DE60005682D1 - Verfahren zur herstellung von naproxennitroxyalkylestern - Google Patents

Verfahren zur herstellung von naproxennitroxyalkylestern

Info

Publication number
DE60005682D1
DE60005682D1 DE60005682T DE60005682T DE60005682D1 DE 60005682 D1 DE60005682 D1 DE 60005682D1 DE 60005682 T DE60005682 T DE 60005682T DE 60005682 T DE60005682 T DE 60005682T DE 60005682 D1 DE60005682 D1 DE 60005682D1
Authority
DE
Germany
Prior art keywords
naproxennitroxyalkylesters
producing
naphthyl
methoxy
equal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60005682T
Other languages
English (en)
Other versions
DE60005682T2 (de
Inventor
Francesca Benedini
Erminio Oldani
Graziano Castaldi
Antonio Tarquini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nicox SA
Original Assignee
Nicox SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox SA filed Critical Nicox SA
Publication of DE60005682D1 publication Critical patent/DE60005682D1/de
Application granted granted Critical
Publication of DE60005682T2 publication Critical patent/DE60005682T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60005682T 1999-08-04 2000-07-27 Verfahren zur herstellung von naproxennitroxyalkylestern Expired - Lifetime DE60005682T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI991753 1999-08-04
IT1999MI001753A IT1313596B1 (it) 1999-08-04 1999-08-04 Processo per la preparazione di nitrossialchil esteri del naproxene
PCT/EP2000/007222 WO2001010814A1 (en) 1999-08-04 2000-07-27 Process for the preparation of naproxene nitroxyalkylesters

Publications (2)

Publication Number Publication Date
DE60005682D1 true DE60005682D1 (de) 2003-11-06
DE60005682T2 DE60005682T2 (de) 2004-09-16

Family

ID=11383500

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60020753T Expired - Lifetime DE60020753T2 (de) 1999-08-04 2000-07-27 4-Nitroxybutylester von Naproxen
DE60005682T Expired - Lifetime DE60005682T2 (de) 1999-08-04 2000-07-27 Verfahren zur herstellung von naproxennitroxyalkylestern

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60020753T Expired - Lifetime DE60020753T2 (de) 1999-08-04 2000-07-27 4-Nitroxybutylester von Naproxen

Country Status (23)

Country Link
US (2) US6700011B1 (de)
EP (2) EP1384707B1 (de)
JP (2) JP4667691B2 (de)
KR (1) KR100687820B1 (de)
CN (1) CN1198786C (de)
AT (2) ATE297372T1 (de)
AU (1) AU778694B2 (de)
BR (1) BRPI0012915B1 (de)
CA (1) CA2380116C (de)
DE (2) DE60020753T2 (de)
DK (2) DK1200386T3 (de)
ES (2) ES2243859T3 (de)
HU (1) HU227109B1 (de)
IL (1) IL147639A0 (de)
IT (1) IT1313596B1 (de)
MX (1) MXPA02001256A (de)
NO (1) NO327669B1 (de)
PL (1) PL200165B1 (de)
PT (2) PT1200386E (de)
RU (1) RU2248348C2 (de)
TR (1) TR200200290T2 (de)
WO (1) WO2001010814A1 (de)
ZA (2) ZA200200478B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1126838A4 (de) 1998-10-30 2005-02-16 Nitromed Inc Nitrosierte und nitrosylierte nichtsteroidale antiphlogistishe verbindungen, zusammenstellungen und verwendungsmethoden
WO2002060378A2 (en) 2000-12-21 2002-08-08 Nitromed, Inc. Substituted aryl compounds as cyclooxygenase-2 selective inhibitors, compositions and methods of use
CA2465697C (en) * 2001-11-27 2010-05-11 Astrazeneca Ab Process for the preparation of (s)-naproxen 4-nitrooxybutyl ester
AU2003248642A1 (en) 2002-06-11 2003-12-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
JP2005539089A (ja) 2002-07-03 2005-12-22 ニトロメッド インコーポレーティッド ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法
AU2003261281A1 (en) 2002-07-29 2004-02-16 Nicox S.A. Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI20022409A1 (it) * 2002-11-14 2004-05-15 Dinamite Dipharma S P A Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
KR20080097989A (ko) * 2006-02-03 2008-11-06 니콕스 에스. 에이. 근위축증 치료를 위한 의약의 니트록시 유도체의 용도
CN100427475C (zh) * 2006-11-30 2008-10-22 华南理工大学 萘普生-2-芳基吗啉乙酯及其制备方法与应用
US20100137599A1 (en) * 2007-06-28 2010-06-03 Nicox S.A. Process for preparing 1,4-butandiol monitrate
WO2009149053A2 (en) * 2008-06-02 2009-12-10 Dr. Reddy's Laboratories Ltd. Naproxcinod process and solid dispersion
ITRM20080325A1 (it) * 2008-06-20 2009-12-21 Nicox Sa Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
TW201139337A (en) 2010-03-31 2011-11-16 Lonza Ag Process for the production of esters of nitric acid
TWI417276B (zh) 2011-03-01 2013-12-01 Everlight Chem Ind Corp ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
WO2021160543A1 (en) 2020-02-10 2021-08-19 Nicox S.A. Method for treating vaso occlusive crises associated with sickle cell disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57145841A (en) * 1981-03-05 1982-09-09 Nissan Chem Ind Ltd L-menthyl naphthylpropionate and its preparation
IT1243367B (it) 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
DE69412109T2 (de) * 1993-10-06 1999-01-21 Nicox S.A., Paris Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung
DK0759899T3 (da) 1994-05-10 1999-12-20 Nicox Sa Nitroforbindelser og sammensætninger deraf med antiinflammatoriske, analgetiske og antitrombotiske aktiviteter
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
CN1144092A (zh) * 1995-08-25 1997-03-05 蔡雄 可释放一氧化氮的新型非类固醇类抗炎药、它们的制备方法和用途
AU6835696A (en) * 1995-10-09 1997-04-30 Russinsky Limited Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
FR2757159B1 (fr) 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments

Also Published As

Publication number Publication date
EP1200386A1 (de) 2002-05-02
CN1198786C (zh) 2005-04-27
ITMI991753A0 (it) 1999-08-04
CA2380116A1 (en) 2001-02-15
ZA200304525B (en) 2004-04-28
PT1384707E (pt) 2005-08-31
CN1367773A (zh) 2002-09-04
NO327669B1 (no) 2009-09-07
ES2243859T3 (es) 2005-12-01
DE60020753D1 (de) 2005-07-14
RU2248348C2 (ru) 2005-03-20
EP1384707B1 (de) 2005-06-08
US7238829B2 (en) 2007-07-03
IL147639A0 (en) 2002-08-14
IT1313596B1 (it) 2002-09-09
HUP0202435A3 (en) 2004-03-01
US20050119339A1 (en) 2005-06-02
US6700011B1 (en) 2004-03-02
TR200200290T2 (tr) 2002-05-21
JP2011042690A (ja) 2011-03-03
BR0012915A (pt) 2002-06-04
CA2380116C (en) 2011-07-05
ATE251109T1 (de) 2003-10-15
KR20020013974A (ko) 2002-02-21
EP1200386B1 (de) 2003-10-01
DE60020753T2 (de) 2006-03-16
HUP0202435A2 (hu) 2002-11-28
DE60005682T2 (de) 2004-09-16
BRPI0012915B1 (pt) 2015-09-01
KR100687820B1 (ko) 2007-02-28
EP1384707A1 (de) 2004-01-28
DK1384707T3 (da) 2005-08-15
MXPA02001256A (es) 2005-06-06
ZA200200478B (en) 2003-10-29
ATE297372T1 (de) 2005-06-15
ITMI991753A1 (it) 2001-02-04
HU227109B1 (en) 2010-07-28
NO20020515D0 (no) 2002-02-01
WO2001010814A1 (en) 2001-02-15
DK1200386T3 (da) 2003-12-22
AU778694B2 (en) 2004-12-16
NO20020515L (no) 2002-02-01
PL200165B1 (pl) 2008-12-31
JP2003506425A (ja) 2003-02-18
ES2208390T3 (es) 2004-06-16
PT1200386E (pt) 2004-02-27
AU6438500A (en) 2001-03-05
PL353092A1 (en) 2003-10-06
JP4667691B2 (ja) 2011-04-13

Similar Documents

Publication Publication Date Title
DE60005682D1 (de) Verfahren zur herstellung von naproxennitroxyalkylestern
ATE283836T1 (de) Verfahren zur herstellung von fettsäureestern
DE69801797D1 (de) Verfahren zur Herstellung von Acrylsäure
DE69702354D1 (de) Verfahren zur Herstellung von Acrylsäure
DE59704095D1 (de) Verfahren zur kontinuierlichen Herstellung von Alkylestern der (Meth)acrylsäure
DE69903698D1 (de) Verfahren zur Herstellung von Acrylsäure
DE59709118D1 (de) Verfahren zur herstellung von aluminumsalzen organischer phosphorsäuren
DE69920568D1 (de) Verfahren zur Herstellung von optisch aktivem 4-Halo-3-hydroxybuttersäureester
ATE272051T1 (de) Verfahren zur herstellung von hydroxymethylbuttersäureestern
DE69512639D1 (de) Verfahren zur herstellung von zimtsäurederivaten
DE59704450D1 (de) Verfahren zur herstellung von 2-(2-methylphenyl)-3-methoxyacrylsäure-methylester
ATE230722T1 (de) Verfahren zur herstellung von cyanvaleriansäure oder -estern
DE59804673D1 (de) Verfahren zur herstellung von vinylphosphonsäure-verbindungen
DE59914298D1 (de) Verfahren zur Racematspaltung von Arylalkylcarbonsäureestern
DE59407019D1 (de) Verfahren zur herstellung von fettsäureniedrigalkylestern
DE3677838D1 (de) Verfahren zur herstellung von alkylestern von 3,4-epoxybuttersaeure.
DE69819335D1 (de) Verfahren zur herstellung von phosphorsäureester-verbindungen
DE69407973D1 (de) Verfahren zur herstellung weisser mikrokieselsäure
DE60213998D1 (de) Verfahren zur herstellung von 2 oxocarbonsäureestern
DE59902581D1 (de) Verfahren zur herstellung von vinylphosphonsäure-verbindungen
DE59804451D1 (de) Verfahren zur herstellung von hellfarbigen ethercarbonsäuren
DE69930275D1 (de) Verfahren zur herstellung von sorbinsäuren oder sorbinsäuresalzen
DE69930274D1 (de) Verfahren zur herstellung von sorbinsäuren
ATE241605T1 (de) Verfahren zur herstellung von phenoxy- propionsäure derivate
DE69821755D1 (de) Verfahren zur Herstellung von alpha-Tocopherol-4-aminobenzoesäureester-Verbindungen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NICOX S.A., SOPHIA ANTIPOLIS, FR