JP4667691B2 - ナプロキセンのニトロキシアルキルエステルの製造法 - Google Patents

ナプロキセンのニトロキシアルキルエステルの製造法 Download PDF

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Publication number
JP4667691B2
JP4667691B2 JP2001515282A JP2001515282A JP4667691B2 JP 4667691 B2 JP4667691 B2 JP 4667691B2 JP 2001515282 A JP2001515282 A JP 2001515282A JP 2001515282 A JP2001515282 A JP 2001515282A JP 4667691 B2 JP4667691 B2 JP 4667691B2
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Japan
Prior art keywords
alkylene
naphthyl
methoxy
defined above
amount
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Expired - Lifetime
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JP2001515282A
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English (en)
Japanese (ja)
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JP2003506425A (ja
JP2003506425A5 (https=
Inventor
ベネディーニ，フランチェスカ
オルダニ，エルミニオ
カスタルディ，グラツィアーノ
タルクイーニ，アントニオ
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ニコックス エス エイ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2001515282A 1999-08-04 2000-07-27 ナプロキセンのニトロキシアルキルエステルの製造法 Expired - Lifetime JP4667691B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT1999MI001753A IT1313596B1 (it) 1999-08-04 1999-08-04 Processo per la preparazione di nitrossialchil esteri del naproxene
IT99A001753 1999-08-04
PCT/EP2000/007222 WO2001010814A1 (en) 1999-08-04 2000-07-27 Process for the preparation of naproxene nitroxyalkylesters

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010266860A Division JP2011042690A (ja) 1999-08-04 2010-11-30 ナプロキセンのニトロキシアルキルエステル

Publications (3)

Publication Number Publication Date
JP2003506425A JP2003506425A (ja) 2003-02-18
JP2003506425A5 JP2003506425A5 (https=) 2007-09-13
JP4667691B2 true JP4667691B2 (ja) 2011-04-13

Family

ID=11383500

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2001515282A Expired - Lifetime JP4667691B2 (ja) 1999-08-04 2000-07-27 ナプロキセンのニトロキシアルキルエステルの製造法
JP2010266860A Pending JP2011042690A (ja) 1999-08-04 2010-11-30 ナプロキセンのニトロキシアルキルエステル

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010266860A Pending JP2011042690A (ja) 1999-08-04 2010-11-30 ナプロキセンのニトロキシアルキルエステル

Country Status (23)

