JP5191391B2 - キナーゼのビ−アリールメタ−ピリミジン阻害剤 - Google Patents
キナーゼのビ−アリールメタ−ピリミジン阻害剤 Download PDFInfo
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- JP5191391B2 JP5191391B2 JP2008538935A JP2008538935A JP5191391B2 JP 5191391 B2 JP5191391 B2 JP 5191391B2 JP 2008538935 A JP2008538935 A JP 2008538935A JP 2008538935 A JP2008538935 A JP 2008538935A JP 5191391 B2 JP5191391 B2 JP 5191391B2
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- methyl
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- 0 CC(C)(C)OC([n](ccc1c2)c1ccc2Nc1nc(*c(cc2)ccc2OC(CC2)CCN2C(OC(C)(C)C)=O)ncc1C)=O Chemical compound CC(C)(C)OC([n](ccc1c2)c1ccc2Nc1nc(*c(cc2)ccc2OC(CC2)CCN2C(OC(C)(C)C)=O)ncc1C)=O 0.000 description 2
- RCANCXBUPLNOOD-UHFFFAOYSA-N CC(C)(C)NC(c1cccc(Br)c1)=O Chemical compound CC(C)(C)NC(c1cccc(Br)c1)=O RCANCXBUPLNOOD-UHFFFAOYSA-N 0.000 description 1
- NSHFWVLXMZETGA-IDQYUAKCSA-N CC(C)(C)NS(/C(/C)=C/C(/Nc1c(C)cnc(Nc2ccc(C[n]3c(C)ncc3)cc2)n1)=C\C)(=O)=O Chemical compound CC(C)(C)NS(/C(/C)=C/C(/Nc1c(C)cnc(Nc2ccc(C[n]3c(C)ncc3)cc2)n1)=C\C)(=O)=O NSHFWVLXMZETGA-IDQYUAKCSA-N 0.000 description 1
- AHUXEFWSXHFQIP-UHFFFAOYSA-N CC(C)(C)NS(c1cc(Br)ccc1C)(=O)=O Chemical compound CC(C)(C)NS(c1cc(Br)ccc1C)(=O)=O AHUXEFWSXHFQIP-UHFFFAOYSA-N 0.000 description 1
- DOUQFQVSSQEZEI-UHFFFAOYSA-N CC(C)(C)NS(c1cc(NC2=NC(Nc3ccc(CN4CCN(C)CC4)cc3)NC=C2C)ccc1)(=O)=O Chemical compound CC(C)(C)NS(c1cc(NC2=NC(Nc3ccc(CN4CCN(C)CC4)cc3)NC=C2C)ccc1)(=O)=O DOUQFQVSSQEZEI-UHFFFAOYSA-N 0.000 description 1
- LUAWAPKBNKKRGZ-UHFFFAOYSA-N CC(C)(C)NS(c1cc(Nc2c(C)cnc(NCc(cc3)ccc3OCCN3CCCC3)n2)ccc1)(=O)=O Chemical compound CC(C)(C)NS(c1cc(Nc2c(C)cnc(NCc(cc3)ccc3OCCN3CCCC3)n2)ccc1)(=O)=O LUAWAPKBNKKRGZ-UHFFFAOYSA-N 0.000 description 1
- VHVHGHZSQQLXTI-UHFFFAOYSA-N CC(C)(C)NS(c1cc(Nc2c(C)cnc(Nc3ccc(C[n]4nccc4)cc3)n2)ccc1)(=O)=O Chemical compound CC(C)(C)NS(c1cc(Nc2c(C)cnc(Nc3ccc(C[n]4nccc4)cc3)n2)ccc1)(=O)=O VHVHGHZSQQLXTI-UHFFFAOYSA-N 0.000 description 1
- VINYOUWDZHOVFB-UHFFFAOYSA-N CC(C)(C)NS(c1cc(Nc2nc(Cl)ncc2C)ccc1)(=O)=O Chemical compound CC(C)(C)NS(c1cc(Nc2nc(Cl)ncc2C)ccc1)(=O)=O VINYOUWDZHOVFB-UHFFFAOYSA-N 0.000 description 1
- KPVFQBNXSPHPKM-UHFFFAOYSA-N CC(C)(C)NS(c1cccc(Nc2c(C)cnc(Nc(cc3)ccc3N3CCN(CCO)CC3)n2)c1)(=O)=O Chemical compound CC(C)(C)NS(c1cccc(Nc2c(C)cnc(Nc(cc3)ccc3N3CCN(CCO)CC3)n2)c1)(=O)=O KPVFQBNXSPHPKM-UHFFFAOYSA-N 0.000 description 1
- RCWJWXBGMGJCNK-UHFFFAOYSA-N CC(C1)C(N)=CN=C1OCCO Chemical compound CC(C1)C(N)=CN=C1OCCO RCWJWXBGMGJCNK-UHFFFAOYSA-N 0.000 description 1
