ITMI991753A0 - Processo per la preparazione di nitrossialchil esteri del naproxene - Google Patents
Processo per la preparazione di nitrossialchil esteri del naproxeneInfo
- Publication number
- ITMI991753A0 ITMI991753A0 IT99MI001753A ITMI991753A ITMI991753A0 IT MI991753 A0 ITMI991753 A0 IT MI991753A0 IT 99MI001753 A IT99MI001753 A IT 99MI001753A IT MI991753 A ITMI991753 A IT MI991753A IT MI991753 A0 ITMI991753 A0 IT MI991753A0
- Authority
- IT
- Italy
- Prior art keywords
- naproxen
- preparation
- nitroxyalkyl
- esters
- nitroxyalkyl esters
- Prior art date
Links
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 title 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 title 1
- 229960002009 naproxen Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/02—Preparation of esters of nitric acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (33)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI001753A IT1313596B1 (it) | 1999-08-04 | 1999-08-04 | Processo per la preparazione di nitrossialchil esteri del naproxene |
CA2380116A CA2380116C (en) | 1999-08-04 | 2000-07-27 | Process for the preparation of naproxene nitroxyalkylesters |
PL353092A PL200165B1 (pl) | 1999-08-04 | 2000-07-27 | Sposób wytwarzania estrów nitroksyalkilowych naproksenu oraz ester nitroksybutylowy kwasu 2-(S)-(6-metoksy-2-naftylo)propanowego o wysokim nadmiarze enancjomerycznym |
PT00951456T PT1200386E (pt) | 1999-08-04 | 2000-07-27 | Processo para a preparacao de esteres nitroxialquilicos de naproxeno |
ES00951456T ES2208390T3 (es) | 1999-08-04 | 2000-07-27 | Proceso para la preparacion de nitroalquil esteres de naproxeno. |
PCT/EP2000/007222 WO2001010814A1 (en) | 1999-08-04 | 2000-07-27 | Process for the preparation of naproxene nitroxyalkylesters |
US10/031,412 US6700011B1 (en) | 1999-08-04 | 2000-07-27 | Process for the preparation of naproxene nitroxyalkylesters |
ES03102132T ES2243859T3 (es) | 1999-08-04 | 2000-07-27 | 4-nitrobutilester de naproxeno. |
IL14763900A IL147639A0 (en) | 1999-08-04 | 2000-07-27 | Process for the preparation of naproxene nitroxyalkylesters |
TR2002/00290T TR200200290T2 (tr) | 1999-08-04 | 2000-07-27 | Naproksen nitroksialkilesterlerin hazırlanması için işlem |
CNB008111588A CN1198786C (zh) | 1999-08-04 | 2000-07-27 | 萘普生硝基氧基烷基酯的制备方法 |
AT03102132T ATE297372T1 (de) | 1999-08-04 | 2000-07-27 | 4-nitroxybutylester von naproxen |
DK00951456T DK1200386T3 (da) | 1999-08-04 | 2000-07-27 | Fremgangsmåde til fremstilling af nitroxyalkylestere af naproxen |
AT00951456T ATE251109T1 (de) | 1999-08-04 | 2000-07-27 | Verfahren zur herstellung von naproxennitroxyalkylestern |
AU64385/00A AU778694B2 (en) | 1999-08-04 | 2000-07-27 | Process for the preparation of naproxene nitroxyalkylesters |
DE60020753T DE60020753T2 (de) | 1999-08-04 | 2000-07-27 | 4-Nitroxybutylester von Naproxen |
HU0202435A HU227109B1 (en) | 1999-08-04 | 2000-07-27 | Process for the preparation of naproxene nitroxyalkylesters |
DK03102132T DK1384707T3 (da) | 1999-08-04 | 2000-07-27 | 4-Nitroxybutylester af naproxen |
EP03102132A EP1384707B1 (en) | 1999-08-04 | 2000-07-27 | 4-Nitroxybutylester of naproxene |
JP2001515282A JP4667691B2 (ja) | 1999-08-04 | 2000-07-27 | ナプロキセンのニトロキシアルキルエステルの製造法 |
RU2002102860/04A RU2248348C2 (ru) | 1999-08-04 | 2000-07-27 | Способ получения нитроксиалкиловых эфиров напроксена |
PT03102132T PT1384707E (pt) | 1999-08-04 | 2000-07-27 | Ester 4-nitroxibutilico de naproxeno |
DE60005682T DE60005682T2 (de) | 1999-08-04 | 2000-07-27 | Verfahren zur herstellung von naproxennitroxyalkylestern |
BRPI0012915-1A BRPI0012915B1 (pt) | 1999-08-04 | 2000-07-27 | Processo para obter nitroxialquilésteres do ácido 2-(s)-(6-metoxi-2-naftil)-propanóico |
EP00951456A EP1200386B1 (en) | 1999-08-04 | 2000-07-27 | Process for the preparation of naproxene nitroxyalkylesters |
