation Dry powder inhaler
USD636869S1 (en) 2010-06-14 2011-04-26 Mannkind Corporation Dry powder inhaler
CN101851213A (zh) 2010-06-21 2010-10-06 于清 3，6-双(4-双反丁烯二酰基氨丁基)-2，5-二酮哌嗪及其盐取代物的合成方法
CN102985125A (zh) 2010-06-21 2013-03-20 曼金德公司 干粉药物输送系统和方法
US9152829B2 (en) 2010-08-19 2015-10-06 Sanofi-Aventis Deutschland Gmbh Method and system for determining information related to a drug reservoir using an electronic sensor
USD643308S1 (en) 2010-09-28 2011-08-16 Mannkind Corporation Blister packaging
WO2012050945A1 (en) 2010-09-29 2012-04-19 Pulmatrix, Inc. Cationic dry powders
KR101931392B1 (ko) 2010-11-09 2018-12-20 맨카인드 코포레이션 세로토닌 수용체 작용제 및 디케토피페라진을 포함하는 편두통 치료용 조성물
CA140810S (en) 2010-12-01 2012-05-23 Teva Pharma Inhaler cap
USD642483S1 (en) 2010-12-03 2011-08-02 Mccormick & Company, Incorporated Seasoning package
BR112013020514B1 (pt) 2011-02-10 2020-12-08 Mannkind Corporation método para a síntese de 3,6-bis-4-(ntrifluoroacetil)aminobutil-2,5-dicetopiperazina
KR101940832B1 (ko) 2011-04-01 2019-01-21 맨카인드 코포레이션 의약 카트리지용 블리스터 패키지
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
PL2739268T3 (pl) 2011-08-01 2019-07-31 Monash University Sposób i formulacja do inhalacji
USD674893S1 (en) 2011-10-20 2013-01-22 Mannkind Corporation Inhaler device
HK1201475A1 (en) 2011-10-24 2015-09-04 Mannkind Corporation Methods and compositions for treating pain
CN102436238B (zh) 2011-11-03 2014-04-16 广东轻工职业技术学院 基于生产线数据采集及信息管理系统的数据采集方法
CA2871126C (en) 2012-04-27 2020-07-14 Mannkind Corp. Methods for the synthesis of activated ethylfumarates and their use as intermediates
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
CN104755097A (zh) 2012-08-29 2015-07-01 曼金德公司 用于治疗高血糖症的方法和组合物
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
CN103110611A (zh) 2012-12-11 2013-05-22 苏州惠仁生物科技有限公司 吸入剂及其制备方法与普鲁兰糖作为吸入剂载体的应用
USD711740S1 (en) 2013-01-22 2014-08-26 H204K9, Inc. Bottle cap
JP6523247B2 (ja) 2013-03-15 2019-05-29 マンカインド コーポレイション 微結晶性ジケトピペラジン粒子の製造方法および乾燥粉末組成物の製造方法
KR102465025B1 (ko) 2013-07-18 2022-11-09 맨카인드 코포레이션 열-안정성 건조 분말 약제학적 조성물 및 방법
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
GB201319265D0 (en) 2013-10-31 2013-12-18 Norton Waterford Ltd Medicament inhaler
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
USD771237S1 (en) 2014-10-02 2016-11-08 Mannkind Corporation Mouthpiece cover
SG11201806304PA (en) 2016-01-29 2018-08-30 Mannkind Corp Dry powder inhaler
EP3458133B1 (en) 2016-05-19 2023-11-15 MannKind Corporation Apparatus, system and method for detecting and monitoring inhalations

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Publication number Priority date Publication date Assignee Title
US12061484B2 (en) 2016-12-23 2024-08-13 Gecko Robotics, Inc. Inspection robot having adjustable resolution
US12061483B2 (en) 2016-12-23 2024-08-13 Gecko Robotics, Inc. System, method, and apparatus for inspecting a surface
US12022617B2 (en) 2021-04-20 2024-06-25 Gecko Robotics, Inc. Inspection robots with a payload engagement device
US12156334B2 (en) 2021-04-20 2024-11-26 Gecko Robotics, Inc. Inspection robot and methods utilizing coolant for temperature management
US12160956B2 (en) 2021-04-20 2024-12-03 Gecko Robotics, Inc. Inspection robots with independent, swappable, drive modules
US12200868B2 (en) 2021-04-20 2025-01-14 Gecko Robotics, Inc. Inspection robots with a payload engagement device
US12050202B2 (en) 2021-04-22 2024-07-30 Gecko Robotics, Inc. Robotic systems for surface inspection with simultaneous measurements at multiple orientations
US12061173B2 (en) 2021-04-22 2024-08-13 Gecko Robotics, Inc. Robotic inspection devices for simultaneous surface measurements at multiple orientations
US12072319B2 (en) 2021-04-22 2024-08-27 Gecko Robotics, Inc. Systems for assessment of weld adjacent heat affected zones

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US9610351B2 (en) 2017-04-04
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JP2016222689A (ja) 2016-12-28
JP6165300B2 (ja) 2017-07-19
MX2014004983A (es) 2014-09-22
JP2014530914A (ja) 2014-11-20
WO2013063160A1 (en) 2013-05-02
KR20140095483A (ko) 2014-08-01
US9233159B2 (en) 2016-01-12
US20170209525A1 (en) 2017-07-27
AU2012328885A1 (en) 2014-04-17
US20150150980A1 (en) 2015-06-04
HK1200318A1 (en) 2015-08-07
HK1201475A1 (en) 2015-09-04
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US20140302151A1 (en) 2014-10-09
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CA2852536A1 (en) 2013-05-02

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