- TYQPMXCHULTJOG-UHFFFAOYSA-N CC(C1)C(NC2=NCC(C)C(Nc3cccc(S(N)(=O)=O)c3)=N2)=CC=C1OCCN1CCCC1 Chemical compound CC(C1)C(NC2=NCC(C)C(Nc3cccc(S(N)(=O)=O)c3)=N2)=CC=C1OCCN1CCCC1 TYQPMXCHULTJOG-UHFFFAOYSA-N 0.000 description 1
- XIJQDWHJGDTTCL-UHFFFAOYSA-N CC(CCCC1)N1S(c1cccc(Nc2c(C)cnc(Nc(cc3)ccc3N3CCN(C)CC3)n2)c1)(=O)=O Chemical compound CC(CCCC1)N1S(c1cccc(Nc2c(C)cnc(Nc(cc3)ccc3N3CCN(C)CC3)n2)c1)(=O)=O XIJQDWHJGDTTCL-UHFFFAOYSA-N 0.000 description 1
- NRORBCCEEWLAPQ-UHFFFAOYSA-N CC1=CC(Nc2c(C)cnc(Nc(cc3)ccc3OC3CCNCC3)n2)=CCC1Cl Chemical compound CC1=CC(Nc2c(C)cnc(Nc(cc3)ccc3OC3CCNCC3)n2)=CCC1Cl NRORBCCEEWLAPQ-UHFFFAOYSA-N 0.000 description 1
- KARZHXLNKYSHNQ-UHFFFAOYSA-N CC1C(S(NC(C)(C)C)(=O)=O)=CC(Nc2c(C)cnc(Nc3ccc(CN4CCNCC4)cc3)n2)=CC1 Chemical compound CC1C(S(NC(C)(C)C)(=O)=O)=CC(Nc2c(C)cnc(Nc3ccc(CN4CCNCC4)cc3)n2)=CC1 KARZHXLNKYSHNQ-UHFFFAOYSA-N 0.000 description 1
- PEXMXQCAVGEDPR-UHFFFAOYSA-N CCCCCNCCOc(cc1)ccc1NC(C)(NC=C1C)N=C1Nc1c2OCOc2ccc1 Chemical compound CCCCCNCCOc(cc1)ccc1NC(C)(NC=C1C)N=C1Nc1c2OCOc2ccc1 PEXMXQCAVGEDPR-UHFFFAOYSA-N 0.000 description 1
- WYLNGZIPDRWJPR-UHFFFAOYSA-N CCCN(CCN)Cc(cc1)ccc1NCc1nc(Nc2c(cc[nH]3)c3ccc2)c(C)cn1 Chemical compound CCCN(CCN)Cc(cc1)ccc1NCc1nc(Nc2c(cc[nH]3)c3ccc2)c(C)cn1 WYLNGZIPDRWJPR-UHFFFAOYSA-N 0.000 description 1
- QOYBYEISICUGLL-UHFFFAOYSA-N CCCS(c1cc(Nc2c(C)cnc(Nc(cc3)ccc3N3CCN(C)CC3)n2)ccc1)(=O)=O Chemical compound CCCS(c1cc(Nc2c(C)cnc(Nc(cc3)ccc3N3CCN(C)CC3)n2)ccc1)(=O)=O QOYBYEISICUGLL-UHFFFAOYSA-N 0.000 description 1
- AUQBZYWIAACKSD-UHFFFAOYSA-N Cc(c(OC)c1)ccc1Nc1nc(Nc2cccc(CN3CCNCC3)c2)ncc1C Chemical compound Cc(c(OC)c1)ccc1Nc1nc(Nc2cccc(CN3CCNCC3)c2)ncc1C AUQBZYWIAACKSD-UHFFFAOYSA-N 0.000 description 1
- QKEZDVNFWXYUQW-UHFFFAOYSA-N Cc1c(Nc(cc2OC)ccc2Cl)nc(Nc2ccc(CN3CCN(C)CC3)cc2)nc1 Chemical compound Cc1c(Nc(cc2OC)ccc2Cl)nc(Nc2ccc(CN3CCN(C)CC3)cc2)nc1 QKEZDVNFWXYUQW-UHFFFAOYSA-N 0.000 description 1
- SQZKSNJACMPGSE-UHFFFAOYSA-N Cc1c(Nc2c3OCOc3ccc2)nc(Nc(cc2)cc(C(OC)=O)c2OCCN2CCCC2)nc1 Chemical compound Cc1c(Nc2c3OCOc3ccc2)nc(Nc(cc2)cc(C(OC)=O)c2OCCN2CCCC2)nc1 SQZKSNJACMPGSE-UHFFFAOYSA-N 0.000 description 1
- TZYJKJKOMGCYDT-UHFFFAOYSA-N Cc1cnc(C)nc1NCc1cccc(C(NC)=O)c1 Chemical compound Cc1cnc(C)nc1NCc1cccc(C(NC)=O)c1 TZYJKJKOMGCYDT-UHFFFAOYSA-N 0.000 description 1
- DIYRIYJMMLUTQP-UHFFFAOYSA-N O=S(c(cc1)ccc1Br)(NCCN1CCCC1)=O Chemical compound O=S(c(cc1)ccc1Br)(NCCN1CCCC1)=O DIYRIYJMMLUTQP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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