ATE297372T1 - 4-nitroxybutylester von naproxen - Google Patents
4-nitroxybutylester von naproxenInfo
- Publication number
- ATE297372T1 ATE297372T1 AT03102132T AT03102132T ATE297372T1 AT E297372 T1 ATE297372 T1 AT E297372T1 AT 03102132 T AT03102132 T AT 03102132T AT 03102132 T AT03102132 T AT 03102132T AT E297372 T1 ATE297372 T1 AT E297372T1
- Authority
- AT
- Austria
- Prior art keywords
- naproxen
- nitroxybutyl ester
- nitroxybutyl
- ester
- naphthyl
- Prior art date
Links
- -1 4-NITROXYBUTYL Chemical class 0.000 title abstract 2
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 title abstract 2
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 title 1
- 229960002009 naproxen Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/02—Preparation of esters of nitric acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI001753A IT1313596B1 (it) | 1999-08-04 | 1999-08-04 | Processo per la preparazione di nitrossialchil esteri del naproxene |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE297372T1 true ATE297372T1 (de) | 2005-06-15 |
Family
ID=11383500
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00951456T ATE251109T1 (de) | 1999-08-04 | 2000-07-27 | Verfahren zur herstellung von naproxennitroxyalkylestern |
AT03102132T ATE297372T1 (de) | 1999-08-04 | 2000-07-27 | 4-nitroxybutylester von naproxen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00951456T ATE251109T1 (de) | 1999-08-04 | 2000-07-27 | Verfahren zur herstellung von naproxennitroxyalkylestern |
Country Status (23)
Country | Link |
---|---|
US (2) | US6700011B1 (de) |
EP (2) | EP1384707B1 (de) |
JP (2) | JP4667691B2 (de) |
KR (1) | KR100687820B1 (de) |
CN (1) | CN1198786C (de) |
AT (2) | ATE251109T1 (de) |
AU (1) | AU778694B2 (de) |
BR (1) | BRPI0012915B1 (de) |
CA (1) | CA2380116C (de) |
DE (2) | DE60020753T2 (de) |
DK (2) | DK1200386T3 (de) |
ES (2) | ES2208390T3 (de) |
HU (1) | HU227109B1 (de) |
IL (1) | IL147639A0 (de) |
IT (1) | IT1313596B1 (de) |
MX (1) | MXPA02001256A (de) |
NO (1) | NO327669B1 (de) |
PL (1) | PL200165B1 (de) |
PT (2) | PT1200386E (de) |
RU (1) | RU2248348C2 (de) |
TR (1) | TR200200290T2 (de) |
WO (1) | WO2001010814A1 (de) |
ZA (2) | ZA200200478B (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2348741C (en) | 1998-10-30 | 2010-04-20 | Nitromed Inc. | Nitrosasted and nitrosylated nonsteroidal antiinflammatory compounds, comositions and methods of use |
CA2432642A1 (en) | 2000-12-21 | 2002-08-08 | Subhash P. Khanapure | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use |
US20050234123A1 (en) * | 2001-11-27 | 2005-10-20 | Aldo Belli | Process |
US7220749B2 (en) | 2002-06-11 | 2007-05-22 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
US7163958B2 (en) | 2002-07-03 | 2007-01-16 | Nitromed Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
AU2003261281A1 (en) | 2002-07-29 | 2004-02-16 | Nicox S.A. | Cyclooxygenase- 2 selective inhibitors, compositions and methods of use |
ITMI20021861A1 (it) * | 2002-08-29 | 2004-02-29 | Nicox Sa | Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione. |
ITMI20022409A1 (it) * | 2002-11-14 | 2004-05-15 | Dinamite Dipharma S P A | Procedimento per la purificazione di 1, 4-butandiolo mononitrato. |
CA2641816C (en) * | 2006-02-03 | 2016-01-05 | Nicox S.A. | Use of nitrooxyderivative of drug for the treatment of muscular dystrophies |
CN100427475C (zh) * | 2006-11-30 | 2008-10-22 | 华南理工大学 | 萘普生-2-芳基吗啉乙酯及其制备方法与应用 |
EP2170803A1 (de) * | 2007-06-28 | 2010-04-07 | Nicox S.A. | Verfahren zur herstellung von 1,4-butandiolmononitrat |
WO2009149053A2 (en) * | 2008-06-02 | 2009-12-10 | Dr. Reddy's Laboratories Ltd. | Naproxcinod process and solid dispersion |
ITRM20080325A1 (it) * | 2008-06-20 | 2009-12-21 | Nicox Sa | Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato |
TW201139337A (en) | 2010-03-31 | 2011-11-16 | Lonza Ag | Process for the production of esters of nitric acid |