KR1020027000946A KR100687820B1 (ko) | 1999-08-04 | 2000-07-27 | 나프록센 니트록시알킬에스테르의 제조방법 |
MXPA02001256A MXPA02001256A (es) | 1999-08-04 | 2000-07-27 | Procedimiento para la preparacion de esteres nitroxialquilicos de naproxeno. |
SI200030256T SI1200386T1 (en) | 1999-08-04 | 2000-07-27 | Process for the preparation of naproxene nitroxyalkylesters |
ZA200200478A ZA200200478B (en) | 1999-08-04 | 2002-01-18 | Process for the preparation of naproxene nitroxyalkylesters. |
NO20020515A NO327669B1 (no) | 1999-08-04 | 2002-02-01 | Fremgangsmate for fremstilling av naproxen-nitroksyalkylester, og slik forbindelse |
ZA200304525A ZA200304525B (en) | 1999-08-04 | 2003-06-10 | Naproxene nitroxyalkylesters. |
US10/625,558 US7238829B2 (en) | 1999-08-04 | 2003-07-24 | Process for the preparation of naproxene nitroxyalkylesters |
JP2010266860A JP2011042690A (ja) | 1999-08-04 | 2010-11-30 | ナプロキセンのニトロキシアルキルエステル |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI001753A IT1313596B1 (it) | 1999-08-04 | 1999-08-04 | Processo per la preparazione di nitrossialchil esteri del naproxene |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI991753A0 true ITMI991753A0 (it) | 1999-08-04 |
ITMI991753A1 ITMI991753A1 (it) | 2001-02-04 |
IT1313596B1 IT1313596B1 (it) | 2002-09-09 |
Family
ID=11383500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT1999MI001753A IT1313596B1 (it) | 1999-08-04 | 1999-08-04 | Processo per la preparazione di nitrossialchil esteri del naproxene |
Country Status (23)
Country | Link |
---|---|
US (2) | US6700011B1 (it) |
EP (2) | EP1384707B1 (it) |
JP (2) | JP4667691B2 (it) |
KR (1) | KR100687820B1 (it) |
CN (1) | CN1198786C (it) |
AT (2) | ATE297372T1 (it) |
AU (1) | AU778694B2 (it) |
BR (1) | BRPI0012915B1 (it) |
CA (1) | CA2380116C (it) |
DE (2) | DE60020753T2 (it) |
DK (2) | DK1200386T3 (it) |
ES (2) | ES2208390T3 (it) |
HU (1) | HU227109B1 (it) |
IL (1) | IL147639A0 (it) |
IT (1) | IT1313596B1 (it) |
MX (1) | MXPA02001256A (it) |
NO (1) | NO327669B1 (it) |
PL (1) | PL200165B1 (it) |
PT (2) | PT1200386E (it) |
RU (1) | RU2248348C2 (it) |
TR (1) | TR200200290T2 (it) |
WO (1) | WO2001010814A1 (it) |
ZA (2) | ZA200200478B (it) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU763000B2 (en) | 1998-10-30 | 2003-07-10 | Nicox S.A. | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use |
US6706724B2 (en) | 2000-12-21 | 2004-03-16 | Nitromed, Inc. | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use |
WO2003045896A1 (en) * | 2001-11-27 | 2003-06-05 | Astrazeneca Ab | New process |
US7220749B2 (en) | 2002-06-11 | 2007-05-22 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
JP2005539089A (ja) | 2002-07-03 | 2005-12-22 | ニトロメッド インコーポレーティッド | ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法 |
CA2493156A1 (en) | 2002-07-29 | 2004-02-05 | Nitromed, Inc. | Cyclooxygenase-2 selective inhibitors, compositions and methods of use |
ITMI20021861A1 (it) * | 2002-08-29 | 2004-02-29 | Nicox Sa | Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione. |
ITMI20022409A1 (it) * | 2002-11-14 | 2004-05-15 | Dinamite Dipharma S P A | Procedimento per la purificazione di 1, 4-butandiolo mononitrato. |
PT1978947E (pt) * | 2006-02-03 | 2014-11-03 | Nicox Science Ireland | Derivados nitro-óxido para utilização no tratamento de distrofias musculares |
CN100427475C (zh) * | 2006-11-30 | 2008-10-22 | 华南理工大学 | 萘普生-2-芳基吗啉乙酯及其制备方法与应用 |
CN101730676A (zh) * | 2007-06-28 | 2010-06-09 | 尼科克斯公司 | 1,4-丁二醇单硝酸酯的制备方法 |
WO2009149053A2 (en) * | 2008-06-02 | 2009-12-10 | Dr. Reddy's Laboratories Ltd. | Naproxcinod process and solid dispersion |
ITRM20080325A1 (it) | 2008-06-20 | 2009-12-21 | Nicox Sa | Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato |
TW201139337A (en) | 2010-03-31 | 2011-11-16 | Lonza Ag | Process for the production of esters of nitric acid |