Country Link
US (2) US6700011B1 (https=)
EP (2) EP1200386B1 (https=)
JP (2) JP4667691B2 (https=)
KR (1) KR100687820B1 (https=)
CN (1) CN1198786C (https=)
AT (2) ATE251109T1 (https=)
AU (1) AU778694B2 (https=)
BR (1) BRPI0012915B1 (https=)
CA (1) CA2380116C (https=)
DE (2) DE60005682T2 (https=)
DK (2) DK1200386T3 (https=)
ES (2) ES2243859T3 (https=)
HU (1) HU227109B1 (https=)
IL (1) IL147639A0 (https=)
IT (1) IT1313596B1 (https=)
MX (1) MXPA02001256A (https=)
NO (1) NO327669B1 (https=)
PL (1) PL200165B1 (https=)
PT (2) PT1384707E (https=)
RU (1) RU2248348C2 (https=)
TR (1) TR200200290T2 (https=)
WO (1) WO2001010814A1 (https=)
ZA (2) ZA200200478B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6297260B1 (en) 1998-10-30 2001-10-02 Nitromed, Inc. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
AP2002002582A0 (en) 1999-12-23 2002-09-30 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
DE60122939T2 (de) 2000-12-21 2007-01-11 Nitromed, Inc., Bedford Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren
AU2002365372A1 (en) * 2001-11-27 2003-06-10 Astrazeneca Ab New process
CA2487414A1 (en) 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
AU2003247792B2 (en) 2002-07-03 2009-09-24 Nicox S.A. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
US7244753B2 (en) 2002-07-29 2007-07-17 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it) 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI20022409A1 (it) * 2002-11-14 2004-05-15 Dinamite Dipharma S P A Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
NZ569396A (en) * 2006-02-03 2011-06-30 Nicox Sa Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
CN100427475C (zh) * 2006-11-30 2008-10-22 华南理工大学 萘普生-2-芳基吗啉乙酯及其制备方法与应用
JP2010531324A (ja) * 2007-06-28 2010-09-24 ニコックス エス エイ １，４−ブタンジオールモノナイトレートの製造方法
WO2009149053A2 (en) * 2008-06-02 2009-12-10 Dr. Reddy's Laboratories Ltd. Naproxcinod process and solid dispersion
ITRM20080325A1 (it) * 2008-06-20 2009-12-21 Nicox Sa Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
TW201139337A (en) 2010-03-31 2011-11-16 Lonza Ag Process for the production of esters of nitric acid
TWI417276B (zh) 2011-03-01 2013-12-01 Everlight Chem Ind Corp ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
CA3167343A1 (en) 2020-02-10 2021-08-19 Brigitte DUQUESROIX-CHAKROUN Method for treating vaso occlusive crises associated with sickle cell disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57145841A (en) * 1981-03-05 1982-09-09 Nissan Chem Ind Ltd L-menthyl naphthylpropionate and its preparation
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
EP0722434B1 (en) * 1993-10-06 1998-07-29 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
WO1995030641A1 (en) * 1994-05-10 1995-11-16 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
CN1144092A (zh) * 1995-08-25 1997-03-05 蔡雄 可释放一氧化氮的新型非类固醇类抗炎药、它们的制备方法和用途
WO1997013519A1 (en) * 1995-10-09 1997-04-17 Russinsky Limited Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products
IT1276071B1 (it) 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
FR2757159B1 (fr) 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments

Also Published As

Publication number Publication date
DE60020753T2 (de) 2006-03-16
JP2003506425A (ja) 2003-02-18
CA2380116C (en) 2011-07-05
CN1198786C (zh) 2005-04-27
MXPA02001256A (es) 2005-06-06
EP1384707A1 (en) 2004-01-28
DE60020753D1 (de) 2005-07-14
HUP0202435A2 (hu) 2002-11-28
EP1200386A1 (en) 2002-05-02
ATE251109T1 (de) 2003-10-15
PL200165B1 (pl) 2008-12-31
RU2248348C2 (ru) 2005-03-20
KR100687820B1 (ko) 2007-02-28
DE60005682T2 (de) 2004-09-16
CA2380116A1 (en) 2001-02-15
HU227109B1 (en) 2010-07-28
IT1313596B1 (it) 2002-09-09
WO2001010814A1 (en) 2001-02-15
US7238829B2 (en) 2007-07-03
NO20020515D0 (no) 2002-02-01
DE60005682D1 (de) 2003-11-06
ITMI991753A0 (it) 1999-08-04
PT1384707E (pt) 2005-08-31
CN1367773A (zh) 2002-09-04
ES2208390T3 (es) 2004-06-16
ES2243859T3 (es) 2005-12-01
NO327669B1 (no) 2009-09-07
HUP0202435A3 (en) 2004-03-01
ITMI991753A1 (it) 2001-02-04
IL147639A0 (en) 2002-08-14
EP1200386B1 (en) 2003-10-01
BR0012915A (pt) 2002-06-04
EP1384707B1 (en) 2005-06-08
JP2011042690A (ja) 2011-03-03
BRPI0012915B1 (pt) 2015-09-01
ZA200304525B (en) 2004-04-28
KR20020013974A (ko) 2002-02-21
DK1384707T3 (da) 2005-08-15
DK1200386T3 (da) 2003-12-22
PT1200386E (pt) 2004-02-27
ATE297372T1 (de) 2005-06-15
US20050119339A1 (en) 2005-06-02
PL353092A1 (en) 2003-10-06
ZA200200478B (en) 2003-10-29
NO20020515L (no) 2002-02-01
TR200200290T2 (tr) 2002-05-21
AU778694B2 (en) 2004-12-16
US6700011B1 (en) 2004-03-02
AU6438500A (en) 2001-03-05

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