TWI417276B (zh) | 2011-03-01 | 2013-12-01 | Everlight Chem Ind Corp | 2-(s)-(6-甲氧基-2-萘基)-丙酸之酸酐衍生物、其製法暨及其用途 |
CA2897571C (en) | 2013-01-21 | 2018-12-18 | Apparao Satyam | Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group |
EP4103171A1 (de) | 2020-02-10 | 2022-12-21 | Nicox S.A. | Verfahren zur behandlung von vasookklusiven krisen in verbindung mit sichelzellanämie |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57145841A (en) * | 1981-03-05 | 1982-09-09 | Nissan Chem Ind Ltd | L-menthyl naphthylpropionate and its preparation |
IT1243367B (it) | 1990-07-26 | 1994-06-10 | Italfarmaco Spa | Derivati acidi benzoici sostituiti ad attivita' cardiovascolare |
ATE168986T1 (de) * | 1993-10-06 | 1998-08-15 | Nicox Sa | Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung |
WO1995030641A1 (en) | 1994-05-10 | 1995-11-16 | Nicox S.A. | Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities |
US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
CN1144092A (zh) * | 1995-08-25 | 1997-03-05 | 蔡雄 | 可释放一氧化氮的新型非类固醇类抗炎药、它们的制备方法和用途 |
WO1997013519A1 (en) * | 1995-10-09 | 1997-04-17 | Russinsky Limited | Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products |
IT1276071B1 (it) * | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
FR2757159B1 (fr) | 1996-12-12 | 1999-12-17 | Hoechst Marion Roussel Inc | Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments |
-
1999
- 1999-08-04 IT IT1999MI001753A patent/IT1313596B1/it active
-
2000
- 2000-07-27 US US10/031,412 patent/US6700011B1/en not_active Expired - Lifetime
- 2000-07-27 TR TR2002/00290T patent/TR200200290T2/xx unknown
- 2000-07-27 DK DK00951456T patent/DK1200386T3/da active
- 2000-07-27 DE DE60020753T patent/DE60020753T2/de not_active Expired - Lifetime
- 2000-07-27 RU RU2002102860/04A patent/RU2248348C2/ru active
- 2000-07-27 DE DE60005682T patent/DE60005682T2/de not_active Expired - Lifetime
- 2000-07-27 DK DK03102132T patent/DK1384707T3/da active
- 2000-07-27 EP EP03102132A patent/EP1384707B1/de not_active Expired - Lifetime
- 2000-07-27 ES ES00951456T patent/ES2208390T3/es not_active Expired - Lifetime
- 2000-07-27 CN CNB008111588A patent/CN1198786C/zh not_active Expired - Fee Related
- 2000-07-27 KR KR1020027000946A patent/KR100687820B1/ko not_active IP Right Cessation
- 2000-07-27 AT AT00951456T patent/ATE251109T1/de active
- 2000-07-27 PT PT00951456T patent/PT1200386E/pt unknown
- 2000-07-27 MX MXPA02001256A patent/MXPA02001256A/es active IP Right Grant
- 2000-07-27 ES ES03102132T patent/ES2243859T3/es not_active Expired - Lifetime
- 2000-07-27 JP JP2001515282A patent/JP4667691B2/ja not_active Expired - Lifetime
- 2000-07-27 AT AT03102132T patent/ATE297372T1/de active
- 2000-07-27 PL PL353092A patent/PL200165B1/pl unknown
- 2000-07-27 AU AU64385/00A patent/AU778694B2/en not_active Ceased
- 2000-07-27 IL IL14763900A patent/IL147639A0/xx not_active IP Right Cessation
- 2000-07-27 WO PCT/EP2000/007222 patent/WO2001010814A1/en active IP Right Grant
- 2000-07-27 PT PT03102132T patent/PT1384707E/pt unknown
- 2000-07-27 CA CA2380116A patent/CA2380116C/en not_active Expired - Lifetime
- 2000-07-27 HU HU0202435A patent/HU227109B1/hu not_active IP Right Cessation
- 2000-07-27 BR BRPI0012915-1A patent/BRPI0012915B1/pt not_active IP Right Cessation
- 2000-07-27 EP EP00951456A patent/EP1200386B1/de not_active Expired - Lifetime
-
2002
- 2002-01-18 ZA ZA200200478A patent/ZA200200478B/en unknown
- 2002-02-01 NO NO20020515A patent/NO327669B1/no not_active IP Right Cessation
-
2003
- 2003-06-10 ZA ZA200304525A patent/ZA200304525B/xx unknown
- 2003-07-24 US US10/625,558 patent/US7238829B2/en not_active Expired - Lifetime
-
2010
- 2010-11-30 JP JP2010266860A patent/JP2011042690A/ja active Pending
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Legal Events
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