TWI417276B (zh) | 2011-03-01 | 2013-12-01 | Everlight Chem Ind Corp | 2-(s)-(6-甲氧基-2-萘基)-丙酸之酸酐衍生物、其製法暨及其用途 |
CA2897571C (en) | 2013-01-21 | 2018-12-18 | Apparao Satyam | Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group |
US11660282B2 (en) | 2020-02-10 | 2023-05-30 | Nicox Sa | Method for treating vaso occlusive crises associated with sickle cell disease |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57145841A (en) * | 1981-03-05 | 1982-09-09 | Nissan Chem Ind Ltd | L-menthyl naphthylpropionate and its preparation |
IT1243367B (it) * | 1990-07-26 | 1994-06-10 | Italfarmaco Spa | Derivati acidi benzoici sostituiti ad attivita' cardiovascolare |
US5700947A (en) | 1993-10-06 | 1997-12-23 | Nicox S.A. | Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation |
SI0759899T1 (en) * | 1994-05-10 | 1999-12-31 | Nicox S.A. | Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities |
US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
CN1144092A (zh) * | 1995-08-25 | 1997-03-05 | 蔡雄 | 可释放一氧化氮的新型非类固醇类抗炎药、它们的制备方法和用途 |
WO1997013519A1 (en) * | 1995-10-09 | 1997-04-17 | Russinsky Limited | Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products |
IT1276071B1 (it) * | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
FR2757159B1 (fr) * | 1996-12-12 | 1999-12-17 | Hoechst Marion Roussel Inc | Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments |
-
1999
- 1999-08-04 IT IT1999MI001753A patent/IT1313596B1/it active
-
2000
- 2000-07-27 IL IL14763900A patent/IL147639A0/xx not_active IP Right Cessation
- 2000-07-27 MX MXPA02001256A patent/MXPA02001256A/es active IP Right Grant
- 2000-07-27 JP JP2001515282A patent/JP4667691B2/ja not_active Expired - Lifetime
- 2000-07-27 AT AT03102132T patent/ATE297372T1/de active
- 2000-07-27 PL PL353092A patent/PL200165B1/pl unknown
- 2000-07-27 DK DK00951456T patent/DK1200386T3/da active
- 2000-07-27 CA CA2380116A patent/CA2380116C/en not_active Expired - Lifetime
- 2000-07-27 RU RU2002102860/04A patent/RU2248348C2/ru active
- 2000-07-27 TR TR2002/00290T patent/TR200200290T2/xx unknown
- 2000-07-27 HU HU0202435A patent/HU227109B1/hu not_active IP Right Cessation
- 2000-07-27 AT AT00951456T patent/ATE251109T1/de active
- 2000-07-27 US US10/031,412 patent/US6700011B1/en not_active Expired - Lifetime
- 2000-07-27 BR BRPI0012915-1A patent/BRPI0012915B1/pt not_active IP Right Cessation
- 2000-07-27 PT PT00951456T patent/PT1200386E/pt unknown
- 2000-07-27 ES ES00951456T patent/ES2208390T3/es not_active Expired - Lifetime
- 2000-07-27 CN CNB008111588A patent/CN1198786C/zh not_active Expired - Fee Related
- 2000-07-27 KR KR1020027000946A patent/KR100687820B1/ko not_active IP Right Cessation
- 2000-07-27 EP EP03102132A patent/EP1384707B1/en not_active Expired - Lifetime
- 2000-07-27 PT PT03102132T patent/PT1384707E/pt unknown
- 2000-07-27 DE DE60020753T patent/DE60020753T2/de not_active Expired - Lifetime
- 2000-07-27 WO PCT/EP2000/007222 patent/WO2001010814A1/en active IP Right Grant
- 2000-07-27 ES ES03102132T patent/ES2243859T3/es not_active Expired - Lifetime
- 2000-07-27 DE DE60005682T patent/DE60005682T2/de not_active Expired - Lifetime
- 2000-07-27 DK DK03102132T patent/DK1384707T3/da active
- 2000-07-27 EP EP00951456A patent/EP1200386B1/en not_active Expired - Lifetime
- 2000-07-27 AU AU64385/00A patent/AU778694B2/en not_active Ceased
-
2002
- 2002-01-18 ZA ZA200200478A patent/ZA200200478B/en unknown
- 2002-02-01 NO NO20020515A patent/NO327669B1/no not_active IP Right Cessation
-
2003
- 2003-06-10 ZA ZA200304525A patent/ZA200304525B/xx unknown
- 2003-07-24 US US10/625,558 patent/US7238829B2/en not_active Expired - Lifetime
-
2010
- 2010-11-30 JP JP2010266860A patent/JP2011042690A/ja active Pending
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