ZA200304525B - Naproxene nitroxyalkylesters. - Google Patents

Naproxene nitroxyalkylesters.

Info

Publication number
ZA200304525B
ZA200304525B ZA200304525A ZA200304525A ZA200304525B ZA 200304525 B ZA200304525 B ZA 200304525B ZA 200304525 A ZA200304525 A ZA 200304525A ZA 200304525 A ZA200304525 A ZA 200304525A ZA 200304525 B ZA200304525 B ZA 200304525B
Authority
ZA
South Africa
Prior art keywords
nitroxyalkylesters
naproxene
naproxene nitroxyalkylesters
naphthyl
methoxy
Prior art date
Application number
ZA200304525A
Other languages
English (en)
Inventor
Francesca Benedini
Graziano Castaldi
Erminio Oldani
Antonio Tarquini
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of ZA200304525B publication Critical patent/ZA200304525B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ZA200304525A 1999-08-04 2003-06-10 Naproxene nitroxyalkylesters. ZA200304525B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI001753A IT1313596B1 (it) 1999-08-04 1999-08-04 Processo per la preparazione di nitrossialchil esteri del naproxene

Publications (1)

Publication Number Publication Date
ZA200304525B true ZA200304525B (en) 2004-04-28

Family

ID=11383500

Family Applications (2)

Application Number Title Priority Date Filing Date
ZA200200478A ZA200200478B (en) 1999-08-04 2002-01-18 Process for the preparation of naproxene nitroxyalkylesters.
ZA200304525A ZA200304525B (en) 1999-08-04 2003-06-10 Naproxene nitroxyalkylesters.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ZA200200478A ZA200200478B (en) 1999-08-04 2002-01-18 Process for the preparation of naproxene nitroxyalkylesters.

Country Status (23)

Country Link
US (2) US6700011B1 (xx)
EP (2) EP1200386B1 (xx)
JP (2) JP4667691B2 (xx)
KR (1) KR100687820B1 (xx)
CN (1) CN1198786C (xx)
AT (2) ATE251109T1 (xx)
AU (1) AU778694B2 (xx)
BR (1) BRPI0012915B1 (xx)
CA (1) CA2380116C (xx)
DE (2) DE60020753T2 (xx)
DK (2) DK1384707T3 (xx)
ES (2) ES2208390T3 (xx)
HU (1) HU227109B1 (xx)
IL (1) IL147639A0 (xx)
IT (1) IT1313596B1 (xx)
MX (1) MXPA02001256A (xx)
NO (1) NO327669B1 (xx)
PL (1) PL200165B1 (xx)
PT (2) PT1200386E (xx)
RU (1) RU2248348C2 (xx)
TR (1) TR200200290T2 (xx)
WO (1) WO2001010814A1 (xx)
ZA (2) ZA200200478B (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1126838A4 (en) 1998-10-30 2005-02-16 Nitromed Inc NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
CA2432642A1 (en) 2000-12-21 2002-08-08 Subhash P. Khanapure Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
JP4771659B2 (ja) * 2001-11-27 2011-09-14 ニコックス・ソシエテ・アノニム 新規な方法
JP2006501161A (ja) 2002-06-11 2006-01-12 ニトロメッド インク． ニトロソ化および／またはニトロシル化シクロオキシゲナーゼ−２選択的阻害剤、組成物ならびに使用方法
AU2003247792B2 (en) 2002-07-03 2009-09-24 Nicox S.A. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
CA2493156A1 (en) 2002-07-29 2004-02-05 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI20022409A1 (it) * 2002-11-14 2004-05-15 Dinamite Dipharma S P A Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
SI1978947T1 (sl) * 2006-02-03 2014-12-31 Nicox Science Ireland Riverside One Nitrooksiderivati za uporabo pri zdravljenju mišičnih distrofij
CN100427475C (zh) * 2006-11-30 2008-10-22 华南理工大学 萘普生-2-芳基吗啉乙酯及其制备方法与应用
KR20100032856A (ko) * 2007-06-28 2010-03-26 니콕스 에스. 에이. 1,4-부탄디올 모노니트레이트의 제조방법
WO2009149053A2 (en) * 2008-06-02 2009-12-10 Dr. Reddy's Laboratories Ltd. Naproxcinod process and solid dispersion
ITRM20080325A1 (it) 2008-06-20 2009-12-21 Nicox Sa Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
TW201139337A (en) 2010-03-31 2011-11-16 Lonza Ag Process for the production of esters of nitric acid
TWI417276B (zh) 2011-03-01 2013-12-01 Everlight Chem Ind Corp ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
CA3167343A1 (en) 2020-02-10 2021-08-19 Brigitte DUQUESROIX-CHAKROUN Method for treating vaso occlusive crises associated with sickle cell disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57145841A (en) * 1981-03-05 1982-09-09 Nissan Chem Ind Ltd L-menthyl naphthylpropionate and its preparation
IT1243367B (it) 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
HU218923B (hu) * 1993-10-06 2000-12-28 Nicox S.A. Gyulladásgátló és/vagy fájdalomcsillapító hatású nitrát-észterek, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására
CA2190087C (en) * 1994-05-10 2005-08-02 Piero Del Soldato Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
CN1144092A (zh) * 1995-08-25 1997-03-05 蔡雄 可释放一氧化氮的新型非类固醇类抗炎药、它们的制备方法和用途
WO1997013519A1 (en) * 1995-10-09 1997-04-17 Russinsky Limited Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
FR2757159B1 (fr) 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments

Also Published As

Publication number Publication date
ATE297372T1 (de) 2005-06-15
NO20020515D0 (no) 2002-02-01
EP1200386A1 (en) 2002-05-02
US6700011B1 (en) 2004-03-02
HU227109B1 (en) 2010-07-28
ZA200200478B (en) 2003-10-29
EP1384707B1 (en) 2005-06-08
NO20020515L (no) 2002-02-01
NO327669B1 (no) 2009-09-07
DE60020753D1 (de) 2005-07-14
HUP0202435A2 (hu) 2002-11-28
JP2003506425A (ja) 2003-02-18
ES2243859T3 (es) 2005-12-01
IL147639A0 (en) 2002-08-14
DK1200386T3 (da) 2003-12-22
BR0012915A (pt) 2002-06-04
ITMI991753A1 (it) 2001-02-04
JP2011042690A (ja) 2011-03-03
CN1198786C (zh) 2005-04-27
CA2380116A1 (en) 2001-02-15
MXPA02001256A (es) 2005-06-06
KR20020013974A (ko) 2002-02-21
ATE251109T1 (de) 2003-10-15
JP4667691B2 (ja) 2011-04-13
HUP0202435A3 (en) 2004-03-01
PT1200386E (pt) 2004-02-27
WO2001010814A1 (en) 2001-02-15
DE60005682D1 (de) 2003-11-06
DE60005682T2 (de) 2004-09-16
DE60020753T2 (de) 2006-03-16
AU778694B2 (en) 2004-12-16
DK1384707T3 (da) 2005-08-15
RU2248348C2 (ru) 2005-03-20
IT1313596B1 (it) 2002-09-09
CN1367773A (zh) 2002-09-04
PT1384707E (pt) 2005-08-31
EP1200386B1 (en) 2003-10-01
CA2380116C (en) 2011-07-05
ITMI991753A0 (it) 1999-08-04
KR100687820B1 (ko) 2007-02-28
BRPI0012915B1 (pt) 2015-09-01
PL353092A1 (en) 2003-10-06
EP1384707A1 (en) 2004-01-28
ES2208390T3 (es) 2004-06-16
US20050119339A1 (en) 2005-06-02
TR200200290T2 (tr) 2002-05-21
US7238829B2 (en) 2007-07-03
AU6438500A (en) 2001-03-05
PL200165B1 (pl) 2008-12-31

Similar Documents

Publication Publication Date Title
ZA200304525B (en) Naproxene nitroxyalkylesters.
DE69813540T2 (de) Kosmetische zusammensetzung enthaltend ferulasäureester
ATE249418T1 (de) Neuartige ester abgeleitet von substituierten phenyl-cyclohexyl-verbindungen
KR970706824A (ko) 붕산 에스테르 및 붕산 화합물, 이의 합성 방법 및 용도(boronic ester and acid compounds, synthesis and uses)
AU7431398A (en) Conjugated linolenic acid-based synthetic triglycerides
ID22095A (id) Asam aril-akrilat ester
DE50113582D1 (de) Verwendung einer Pulver-Zusammensetzung zur Hydrophobierung von Baustoffmassen
DE69430972T2 (de) Carbonsäureester enthaltendes Schmiermittel
WO2001002367A3 (en) Diester prodrugs of a decahydroisoquinoline-3-carboxylic acid
DE69920568D1 (de) Verfahren zur Herstellung von optisch aktivem 4-Halo-3-hydroxybuttersäureester
DE59810578D1 (de) Mischungen von langkettigen Phosphorsäurealkylestern
NO993796D0 (no) Fremgangsmåte for omforestring av <alfa>-ketokarboksylsyreestre
ATE241672T1 (de) Verwendung von fettsäureniedrigalkylestern in abbeizmitteln
EP0997534A3 (de) Verfahren zur Racematspaltung von Arylalkylcarbonsäureestern
DE3380024D1 (en) Process for the preparation of the 1'-ethoxycarbonyloxyethyl ester of benzylpenicillin
ITRM950193A0 (it) Procedimento per la produzione di miscugli di diesteri polietilenglicolici dell'acido 2-(4-cloro-2-metilfenossi)-propionico.
ATE263134T1 (de) Herstellung von optisch aktiver cyclohexylphenylglykolsäure und ihrer ester
DE69821755D1 (de) Verfahren zur Herstellung von alpha-Tocopherol-4-aminobenzoesäureester-Verbindungen
DK0775692T3 (da) Guanidinomethylcyclohexancarboxylsyreesterderivater
GR3036631T3 (en) Preparation and utilisation of pure enantiomers of 8-halogen-6-hydroxyoctanoic acid, their alkyl esters and their salts with pure enantiomers of alpha-methyl-benzylamines
DE69809692D1 (de) Herstellung von Carbonsäureestern
GR3001577T3 (en) Thionophosphonic-acid ester
FI953519A (fi) Uudet substituoidut tiosemikarbatsonihappoesterit